Asl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Asl
Entrez Gene ID	59085
Full Name	argininosuccinate lyase
General protein information	Preferred Names argininosuccinate lyase Names argininosuccinate lyase ASAL arginosuccinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12

mRNA and Protein(s)

mRNA	Protein	Name
XM_006249247.3	XP_006249309.1	argininosuccinate lyase isoform X1
XM_006249245.3	XP_006249307.1	argininosuccinate lyase isoform X1
NM_021577.3	NP_067588.2	argininosuccinate lyase

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ASL	NP_001029600.1
Gallus gallus (chicken)	ASL2	NP_001025885.1
Saccharomyces cerevisiae (baker's yeast)	ARG4	NP_011882.1
Rattus norvegicus (Norway rat)	Asl	NP_067588.2
Drosophila melanogaster (fruit fly)	CG9510	NP_001027234.1
Eremothecium gossypii	AGOS_AEL019W	NP_984842.1
Magnaporthe oryzae (rice blast fungus)	MGG_17278	XP_003717639.1
Homo sapiens (human)	ASL	NP_000039.2
Pan troglodytes (chimpanzee)	ASL	XP_519125.3
Mus musculus (house mouse)	Asl	NP_598529.1
Oryza sativa (rice)	Os03g0305500	NP_001049883.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008141	XP_317320.4
Canis lupus familiaris (dog)	LOC479704	XP_536832.2
Gallus gallus (chicken)	ASL1	NP_990832.1
Danio rerio (zebrafish)	asl	NP_956745.1
Kluyveromyces lactis	KLLA0A08404g	XP_451371.1
Schizosaccharomyces pombe (fission yeast)	SPBC1539.03c	NP_596817.1
Schizosaccharomyces pombe (fission yeast)	arg7	NP_595129.1
Neurospora crassa	NCU08162	XP_959654.1
Arabidopsis thaliana (thale cress)	AT5G10920	NP_196653.1
Xenopus tropicalis (tropical clawed frog)	asl	NP_001106586.1

Gene Ontology
Bibliography

Related articles in PubMed

Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson B, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B
American journal of physiology. Gastrointestinal and liver physiology307(3)G347-54(2014 Aug)

Toward an understanding of the protein interaction network of the human liver.
Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X
Molecular systems biology7536(2011 Oct)

L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats.
Vadivel A, Aschner JL, Rey-Parra GJ, Magarik J, Zeng H, Summar M, Eaton F, Th?baud B
Pediatric research68(6)519-25(2010 Dec)

Urea cycle gene expression is suppressed by PFOA treatment in rats.
Walters MW, Wallace KB
Toxicology letters197(1)46-50(2010 Aug)

Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain.
Swamy M, Salleh MJ, Sirajudeen KN, Yusof WR, Chandran G
International journal of medical sciences7(3)147-54(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Enterocyte-derived ASL has a protective role in necrotizing enterocolitis.
Title: Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.

Local factors such as the NO produced by nNOS/ASS/ASL-positive neurons, could influence ASS/ASL-positive microglia cells avoiding or allowing the induction, in these cells, of iNOS.
Title: Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia.

24 h after reperfusion, number of nNOS-positive neurons and tpercentage of those co-expressing ASS and ASL were significantly increased in the animals with a longer survival. 144 h after ischemia there was almost complete restore of these neurons.
Title: Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons.

The following Asl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Asl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04845	NM_021577.3 Latest version!	Rattus norvegicus argininosuccinate lyase (Asl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa04845	XM_006249245.3 Latest version!	Rattus norvegicus argininosuccinate lyase (Asl), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa04845	XM_006249247.3 Latest version!	Rattus norvegicus argininosuccinate lyase (Asl), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Asl ( NM_021577.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067588.2 Rattus norvegicus argininosuccinate lyase (Asl), mRNA.

