Ptges cDNA ORF clone, Rattus norvegicus(Norway rat)

Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu SS, Xu Q, Zhu Y, Guan Y, Wang X, Kong W
Arteriosclerosis, thrombosis, and vascular biology36(1)108-21(2016 Jan)

Functional consequences of knocking down porcine prostaglandin synthases in SK-6 swine kidney cell line.
Waclawik A, Rivero-M?ller A, Rahman NA, Ziecik AJ
Reproductive biology15(1)42-7(2015 Mar)

Amide hydrolysis of a novel chemical series of microsomal prostaglandin E synthase-1 inhibitors induces kidney toxicity in the rat.
Bylund J, Annas A, Hellgren D, Bjurstr?m S, Andersson H, Svanhagen A
Drug metabolism and disposition: the biological fate of chemicals41(3)634-41(2013 Mar)

Prostanoids as regulators of innate and adaptive immunity.
Hirata T, Narumiya S
Advances in immunology116143-74(2012)

Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.
Title: Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.

Using metabolic profiling and exploratory rat toxicity studies, a new and active mPGES-1 inhibitor with improved margins to chemically induced kidney toxicity in rats has been identified.
Title: Amide hydrolysis of a novel chemical series of microsomal prostaglandin E synthase-1 inhibitors induces kidney toxicity in the rat.

Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
Title: Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1?-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets.

Suggest that COX-2 and PGES, and in turn PGE(2), might play important roles in follicular cell proliferation but do not affect tumor induction in N-bis(2-hydroxypropyl)nitrosamine-induced thyroid carcinogenesis model.
Title: Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.

study has shown that circulating IL-6 can directly induce mPGES-1 linked to STAT3-activation in the brain but not peripheral tissues of rats during localised peripheral inflammation
Title: Circulating IL-6 contributes to peripheral LPS-induced mPGES-1 expression in the rat brain.