Rabggta cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rabggta
Entrez Gene ID	58983
Full Name	Rab geranylgeranyltransferase, alpha subunit
General protein information	Preferred Names Rab geranylgeranyltransferase, alpha subunit Names geranylgeranyl transferase type-2 subunit alpha Rab geranylgeranyl transferase, a subunit Rab geranylgeranyltransferase alpha geranylgeranyl transferase type II subunit alpha rab GG transferase alpha rab GGTase alpha rab geranyl-geranyltransferase subunit alpha rab geranylgeranyltransferase subunit alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p13
Summary	subunit of Rab geranylgeranyl transferase, which catalyses the transfer of geranylgeranyl groups to Rab protein cysteine residues [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252009.3	XP_006252071.1	geranylgeranyl transferase type-2 subunit alpha isoform X1
XM_006252010.3	XP_006252072.1	geranylgeranyl transferase type-2 subunit alpha isoform X1
NM_031654.2	NP_113842.1	geranylgeranyl transferase type-2 subunit alpha

Pathways from BioSystems

Homologies

	LOC714521	XP_001104317.1
Mus musculus (house mouse)	Rabggta	NP_062392.1
Drosophila melanogaster (fruit fly)	CG12007	NP_649512.1
Caenorhabditis elegans (roundworm)	M57.2	NP_500367.1
Bos taurus (cattle)	RABGGTA	NP_001015614.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009724	XP_318802.4
Pan troglodytes (chimpanzee)	RABGGTA	XP_509870.3
Xenopus tropicalis (tropical clawed frog)	rabggta	NP_001006728.1
Homo sapiens (human)	RABGGTA	NP_004572.3
Canis lupus familiaris (dog)	RABGGTA	XP_850528.1
Rattus norvegicus (Norway rat)	Rabggta	NP_113842.1
Danio rerio (zebrafish)	rabggta	NP_001070131.1

Gene Ontology
Bibliography

Related articles in PubMed

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic ? cells.
Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A
Islets4(5)354-8(2012 Sep-Oct)

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W
The EMBO journal27(18)2444-56(2008 Sep)

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thom? NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K
Molecular cell11(2)483-94(2003 Feb)

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Detter JC, Zhang Q, Mules EH, Novak EK, Mishra VS, Li W, McMurtrie EB, Tchernev VT, Wallace MR, Seabra MC, Swank RT, Kingsmore SF
Proceedings of the National Academy of Sciences of the United States of America97(8)4144-9(2000 Apr)

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Zhang H, Seabra MC, Deisenhofer J
Structure (London, England : 1993)8(3)241-51(2000 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

siRNA-mediated knockdown of alpha- or beta-subunits of RGGT and REP1 markedly attenuates glucose-stimulated insulin secretion in insulin 832/13 cells
Title: Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic ? cells.

The following Rabggta gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rabggta cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08390	NM_031654.2 Latest version!	Rattus norvegicus Rab geranylgeranyltransferase subunit alpha (Rabggta), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa08390	XM_006252010.3 Latest version!	Rattus norvegicus Rab geranylgeranyltransferase, alpha subunit (Rabggta), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa08390	XM_006252009.3 Latest version!	Rattus norvegicus Rab geranylgeranyltransferase, alpha subunit (Rabggta), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rabggta ( NM_031654.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113842.1 Rattus norvegicus Rab geranylgeranyltransferase subunit alpha (Rabggta), mRNA.

