Klrg1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klrg1
Entrez Gene ID	58975
Full Name	killer cell lectin like receptor G1
Synonyms	MAFA
General protein information	Preferred Names killer cell lectin like receptor G1 Names killer cell lectin-like receptor subfamily G member 1 killer cell lectin-like receptor subfamily G, member 1 mast cell function-associated antigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	a membrane glycoprotein that interferes with the coupling cascade of the type 1 Fc epsilon receptor induced mast cell secretory response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006237313.3	XP_006237375.1	killer cell lectin-like receptor subfamily G member 1 isoform X1
NM_031649.2	NP_113837.1	killer cell lectin-like receptor subfamily G member 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KLRG1	XP_002687892.1
Pan troglodytes (chimpanzee)	KLRG1	XP_001140410.1
	KLRG1	XP_001114131.1
Mus musculus (house mouse)	Klrg1	NP_058666.1
Rattus norvegicus (Norway rat)	Klrg1	NP_113837.1
Homo sapiens (human)	KLRG1	NP_005801.3
Canis lupus familiaris (dog)	KLRG1	XP_854226.1

Gene Ontology
Bibliography

Related articles in PubMed

PPAR? activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.
Zhu Y, Ma A, Zhang H, Li C
PloS one8(2)e56386(2013)

Compartmentalization of the Type I Fc epsilon receptor and MAFA on mast cell membranes.
Barisas BG, Smith SM, Liu J, Song J, Hagen GM, Pecht I, Roess DA
Biophysical chemistry126(1-3)209-17(2007 Mar)

MAFA controls genes implicated in insulin biosynthesis and secretion.
Wang H, Brun T, Kataoka K, Sharma AJ, Wollheim CB
Diabetologia50(2)348-58(2007 Feb)

MafA differentiates rat intestinal cells into insulin-producing cells.
Nomura S, Nakamura T, Hashimoto T, Nishio Y, Maegawa H, Kudo M, Kashiwagi A
Biochemical and biophysical research communications349(1)136-43(2006 Oct)

Selective inhibition of the Fc epsilon RI-induced de novo synthesis of mediators by an inhibitory receptor.
Abramson J, Licht A, Pecht I
The EMBO journal25(2)323-34(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a key role of PPARgamma in regulating pancreatic beta-cell function by improving the stability of Pdx1 and Mafa proteins
Title: PPAR? activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.

This provides additional indication of constitutive interactions between Fc epsilon RI and MAFA.
Title: Compartmentalization of the Type I Fc epsilon receptor and MAFA on mast cell membranes.

Regulates beta-cell-specific gene expression and function.
Title: MAFA controls genes implicated in insulin biosynthesis and secretion.

overexpression in the intestine induces intestinal epithelial cells newly to produce and release insulin
Title: MafA differentiates rat intestinal cells into insulin-producing cells.

(MAFA), selectively regulates the Fc-epsilon-RI stimulus-response coupling network and the subsequent de novo production and secretion of inflammatory mediators.
Title: Selective inhibition of the Fc epsilon RI-induced de novo synthesis of mediators by an inhibitory receptor.

The following Klrg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klrg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08372	NM_031649.2 Latest version!	Rattus norvegicus killer cell lectin like receptor G1 (Klrg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa27738	XM_006237313.3 Latest version!	Rattus norvegicus killer cell lectin like receptor G1 (Klrg1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klrg1 ( NM_031649.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113837.1 Rattus norvegicus killer cell lectin like receptor G1 (Klrg1), mRNA.

Price & Availability↑

CloneID	ORa08372
Clone ID Related Accession (Same CDS sequence)	NM_031649.2
Accession Version	NM_031649.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	killer cell lectin-like receptor subfamily G member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X97191.1. On Aug 16, 2008 this sequence version replaced NM_031649.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X79812.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689594, SAMEA2689596 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGACA ACTCTATCTA CTCAACATTA GAGCTGCCTG CTGCACCTCG AGTCCAAGAT 
GACTCCAGAT GGAAGGTCAA AGCTGTCTTA CACCGACCCT GTGTTTCCTA CCTTGTGATG 
GTGGCTTTGG GGCTTTTGAC TGTGATTCTC ATGAGTCTAC TGTTGTACCA ACGGACTCTG 
TGCTGTGGCT CCAAGGGCTT TATGTGTTCC CAGTGCTCCA GGTGCCCCAA CCTCTGGATG 
AGGAACGGGA GCCACTGTTA CTACTTCTCA ATGGAGAAAA GGGACTGGAA CTCTAGTCTG 
AAGTTCTGTG CAGACAAAGG CTCGCATCTC CTTACATTTC CGGACAACCA GGGAGTGAAC 
CTGTTCCAGG AGTATGTGGG CGAGGACTTT TACTGGATTG GCTTGAGGGA CATCGATGGC 
TGGAGGTGGG AAGATGGCCC AGCTCTCAGC TTAAGCATTC TCTCTAACAG CGTGGTACAG 
AAGTGTGGCA CCATCCACAG GTGTGGCCTC CACGCCTCCA GTTGTGAGGT TGCTTTGCAG 
TGGATCTGTG AGAAGGTCCT GCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113837.1
CDS	1..567
Translation	MADNSIYSTLELPAAPRVQDDSRWKVKAVLHRPCVSYLVMVALGLLTVILMSLLLYQRTLCCGSKGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSSLKFCADKGSHLLTFPDNQGVNLFQEYVGEDFYWIGLRDIDGWRWEDGPALSLSILSNSVVQKCGTIHRCGLHASSCEVALQWICEKVLP

