Phlpp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phlpp1
Entrez Gene ID	59265
Full Name	PH domain and leucine rich repeat protein phosphatase 1
Synonyms	Phlpp,Plekhe1,Scop
General protein information	Preferred Names PH domain and leucine rich repeat protein phosphatase 1 Names PH domain leucine-rich repeat protein phosphatase 1 Circadian Oscillatory Protein (SCOP) PH domain leucine-rich repeat-containing protein phosphatase 1 PH domain-containing family E member 1 SCN circadian oscillatory protein pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 pleckstrin homology domain-containing family E member 1 pleckstrin homology domain-containing family E protein 1 suprachiasmatic nucleus circadian oscillatory protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13p11
Summary	a circadian rhythm protein; may have a role in the intracellular signaling in the suprachiasmatic nucleus [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021657.1	NP_067689.1	PH domain leucine-rich repeat protein phosphatase 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PHLPP1	XP_523952.2
Rattus norvegicus (Norway rat)	Phlpp1	NP_067689.1
Mus musculus (house mouse)	Phlpp1	NP_598582.3
Canis lupus familiaris (dog)	PHLPP1	XP_005615724.1
Bos taurus (cattle)	PHLPP1	XP_002707832.2
Xenopus tropicalis (tropical clawed frog)	LOC100497530	XP_004915365.1
Homo sapiens (human)	PHLPP1	NP_919431.2
	PHLPP1	XP_001094216.1
Gallus gallus (chicken)	PHLPP1	XP_418990.4

Gene Ontology
Bibliography

Related articles in PubMed

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Li X, Stevens PD, Liu J, Yang H, Wang W, Wang C, Zeng Z, Schmidt MD, Yang M, Lee EY, Gao T
Gastroenterology146(5)1301-12.e1-10(2014 May)

Signaling specificity in the Akt pathway in biology and disease.
Toker A, Marmiroli S
Advances in biological regulation5528-38(2014 May)

PHLiPPing the switch on Akt and protein kinase C signaling.
Brognard J, Newton AC
Trends in endocrinology and metabolism: TEM19(6)223-30(2008 Aug)

A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer.
Hellwinkel OJ, Rogmann JP, Asong LE, Luebke AM, Eichelberg C, Ahyai S, Isbarn H, Graefen M, Huland H, Schlomm T
BJU international101(11)1454-60(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rapid SCOP breakdown is necessary for memory encoding. Early SCOP degradation is specifically catalysed by mu-calpain, whereas late SCOP resynthesis is mediated by m-calpain.
Title: A molecular brake controls the magnitude of long-term potentiation.

Splice variant PHLPP1alpha inhibits protein kinase B (AKT) in hippocampal neurons; in a novel role, splice variant PHLPP1beta promotes AKT activation.
Title: PHLPP1 splice variants differentially regulate AKT and PKC? signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.

SCOP bound through its LRR domain with a subset of K-ras in the raft fraction, interfering with the binding of added guanine nucleotide to K-Ras.
Title: Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway.

The following Phlpp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phlpp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04965	NM_021657.1 Latest version!	Rattus norvegicus PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$1497.30 $2139.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phlpp1 ( NM_021657.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067689.1 Rattus norvegicus PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), mRNA.

