Gas6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gas6
Entrez Gene ID	58935
Full Name	growth arrest specific 6
General protein information	Preferred Names growth arrest specific 6 Names growth arrest-specific protein 6 AXL receptor tyrosine kinase ligand GAS-6 GPF growth-potentiating factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5
Summary	provides protection of neurons against serum deprivation-induced apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057100.2	NP_476441.2	growth arrest-specific protein 6 precursor
XM_017600238.1	XP_017455727.1	growth arrest-specific protein 6 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GAS6	XP_001146448.2
Canis lupus familiaris (dog)	GAS6	XP_849623.2
Gallus gallus (chicken)	GAS6	XP_416936.4
Danio rerio (zebrafish)	gas6	NP_956272.1
Xenopus tropicalis (tropical clawed frog)	gas6	NP_001015965.1
	GAS6	XP_002800893.1
Bos taurus (cattle)	GAS6	XP_005214103.1
Rattus norvegicus (Norway rat)	Gas6	NP_476441.2
Homo sapiens (human)	GAS6	NP_000811.1
Mus musculus (house mouse)	Gas6	NP_062394.2

Gene Ontology
Bibliography

Related articles in PubMed

Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-?B pathway after MCAO in rats.
Wu G, McBride DW, Zhang JH
Neurobiology of disease11059-67(2018 Feb)

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Qiu C, Zheng H, Tao H, Yu W, Jiang X, Li A, Jin H, Lv A, Li H
Molecular and cellular biochemistry433(1-2)149-159(2017 Sep)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.
Haase TN, Rasmussen M, Jaksch CA, Gaarn LW, Petersen CK, Billestrup N, Nielsen JH
Diabetologia56(4)763-73(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GAS6 has a role in the regulation of pancreatic beta cells in the critical period around the time of birth
Title: Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.

Glucose alters Axl signaling through coupling to binding partners and suggests a mechanism by which Axl contributes to vascular smooth muscle cells dysfunction in diabetes.
Title: Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells.

expression of gamma-carboxylated Gas6 was strongly induced in HSC along with their transformation into myofibroblasts, and it exerted an anti-apoptotic effect on both HSC and HSC/MFB mediated by the Axl/PI3-kinase/Akt pathway.
Title: Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells.

Our data demonstrate an expression of Gas6 and of its receptor Axl by oval cells during hepatic regeneration
Title: Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat.

Akt/mTOR pathway is a key signaling cascade in Gas6-mediated mesangial and glomerular hypertrophy and there is a crucial role of Gas6/Axl and the Akt/mTOR pathway in the development of diabetic nephropathy
Title: Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy.

The following Gas6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gas6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09265	NM_057100.2 Latest version!	Rattus norvegicus growth arrest specific 6 (Gas6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$398.30 $569.00
ORa58898	XM_017600238.1 Latest version!	Rattus norvegicus growth arrest specific 6 (Gas6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gas6 ( NM_057100.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476441.2 Rattus norvegicus growth arrest specific 6 (Gas6), mRNA.