Target ORF information:

RefSeq Version	NM_031649.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor G1 (Klrg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031649.2

ORF Insert Sequence:

ATGGCCGACA ACTCTATCTA CTCAACATTA GAGCTGCCTG CTGCACCTCG AGTCCAAGAT 
GACTCCAGAT GGAAGGTCAA AGCTGTCTTA CACCGACCCT GTGTTTCCTA CCTTGTGATG 
GTGGCTTTGG GGCTTTTGAC TGTGATTCTC ATGAGTCTAC TGTTGTACCA ACGGACTCTG 
TGCTGTGGCT CCAAGGGCTT TATGTGTTCC CAGTGCTCCA GGTGCCCCAA CCTCTGGATG 
AGGAACGGGA GCCACTGTTA CTACTTCTCA ATGGAGAAAA GGGACTGGAA CTCTAGTCTG 
AAGTTCTGTG CAGACAAAGG CTCGCATCTC CTTACATTTC CGGACAACCA GGGAGTGAAC 
CTGTTCCAGG AGTATGTGGG CGAGGACTTT TACTGGATTG GCTTGAGGGA CATCGATGGC 
TGGAGGTGGG AAGATGGCCC AGCTCTCAGC TTAAGCATTC TCTCTAACAG CGTGGTACAG 
AAGTGTGGCA CCATCCACAG GTGTGGCCTC CACGCCTCCA GTTGTGAGGT TGCTTTGCAG 
TGGATCTGTG AGAAGGTCCT GCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klrg1 ( XM_006237313.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237375.1 Rattus norvegicus killer cell lectin like receptor G1 (Klrg1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27738
Clone ID Related Accession (Same CDS sequence)	XM_006237313.3
Accession Version	XM_006237313.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	killer cell lectin-like receptor subfamily G member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237313.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGACA ACTCTATCTA CTCAACATTA GAGCTGCCTG CTGCACCTCG AGTCCAAGAT 
GACTCCAGAT GGAAGGTCAA AGGCTCCAAG GGCTTTATGT GTTCCCAGTG CTCCAGGTGC 
CCCAACCTCT GGATGAGGAA CGGGAGCCAC TGTTACTACT TCTCAATGGA GAAAAGGGAC 
TGGAACTCTA GTCTGAAGTT CTGTGCAGAC AAAGGCTCGC ATCTCCTTAC ATTTCCGGAC 
AACCAGGGAG TGAACCTGTT CCAGGAGTAT GTGGGCGAGG ACTTTTACTG GATTGGCTTG 
AGGGACATCG ATGGCTGGAG GTGGGAAGAT GGCCCAGCTC TCAGCTTAAG CATTCTCTCT 
AACAGCGTGG TACAGAAGTG TGGCACCATC CACAGGTGTG GCCTCCACGC CTCCAGTTGT 
GAGGTTGCTT TGCAGTGGAT CTGTGAGAAG GTCCTGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237375.1
CDS	74..535
Translation	MADNSIYSTLELPAAPRVQDDSRWKVKGSKGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSSLKFCADKGSHLLTFPDNQGVNLFQEYVGEDFYWIGLRDIDGWRWEDGPALSLSILSNSVVQKCGTIHRCGLHASSCEVALQWICEKVLP

Target ORF information:

RefSeq Version	XM_006237313.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus killer cell lectin like receptor G1 (Klrg1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237313.3

ORF Insert Sequence:

ATGGCCGACA ACTCTATCTA CTCAACATTA GAGCTGCCTG CTGCACCTCG AGTCCAAGAT 
GACTCCAGAT GGAAGGTCAA AGGCTCCAAG GGCTTTATGT GTTCCCAGTG CTCCAGGTGC 
CCCAACCTCT GGATGAGGAA CGGGAGCCAC TGTTACTACT TCTCAATGGA GAAAAGGGAC 
TGGAACTCTA GTCTGAAGTT CTGTGCAGAC AAAGGCTCGC ATCTCCTTAC ATTTCCGGAC 
AACCAGGGAG TGAACCTGTT CCAGGAGTAT GTGGGCGAGG ACTTTTACTG GATTGGCTTG 
AGGGACATCG ATGGCTGGAG GTGGGAAGAT GGCCCAGCTC TCAGCTTAAG CATTCTCTCT 
AACAGCGTGG TACAGAAGTG TGGCACCATC CACAGGTGTG GCCTCCACGC CTCCAGTTGT 
GAGGTTGCTT TGCAGTGGAT CTGTGAGAAG GTCCTGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PPAR? activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.
PloS one8(2)e56386(2013)
Zhu Y,Ma A,Zhang H,Li C

Compartmentalization of the Type I Fc epsilon receptor and MAFA on mast cell membranes.
Biophysical chemistry126(1-3)209-17(2007 Mar)
Barisas BG,Smith SM,Liu J,Song J,Hagen GM,Pecht I,Roess DA

MAFA controls genes implicated in insulin biosynthesis and secretion.
Diabetologia50(2)348-58(2007 Feb)
Wang H,Brun T,Kataoka K,Sharma AJ,Wollheim CB

MafA differentiates rat intestinal cells into insulin-producing cells.
Biochemical and biophysical research communications349(1)136-43(2006 Oct)
Nomura S,Nakamura T,Hashimoto T,Nishio Y,Maegawa H,Kudo M,Kashiwagi A

Selective inhibition of the Fc epsilon RI-induced de novo synthesis of mediators by an inhibitory receptor.
The EMBO journal25(2)323-34(2006 Jan)
Abramson J,Licht A,Pecht I

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Klrg1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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