Ramp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ramp2
Entrez Gene ID	58966
Full Name	receptor activity modifying protein 2
General protein information	Preferred Names receptor activity modifying protein 2 Names receptor activity-modifying protein 2 receptor (G protein-coupled) activity modifying protein 2 receptor (calcitonin) activity modifying protein 2 receptor activity modifying protein 2 isoform
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state and ligand specificity as a functional adrenomedullin receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597491.1	XP_017452980.1	receptor activity-modifying protein 2 isoform X1
NM_031646.1	NP_113834.1	receptor activity-modifying protein 2 precursor
XM_017597492.1	XP_017452981.1	receptor activity-modifying protein 2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RAMP2	XP_537636.1
	RAMP2	XP_001096145.2
Homo sapiens (human)	RAMP2	NP_005845.2
Gallus gallus (chicken)	RAMP2	NP_001099080.1
Pan troglodytes (chimpanzee)	RAMP2	XP_001160651.1
Bos taurus (cattle)	RAMP2	NP_001092330.1
Mus musculus (house mouse)	Ramp2	NP_062317.1
Rattus norvegicus (Norway rat)	Ramp2	NP_113834.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
Meng Q, Shi D, Feng J, Su Y, Long Y, He S, Wang S, Wang Y, Zhang X, Chen X
Annals of clinical and laboratory science46(1)5-17(2016)

Adrenomedullin promotes rat trophoblast stem cell differentiation.
Gao H, Liebenthal DA, Yallampalli U, Yallampalli C
Biology of reproduction91(3)65(2014 Sep)

Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T
PloS one9(2)e87667(2014)

Amyloid ? (A?) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.
Fu W, Ruangkittisakul A, MacTavish D, Shi JY, Ballanyi K, Jhamandas JH
The Journal of biological chemistry287(22)18820-30(2012 May)

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S
Protein science : a publication of the Protein Society21(2)199-210(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia.
Title: Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.

Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2).
Title: Adrenomedullin promotes rat trophoblast stem cell differentiation.

Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
Title: Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.

ADM peptide concentration exhibited a spatio-temporal pattern in the rat female reproductive system during gestation and this suggests that ADM may play important roles in gestation.
Title: Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation.

Results suggest that liver cirrhosis increases mRNA expressions of adrenomedullin (AM), calcitonin-like-receptor and receptor activity modifying proteins 1, 2 and 3 and that the increase in AM gene expression precedes the development of cirrhosis.
Title: The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis.

The following Ramp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ramp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08361	NM_031646.1 Latest version!	Rattus norvegicus receptor activity modifying protein 2 (Ramp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa57460	XM_017597492.1 Latest version!	Rattus norvegicus receptor activity modifying protein 2 (Ramp2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa57460	XM_017597491.1 Latest version!	Rattus norvegicus receptor activity modifying protein 2 (Ramp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ramp2 ( NM_031646.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113834.1 Rattus norvegicus receptor activity modifying protein 2 (Ramp2), mRNA.

Price & Availability↑

CloneID	ORa08361
Clone ID Related Accession (Same CDS sequence)	NM_031646.1
Accession Version	NM_031646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	receptor activity-modifying protein 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB042888.1. On Jun 25, 2006 this sequence version replaced XM_001081831.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB042888.1, FQ226087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCGC TCCGGGTAGA GCGCGCCCCG GGTGGATCAC AGCTCGCTGT GACCAGCGCC 
CAGCGGCCCG CAGCGCTCCG CCTCCCTCCG CTGTTACTGC TGCTGTTGCT GCTGCTGCTG 
GGCGCTGTCT CAACCTCTCC GGAGTCCCTG AATCAATCTC ATCCTACTGA GGACAGCCTT 
CTGTCAAAAG GGAAGATGGA GGACTACGAA ACAAATGTCC TACCTTGCTG GTATTATTAC 
AAGACTTCCA TGGACTCTGT CAAGGACTGG TGCAACTGGA CTTTGATTAG CAGGTATTAC 
AGCAACCTGC GGTATTGCTT GGAGTACGAG GCAGACAAGT TTGGCCTGGG CTTCCCAAAT 
CCCTTGGCAG AAAGTATCAT CCTTGAGGCT CACCTGATAC ACTTTGCCAA CTGCTCCTTG 
GTGCAGCCTA CCTTCTCCGA TCCCCCAGAG GATGTGCTTC TGGCCATGAT CATAGCCCCC 
ATCTGCCTCA TCCCTTTCCT CGTTACGCTT GTGGTGTGGA GGAGTAAAGA CGGCGATGCG 
CAGGCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113834.1
CDS	15..563
Translation	MAPLRVERAPGGSQLAVTSAQRPAALRLPPLLLLLLLLLLGAVSTSPESLNQSHPTEDSLLSKGKMEDYETNVLPCWYYYKTSMDSVKDWCNWTLISRYYSNLRYCLEYEADKFGLGFPNPLAESIILEAHLIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLVTLVVWRSKDGDAQA

