H2az1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2az1
Entrez Gene ID	58940
Full Name	H2A histone family, member Z
Synonyms	H2A.Z-1
General protein information	Preferred Names H2A histone family, member Z Names histone H2A.Z H2A/z
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q44
Summary	variant of the histone family H2a, synthesized throughout cell cycle, function is unknown but appears to be different from classical S-phase regulated H2a family members [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022674.1	NP_073165.1	histone H2A.Z

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	H2afz	NP_073165.1
Arabidopsis thaliana (thale cress)	HTA9	NP_175683.1
Homo sapiens (human)	H2AFZ	NP_002097.1
Bos taurus (cattle)	H2AFZ	NP_777234.1
Xenopus tropicalis (tropical clawed frog)	h2afz	NP_001005097.1
Danio rerio (zebrafish)	h2afvb	NP_001036788.1
Gallus gallus (chicken)	H2AFZ	NP_001026545.1
Pan troglodytes (chimpanzee)	H2AFZ	XP_517363.3
	H2AFZ	XP_001108128.1
Canis lupus familiaris (dog)	H2AFZ	XP_535671.1
Mus musculus (house mouse)	H2afz	NP_058030.1

Gene Ontology
Bibliography

Related articles in PubMed

Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of
Dunn CJ, Sarkar P, Bailey ER, Farris S, Zhao M, Ward JM, Dudek SM, Saha RN
eNeuro4(4)(2017 Jul-Aug)

Histone variants: dynamic punctuation in transcription.
Weber CM, Henikoff S
Genes & development28(7)672-82(2014 Apr)

Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site.
Zerzaihi O, Chriett S, Vidal H, Pirola L
Biochemistry and cell biology = Biochimie et biologie cellulaire92(1)61-7(2014 Feb)

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription.
Dalvai M, Fleury L, Bellucci L, Kocanova S, Bystricky K
PLoS genetics9(4)e1003387(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Histone H2A.z is required for cardiac hypertrophy, where its stability and the extent of cell growth and apoptosis are moderated by Sir2alpha
Title: Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.

The following H2az1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2az1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12453	NM_022674.1 Latest version!	Rattus norvegicus H2A.Z variant histone 1 (H2az1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2az1 ( NM_022674.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_073165.1 Rattus norvegicus H2A.Z variant histone 1 (H2az1), mRNA.

Price & Availability↑

CloneID	ORa12453
Clone ID Related Accession (Same CDS sequence)	NM_022674.1
Accession Version	NM_022674.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-30
Organism	Rattus norvegicus(Norway rat)
Product	histone H2A.Z
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M37584.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M37584.1, FQ213837.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGGCG GTAAGGCTGG AAAGGACTCC GGAAAGGCCA AGACAAAGGC GGTTTCCCGC 
TCCCAGCGAG CGGGCTTGCA GTTCCCTGTG GGCCGTATTC ATCGACACCT GAAATCTAGG 
ACAACAAGCC ACGGACGTGT GGGCGCGACC GCAGCTGTGT ACAGCGCAGC CATCCTGGAG 
TACCTCACCG CAGAGGTACT TGAGTTGGCA GGAAATGCAT CAAAAGACTT GAAGGTAAAG 
CGTATTACCC CTCGTCACTT GCAACTTGCT ATCCGCGGAG ATGAAGAGTT GGACTCTCTG 
ATCAAGGCTA CGATTGCTGG TGGTGGTGTC ATCCCACACA TCCACAAATC ACTGATTGGG 
AAGAAAGGAC AACAGAAGAC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073165.1
CDS	45..431
Translation	MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV

Target ORF information:

RefSeq Version	NM_022674.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus H2A.Z variant histone 1 (H2az1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022674.1

ORF Insert Sequence:

ATGGCTGGCG GTAAGGCTGG AAAGGACTCC GGAAAGGCCA AGACAAAGGC GGTTTCCCGC 
TCCCAGCGAG CGGGCTTGCA GTTCCCTGTG GGCCGTATTC ATCGACACCT GAAATCTAGG 
ACAACAAGCC ACGGACGTGT GGGCGCGACC GCAGCTGTGT ACAGCGCAGC CATCCTGGAG 
TACCTCACCG CAGAGGTACT TGAGTTGGCA GGAAATGCAT CAAAAGACTT GAAGGTAAAG 
CGTATTACCC CTCGTCACTT GCAACTTGCT ATCCGCGGAG ATGAAGAGTT GGACTCTCTG 
ATCAAGGCTA CGATTGCTGG TGGTGGTGTC ATCCCACACA TCCACAAATC ACTGATTGGG 
AAGAAAGGAC AACAGAAGAC TGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of
eNeuro4(4)(2017 Jul-Aug)
Dunn CJ,Sarkar P,Bailey ER,Farris S,Zhao M,Ward JM,Dudek SM,Saha RN

Histone variants: dynamic punctuation in transcription.
Genes & development28(7)672-82(2014 Apr)
Weber CM,Henikoff S

Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site.
Biochemistry and cell biology = Biochimie et biologie cellulaire92(1)61-7(2014 Feb)
Zerzaihi O,Chriett S,Vidal H,Pirola L

TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription.
PLoS genetics9(4)e1003387(2013 Apr)
Dalvai M,Fleury L,Bellucci L,Kocanova S,Bystricky K