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CloneID	ORa04965
Clone ID Related Accession (Same CDS sequence)	NM_021657.1
Accession Version	NM_021657.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	PH domain leucine-rich repeat protein phosphatase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB023624.1. On Jun 25, 2006 this sequence version replaced XM_001063791.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AB023624.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCG CCGCCGCAGC CCCGGCACAG CGACTCGCGG ACCCCACGGG TGAGGACCGA 
GCCCCGGCGG CGGCGGCGGC GGCCGAGGGC GGACGGAGTC CGGATTCTGT GCTGAGCGCG 
GCGGCCCCGA GCGGCGGGAA CGGCGGCGCG GCGCGAGAGG AGGCCCCCTG CGAGGCGCCG 
CCGGGGCCGC TGCCCGGCCG CGCGGGAGGC ACCGGACGCA GGCGTCGGCG CGGGGTGCCC 
CAGCCCGCGG CCGGCGGGGC CGCCCCGGTG ACCGCGGCCG GCGGCGGCGC CAACTCGCTG 
CTGCTGAGGA GAGGGCGGCT GAAGAGGAAT CTGTCGGCCG CCGCTTCGTC GTCCTCATCG 
CCGTCCTCGG CGTCTTCGGC CGCTGGCGGC CTCCCGGCGT CCTGCTCGGC CTCGGCGTCG 
CTGTGCACCC GGAGTCTGGA CAGGAAGACG CTGCTCCAGA AGCACCGGCA GCTGCTTCAG 
CTGCAGCCGT CGGACCGGGA CTGGGTGAGG CACCAGCTCC AGCGGGGCTG TGTGCACGTC 
TTTGACCGCC ACATGGCCTC GTCCTACCTG CGCCCAGTGC TCTGCACGCT GGACACCACA 
GCCGCCGAGG TGGCCGCCCG GCTTCTGCAG CTGGGCCACA AAGGCGGCGG GGTGGTGAAG 
GTGCTGGGCC ACGGGCCACC TCCGGCCGCT GCCCCGGCCG CCAGCGATCA GACCCCGGCC 
ACAGAGCTCG GAAGAGACGT GGAGCCACCG CCCTCGAGCA GCACGGTCGG TGCTGTCCGG 
GGCCCTGCGC GCGCGCCTCC TGCCGATCTG CCGCTGCCCG GGGGCGCCTG GACGCGCTGT 
GCACCTCGGG TCAACCCTGC GCCCTCGGAC TCCAGCCCCG GAGAGCTGTT CGCGGGCGGC 
CCCTGTTCCC CGTCCCGCGC CCCGCGCCCG GCCTCCGACA CCGAGAGCTT CAGCCTGAGC 
CCCAGCGCCG AGAGCGTGTC AGACCGGCTG GACCCCTATA GCAGCGGCGG CGGCTCCTCC 
TCTTCGTCCG AGGAACTAGA AGCTGACCCG GCCACGGTCT TGACGGGGCC TTCCGGGCCG 
CCCCACCACC CAGTCCGCTC CTCACAGCCT CGACCGCCTT CCCCGAAGAC CTCGGCGTTA 
CTGCAGCCGA AAGCCCCGAC GGGCGTAGAC GGCACTGGCC TAGTGGTGGG CGAAGGTCCC 
GGAGACGACA AGGCGGTGGC AGCTGCAGCT CCAGGCGTTC CTCTGTGGAC TCCAGGGAGG 
ATCCGGGAGA CCGTGCAAAA GACGTCTTCT CCGCCCTCCC TGTATGTACA GCTCCATGGG 
GAGACTACCC GGCGCCTGGA GGCGGACGAG AAGCCATTGC AGATCCAAAA TGACTACCTC 
TTCCAACTGG GATTTGGGGA GCTGTGGAGG GTGCAGGAGG AAGGCATGGA TTCGGAGATT 
GGCTGCCTCA TCCGATTCTA TGCAGGAAAG CCTCATAGCA CTGGGAGCTC TGAGCGGATT 
CAGCTCTCGG GAATGTACAA TGTCCGAAAA GGCAAAATGC AGTTGCCAGT GAACAGATGG 
ACAAGACGCC AGGTCATTCT GTGTGGGACG TGCTTGATAG TGTCGTCTGT GAAAGACAGC 
TCGAGTGGGA AGATGCACGT TCTGCCTCTC ATTGGTGGAA AAGTGGAAGA AGTGAAAAAG 
CACCAGCACT GTCTAGCGTT CAGCTCTTCC GGGCCCCAGA GCCAGACTTA CTACATCTGC 
TTCGATACTT TCACGGAGTA CTTACGATGG CTGCGTCAAG TCTCCAAGGT TGCATCACAA 
CGCATAAGCT CAGTAGACCT CTCATGTTGT AGCCTTGAGC ATCTGCCTGC CAACCTCTTT 