Price & Availability↑

CloneID	ORa08390
Clone ID Related Accession (Same CDS sequence)	XM_006252009.3 , XM_006252010.3 , NM_031654.2
Accession Version	NM_031654.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	geranylgeranyl transferase type-2 subunit alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086547.1. On Jun 10, 2007 this sequence version replaced NM_031654.1. ##Evidence-Data-START## Transcript exon combination :: BC086547.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCATGGGC GCCTGAAGGT GAAGACGTCG GAAGAGCAGG CAGAGGCCAA AAGGCTAGAA 
CGAGAGCAGA AGCTAAAGCT CTACCAGTCA GCCACTCAAG CTGTCTTCCA GAAGCGTCAG 
GCTGGTGAGC TGGATGAATC AGTGCTAGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGTCGAAGA GAAGTACTCC AGCACCTGGA AACCGAGAAG 
TCCCCTGAGG AGTCAGCTGC TCTTGTGAAG GCAGAACTGG GCTTCCTAGA GAGCTGTCTT 
CGTGTGAACC CTAAGTCCTA TGGCACTTGG CACCACCGCT GCTGGCTGCT GAGTCGCCTG 
CCTGAGCCCA ACTGGGCCCG GGAGCTGGAG CTATGCGCTC GCTTCCTCGA GGCCGATGAG 
CGGAACTTTC ATTGCTGGGA CTATCGGCGA TTTGTAGCCG CACAGGCTGC TGTTGCCCCT 
GCAGAGGAAC TAGCCTTCAC TGACAGCCTC ATCACCCGTA ACTTCTCCAA CTATTCCTCC 
TGGCATTATC GCTCCTGCCT CTTGCCACAG CTGCACCCCC AGCCAGACTC TGGCCCACAG 
GGTCGGCTCC CTGAAAATGT ACTGCTGAAA GAGCTGGAGT TGGTGCAGAA TGCCTTCTTT 
ACTGACCCCA ACGATCAGAG TGCCTGGTTC TATCACCGCT GGCTCCTGGG TCGGGCGGAG 
CCCCACGATG TTCTATGCTG TGTGCATGTG AGCCGGGAGG AGGCCTGTCT GTCGGTCTGC 
TTTTCTCGTC CCCTGACAGT GGGCTCCAGA ATGGGGACCT TGCTACTCAT GGTTGATGAG 
GCACCTTTGA GTGTGGAGTG GAGGACTCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCTCTCAAT GACCAGTTGC CCCAGCACAC GTTTCGTGTC 
ATCTGGACAG GAAGTGATAG CCAGAAGGAG TGTGTGCTTT TAAAAGACCG CCCAGAATGC 
TGGTGCCGAG ACTCAGCCAC TGATGAACAG CTATTCAGGT GTGAGCTGTC AGTGGAAAAG 
TCCACAGTGC TGCAGTCTGA GCTTGAATCC TGTAAGGAGC TGCAGGAACT AGAGCCTGAG 
AATAAATGGT GCCTGCTGAC CATCATCCTG CTGATGCGAG CACTGGACCC CCTCCTCTAT 
GAGAAGGAAA CACTGCAGTA CTTCAGTACC CTCAAAGCTG TGGACCCAAT GAGAGCAGCT 
TACTTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAACA GTGTTCTCAA GATGGAGTAC 
GCTGATGTAC GCGTGCTGCA CCTGGCTCAC AAGGATCTCA CAGTGCTCTG CCACCTGGAA 
CAACTGCTCT TGGTCACTCA TCTTGACCTG TCCCATAATC GACTCCGAGC CTTACCCCCA 
GCCCTGGCTG CTCTGCGCTG TCTTGAGGTG CTGCAGGCCA GTGACAATGC CCTGGAGAAC 
GTGGATGGTG TGGCTAACCT TCCCCGGCTA CAAGAGCTGT TACTATGTAA TAACCGCCTC 
CAACAGTCTG CAGCAATCCA GCCTCTTGTC TCCTGCCCCA GGCTAGTCCT CCTCAACCTG 
CAGGGCAACT CGCTGTGCCA AGAAGAGGGC ATCCAGGAGC GTTTGGCTGA GATGCTACCG 
TCTGTCAGCA GCATCCTCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113842.1
CDS	91..1794
Translation	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT

Target ORF information:

RefSeq Version	NM_031654.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Rab geranylgeranyltransferase subunit alpha (Rabggta), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031654.2

ORF Insert Sequence:

ATGCATGGGC GCCTGAAGGT GAAGACGTCG GAAGAGCAGG CAGAGGCCAA AAGGCTAGAA 
CGAGAGCAGA AGCTAAAGCT CTACCAGTCA GCCACTCAAG CTGTCTTCCA GAAGCGTCAG 
GCTGGTGAGC TGGATGAATC AGTGCTAGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGTCGAAGA GAAGTACTCC AGCACCTGGA AACCGAGAAG 
TCCCCTGAGG AGTCAGCTGC TCTTGTGAAG GCAGAACTGG GCTTCCTAGA GAGCTGTCTT 
CGTGTGAACC CTAAGTCCTA TGGCACTTGG CACCACCGCT GCTGGCTGCT GAGTCGCCTG 
CCTGAGCCCA ACTGGGCCCG GGAGCTGGAG CTATGCGCTC GCTTCCTCGA GGCCGATGAG 
CGGAACTTTC ATTGCTGGGA CTATCGGCGA TTTGTAGCCG CACAGGCTGC TGTTGCCCCT 
GCAGAGGAAC TAGCCTTCAC TGACAGCCTC ATCACCCGTA ACTTCTCCAA CTATTCCTCC 
TGGCATTATC GCTCCTGCCT CTTGCCACAG CTGCACCCCC AGCCAGACTC TGGCCCACAG 
GGTCGGCTCC CTGAAAATGT ACTGCTGAAA GAGCTGGAGT TGGTGCAGAA TGCCTTCTTT 
ACTGACCCCA ACGATCAGAG TGCCTGGTTC TATCACCGCT GGCTCCTGGG TCGGGCGGAG 
CCCCACGATG TTCTATGCTG TGTGCATGTG AGCCGGGAGG AGGCCTGTCT GTCGGTCTGC 
TTTTCTCGTC CCCTGACAGT GGGCTCCAGA ATGGGGACCT TGCTACTCAT GGTTGATGAG 
GCACCTTTGA GTGTGGAGTG GAGGACTCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCTCTCAAT GACCAGTTGC CCCAGCACAC GTTTCGTGTC 
ATCTGGACAG GAAGTGATAG CCAGAAGGAG TGTGTGCTTT TAAAAGACCG CCCAGAATGC 
TGGTGCCGAG ACTCAGCCAC TGATGAACAG CTATTCAGGT GTGAGCTGTC AGTGGAAAAG 
TCCACAGTGC TGCAGTCTGA GCTTGAATCC TGTAAGGAGC TGCAGGAACT AGAGCCTGAG 
AATAAATGGT GCCTGCTGAC CATCATCCTG CTGATGCGAG CACTGGACCC CCTCCTCTAT 
GAGAAGGAAA CACTGCAGTA CTTCAGTACC CTCAAAGCTG TGGACCCAAT GAGAGCAGCT 
TACTTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAACA GTGTTCTCAA GATGGAGTAC 
GCTGATGTAC GCGTGCTGCA CCTGGCTCAC AAGGATCTCA CAGTGCTCTG CCACCTGGAA 
CAACTGCTCT TGGTCACTCA TCTTGACCTG TCCCATAATC GACTCCGAGC CTTACCCCCA 
GCCCTGGCTG CTCTGCGCTG TCTTGAGGTG CTGCAGGCCA GTGACAATGC CCTGGAGAAC 
GTGGATGGTG TGGCTAACCT TCCCCGGCTA CAAGAGCTGT TACTATGTAA TAACCGCCTC 
CAACAGTCTG CAGCAATCCA GCCTCTTGTC TCCTGCCCCA GGCTAGTCCT CCTCAACCTG 
CAGGGCAACT CGCTGTGCCA AGAAGAGGGC ATCCAGGAGC GTTTGGCTGA GATGCTACCG 
TCTGTCAGCA GCATCCTCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rabggta ( XM_006252009.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252071.1 Rattus norvegicus Rab geranylgeranyltransferase, alpha subunit (Rabggta), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08390
Clone ID Related Accession (Same CDS sequence)	XM_006252009.3 , XM_006252010.3 , NM_031654.2