Price & Availability↑

CloneID	ORa04845
Clone ID Related Accession (Same CDS sequence)	XM_006249247.3 , XM_006249245.3 , NM_021577.3
Accession Version	NM_021577.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	argininosuccinate lyase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097270.1. On Jun 10, 2007 this sequence version replaced NM_021577.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC 
ATGGACAAGT TCAACTCATC TATCGCCTAT GACCGGCATC TGTGGAATGT GGACCTGCAG 
GGAAGCAAGG CCTACAGCAG GGGCCTGGAG AAGGCAGGGC TTCTCACCAA AGCTGAGATG 
CAGCAGATAC TGCAAGGCCT GGACAAGGTG GCTGAAGAGT GGGCCCAAGG CATCTTCAAA 
TTGTACCCTA ATGATGAAGA CATCCACACG GCCAACGAGC GGCGCCTGAA GGAACTCATT 
GGTGAAGCTG CAGGGAAGTT ACACACAGGC AGAAGTCGCA ATGACCAGGT GGTCACGGAC 
CTCAGGCTGT GGATGAGGCA AACCTGCTCA AAACTCTCCA CCTTCCTCAA GGTGCTCATT 
GAAGCCATGG TAGACCGGGC AGAGGCGGAG TGTGAAGTCC TCTTCCCTGG GTACACACAC 
TTGCAGAGAG CTCAGCCCAT CCGCTGGAGC CACTGGATCC TGAGTCACGC CGTTGCGCTG 
ACACGAGATT TAGAGAGACT GAAGGAGGTG CAGAAGCGGA TCAATGTCCT GCCACTGGGC 
AGTGGGGCCA TTGCAGGCAA CCCTCTGGGT GTGGACCGGG AGTTCCTCTG TGCAGAACTG 
AACTTTGGAG CCATTACGCT CAACAGTATG GATGCCACCA GCGAGAGAGA CTTCGTGGCT 
GAGTTCCTGT TTTGGGCTTC TCTGTGCATG ACCCATCTCA GCAGGATGGC AGAAGACCTG 
ATTCTCTACG GTACCAAGGA ATTCAACTTT GTGCAGCTCT CCGATGCCTA CAGCACCGGA 
AGCAGCTTGA TGCCCCAGAA GAAAAACCCA GACAGCTTGG AGCTGATCCG GAGCAAGGCG 
GGCCGAGTGT TTGGACGGTG CGCAGGACTC CTGATGACCC TCAAGGGACT TCCAAGCACC 
TACAACAAGG ACTTACAGGA AGACAAGGAG GCTGTGTTTG AAGTGTCTGA CACCATGACA 
GCTGTCCTCC AAGTAGCCAC TGGAGTCATC TCTACACTGC AGATTCATCG TGAGAACATG 
GCACAGGCAC TCAGCCCTGA CATGCTGGCT ACCGACCTTG CCTACTACCT GGTCCGCAAA 
GGGATGCCAT TCCGCCAGGC CCACGAGGCC TCAGGGAAAG CTGTGGTCGT GGCAGAGATG 
AAAGGGGTGG CTCTCAACCA GCTGTCACTT CAGGAGCTGC AGACCGTCAG TCCCCTGTTC 
TCGAGTGACG TGAATCTCGT GTGGGACTAC AGCCACAGCG TGGAGCAGTA CACAGCCTTG 
GGTGGCACAG CACAGTCCAG TGTTGAGTGG CAGATCAGCC AGGTGCGGGC CCTGCTGCAG 
ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067588.2
CDS	620..2005
Translation	MASESGKLWGGRFAGSVDPTMDKFNSSIAYDRHLWNVDLQGSKAYSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGIFKLYPNDEDIHTANERRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSTFLKVLIEAMVDRAEAECEVLFPGYTHLQRAQPIRWSHWILSHAVALTRDLERLKEVQKRINVLPLGSGAIAGNPLGVDREFLCAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFNFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMTAVLQVATGVISTLQIHRENMAQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVVVAEMKGVALNQLSLQELQTVSPLFSSDVNLVWDYSHSVEQYTALGGTAQSSVEWQISQVRALLQM