TACAGCCAAG ACCTTACTCA TCTCAATTTA AAACAGAACT TCCTAAGGCA GAACCCCAGC 
CTCCCAGCTG CCAGAGGACT TGGTGAACTG CAGAGATTCA CCAAATTGAA GAGCCTTAAC 
CTTTCCAATA ACCACCTAGG AGCCTTTCCG TCAGCAGTCT GCAGCATCCC AACCCTGGCA 
GAGCTGAATG TGTCTTGCAA TGCCCTGCAA GAAGTCCCAG CAGCTGTTGG AGCTATGCAG 
AACTTACAGA CGTTCTTGCT GGATGGAAAT TTTCTCCAGT CCCTTCCTGC TGAGTTGGAG 
AACATGCACC AGCTCAGCTA TTTGGGTCTT TCCTTTAATG AATTCACTGA CATTCCAGAG 
GTATTGGAGA AGCTGACTGC TGTGGATAAA CTGTGCATGG CTGGGAACTG TATGGAGACC 
CTTAGACTAC AGGCCTTAAG AAGGATGCCT CATATTAAAC ACGTGGACCT AAGACTGAAC 
ATACTCAGAA AGCTTATAAC AGATGAAGTG GACTTTCTGC AACATGTCAC TCAGCTTGAC 
CTGCGAGACA ATAAACTTGG TGATCTAGAT GCTATGATCT TCAACAACAT AGAAGTTCTG 
CACTGCGAGA GGAATCAGCT GGTGACACTG AACATTTGTG GCTATTTCCT AAAAGCACTC 
TATGCTTCTT CTAACGAACT CGTTCAACTT GATGTCTACC CAGTTCCAAA TTATCTATCG 
TACATGGATG TCTCAAGAAA CTGCCTAGAA AGTGTGCCTG AGTGGGTATG TGAAAGCCGG 
AAGTTAGAAG TTTTGGATAT TGGCCATAAT CAAATATGTG AACTTCCTGC CCGCTTATTT 
TGTAATAGTA GTCTCCGGAA ATTGCTGGCA GGACACAACC GGTTGGCAAG GCTTCCTGAA 
AGGCTGGAGA GAACATCAGT GGAGGTCTTG GACGTACAGC ATAACCAGAT CATTGAGCTC 
CCACCAAACC TTCTCATGAA GGCTGACAGC CTGAGATTCC TCAATGCGTC CGCAAACAAA 
CTGGAAACCC TGCCTCCAGC CACACTTTCT GAGGAGACAA GCAGTATATT ACAGGAGTTG 
TACTTGACAA ACAACAGCCT CACTGATAAG TGTGTGCCCT TGTTAACAGG GCACCCCCGC 
CTGAAGATCC TACACATGGC TTATAACCGG CTTCAGAGCT TCCCAGCAAG TAAAATGGCG 
AAACTGGAGG AGCTTGAAGA AATCGATATC AGTGGGAATA AGCTGAAAGC CATCCCAACA 
ACCATCATGA ACTGCAGGCG CATGCACACG GTGATTGCTC ACTCGAACTG CATCGAAGTC 
TTTCCTGAAG TCATGCAGCT CCCAGAAGTC AAGTGTGTAG ATCTGAGCTG TAATGAGCTG 
AGTGAAATCA CCCTACCAGA AAACCTGCCA CCTAAACTGC AGGAACTAGA TCTGACCGGA 
AACCCACGCC TTGCCCTGGA CCACAAAAGC TTGGAGCTGC TCAATAACAT CCGCTGTTTC 
AAGATTGACC AGCCGTCAGC TGGAGATGCA TCTGGAGCCC CAGCAGTATG GAGTCATGGT 
TACACTGAAG CATCGGGAGT AAAAAACAAG CTGTGTGTCG CAGCCCTGTC TGTGAATAAC 
TTCCGTGACA ACCGAGAGGC TCTCTACGGT GTGTTTGATG GAGACCGGAA TGTGGAAGTG 
CCCTACCTTC TCCAGTGCAC CATGAGTGAC ATCTTAGCTG AGGAGCTTCA GAAAACAAAA 
AATGAAGAAG AATACATGGT CAATACATTT ATAGTCATGC AAAGGAAACT GGGAACGGCT 
GGGCAGAAAC TCGGTGGTGC TGCTGTCCTG TGTCACATCA GGCATGACCC TGTGGACCTG 
GGAGGATCCT TTACCCTGAC CTCTGCTAAT GTTGGCAAGT GCCAAACGGT TCTCTGTCGA 
AACGGGAAGC CGCTGTCTCT GTCCAGGTCC TATACCATGA GCTGTGAAGA AGAGCGGAAG 
AGGATTAAGC AGCACAAAGC CATCATCACT GAGGATGGCA AGGTCAATGG AGTGACAGAG 
TCCACACGCA TCCTGGGCTA CACCTTCCTT CACCCCAGTG TGGTGCCTCG CCCCCACGTA 
CAGTCGGTGC TTCTGACTCC ACAGGATGAG TTTTTCATCC TGGGCAGCAA AGGGCTGTGG 
GACAGCCTGT CCATCGAAGA GGCTGTGGAA GCCGTGCGCA ACGTTCCAGA TGCTCTAGCC 
GCCGCCAAGA AGCTATGCAC CCTGGCCCAG AGCTACGGCT GCCACGACAG CATCAGTGCT 
GTGGTGGTGC AACTCAGTGT CACGGAAGAC AGCTTCTGCT GCTGTGAGCT CAGTGTGGGA 