Price & Availability↑

CloneID	ORa09265
Clone ID Related Accession (Same CDS sequence)	NM_057100.2
Accession Version	NM_057100.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	growth arrest-specific protein 6 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070881.1. On Apr 14, 2007 this sequence version replaced NM_057100.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070881.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCGCCAC CGCCCGGGCC CACCGCCGCC CTGGGCACTG CGCTTCTGCT GCTCCTGCTG 
GCCTCCGAGT CTTCGCACAC TGTGCTGTTG CGGGCGCGTG AGGCGGCGCA GTTCCTGCGG 
CCCAGGCAGC GCCGCGCCTA CCAAGTCTTC GAGGAGGCCA AGCAGGGCCA CCTGGAACGG 
GAGTGCGTGG AGGAGGTGTG CAGCAAGGAG GAGGCTAGAG AGGTGTTCGA GAACGACCCC 
GAGACGGACT ATTTCTATCC AAGATATCAA GAGTGCATGA GGAAATATGG CCGGCCCGAA 
GATAAAAACC CAAATTTCGC CACCTGTGTT AAGAACTTAC CTGACCAATG CACCCCAAAC 
CCCTGTGATA AGAAGGGCAC TCAACTCTGC CAAGACCTCA TGGGCAACTT CTTCTGCTTG 
TGCAAAGATG GCTGGGGAGG CCGGCTCTGT GACAAAGATG TCAACGAGTG TAGTCAGAAG 
AATGGGGGCT GCAGCCAGGT CTGCCATAAC AAACCAGGAA GCTTCCAATG TGCCTGCCAC 
AGTGGCTTCT CACTTCAATC AGACAACAAG AGCTGCCAAG ATATAGATGA ATGCACAGAC 
TCAGACACCT GTGGGGATGC GCGTTGCAAG AACCTTCCGG GCTCCTACTC CTGCCTCTGC 
GACAAGGGGT ACACTTACAG CTCCAAGGAG AAGACCTGCC AAGATGTGGA TGAGTGCCAG 
CAGGACCGTT GTGAGCAGAC CTGTGTCAAC TCCCCAGGCA GCTATACCTG CCACTGTAAT 
GGGCGCGGGG GCCTAAAACT GTCCCCAGAC ATGGATACCT GTGAGGACAT CTTACCGTGT 
GTGCCCTTCA GCATGGCCAA GAGCGTCAAG TCCTTGTACC TGGGCCGCAT GTTCAGCGGG 
ACCCCCGTGA TTAGACTACG CTTCAAGAGG CTCCAGCCTA CCAGGCTGCT GGCCGAATTT 
GACTTCCGTA CTTTTGACCC TGAGGGAGTC CTCTTCTTCG CCGGAGGTCG CTCGGATAGC 
ACCTGGATCG TCCTGGGCTT CAGGGCTGGG CGACTTGAGT TGCAGCTACG GTACAATGGC 
GTTGGACGCA TCACCAGCAG TGGGCCAACC ATCAACCACG GCATGTGGCA AACGATCTCT 
GTGGAAGAAC TGGACCGCAA CCTTGTCATC AAGGTCAACA AAGATGCCGT GATGAAGATT 
GCGGTGGCTG GGGGGCTGTT CCAGCTAGAG AGAGGCCTGT ACCACCTGAA TCTCACTGTG 
GGGGGCATTC CCTTCAAGGA GAGTGACCTC GTCCAGCCGA TTAACCCTCG CCTGGACGGG 
TGCATGAGGA GCTGGAACTG GCTGAATGGG GAAGACAGTG CCATTCAGGA AACGGTCAAG 
GCCAATACAA AAATGCAGTG CTTCTCTGTG ACAGAGAGGG GCTCCTTCTT CCCGGGGAAT 
GGATTTGCCT TCTATAGCCT CAACTACACC CGGACATCGC TGGATGTCGG CACGGAAACC 
ACCTGGGAAG TAGAAGTCGT GGCTCGCATT CGCCCTGCCA CTGACACGGG GGTGCTGATG 
GCACTGGTGG GGGACAAAGA CGTCGTCCTC CTCTCTGTGG CCCTGGTCGA CTACCACTCC 
ACAAAGAAGC TCAAGAAGCA GCTGGTGGTC CTGGCAGTTG AGAATGTTGC CCTGGCCCTG 
ATGGAAATCA AGGTGTGCGA CAGCCAGGAA CACACTGTCA CTGTCTCCCT GCGGGATGGC 
GAGGCCACCC TGGAAGTGGA TGGTACCAAG GGCCAGAGCG AAGTGAGCAC CGCACAGCTG 
CAGGAGCGAC TGGACCTGCT TAAGACACGT CTGCAAGGCT CCGTGCTCAC CTTTGTGGGG 
GGCCTGCCAG ATGTACAAGT GACTTCCACA CCCGTCACGG CGTTCTACCG TGGATGCATG 
ACTCTGGAGG TAAACGGGAA GACCCTGGAC CTGGATACGG CCTCCTACAA GCACAGTGAC 
ATCACCTCCC ACTCCTGCCC GCCTGTGGAG CACGTCACAG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476441.2
CDS	131..2155
Translation	MPPPPGPTAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETDYFYPRYQECMRKYGRPEDKNPNFATCVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQKNGGCSQVCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKNLPGSYSCLCDKGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGFRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELDRNLVIKVNKDAVMKIAVAGGLFQLERGLYHLNLTVGGIPFKESDLVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEVEVVARIRPATDTGVLMALVGDKDVVLLSVALVDYHSTKKLKKQLVVLAVENVALALMEIKVCDSQEHTVTVSLRDGEATLEVDGTKGQSEVSTAQLQERLDLLKTRLQGSVLTFVGGLPDVQVTSTPVTAFYRGCMTLEVNGKTLDLDTASYKHSDITSHSCPPVEHVTA