Target ORF information:

RefSeq Version	NM_021577.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus argininosuccinate lyase (Asl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021577.3

ORF Insert Sequence:

ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC 
ATGGACAAGT TCAACTCATC TATCGCCTAT GACCGGCATC TGTGGAATGT GGACCTGCAG 
GGAAGCAAGG CCTACAGCAG GGGCCTGGAG AAGGCAGGGC TTCTCACCAA AGCTGAGATG 
CAGCAGATAC TGCAAGGCCT GGACAAGGTG GCTGAAGAGT GGGCCCAAGG CATCTTCAAA 
TTGTACCCTA ATGATGAAGA CATCCACACG GCCAACGAGC GGCGCCTGAA GGAACTCATT 
GGTGAAGCTG CAGGGAAGTT ACACACAGGC AGAAGTCGCA ATGACCAGGT GGTCACGGAC 
CTCAGGCTGT GGATGAGGCA AACCTGCTCA AAACTCTCCA CCTTCCTCAA GGTGCTCATT 
GAAGCCATGG TAGACCGGGC AGAGGCGGAG TGTGAAGTCC TCTTCCCTGG GTACACACAC 
TTGCAGAGAG CTCAGCCCAT CCGCTGGAGC CACTGGATCC TGAGTCACGC CGTTGCGCTG 
ACACGAGATT TAGAGAGACT GAAGGAGGTG CAGAAGCGGA TCAATGTCCT GCCACTGGGC 
AGTGGGGCCA TTGCAGGCAA CCCTCTGGGT GTGGACCGGG AGTTCCTCTG TGCAGAACTG 
AACTTTGGAG CCATTACGCT CAACAGTATG GATGCCACCA GCGAGAGAGA CTTCGTGGCT 
GAGTTCCTGT TTTGGGCTTC TCTGTGCATG ACCCATCTCA GCAGGATGGC AGAAGACCTG 
ATTCTCTACG GTACCAAGGA ATTCAACTTT GTGCAGCTCT CCGATGCCTA CAGCACCGGA 
AGCAGCTTGA TGCCCCAGAA GAAAAACCCA GACAGCTTGG AGCTGATCCG GAGCAAGGCG 
GGCCGAGTGT TTGGACGGTG CGCAGGACTC CTGATGACCC TCAAGGGACT TCCAAGCACC 
TACAACAAGG ACTTACAGGA AGACAAGGAG GCTGTGTTTG AAGTGTCTGA CACCATGACA 
GCTGTCCTCC AAGTAGCCAC TGGAGTCATC TCTACACTGC AGATTCATCG TGAGAACATG 
GCACAGGCAC TCAGCCCTGA CATGCTGGCT ACCGACCTTG CCTACTACCT GGTCCGCAAA 
GGGATGCCAT TCCGCCAGGC CCACGAGGCC TCAGGGAAAG CTGTGGTCGT GGCAGAGATG 
AAAGGGGTGG CTCTCAACCA GCTGTCACTT CAGGAGCTGC AGACCGTCAG TCCCCTGTTC 
TCGAGTGACG TGAATCTCGT GTGGGACTAC AGCCACAGCG TGGAGCAGTA CACAGCCTTG 
GGTGGCACAG CACAGTCCAG TGTTGAGTGG CAGATCAGCC AGGTGCGGGC CCTGCTGCAG 
ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Asl ( XM_006249247.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249309.1 Rattus norvegicus argininosuccinate lyase (Asl), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa04845
Clone ID Related Accession (Same CDS sequence)	XM_006249247.3 , XM_006249245.3 , NM_021577.3