GGAAGCATGC CACCGCCCAG TCCCGGAATC TTCCCGCCCT CCGTCAGCAT GGTGATCAAG 
GACCGGCCCT CAGATGGGCT GGGCGTGCCG TCCTCCAGCA GCGGCATGGC ATCTGAGATC 
AGCAGTGAAT TGTCTACCTC TGAGATGAGT AGTGAGGTGG GCTCCACAGC TTCTGACGAG 
CCGCCGTCGG GAGCCCTGAG TGAGAGCAGC CCCGCCTACC CCAGCGAGCA GCGCTGCATG 
CTCCACCCGG TCTGCCTGTC CAACTCCTTC CAGCGCCAGC TGTCCAGCGC CACTTTCTCC 
AGTGCGTTCT CTGACAACGG CCTTGACAGT GATGACGAGG AACCCATTGA GGGCGTGTTC 
AGCAACGGCA GCCGGGTGGA GGTGGAAGTG GACATCCATT GCAGCCGGGC CAAGGAGAAG 
GAGAGACAGC AGCACCTGCT TCAGGTACCA GCTGAAGCCA GTGATGAGGG CATTGTCATC 
AGTGCCAATG AGGATGAGTC AGGTCTGTCC AAGAAGACAG ACATTTCTGC TGTGGGGACC 
ATTGGGCGAC GCAGGGCTAA CGGCTCTGTA CCTCCCCAGG AAAGGAGCCA TAATGTAATA 
GAGGTTGCCA CAGATGCACC TCTCCGGAAG CCGGGAGGCT ATTTTGCAGC CCCTGCTCAA 
CCAGATCCAG ATGATCAGTT TATCATCCCC CCAGAGCTGG AAGAGGAAGT CAAAGAAATC 
ATGAAACATC ACCAGGAGCA GCAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCCACCAC CTCCACCCCA GCCGCCACAG GCACAGGCAC AGGCACAGGC ACAGGCACAG 
AGGCCCTTCC AGATGGATCA CCTGCCGGAC TGTTACGACA CACCACTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067689.1
CDS	255..5345
Translation	MEPAAAAPAQRLADPTGEDRAPAAAAAAEGGRSPDSVLSAAAPSGGNGGAAREEAPCEAPPGPLPGRAGGTGRRRRRGVPQPAAGGAAPVTAAGGGANSLLLRRGRLKRNLSAAASSSSSPSSASSAAGGLPASCSASASLCTRSLDRKTLLQKHRQLLQLQPSDRDWVRHQLQRGCVHVFDRHMASSYLRPVLCTLDTTAAEVAARLLQLGHKGGGVVKVLGHGPPPAAAPAASDQTPATELGRDVEPPPSSSTVGAVRGPARAPPADLPLPGGAWTRCAPRVNPAPSDSSPGELFAGGPCSPSRAPRPASDTESFSLSPSAESVSDRLDPYSSGGGSSSSSEELEADPATVLTGPSGPPHHPVRSSQPRPPSPKTSALLQPKAPTGVDGTGLVVGEGPGDDKAVAAAAPGVPLWTPGRIRETVQKTSSPPSLYVQLHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSSSGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLGELQRFTKLKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALQEVPAAVGAMQNLQTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKALYASSNELVQLDVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEVLDVQHNQIIELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNSLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEVKCVDLSCNELSEITLPENLPPKLQELDLTGNPRLALDHKSLELLNNIRCFKIDQPSAGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFRDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIRHDPVDLGGSFTLTSANVGKCQTVLCRNGKPLSLSRSYTMSCEEERKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSVGGSMPPPSPGIFPPSVSMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPSGALSESSPAYPSEQRCMLHPVCLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFSNGSRVEVEVDIHCSRAKEKERQQHLLQVPAEASDEGIVISANEDESGLSKKTDISAVGTIGRRRANGSVPPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQQQQQQQQQQPPPPPQPPQAQAQAQAQAQRPFQMDHLPDCYDTPL

