Lxn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lxn
Entrez Gene ID	59073
Full Name	latexin
General protein information	Preferred Names latexin Names latexin ECI TCI endogenous carboxypeptidase inhibitor tissue carboxypeptidase inhibitor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q32
Summary	inhibits the proteolytic activity of carboxypeptidase A; may mediate prevention of cytosolic protein degradation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031655.1	NP_113843.1	latexin

Pathways from BioSystems

Homologies

	LXN	XP_001101220.1
Gallus gallus (chicken)	LXN	NP_001264417.1
Xenopus tropicalis (tropical clawed frog)	lxn	XP_002933286.1
Homo sapiens (human)	LXN	NP_064554.3
Pan troglodytes (chimpanzee)	LXN	XP_003310115.1
Mus musculus (house mouse)	Lxn	NP_058033.2
Danio rerio (zebrafish)	lxn	NP_001008596.1
Canis lupus familiaris (dog)	LXN	XP_852979.1
Bos taurus (cattle)	LXN	NP_001073809.1
Rattus norvegicus (Norway rat)	Lxn	NP_113843.1

Gene Ontology
Bibliography

Related articles in PubMed

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.
K?hlein HN, Tegeder I, M?ser C, Lim HY, H?ussler A, Spieth K, Jennes I, Marschalek R, Beckhaus T, Karas M, Fauth M, Ehnert C, Geisslinger G, Niederberger E
PloS one6(4)e19270(2011 Apr)

Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases.
Jin M, Ishida M, Katoh-Fukui Y, Tsuchiya R, Higashinakagawa T, Ikegami S, Arimatsu Y
Brain research1075(1)117-21(2006 Feb)

Genomic organization and regulatory elements of the rat latexin gene, which is expressed in a cell type-specific manner in both central and peripheral nervous systems.
Miyasaka N, Hatanaka Y, Jin M, Arimatsu Y
Brain research. Molecular brain research69(1)62-72(1999 May)

Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor.
Normant E, Martres MP, Schwartz JC, Gros C
Proceedings of the National Academy of Sciences of the United States of America92(26)12225-9(1995 Dec)

Intracortical regionality represented by specific transcription for a novel protein, latexin.
Hatanaka Y, Uratani Y, Takiguchi-Hayashi K, Omori A, Sato K, Miyamoto M, Arimatsu Y
The European journal of neuroscience6(6)973-82(1994 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that latexin protein expression was reduced after SNI, and the decrease of latexin was associated with an increase of the activity of carboxypeptidase A.
Title: Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

The following Lxn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lxn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08395	NM_031655.1 Latest version!	Rattus norvegicus latexin (Lxn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lxn ( NM_031655.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113843.1 Rattus norvegicus latexin (Lxn), mRNA.

Price & Availability↑

CloneID	ORa08395
Clone ID Related Accession (Same CDS sequence)	NM_031655.1
Accession Version	NM_031655.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	latexin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X76985.1. ##Evidence-Data-START## Transcript exon combination :: X76985.1, FQ220594.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00632259 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGAAA TCCCACCCAC CCACTACGCT GCGTCCAGGG CTGCCTCGGT GGCAGAGAAC 
TGTATAAATT ATCAGCAAGG GACCCCCAAC AAGGTATTCA AGGTGCAGAC GGTCCAGCAG 
GCAAGCAAGG AGGATATCCC AGGAAGAGGC CACAAGTACC ATCTGAAGTT TTCTGTGGAA 
GAAATTATCC AAAAACAAGT TACAGTGAGC TGCACGGCTG AAGTTCTTTA CCCTCGAATG 
GGACAAGGCT CTGCACCGGA AGTCAACTTC ACATTTGAAG GAGAAATCGG CAAGAACCCA 
GATGAGGAAG ACAACACGTT TTATCAAAGA CTCATGTCCA TGAAGGAACC ACTACAAGCA 
CAAAATATTC CAGACAATTT TGGAAATGTG TCTCCACAAA TGAAGCCGGT CCACCACTTA 
GCCTGGGTCG CCTGTGGTTA TGTAATGTGG CAGAACTCGA CTGAAGACAC ATGGTATAAA 
ATGGCAAAGA TTCAAACGGT CAAGCAAGTG CAAAGAAACG ATGACTTCAT TGAGTTAGAC 
TACACCGTCC TACTCCACGA CGTTGCATCG CAGGAGATTA TCCCCTGGCA AATGCAAGTT 
CTGTGGCACC CACAATACGG CACAAAAGTA AAGCACAACA GCCGCCTCCC AAAGGAAGCA 
CCAGCAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113843.1
CDS	170..841
Translation	MEEIPPTHYAASRAASVAENCINYQQGTPNKVFKVQTVQQASKEDIPGRGHKYHLKFSVEEIIQKQVTVSCTAEVLYPRMGQGSAPEVNFTFEGEIGKNPDEEDNTFYQRLMSMKEPLQAQNIPDNFGNVSPQMKPVHHLAWVACGYVMWQNSTEDTWYKMAKIQTVKQVQRNDDFIELDYTVLLHDVASQEIIPWQMQVLWHPQYGTKVKHNSRLPKEAPAE