Accession Version	XM_006249247.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	argininosuccinate lyase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249247.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC 
ATGGACAAGT TCAACTCATC TATCGCCTAT GACCGGCATC TGTGGAATGT GGACCTGCAG 
GGAAGCAAGG CCTACAGCAG GGGCCTGGAG AAGGCAGGGC TTCTCACCAA AGCTGAGATG 
CAGCAGATAC TGCAAGGCCT GGACAAGGTG GCTGAAGAGT GGGCCCAAGG CATCTTCAAA 
TTGTACCCTA ATGATGAAGA CATCCACACG GCCAACGAGC GGCGCCTGAA GGAACTCATT 
GGTGAAGCTG CAGGGAAGTT ACACACAGGC AGAAGTCGCA ATGACCAGGT GGTCACGGAC 
CTCAGGCTGT GGATGAGGCA AACCTGCTCA AAACTCTCCA CCTTCCTCAA GGTGCTCATT 
GAAGCCATGG TAGACCGGGC AGAGGCGGAG TGTGAAGTCC TCTTCCCTGG GTACACACAC 
TTGCAGAGAG CTCAGCCCAT CCGCTGGAGC CACTGGATCC TGAGTCACGC CGTTGCGCTG 
ACACGAGATT TAGAGAGACT GAAGGAGGTG CAGAAGCGGA TCAATGTCCT GCCACTGGGC 
AGTGGGGCCA TTGCAGGCAA CCCTCTGGGT GTGGACCGGG AGTTCCTCTG TGCAGAACTG 
AACTTTGGAG CCATTACGCT CAACAGTATG GATGCCACCA GCGAGAGAGA CTTCGTGGCT 
GAGTTCCTGT TTTGGGCTTC TCTGTGCATG ACCCATCTCA GCAGGATGGC AGAAGACCTG 
ATTCTCTACG GTACCAAGGA ATTCAACTTT GTGCAGCTCT CCGATGCCTA CAGCACCGGA 
AGCAGCTTGA TGCCCCAGAA GAAAAACCCA GACAGCTTGG AGCTGATCCG GAGCAAGGCG 
GGCCGAGTGT TTGGACGGTG CGCAGGACTC CTGATGACCC TCAAGGGACT TCCAAGCACC 
TACAACAAGG ACTTACAGGA AGACAAGGAG GCTGTGTTTG AAGTGTCTGA CACCATGACA 
GCTGTCCTCC AAGTAGCCAC TGGAGTCATC TCTACACTGC AGATTCATCG TGAGAACATG 
GCACAGGCAC TCAGCCCTGA CATGCTGGCT ACCGACCTTG CCTACTACCT GGTCCGCAAA 
GGGATGCCAT TCCGCCAGGC CCACGAGGCC TCAGGGAAAG CTGTGGTCGT GGCAGAGATG 
AAAGGGGTGG CTCTCAACCA GCTGTCACTT CAGGAGCTGC AGACCGTCAG TCCCCTGTTC 
TCGAGTGACG TGAATCTCGT GTGGGACTAC AGCCACAGCG TGGAGCAGTA CACAGCCTTG 
GGTGGCACAG CACAGTCCAG TGTTGAGTGG CAGATCAGCC AGGTGCGGGC CCTGCTGCAG 
ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249309.1
CDS	388..1773
Translation	MASESGKLWGGRFAGSVDPTMDKFNSSIAYDRHLWNVDLQGSKAYSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGIFKLYPNDEDIHTANERRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSTFLKVLIEAMVDRAEAECEVLFPGYTHLQRAQPIRWSHWILSHAVALTRDLERLKEVQKRINVLPLGSGAIAGNPLGVDREFLCAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFNFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMTAVLQVATGVISTLQIHRENMAQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVVVAEMKGVALNQLSLQELQTVSPLFSSDVNLVWDYSHSVEQYTALGGTAQSSVEWQISQVRALLQM