Accession Version	XM_006252009.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	geranylgeranyl transferase type-2 subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252009.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATGGGC GCCTGAAGGT GAAGACGTCG GAAGAGCAGG CAGAGGCCAA AAGGCTAGAA 
CGAGAGCAGA AGCTAAAGCT CTACCAGTCA GCCACTCAAG CTGTCTTCCA GAAGCGTCAG 
GCTGGTGAGC TGGATGAATC AGTGCTAGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGTCGAAGA GAAGTACTCC AGCACCTGGA AACCGAGAAG 
TCCCCTGAGG AGTCAGCTGC TCTTGTGAAG GCAGAACTGG GCTTCCTAGA GAGCTGTCTT 
CGTGTGAACC CTAAGTCCTA TGGCACTTGG CACCACCGCT GCTGGCTGCT GAGTCGCCTG 
CCTGAGCCCA ACTGGGCCCG GGAGCTGGAG CTATGCGCTC GCTTCCTCGA GGCCGATGAG 
CGGAACTTTC ATTGCTGGGA CTATCGGCGA TTTGTAGCCG CACAGGCTGC TGTTGCCCCT 
GCAGAGGAAC TAGCCTTCAC TGACAGCCTC ATCACCCGTA ACTTCTCCAA CTATTCCTCC 
TGGCATTATC GCTCCTGCCT CTTGCCACAG CTGCACCCCC AGCCAGACTC TGGCCCACAG 
GGTCGGCTCC CTGAAAATGT ACTGCTGAAA GAGCTGGAGT TGGTGCAGAA TGCCTTCTTT 
ACTGACCCCA ACGATCAGAG TGCCTGGTTC TATCACCGCT GGCTCCTGGG TCGGGCGGAG 
CCCCACGATG TTCTATGCTG TGTGCATGTG AGCCGGGAGG AGGCCTGTCT GTCGGTCTGC 
TTTTCTCGTC CCCTGACAGT GGGCTCCAGA ATGGGGACCT TGCTACTCAT GGTTGATGAG 
GCACCTTTGA GTGTGGAGTG GAGGACTCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCTCTCAAT GACCAGTTGC CCCAGCACAC GTTTCGTGTC 
ATCTGGACAG GAAGTGATAG CCAGAAGGAG TGTGTGCTTT TAAAAGACCG CCCAGAATGC 
TGGTGCCGAG ACTCAGCCAC TGATGAACAG CTATTCAGGT GTGAGCTGTC AGTGGAAAAG 
TCCACAGTGC TGCAGTCTGA GCTTGAATCC TGTAAGGAGC TGCAGGAACT AGAGCCTGAG 
AATAAATGGT GCCTGCTGAC CATCATCCTG CTGATGCGAG CACTGGACCC CCTCCTCTAT 
GAGAAGGAAA CACTGCAGTA CTTCAGTACC CTCAAAGCTG TGGACCCAAT GAGAGCAGCT 
TACTTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAACA GTGTTCTCAA GATGGAGTAC 
GCTGATGTAC GCGTGCTGCA CCTGGCTCAC AAGGATCTCA CAGTGCTCTG CCACCTGGAA 
CAACTGCTCT TGGTCACTCA TCTTGACCTG TCCCATAATC GACTCCGAGC CTTACCCCCA 
GCCCTGGCTG CTCTGCGCTG TCTTGAGGTG CTGCAGGCCA GTGACAATGC CCTGGAGAAC 
GTGGATGGTG TGGCTAACCT TCCCCGGCTA CAAGAGCTGT TACTATGTAA TAACCGCCTC 
CAACAGTCTG CAGCAATCCA GCCTCTTGTC TCCTGCCCCA GGCTAGTCCT CCTCAACCTG 
CAGGGCAACT CGCTGTGCCA AGAAGAGGGC ATCCAGGAGC GTTTGGCTGA GATGCTACCG 
TCTGTCAGCA GCATCCTCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252071.1
CDS	186..1889
Translation	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT

Target ORF information:

RefSeq Version	XM_006252009.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Rab geranylgeranyltransferase, alpha subunit (Rabggta), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252009.3

ORF Insert Sequence:

ATGCATGGGC GCCTGAAGGT GAAGACGTCG GAAGAGCAGG CAGAGGCCAA AAGGCTAGAA 
CGAGAGCAGA AGCTAAAGCT CTACCAGTCA GCCACTCAAG CTGTCTTCCA GAAGCGTCAG 
GCTGGTGAGC TGGATGAATC AGTGCTAGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGTCGAAGA GAAGTACTCC AGCACCTGGA AACCGAGAAG 
TCCCCTGAGG AGTCAGCTGC TCTTGTGAAG GCAGAACTGG GCTTCCTAGA GAGCTGTCTT 
CGTGTGAACC CTAAGTCCTA TGGCACTTGG CACCACCGCT GCTGGCTGCT GAGTCGCCTG 
CCTGAGCCCA ACTGGGCCCG GGAGCTGGAG CTATGCGCTC GCTTCCTCGA GGCCGATGAG 
CGGAACTTTC ATTGCTGGGA CTATCGGCGA TTTGTAGCCG CACAGGCTGC TGTTGCCCCT 
GCAGAGGAAC TAGCCTTCAC TGACAGCCTC ATCACCCGTA ACTTCTCCAA CTATTCCTCC 
TGGCATTATC GCTCCTGCCT CTTGCCACAG CTGCACCCCC AGCCAGACTC TGGCCCACAG 
GGTCGGCTCC CTGAAAATGT ACTGCTGAAA GAGCTGGAGT TGGTGCAGAA TGCCTTCTTT 
ACTGACCCCA ACGATCAGAG TGCCTGGTTC TATCACCGCT GGCTCCTGGG TCGGGCGGAG 
CCCCACGATG TTCTATGCTG TGTGCATGTG AGCCGGGAGG AGGCCTGTCT GTCGGTCTGC 
TTTTCTCGTC CCCTGACAGT GGGCTCCAGA ATGGGGACCT TGCTACTCAT GGTTGATGAG 
GCACCTTTGA GTGTGGAGTG GAGGACTCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCTCTCAAT GACCAGTTGC CCCAGCACAC GTTTCGTGTC 
ATCTGGACAG GAAGTGATAG CCAGAAGGAG TGTGTGCTTT TAAAAGACCG CCCAGAATGC 
TGGTGCCGAG ACTCAGCCAC TGATGAACAG CTATTCAGGT GTGAGCTGTC AGTGGAAAAG 
TCCACAGTGC TGCAGTCTGA GCTTGAATCC TGTAAGGAGC TGCAGGAACT AGAGCCTGAG 
AATAAATGGT GCCTGCTGAC CATCATCCTG CTGATGCGAG CACTGGACCC CCTCCTCTAT 
GAGAAGGAAA CACTGCAGTA CTTCAGTACC CTCAAAGCTG TGGACCCAAT GAGAGCAGCT 
TACTTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAACA GTGTTCTCAA GATGGAGTAC 
GCTGATGTAC GCGTGCTGCA CCTGGCTCAC AAGGATCTCA CAGTGCTCTG CCACCTGGAA 
CAACTGCTCT TGGTCACTCA TCTTGACCTG TCCCATAATC GACTCCGAGC CTTACCCCCA 
GCCCTGGCTG CTCTGCGCTG TCTTGAGGTG CTGCAGGCCA GTGACAATGC CCTGGAGAAC 
GTGGATGGTG TGGCTAACCT TCCCCGGCTA CAAGAGCTGT TACTATGTAA TAACCGCCTC 
CAACAGTCTG CAGCAATCCA GCCTCTTGTC TCCTGCCCCA GGCTAGTCCT CCTCAACCTG 
CAGGGCAACT CGCTGTGCCA AGAAGAGGGC ATCCAGGAGC GTTTGGCTGA GATGCTACCG 
TCTGTCAGCA GCATCCTCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rabggta ( XM_006252010.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252072.1 Rattus norvegicus Rab geranylgeranyltransferase, alpha subunit (Rabggta), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa08390
