Slc9a3r1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc9a3r1
Entrez Gene ID	59114
Full Name	SLC9A3 regulator 1
General protein information	Preferred Names SLC9A3 regulator 1 Names Na(+)/H(+) exchange regulatory cofactor NHE-RF1 EBP50 ERM-binding phosphoprotein NHERF-1 ezrin-radixin-moesin-binding phosphoprotein 50 regulatory cofactor of Na(+)/H(+) exchanger sodium-hydrogen exchanger regulatory factor 1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 solute carrier family 9 isoform A3 regulatory factor 1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	a membrane-cytoskeleton linking protein thought to be involved in sequestering and regulating the activity of integral membrane proteins, and in modulating membrane protein trafficking [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021594.1	NP_067605.1	Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Slc9a3r1	NP_036160.1
Danio rerio (zebrafish)	slc9a3r1	NP_997872.1
	SLC9A3R1	XP_001092275.2
Rattus norvegicus (Norway rat)	Slc9a3r1	NP_067605.1
Xenopus tropicalis (tropical clawed frog)	slc9a3r1	NP_001006751.1
Pan troglodytes (chimpanzee)	SLC9A3R1	XP_511663.2
Danio rerio (zebrafish)	LOC100329719	XP_005174596.1
Homo sapiens (human)	SLC9A3R1	NP_004243.1
Canis lupus familiaris (dog)	SLC9A3R1	XP_540418.4
Gallus gallus (chicken)	SLC9A3R1	NP_001006424.1
Bos taurus (cattle)	SLC9A3R1	NP_001071320.1

Gene Ontology
Bibliography

Related articles in PubMed

NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation.
Lu X, He L, Zhou Q, Wang M, Shen WJ, Azhar S, Pan F, Guo Z, Hu Z
Biochemical and biophysical research communications490(4)1168-1175(2017 09)

Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.
Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ
American journal of physiology. Cell physiology313(2)C197-C206(2017 Aug)

Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase expression in the kidney.
Briffa JF, Grinfeld E, Jenkin KA, Mathai ML, Poronnik P, McAinch AJ, Hryciw DH
Clinical and experimental pharmacology & physiology42(10)1118-26(2015 Oct)

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.
Kamiya K, Michel V, Giraudet F, Riederer B, Foucher I, Papal S, Perfettini I, Le Gal S, Verpy E, Xia W, Seidler U, Georgescu MM, Avan P, El-Amraoui A, Petit C
Proceedings of the National Academy of Sciences of the United States of America111(25)9307-12(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway.
Title: NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation.

These results suggest that decreased renal NHERF-1 expression contributes to the impaired dopamine-mediated inhibition of NKA in PTCs from animal models of hypertension.
Title: Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.

data establish NHERF1 and NHERF2 as SR-BI protein binding partners that play a negative role in the regulation of SR-BI expression, selective CE transport, and steroidogenesis.
Title: Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs).

that NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation.
Title: NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli.

Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
Title: Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains.

The following Slc9a3r1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc9a3r1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13036	NM_021594.1 Latest version!	Rattus norvegicus SLC9A3 regulator 1 (Slc9a3r1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc9a3r1 ( NM_021594.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067605.1 Rattus norvegicus SLC9A3 regulator 1 (Slc9a3r1), mRNA.

Price & Availability↑

CloneID	ORa13036
Clone ID Related Accession (Same CDS sequence)	NM_021594.1
Accession Version	NM_021594.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF154336.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF154336.1, FQ213792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGCGG ACGCAGCGGC CGGGGAGCCT CTGCCCCGGC TCTGCTGCCT CGAGAAGGGT 
CCGAACGGCT ACGGCTTCCA CCTGCACGGG GAGAAAGGCA AGGTGGGCCA GTTTATTCGG 
CTAGTGGAGC CTGGCTCGCC GGCCGAGAAG TCGGGGTTGC TGGCCGGGGA CCGATTGGTG 
GAGGTGAACG GTGAGAATGT GGAGAAGGAG ACGCATCAGC AGGTGGTGAG CCGCATCCGC 
GCGGCGCTGA ACGCCGTGCG CCTGCTGGTG GTCGACCCTG AGACCGACGA GCAACTCAAG 
AAGCTGGGCG TCCCGATCCG GGAAGAGCTG CTGCGCGCCC AGGAGAAGTC CGAGCACACC 
GAGCCGCCAG CGGCCGCCGA CACTAAGAAG GCTGGGGACC AGAATGAGGC CGAAAAGAGC 
CACTTGGAGC GGTGTGAGCT CCGACCCCGG CTCTGCACCA TGAAGAAAGG CCCCAATGGT 
TATGGCTTCA ACCTGCACAG TGACAAATCC AAGCCAGGCC AGTTCATCCG AGCAGTGGAC 
CCGGACTCAC CAGCAGAGGC GTCTGGCCTC CGGGCCCAGG ACCGGATTGT GGAGGTCAAT 
GGCGTCTGCA TGGAGGGCAA ACAGCACGGG GACGTCGTGT CTGCCATCAA GGCTGGAGGT 
GATGAAGCCA AGCTGCTGGT GGTAGACAAG GAAACAGATG AGTTCTTTAA GAAGTGCAGA 
GTGACCCCGT CCCAGGAGCA CCTGGATGGC CCCTTGCCTG AACCCTTCAG CAATGGAGAG 
ATACAGAAGG AGAACAGCCG TGAAGCCCTG GTAGAGCCAG CTTCAGAAAG CCCCAGGCCA 
GCCCTGGCAA GATCTGCCTC CAGCGATACC AGTGAGGAGC TAAATGCCCA AGATAGTCCC 
AAGAGACACG ATTCCACAGA GCCCTCATCT ACCTCCTCCT CCTCTGACCC CATCTTGGAC 
TTCAACATCT CCCTGGCTGT GGCTAAAGAG AGGGCCCACC AGAAGCGCAG TAGCAAGCGG 
GCCCCGCAGA TGGACTGGAG CAAGAAAAAT GAACTCTTCA GCAACCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067605.1
CDS	70..1140
Translation	MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLKKLGVPIREELLRAQEKSEHTEPPAAADTKKAGDQNEAEKSHLERCELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKAGGDEAKLLVVDKETDEFFKKCRVTPSQEHLDGPLPEPFSNGEIQKENSREALVEPASESPRPALARSASSDTSEELNAQDSPKRHDSTEPSSTSSSSDPILDFNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL

Target ORF information:

RefSeq Version	NM_021594.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SLC9A3 regulator 1 (Slc9a3r1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021594.1

ORF Insert Sequence:

ATGAGCGCGG ACGCAGCGGC CGGGGAGCCT CTGCCCCGGC TCTGCTGCCT CGAGAAGGGT 
CCGAACGGCT ACGGCTTCCA CCTGCACGGG GAGAAAGGCA AGGTGGGCCA GTTTATTCGG 
CTAGTGGAGC CTGGCTCGCC GGCCGAGAAG TCGGGGTTGC TGGCCGGGGA CCGATTGGTG 
GAGGTGAACG GTGAGAATGT GGAGAAGGAG ACGCATCAGC AGGTGGTGAG CCGCATCCGC 
GCGGCGCTGA ACGCCGTGCG CCTGCTGGTG GTCGACCCTG AGACCGACGA GCAACTCAAG 
AAGCTGGGCG TCCCGATCCG GGAAGAGCTG CTGCGCGCCC AGGAGAAGTC CGAGCACACC 
GAGCCGCCAG CGGCCGCCGA CACTAAGAAG GCTGGGGACC AGAATGAGGC CGAAAAGAGC 
CACTTGGAGC GGTGTGAGCT CCGACCCCGG CTCTGCACCA TGAAGAAAGG CCCCAATGGT 
TATGGCTTCA ACCTGCACAG TGACAAATCC AAGCCAGGCC AGTTCATCCG AGCAGTGGAC 
CCGGACTCAC CAGCAGAGGC GTCTGGCCTC CGGGCCCAGG ACCGGATTGT GGAGGTCAAT 
GGCGTCTGCA TGGAGGGCAA ACAGCACGGG GACGTCGTGT CTGCCATCAA GGCTGGAGGT 
GATGAAGCCA AGCTGCTGGT GGTAGACAAG GAAACAGATG AGTTCTTTAA GAAGTGCAGA 
GTGACCCCGT CCCAGGAGCA CCTGGATGGC CCCTTGCCTG AACCCTTCAG CAATGGAGAG 
ATACAGAAGG AGAACAGCCG TGAAGCCCTG GTAGAGCCAG CTTCAGAAAG CCCCAGGCCA 
GCCCTGGCAA GATCTGCCTC CAGCGATACC AGTGAGGAGC TAAATGCCCA AGATAGTCCC 
AAGAGACACG ATTCCACAGA GCCCTCATCT ACCTCCTCCT CCTCTGACCC CATCTTGGAC 
TTCAACATCT CCCTGGCTGT GGCTAAAGAG AGGGCCCACC AGAAGCGCAG TAGCAAGCGG 
GCCCCGCAGA TGGACTGGAG CAAGAAAAAT GAACTCTTCA GCAACCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation.
Biochemical and biophysical research communications490(4)1168-1175(2017 09)
Lu X,He L,Zhou Q,Wang M,Shen WJ,Azhar S,Pan F,Guo Z,Hu Z

Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.
American journal of physiology. Cell physiology313(2)C197-C206(2017 Aug)
Barati MT,Ketchem CJ,Merchant ML,Kusiak WB,Jose PA,Weinman EJ,LeBlanc AJ,Lederer ED,Khundmiri SJ

Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase expression in the kidney.
Clinical and experimental pharmacology & physiology42(10)1118-26(2015 Oct)
Briffa JF,Grinfeld E,Jenkin KA,Mathai ML,Poronnik P,McAinch AJ,Hryciw DH

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.
Proceedings of the National Academy of Sciences of the United States of America111(25)9307-12(2014 Jun)
Kamiya K,Michel V,Giraudet F,Riederer B,Foucher I,Papal S,Perfettini I,Le Gal S,Verpy E,Xia W,Seidler U,Georgescu MM,Avan P,El-Amraoui A,Petit C

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Slc9a3r1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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