Target ORF information:

RefSeq Version	XM_006249247.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus argininosuccinate lyase (Asl), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249247.3

ORF Insert Sequence:

ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC 
ATGGACAAGT TCAACTCATC TATCGCCTAT GACCGGCATC TGTGGAATGT GGACCTGCAG 
GGAAGCAAGG CCTACAGCAG GGGCCTGGAG AAGGCAGGGC TTCTCACCAA AGCTGAGATG 
CAGCAGATAC TGCAAGGCCT GGACAAGGTG GCTGAAGAGT GGGCCCAAGG CATCTTCAAA 
TTGTACCCTA ATGATGAAGA CATCCACACG GCCAACGAGC GGCGCCTGAA GGAACTCATT 
GGTGAAGCTG CAGGGAAGTT ACACACAGGC AGAAGTCGCA ATGACCAGGT GGTCACGGAC 
CTCAGGCTGT GGATGAGGCA AACCTGCTCA AAACTCTCCA CCTTCCTCAA GGTGCTCATT 
GAAGCCATGG TAGACCGGGC AGAGGCGGAG TGTGAAGTCC TCTTCCCTGG GTACACACAC 
TTGCAGAGAG CTCAGCCCAT CCGCTGGAGC CACTGGATCC TGAGTCACGC CGTTGCGCTG 
ACACGAGATT TAGAGAGACT GAAGGAGGTG CAGAAGCGGA TCAATGTCCT GCCACTGGGC 
AGTGGGGCCA TTGCAGGCAA CCCTCTGGGT GTGGACCGGG AGTTCCTCTG TGCAGAACTG 
AACTTTGGAG CCATTACGCT CAACAGTATG GATGCCACCA GCGAGAGAGA CTTCGTGGCT 
GAGTTCCTGT TTTGGGCTTC TCTGTGCATG ACCCATCTCA GCAGGATGGC AGAAGACCTG 
ATTCTCTACG GTACCAAGGA ATTCAACTTT GTGCAGCTCT CCGATGCCTA CAGCACCGGA 
AGCAGCTTGA TGCCCCAGAA GAAAAACCCA GACAGCTTGG AGCTGATCCG GAGCAAGGCG 
GGCCGAGTGT TTGGACGGTG CGCAGGACTC CTGATGACCC TCAAGGGACT TCCAAGCACC 
TACAACAAGG ACTTACAGGA AGACAAGGAG GCTGTGTTTG AAGTGTCTGA CACCATGACA 
GCTGTCCTCC AAGTAGCCAC TGGAGTCATC TCTACACTGC AGATTCATCG TGAGAACATG 
GCACAGGCAC TCAGCCCTGA CATGCTGGCT ACCGACCTTG CCTACTACCT GGTCCGCAAA 
GGGATGCCAT TCCGCCAGGC CCACGAGGCC TCAGGGAAAG CTGTGGTCGT GGCAGAGATG 
AAAGGGGTGG CTCTCAACCA GCTGTCACTT CAGGAGCTGC AGACCGTCAG TCCCCTGTTC 
TCGAGTGACG TGAATCTCGT GTGGGACTAC AGCCACAGCG TGGAGCAGTA CACAGCCTTG 
GGTGGCACAG CACAGTCCAG TGTTGAGTGG CAGATCAGCC AGGTGCGGGC CCTGCTGCAG 
ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Asl ( XM_006249245.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249307.1 Rattus norvegicus argininosuccinate lyase (Asl), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa04845
Clone ID Related Accession (Same CDS sequence)	XM_006249247.3 , XM_006249245.3 , NM_021577.3