Clone ID Related Accession (Same CDS sequence)	XM_006252009.3 , XM_006252010.3 , NM_031654.2
Accession Version	XM_006252010.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	geranylgeranyl transferase type-2 subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252010.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATGGGC GCCTGAAGGT GAAGACGTCG GAAGAGCAGG CAGAGGCCAA AAGGCTAGAA 
CGAGAGCAGA AGCTAAAGCT CTACCAGTCA GCCACTCAAG CTGTCTTCCA GAAGCGTCAG 
GCTGGTGAGC TGGATGAATC AGTGCTAGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGTCGAAGA GAAGTACTCC AGCACCTGGA AACCGAGAAG 
TCCCCTGAGG AGTCAGCTGC TCTTGTGAAG GCAGAACTGG GCTTCCTAGA GAGCTGTCTT 
CGTGTGAACC CTAAGTCCTA TGGCACTTGG CACCACCGCT GCTGGCTGCT GAGTCGCCTG 
CCTGAGCCCA ACTGGGCCCG GGAGCTGGAG CTATGCGCTC GCTTCCTCGA GGCCGATGAG 
CGGAACTTTC ATTGCTGGGA CTATCGGCGA TTTGTAGCCG CACAGGCTGC TGTTGCCCCT 
GCAGAGGAAC TAGCCTTCAC TGACAGCCTC ATCACCCGTA ACTTCTCCAA CTATTCCTCC 
TGGCATTATC GCTCCTGCCT CTTGCCACAG CTGCACCCCC AGCCAGACTC TGGCCCACAG 
GGTCGGCTCC CTGAAAATGT ACTGCTGAAA GAGCTGGAGT TGGTGCAGAA TGCCTTCTTT 
ACTGACCCCA ACGATCAGAG TGCCTGGTTC TATCACCGCT GGCTCCTGGG TCGGGCGGAG 
CCCCACGATG TTCTATGCTG TGTGCATGTG AGCCGGGAGG AGGCCTGTCT GTCGGTCTGC 
TTTTCTCGTC CCCTGACAGT GGGCTCCAGA ATGGGGACCT TGCTACTCAT GGTTGATGAG 
GCACCTTTGA GTGTGGAGTG GAGGACTCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCTCTCAAT GACCAGTTGC CCCAGCACAC GTTTCGTGTC 
ATCTGGACAG GAAGTGATAG CCAGAAGGAG TGTGTGCTTT TAAAAGACCG CCCAGAATGC 
TGGTGCCGAG ACTCAGCCAC TGATGAACAG CTATTCAGGT GTGAGCTGTC AGTGGAAAAG 
TCCACAGTGC TGCAGTCTGA GCTTGAATCC TGTAAGGAGC TGCAGGAACT AGAGCCTGAG 
AATAAATGGT GCCTGCTGAC CATCATCCTG CTGATGCGAG CACTGGACCC CCTCCTCTAT 
GAGAAGGAAA CACTGCAGTA CTTCAGTACC CTCAAAGCTG TGGACCCAAT GAGAGCAGCT 
TACTTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAACA GTGTTCTCAA GATGGAGTAC 
GCTGATGTAC GCGTGCTGCA CCTGGCTCAC AAGGATCTCA CAGTGCTCTG CCACCTGGAA 
CAACTGCTCT TGGTCACTCA TCTTGACCTG TCCCATAATC GACTCCGAGC CTTACCCCCA 
GCCCTGGCTG CTCTGCGCTG TCTTGAGGTG CTGCAGGCCA GTGACAATGC CCTGGAGAAC 
GTGGATGGTG TGGCTAACCT TCCCCGGCTA CAAGAGCTGT TACTATGTAA TAACCGCCTC 
CAACAGTCTG CAGCAATCCA GCCTCTTGTC TCCTGCCCCA GGCTAGTCCT CCTCAACCTG 
CAGGGCAACT CGCTGTGCCA AGAAGAGGGC ATCCAGGAGC GTTTGGCTGA GATGCTACCG 
TCTGTCAGCA GCATCCTCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252072.1
CDS	131..1834
Translation	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT

Target ORF information:

RefSeq Version	XM_006252010.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Rab geranylgeranyltransferase, alpha subunit (Rabggta), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252010.3

ORF Insert Sequence:

ATGCATGGGC GCCTGAAGGT GAAGACGTCG GAAGAGCAGG CAGAGGCCAA AAGGCTAGAA 
CGAGAGCAGA AGCTAAAGCT CTACCAGTCA GCCACTCAAG CTGTCTTCCA GAAGCGTCAG 
GCTGGTGAGC TGGATGAATC AGTGCTAGAA CTGACAAGCC AGATTCTGGG AGCCAACCCT 
GATTTTGCCA CCCTCTGGAA CTGTCGAAGA GAAGTACTCC AGCACCTGGA AACCGAGAAG 
TCCCCTGAGG AGTCAGCTGC TCTTGTGAAG GCAGAACTGG GCTTCCTAGA GAGCTGTCTT 
CGTGTGAACC CTAAGTCCTA TGGCACTTGG CACCACCGCT GCTGGCTGCT GAGTCGCCTG 
CCTGAGCCCA ACTGGGCCCG GGAGCTGGAG CTATGCGCTC GCTTCCTCGA GGCCGATGAG 
CGGAACTTTC ATTGCTGGGA CTATCGGCGA TTTGTAGCCG CACAGGCTGC TGTTGCCCCT 
GCAGAGGAAC TAGCCTTCAC TGACAGCCTC ATCACCCGTA ACTTCTCCAA CTATTCCTCC 
TGGCATTATC GCTCCTGCCT CTTGCCACAG CTGCACCCCC AGCCAGACTC TGGCCCACAG 
GGTCGGCTCC CTGAAAATGT ACTGCTGAAA GAGCTGGAGT TGGTGCAGAA TGCCTTCTTT 
ACTGACCCCA ACGATCAGAG TGCCTGGTTC TATCACCGCT GGCTCCTGGG TCGGGCGGAG 
CCCCACGATG TTCTATGCTG TGTGCATGTG AGCCGGGAGG AGGCCTGTCT GTCGGTCTGC 
TTTTCTCGTC CCCTGACAGT GGGCTCCAGA ATGGGGACCT TGCTACTCAT GGTTGATGAG 
GCACCTTTGA GTGTGGAGTG GAGGACTCCA GATGGCAGGA ACCGGCCCAG CCATGTCTGG 
CTCTGTGACC TGCCTGCTGC CTCTCTCAAT GACCAGTTGC CCCAGCACAC GTTTCGTGTC 
ATCTGGACAG GAAGTGATAG CCAGAAGGAG TGTGTGCTTT TAAAAGACCG CCCAGAATGC 
TGGTGCCGAG ACTCAGCCAC TGATGAACAG CTATTCAGGT GTGAGCTGTC AGTGGAAAAG 
TCCACAGTGC TGCAGTCTGA GCTTGAATCC TGTAAGGAGC TGCAGGAACT AGAGCCTGAG 
AATAAATGGT GCCTGCTGAC CATCATCCTG CTGATGCGAG CACTGGACCC CCTCCTCTAT 
GAGAAGGAAA CACTGCAGTA CTTCAGTACC CTCAAAGCTG TGGACCCAAT GAGAGCAGCT 
TACTTGGATG ACCTGCGCAG CAAGTTCTTG CTGGAGAACA GTGTTCTCAA GATGGAGTAC 
GCTGATGTAC GCGTGCTGCA CCTGGCTCAC AAGGATCTCA CAGTGCTCTG CCACCTGGAA 
CAACTGCTCT TGGTCACTCA TCTTGACCTG TCCCATAATC GACTCCGAGC CTTACCCCCA 
GCCCTGGCTG CTCTGCGCTG TCTTGAGGTG CTGCAGGCCA GTGACAATGC CCTGGAGAAC 
GTGGATGGTG TGGCTAACCT TCCCCGGCTA CAAGAGCTGT TACTATGTAA TAACCGCCTC 
CAACAGTCTG CAGCAATCCA GCCTCTTGTC TCCTGCCCCA GGCTAGTCCT CCTCAACCTG 
CAGGGCAACT CGCTGTGCCA AGAAGAGGGC ATCCAGGAGC GTTTGGCTGA GATGCTACCG 
TCTGTCAGCA GCATCCTCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic ? cells.
Islets4(5)354-8(2012 Sep-Oct)
Arora DK,Syed I,Machhadieh B,McKenna CE,Kowluru A

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal27(18)2444-56(2008 Sep)
Guo Z,Wu YW,Das D,Delon C,Cramer J,Yu S,Thuns S,Lupilova N,Waldmann H,Brunsveld L,Goody RS,Alexandrov K,Blankenfeldt W

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell11(2)483-94(2003 Feb)
Pylypenko O,Rak A,Reents R,Niculae A,Sidorovitch V,Cioaca MD,Bessolitsyna E,Thom? NH,Waldmann H,Schlichting I,Goody RS,Alexandrov K

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Proceedings of the National Academy of Sciences of the United States of America97(8)4144-9(2000 Apr)
Detter JC,Zhang Q,Mules EH,Novak EK,Mishra VS,Li W,McMurtrie EB,Tchernev VT,Wallace MR,Seabra MC,Swank RT,Kingsmore SF

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Structure (London, England : 1993)8(3)241-51(2000 Mar)
Zhang H,Seabra MC,Deisenhofer J

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Rabggta cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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