Target ORF information:

RefSeq Version	NM_021657.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021657.1

ORF Insert Sequence:

ATGGAGCCCG CCGCCGCAGC CCCGGCACAG CGACTCGCGG ACCCCACGGG TGAGGACCGA 
GCCCCGGCGG CGGCGGCGGC GGCCGAGGGC GGACGGAGTC CGGATTCTGT GCTGAGCGCG 
GCGGCCCCGA GCGGCGGGAA CGGCGGCGCG GCGCGAGAGG AGGCCCCCTG CGAGGCGCCG 
CCGGGGCCGC TGCCCGGCCG CGCGGGAGGC ACCGGACGCA GGCGTCGGCG CGGGGTGCCC 
CAGCCCGCGG CCGGCGGGGC CGCCCCGGTG ACCGCGGCCG GCGGCGGCGC CAACTCGCTG 
CTGCTGAGGA GAGGGCGGCT GAAGAGGAAT CTGTCGGCCG CCGCTTCGTC GTCCTCATCG 
CCGTCCTCGG CGTCTTCGGC CGCTGGCGGC CTCCCGGCGT CCTGCTCGGC CTCGGCGTCG 
CTGTGCACCC GGAGTCTGGA CAGGAAGACG CTGCTCCAGA AGCACCGGCA GCTGCTTCAG 
CTGCAGCCGT CGGACCGGGA CTGGGTGAGG CACCAGCTCC AGCGGGGCTG TGTGCACGTC 
TTTGACCGCC ACATGGCCTC GTCCTACCTG CGCCCAGTGC TCTGCACGCT GGACACCACA 
GCCGCCGAGG TGGCCGCCCG GCTTCTGCAG CTGGGCCACA AAGGCGGCGG GGTGGTGAAG 
GTGCTGGGCC ACGGGCCACC TCCGGCCGCT GCCCCGGCCG CCAGCGATCA GACCCCGGCC 
ACAGAGCTCG GAAGAGACGT GGAGCCACCG CCCTCGAGCA GCACGGTCGG TGCTGTCCGG 
GGCCCTGCGC GCGCGCCTCC TGCCGATCTG CCGCTGCCCG GGGGCGCCTG GACGCGCTGT 
GCACCTCGGG TCAACCCTGC GCCCTCGGAC TCCAGCCCCG GAGAGCTGTT CGCGGGCGGC 
CCCTGTTCCC CGTCCCGCGC CCCGCGCCCG GCCTCCGACA CCGAGAGCTT CAGCCTGAGC 
CCCAGCGCCG AGAGCGTGTC AGACCGGCTG GACCCCTATA GCAGCGGCGG CGGCTCCTCC 
TCTTCGTCCG AGGAACTAGA AGCTGACCCG GCCACGGTCT TGACGGGGCC TTCCGGGCCG 
CCCCACCACC CAGTCCGCTC CTCACAGCCT CGACCGCCTT CCCCGAAGAC CTCGGCGTTA 
CTGCAGCCGA AAGCCCCGAC GGGCGTAGAC GGCACTGGCC TAGTGGTGGG CGAAGGTCCC 
GGAGACGACA AGGCGGTGGC AGCTGCAGCT CCAGGCGTTC CTCTGTGGAC TCCAGGGAGG 
ATCCGGGAGA CCGTGCAAAA GACGTCTTCT CCGCCCTCCC TGTATGTACA GCTCCATGGG 
GAGACTACCC GGCGCCTGGA GGCGGACGAG AAGCCATTGC AGATCCAAAA TGACTACCTC 
TTCCAACTGG GATTTGGGGA GCTGTGGAGG GTGCAGGAGG AAGGCATGGA TTCGGAGATT 
GGCTGCCTCA TCCGATTCTA TGCAGGAAAG CCTCATAGCA CTGGGAGCTC TGAGCGGATT 
CAGCTCTCGG GAATGTACAA TGTCCGAAAA GGCAAAATGC AGTTGCCAGT GAACAGATGG 
ACAAGACGCC AGGTCATTCT GTGTGGGACG TGCTTGATAG TGTCGTCTGT GAAAGACAGC 
TCGAGTGGGA AGATGCACGT TCTGCCTCTC ATTGGTGGAA AAGTGGAAGA AGTGAAAAAG 
CACCAGCACT GTCTAGCGTT CAGCTCTTCC GGGCCCCAGA GCCAGACTTA CTACATCTGC 
TTCGATACTT TCACGGAGTA CTTACGATGG CTGCGTCAAG TCTCCAAGGT TGCATCACAA 
CGCATAAGCT CAGTAGACCT CTCATGTTGT AGCCTTGAGC ATCTGCCTGC CAACCTCTTT 