Accession Version	XM_006249245.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	argininosuccinate lyase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249245.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC 
ATGGACAAGT TCAACTCATC TATCGCCTAT GACCGGCATC TGTGGAATGT GGACCTGCAG 
GGAAGCAAGG CCTACAGCAG GGGCCTGGAG AAGGCAGGGC TTCTCACCAA AGCTGAGATG 
CAGCAGATAC TGCAAGGCCT GGACAAGGTG GCTGAAGAGT GGGCCCAAGG CATCTTCAAA 
TTGTACCCTA ATGATGAAGA CATCCACACG GCCAACGAGC GGCGCCTGAA GGAACTCATT 
GGTGAAGCTG CAGGGAAGTT ACACACAGGC AGAAGTCGCA ATGACCAGGT GGTCACGGAC 
CTCAGGCTGT GGATGAGGCA AACCTGCTCA AAACTCTCCA CCTTCCTCAA GGTGCTCATT 
GAAGCCATGG TAGACCGGGC AGAGGCGGAG TGTGAAGTCC TCTTCCCTGG GTACACACAC 
TTGCAGAGAG CTCAGCCCAT CCGCTGGAGC CACTGGATCC TGAGTCACGC CGTTGCGCTG 
ACACGAGATT TAGAGAGACT GAAGGAGGTG CAGAAGCGGA TCAATGTCCT GCCACTGGGC 
AGTGGGGCCA TTGCAGGCAA CCCTCTGGGT GTGGACCGGG AGTTCCTCTG TGCAGAACTG 
AACTTTGGAG CCATTACGCT CAACAGTATG GATGCCACCA GCGAGAGAGA CTTCGTGGCT 
GAGTTCCTGT TTTGGGCTTC TCTGTGCATG ACCCATCTCA GCAGGATGGC AGAAGACCTG 
ATTCTCTACG GTACCAAGGA ATTCAACTTT GTGCAGCTCT CCGATGCCTA CAGCACCGGA 
AGCAGCTTGA TGCCCCAGAA GAAAAACCCA GACAGCTTGG AGCTGATCCG GAGCAAGGCG 
GGCCGAGTGT TTGGACGGTG CGCAGGACTC CTGATGACCC TCAAGGGACT TCCAAGCACC 
TACAACAAGG ACTTACAGGA AGACAAGGAG GCTGTGTTTG AAGTGTCTGA CACCATGACA 
GCTGTCCTCC AAGTAGCCAC TGGAGTCATC TCTACACTGC AGATTCATCG TGAGAACATG 
GCACAGGCAC TCAGCCCTGA CATGCTGGCT ACCGACCTTG CCTACTACCT GGTCCGCAAA 
GGGATGCCAT TCCGCCAGGC CCACGAGGCC TCAGGGAAAG CTGTGGTCGT GGCAGAGATG 
AAAGGGGTGG CTCTCAACCA GCTGTCACTT CAGGAGCTGC AGACCGTCAG TCCCCTGTTC 
TCGAGTGACG TGAATCTCGT GTGGGACTAC AGCCACAGCG TGGAGCAGTA CACAGCCTTG 
GGTGGCACAG CACAGTCCAG TGTTGAGTGG CAGATCAGCC AGGTGCGGGC CCTGCTGCAG 
ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249307.1
CDS	445..1830
Translation	MASESGKLWGGRFAGSVDPTMDKFNSSIAYDRHLWNVDLQGSKAYSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGIFKLYPNDEDIHTANERRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSTFLKVLIEAMVDRAEAECEVLFPGYTHLQRAQPIRWSHWILSHAVALTRDLERLKEVQKRINVLPLGSGAIAGNPLGVDREFLCAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFNFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMTAVLQVATGVISTLQIHRENMAQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVVVAEMKGVALNQLSLQELQTVSPLFSSDVNLVWDYSHSVEQYTALGGTAQSSVEWQISQVRALLQM