Target ORF information:

RefSeq Version	NM_031655.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus latexin (Lxn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031655.1

ORF Insert Sequence:

ATGGAAGAAA TCCCACCCAC CCACTACGCT GCGTCCAGGG CTGCCTCGGT GGCAGAGAAC 
TGTATAAATT ATCAGCAAGG GACCCCCAAC AAGGTATTCA AGGTGCAGAC GGTCCAGCAG 
GCAAGCAAGG AGGATATCCC AGGAAGAGGC CACAAGTACC ATCTGAAGTT TTCTGTGGAA 
GAAATTATCC AAAAACAAGT TACAGTGAGC TGCACGGCTG AAGTTCTTTA CCCTCGAATG 
GGACAAGGCT CTGCACCGGA AGTCAACTTC ACATTTGAAG GAGAAATCGG CAAGAACCCA 
GATGAGGAAG ACAACACGTT TTATCAAAGA CTCATGTCCA TGAAGGAACC ACTACAAGCA 
CAAAATATTC CAGACAATTT TGGAAATGTG TCTCCACAAA TGAAGCCGGT CCACCACTTA 
GCCTGGGTCG CCTGTGGTTA TGTAATGTGG CAGAACTCGA CTGAAGACAC ATGGTATAAA 
ATGGCAAAGA TTCAAACGGT CAAGCAAGTG CAAAGAAACG ATGACTTCAT TGAGTTAGAC 
TACACCGTCC TACTCCACGA CGTTGCATCG CAGGAGATTA TCCCCTGGCA AATGCAAGTT 
CTGTGGCACC CACAATACGG CACAAAAGTA AAGCACAACA GCCGCCTCCC AAAGGAAGCA 
CCAGCAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.
PloS one6(4)e19270(2011 Apr)
K?hlein HN,Tegeder I,M?ser C,Lim HY,H?ussler A,Spieth K,Jennes I,Marschalek R,Beckhaus T,Karas M,Fauth M,Ehnert C,Geisslinger G,Niederberger E

Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases.
Brain research1075(1)117-21(2006 Feb)
Jin M,Ishida M,Katoh-Fukui Y,Tsuchiya R,Higashinakagawa T,Ikegami S,Arimatsu Y

Genomic organization and regulatory elements of the rat latexin gene, which is expressed in a cell type-specific manner in both central and peripheral nervous systems.
Brain research. Molecular brain research69(1)62-72(1999 May)
Miyasaka N,Hatanaka Y,Jin M,Arimatsu Y

Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor.
Proceedings of the National Academy of Sciences of the United States of America92(26)12225-9(1995 Dec)
Normant E,Martres MP,Schwartz JC,Gros C

Intracortical regionality represented by specific transcription for a novel protein, latexin.
The European journal of neuroscience6(6)973-82(1994 Jun)
Hatanaka Y,Uratani Y,Takiguchi-Hayashi K,Omori A,Sato K,Miyamoto M,Arimatsu Y

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Lxn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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