TACAGCCAAG ACCTTACTCA TCTCAATTTA AAACAGAACT TCCTAAGGCA GAACCCCAGC 
CTCCCAGCTG CCAGAGGACT TGGTGAACTG CAGAGATTCA CCAAATTGAA GAGCCTTAAC 
CTTTCCAATA ACCACCTAGG AGCCTTTCCG TCAGCAGTCT GCAGCATCCC AACCCTGGCA 
GAGCTGAATG TGTCTTGCAA TGCCCTGCAA GAAGTCCCAG CAGCTGTTGG AGCTATGCAG 
AACTTACAGA CGTTCTTGCT GGATGGAAAT TTTCTCCAGT CCCTTCCTGC TGAGTTGGAG 
AACATGCACC AGCTCAGCTA TTTGGGTCTT TCCTTTAATG AATTCACTGA CATTCCAGAG 
GTATTGGAGA AGCTGACTGC TGTGGATAAA CTGTGCATGG CTGGGAACTG TATGGAGACC 
CTTAGACTAC AGGCCTTAAG AAGGATGCCT CATATTAAAC ACGTGGACCT AAGACTGAAC 
ATACTCAGAA AGCTTATAAC AGATGAAGTG GACTTTCTGC AACATGTCAC TCAGCTTGAC 
CTGCGAGACA ATAAACTTGG TGATCTAGAT GCTATGATCT TCAACAACAT AGAAGTTCTG 
CACTGCGAGA GGAATCAGCT GGTGACACTG AACATTTGTG GCTATTTCCT AAAAGCACTC 
TATGCTTCTT CTAACGAACT CGTTCAACTT GATGTCTACC CAGTTCCAAA TTATCTATCG 
TACATGGATG TCTCAAGAAA CTGCCTAGAA AGTGTGCCTG AGTGGGTATG TGAAAGCCGG 
AAGTTAGAAG TTTTGGATAT TGGCCATAAT CAAATATGTG AACTTCCTGC CCGCTTATTT 
TGTAATAGTA GTCTCCGGAA ATTGCTGGCA GGACACAACC GGTTGGCAAG GCTTCCTGAA 
AGGCTGGAGA GAACATCAGT GGAGGTCTTG GACGTACAGC ATAACCAGAT CATTGAGCTC 
CCACCAAACC TTCTCATGAA GGCTGACAGC CTGAGATTCC TCAATGCGTC CGCAAACAAA 
CTGGAAACCC TGCCTCCAGC CACACTTTCT GAGGAGACAA GCAGTATATT ACAGGAGTTG 
TACTTGACAA ACAACAGCCT CACTGATAAG TGTGTGCCCT TGTTAACAGG GCACCCCCGC 
CTGAAGATCC TACACATGGC TTATAACCGG CTTCAGAGCT TCCCAGCAAG TAAAATGGCG 
AAACTGGAGG AGCTTGAAGA AATCGATATC AGTGGGAATA AGCTGAAAGC CATCCCAACA 
ACCATCATGA ACTGCAGGCG CATGCACACG GTGATTGCTC ACTCGAACTG CATCGAAGTC 
TTTCCTGAAG TCATGCAGCT CCCAGAAGTC AAGTGTGTAG ATCTGAGCTG TAATGAGCTG 
AGTGAAATCA CCCTACCAGA AAACCTGCCA CCTAAACTGC AGGAACTAGA TCTGACCGGA 
AACCCACGCC TTGCCCTGGA CCACAAAAGC TTGGAGCTGC TCAATAACAT CCGCTGTTTC 
AAGATTGACC AGCCGTCAGC TGGAGATGCA TCTGGAGCCC CAGCAGTATG GAGTCATGGT 
TACACTGAAG CATCGGGAGT AAAAAACAAG CTGTGTGTCG CAGCCCTGTC TGTGAATAAC 
TTCCGTGACA ACCGAGAGGC TCTCTACGGT GTGTTTGATG GAGACCGGAA TGTGGAAGTG 
CCCTACCTTC TCCAGTGCAC CATGAGTGAC ATCTTAGCTG AGGAGCTTCA GAAAACAAAA 
AATGAAGAAG AATACATGGT CAATACATTT ATAGTCATGC AAAGGAAACT GGGAACGGCT 
GGGCAGAAAC TCGGTGGTGC TGCTGTCCTG TGTCACATCA GGCATGACCC TGTGGACCTG 
GGAGGATCCT TTACCCTGAC CTCTGCTAAT GTTGGCAAGT GCCAAACGGT TCTCTGTCGA 
AACGGGAAGC CGCTGTCTCT GTCCAGGTCC TATACCATGA GCTGTGAAGA AGAGCGGAAG 