Target ORF information:

RefSeq Version	XM_006249245.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus argininosuccinate lyase (Asl), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249245.3

ORF Insert Sequence:

ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC 
ATGGACAAGT TCAACTCATC TATCGCCTAT GACCGGCATC TGTGGAATGT GGACCTGCAG 
GGAAGCAAGG CCTACAGCAG GGGCCTGGAG AAGGCAGGGC TTCTCACCAA AGCTGAGATG 
CAGCAGATAC TGCAAGGCCT GGACAAGGTG GCTGAAGAGT GGGCCCAAGG CATCTTCAAA 
TTGTACCCTA ATGATGAAGA CATCCACACG GCCAACGAGC GGCGCCTGAA GGAACTCATT 
GGTGAAGCTG CAGGGAAGTT ACACACAGGC AGAAGTCGCA ATGACCAGGT GGTCACGGAC 
CTCAGGCTGT GGATGAGGCA AACCTGCTCA AAACTCTCCA CCTTCCTCAA GGTGCTCATT 
GAAGCCATGG TAGACCGGGC AGAGGCGGAG TGTGAAGTCC TCTTCCCTGG GTACACACAC 
TTGCAGAGAG CTCAGCCCAT CCGCTGGAGC CACTGGATCC TGAGTCACGC CGTTGCGCTG 
ACACGAGATT TAGAGAGACT GAAGGAGGTG CAGAAGCGGA TCAATGTCCT GCCACTGGGC 
AGTGGGGCCA TTGCAGGCAA CCCTCTGGGT GTGGACCGGG AGTTCCTCTG TGCAGAACTG 
AACTTTGGAG CCATTACGCT CAACAGTATG GATGCCACCA GCGAGAGAGA CTTCGTGGCT 
GAGTTCCTGT TTTGGGCTTC TCTGTGCATG ACCCATCTCA GCAGGATGGC AGAAGACCTG 
ATTCTCTACG GTACCAAGGA ATTCAACTTT GTGCAGCTCT CCGATGCCTA CAGCACCGGA 
AGCAGCTTGA TGCCCCAGAA GAAAAACCCA GACAGCTTGG AGCTGATCCG GAGCAAGGCG 
GGCCGAGTGT TTGGACGGTG CGCAGGACTC CTGATGACCC TCAAGGGACT TCCAAGCACC 
TACAACAAGG ACTTACAGGA AGACAAGGAG GCTGTGTTTG AAGTGTCTGA CACCATGACA 
GCTGTCCTCC AAGTAGCCAC TGGAGTCATC TCTACACTGC AGATTCATCG TGAGAACATG 
GCACAGGCAC TCAGCCCTGA CATGCTGGCT ACCGACCTTG CCTACTACCT GGTCCGCAAA 
GGGATGCCAT TCCGCCAGGC CCACGAGGCC TCAGGGAAAG CTGTGGTCGT GGCAGAGATG 
AAAGGGGTGG CTCTCAACCA GCTGTCACTT CAGGAGCTGC AGACCGTCAG TCCCCTGTTC 
TCGAGTGACG TGAATCTCGT GTGGGACTAC AGCCACAGCG TGGAGCAGTA CACAGCCTTG 
GGTGGCACAG CACAGTCCAG TGTTGAGTGG CAGATCAGCC AGGTGCGGGC CCTGCTGCAG 
ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
American journal of physiology. Gastrointestinal and liver physiology307(3)G347-54(2014 Aug)
Premkumar MH,Sule G,Nagamani SC,Chakkalakal S,Nordin A,Jain M,Ruan MZ,Bertin T,Dawson B,Zhang J,Schady D,Bryan NS,Campeau PM,Erez A,Lee B

Toward an understanding of the protein interaction network of the human liver.
Molecular systems biology7536(2011 Oct)
Wang J,Huo K,Ma L,Tang L,Li D,Huang X,Yuan Y,Li C,Wang W,Guan W,Chen H,Jin C,Wei J,Zhang W,Yang Y,Liu Q,Zhou Y,Zhang C,Wu Z,Xu W,Zhang Y,Liu T,Yu D,Zhang Y,Chen L,Zhu D,Zhong X,Kang L,Gan X,Yu X,Ma Q,Yan J,Zhou L,Liu Z,Zhu Y,Zhou T,He F,Yang X

L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats.
Pediatric research68(6)519-25(2010 Dec)
Vadivel A,Aschner JL,Rey-Parra GJ,Magarik J,Zeng H,Summar M,Eaton F,Th?baud B

Urea cycle gene expression is suppressed by PFOA treatment in rats.
Toxicology letters197(1)46-50(2010 Aug)
Walters MW,Wallace KB

Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain.
International journal of medical sciences7(3)147-54(2010 May)
Swamy M,Salleh MJ,Sirajudeen KN,Yusof WR,Chandran G

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Asl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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