Target ORF information:

RefSeq Version	NM_031646.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus receptor activity modifying protein 2 (Ramp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031646.1

ORF Insert Sequence:

ATGGCTCCGC TCCGGGTAGA GCGCGCCCCG GGTGGATCAC AGCTCGCTGT GACCAGCGCC 
CAGCGGCCCG CAGCGCTCCG CCTCCCTCCG CTGTTACTGC TGCTGTTGCT GCTGCTGCTG 
GGCGCTGTCT CAACCTCTCC GGAGTCCCTG AATCAATCTC ATCCTACTGA GGACAGCCTT 
CTGTCAAAAG GGAAGATGGA GGACTACGAA ACAAATGTCC TACCTTGCTG GTATTATTAC 
AAGACTTCCA TGGACTCTGT CAAGGACTGG TGCAACTGGA CTTTGATTAG CAGGTATTAC 
AGCAACCTGC GGTATTGCTT GGAGTACGAG GCAGACAAGT TTGGCCTGGG CTTCCCAAAT 
CCCTTGGCAG AAAGTATCAT CCTTGAGGCT CACCTGATAC ACTTTGCCAA CTGCTCCTTG 
GTGCAGCCTA CCTTCTCCGA TCCCCCAGAG GATGTGCTTC TGGCCATGAT CATAGCCCCC 
ATCTGCCTCA TCCCTTTCCT CGTTACGCTT GTGGTGTGGA GGAGTAAAGA CGGCGATGCG 
CAGGCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ramp2 ( XM_017597491.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452980.1 Rattus norvegicus receptor activity modifying protein 2 (Ramp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57460
Clone ID Related Accession (Same CDS sequence)	XM_017597491.1 , XM_017597492.1
Accession Version	XM_017597491.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	receptor activity-modifying protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGTG GATCCCGGTT CATGGGGTAC AGGGGGAGCT GTCCAGCCCC GCGGTCCGAG 
CTGGAAGCGA GAGTGGGCCA AGGCAATCCA GGCCGAGTGA ATTACGGGTG CGGCAGTGAC 
TCCCTCTGCA GCCCGCCCCC CACGTGGCCG CCGCCGTGCC AGCCCCTCCG AGGAAGCGGC 
GCGGCTTCCT GCGGCTGGGG CCCGGGATAT AGGCGCCCCC GCCCGGGCCA GCTCAGCTCC 
GCCGCCCCTC CTCGCCATCT CGCCCAAGGC GTGATGGCTC CGCTCCGGGT AGAGCGCGCC 
CCGGGTGGAT CACAGCTCGC TGTGACCAGC GCCCAGCGGC CCGCAGCGCT CCGCCTCCCT 
CCGCTGTTAC TGCTGCTTGC TGCTGCTGCT GGGCGCTGTC TCAACCTCTC CGGAGTCCCT 
GAATCAATCT CATCCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452980.1
CDS	464..904
Translation	MGSGSRFMGYRGSCPAPRSELEARVGQGNPGRVNYGCGSDSLCSPPPTWPPPCQPLRGSGAASCGWGPGYRRPRPGQLSSAAPPRHLAQGVMAPLRVERAPGGSQLAVTSAQRPAALRLPPLLLLLAAAAGRCLNLSGVPESISSY

Target ORF information:

RefSeq Version	XM_017597491.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus receptor activity modifying protein 2 (Ramp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597491.1

ORF Insert Sequence:

ATGGGAAGTG GATCCCGGTT CATGGGGTAC AGGGGGAGCT GTCCAGCCCC GCGGTCCGAG 
CTGGAAGCGA GAGTGGGCCA AGGCAATCCA GGCCGAGTGA ATTACGGGTG CGGCAGTGAC 
TCCCTCTGCA GCCCGCCCCC CACGTGGCCG CCGCCGTGCC AGCCCCTCCG AGGAAGCGGC 
GCGGCTTCCT GCGGCTGGGG CCCGGGATAT AGGCGCCCCC GCCCGGGCCA GCTCAGCTCC 
GCCGCCCCTC CTCGCCATCT CGCCCAAGGC GTGATGGCTC CGCTCCGGGT AGAGCGCGCC 
CCGGGTGGAT CACAGCTCGC TGTGACCAGC GCCCAGCGGC CCGCAGCGCT CCGCCTCCCT 
CCGCTGTTAC TGCTGCTTGC TGCTGCTGCT GGGCGCTGTC TCAACCTCTC CGGAGTCCCT 
GAATCAATCT CATCCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ramp2 ( XM_017597492.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452981.1 Rattus norvegicus receptor activity modifying protein 2 (Ramp2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa57460
Clone ID Related Accession (Same CDS sequence)	XM_017597491.1 , XM_017597492.1
Accession Version	XM_017597492.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	receptor activity-modifying protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGTG GATCCCGGTT CATGGGGTAC AGGGGGAGCT GTCCAGCCCC GCGGTCCGAG 
CTGGAAGCGA GAGTGGGCCA AGGCAATCCA GGCCGAGTGA ATTACGGGTG CGGCAGTGAC 
TCCCTCTGCA GCCCGCCCCC CACGTGGCCG CCGCCGTGCC AGCCCCTCCG AGGAAGCGGC 
GCGGCTTCCT GCGGCTGGGG CCCGGGATAT AGGCGCCCCC GCCCGGGCCA GCTCAGCTCC 
GCCGCCCCTC CTCGCCATCT CGCCCAAGGC GTGATGGCTC CGCTCCGGGT AGAGCGCGCC 
CCGGGTGGAT CACAGCTCGC TGTGACCAGC GCCCAGCGGC CCGCAGCGCT CCGCCTCCCT 
CCGCTGTTAC TGCTGCTTGC TGCTGCTGCT GGGCGCTGTC TCAACCTCTC CGGAGTCCCT 
GAATCAATCT CATCCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452981.1
CDS	464..904
Translation	MGSGSRFMGYRGSCPAPRSELEARVGQGNPGRVNYGCGSDSLCSPPPTWPPPCQPLRGSGAASCGWGPGYRRPRPGQLSSAAPPRHLAQGVMAPLRVERAPGGSQLAVTSAQRPAALRLPPLLLLLAAAAGRCLNLSGVPESISSY

Target ORF information:

RefSeq Version	XM_017597492.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus receptor activity modifying protein 2 (Ramp2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597492.1

ORF Insert Sequence:

ATGGGAAGTG GATCCCGGTT CATGGGGTAC AGGGGGAGCT GTCCAGCCCC GCGGTCCGAG 
CTGGAAGCGA GAGTGGGCCA AGGCAATCCA GGCCGAGTGA ATTACGGGTG CGGCAGTGAC 
TCCCTCTGCA GCCCGCCCCC CACGTGGCCG CCGCCGTGCC AGCCCCTCCG AGGAAGCGGC 
GCGGCTTCCT GCGGCTGGGG CCCGGGATAT AGGCGCCCCC GCCCGGGCCA GCTCAGCTCC 
GCCGCCCCTC CTCGCCATCT CGCCCAAGGC GTGATGGCTC CGCTCCGGGT AGAGCGCGCC 
CCGGGTGGAT CACAGCTCGC TGTGACCAGC GCCCAGCGGC CCGCAGCGCT CCGCCTCCCT 
CCGCTGTTAC TGCTGCTTGC TGCTGCTGCT GGGCGCTGTC TCAACCTCTC CGGAGTCCCT 
GAATCAATCT CATCCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress.
Annals of clinical and laboratory science46(1)5-17(2016)
Meng Q,Shi D,Feng J,Su Y,Long Y,He S,Wang S,Wang Y,Zhang X,Chen X

Adrenomedullin promotes rat trophoblast stem cell differentiation.
Biology of reproduction91(3)65(2014 Sep)
Gao H,Liebenthal DA,Yallampalli U,Yallampalli C

Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
PloS one9(2)e87667(2014)
Uetake R,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Yoshizawa T,Koyama T,Yang L,Toriyama Y,Yamauchi A,Igarashi K,Tanaka M,Kuwabara T,Mori K,Yanagita M,Mukoyama M,Shindo T

Amyloid ? (A?) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.
The Journal of biological chemistry287(22)18820-30(2012 May)
Fu W,Ruangkittisakul A,MacTavish D,Shi JY,Ballanyi K,Jhamandas JH

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
Protein science : a publication of the Protein Society21(2)199-210(2012 Feb)
Kusano S,Kukimoto-Niino M,Hino N,Ohsawa N,Okuda K,Sakamoto K,Shirouzu M,Shindo T,Yokoyama S

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Ramp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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