AGGATTAAGC AGCACAAAGC CATCATCACT GAGGATGGCA AGGTCAATGG AGTGACAGAG 
TCCACACGCA TCCTGGGCTA CACCTTCCTT CACCCCAGTG TGGTGCCTCG CCCCCACGTA 
CAGTCGGTGC TTCTGACTCC ACAGGATGAG TTTTTCATCC TGGGCAGCAA AGGGCTGTGG 
GACAGCCTGT CCATCGAAGA GGCTGTGGAA GCCGTGCGCA ACGTTCCAGA TGCTCTAGCC 
GCCGCCAAGA AGCTATGCAC CCTGGCCCAG AGCTACGGCT GCCACGACAG CATCAGTGCT 
GTGGTGGTGC AACTCAGTGT CACGGAAGAC AGCTTCTGCT GCTGTGAGCT CAGTGTGGGA 
GGAAGCATGC CACCGCCCAG TCCCGGAATC TTCCCGCCCT CCGTCAGCAT GGTGATCAAG 
GACCGGCCCT CAGATGGGCT GGGCGTGCCG TCCTCCAGCA GCGGCATGGC ATCTGAGATC 
AGCAGTGAAT TGTCTACCTC TGAGATGAGT AGTGAGGTGG GCTCCACAGC TTCTGACGAG 
CCGCCGTCGG GAGCCCTGAG TGAGAGCAGC CCCGCCTACC CCAGCGAGCA GCGCTGCATG 
CTCCACCCGG TCTGCCTGTC CAACTCCTTC CAGCGCCAGC TGTCCAGCGC CACTTTCTCC 
AGTGCGTTCT CTGACAACGG CCTTGACAGT GATGACGAGG AACCCATTGA GGGCGTGTTC 
AGCAACGGCA GCCGGGTGGA GGTGGAAGTG GACATCCATT GCAGCCGGGC CAAGGAGAAG 
GAGAGACAGC AGCACCTGCT TCAGGTACCA GCTGAAGCCA GTGATGAGGG CATTGTCATC 
AGTGCCAATG AGGATGAGTC AGGTCTGTCC AAGAAGACAG ACATTTCTGC TGTGGGGACC 
ATTGGGCGAC GCAGGGCTAA CGGCTCTGTA CCTCCCCAGG AAAGGAGCCA TAATGTAATA 
GAGGTTGCCA CAGATGCACC TCTCCGGAAG CCGGGAGGCT ATTTTGCAGC CCCTGCTCAA 
CCAGATCCAG ATGATCAGTT TATCATCCCC CCAGAGCTGG AAGAGGAAGT CAAAGAAATC 
ATGAAACATC ACCAGGAGCA GCAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCCACCAC CTCCACCCCA GCCGCCACAG GCACAGGCAC AGGCACAGGC ACAGGCACAG 
AGGCCCTTCC AGATGGATCA CCTGCCGGAC TGTTACGACA CACCACTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Gastroenterology146(5)1301-12.e1-10(2014 May)
Li X,Stevens PD,Liu J,Yang H,Wang W,Wang C,Zeng Z,Schmidt MD,Yang M,Lee EY,Gao T

Signaling specificity in the Akt pathway in biology and disease.
Advances in biological regulation5528-38(2014 May)
Toker A,Marmiroli S

PHLiPPing the switch on Akt and protein kinase C signaling.
Trends in endocrinology and metabolism: TEM19(6)223-30(2008 Aug)
Brognard J,Newton AC

A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer.
BJU international101(11)1454-60(2008 Jun)
Hellwinkel OJ,Rogmann JP,Asong LE,Luebke AM,Eichelberg C,Ahyai S,Isbarn H,Graefen M,Huland H,Schlomm T

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Phlpp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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