Target ORF information:

RefSeq Version	NM_057100.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus growth arrest specific 6 (Gas6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057100.2

ORF Insert Sequence:

ATGCCGCCAC CGCCCGGGCC CACCGCCGCC CTGGGCACTG CGCTTCTGCT GCTCCTGCTG 
GCCTCCGAGT CTTCGCACAC TGTGCTGTTG CGGGCGCGTG AGGCGGCGCA GTTCCTGCGG 
CCCAGGCAGC GCCGCGCCTA CCAAGTCTTC GAGGAGGCCA AGCAGGGCCA CCTGGAACGG 
GAGTGCGTGG AGGAGGTGTG CAGCAAGGAG GAGGCTAGAG AGGTGTTCGA GAACGACCCC 
GAGACGGACT ATTTCTATCC AAGATATCAA GAGTGCATGA GGAAATATGG CCGGCCCGAA 
GATAAAAACC CAAATTTCGC CACCTGTGTT AAGAACTTAC CTGACCAATG CACCCCAAAC 
CCCTGTGATA AGAAGGGCAC TCAACTCTGC CAAGACCTCA TGGGCAACTT CTTCTGCTTG 
TGCAAAGATG GCTGGGGAGG CCGGCTCTGT GACAAAGATG TCAACGAGTG TAGTCAGAAG 
AATGGGGGCT GCAGCCAGGT CTGCCATAAC AAACCAGGAA GCTTCCAATG TGCCTGCCAC 
AGTGGCTTCT CACTTCAATC AGACAACAAG AGCTGCCAAG ATATAGATGA ATGCACAGAC 
TCAGACACCT GTGGGGATGC GCGTTGCAAG AACCTTCCGG GCTCCTACTC CTGCCTCTGC 
GACAAGGGGT ACACTTACAG CTCCAAGGAG AAGACCTGCC AAGATGTGGA TGAGTGCCAG 
CAGGACCGTT GTGAGCAGAC CTGTGTCAAC TCCCCAGGCA GCTATACCTG CCACTGTAAT 
GGGCGCGGGG GCCTAAAACT GTCCCCAGAC ATGGATACCT GTGAGGACAT CTTACCGTGT 
GTGCCCTTCA GCATGGCCAA GAGCGTCAAG TCCTTGTACC TGGGCCGCAT GTTCAGCGGG 
ACCCCCGTGA TTAGACTACG CTTCAAGAGG CTCCAGCCTA CCAGGCTGCT GGCCGAATTT 
GACTTCCGTA CTTTTGACCC TGAGGGAGTC CTCTTCTTCG CCGGAGGTCG CTCGGATAGC 
ACCTGGATCG TCCTGGGCTT CAGGGCTGGG CGACTTGAGT TGCAGCTACG GTACAATGGC 
GTTGGACGCA TCACCAGCAG TGGGCCAACC ATCAACCACG GCATGTGGCA AACGATCTCT 
GTGGAAGAAC TGGACCGCAA CCTTGTCATC AAGGTCAACA AAGATGCCGT GATGAAGATT 
GCGGTGGCTG GGGGGCTGTT CCAGCTAGAG AGAGGCCTGT ACCACCTGAA TCTCACTGTG 
GGGGGCATTC CCTTCAAGGA GAGTGACCTC GTCCAGCCGA TTAACCCTCG CCTGGACGGG 
TGCATGAGGA GCTGGAACTG GCTGAATGGG GAAGACAGTG CCATTCAGGA AACGGTCAAG 
GCCAATACAA AAATGCAGTG CTTCTCTGTG ACAGAGAGGG GCTCCTTCTT CCCGGGGAAT 
GGATTTGCCT TCTATAGCCT CAACTACACC CGGACATCGC TGGATGTCGG CACGGAAACC 
ACCTGGGAAG TAGAAGTCGT GGCTCGCATT CGCCCTGCCA CTGACACGGG GGTGCTGATG 
GCACTGGTGG GGGACAAAGA CGTCGTCCTC CTCTCTGTGG CCCTGGTCGA CTACCACTCC 
ACAAAGAAGC TCAAGAAGCA GCTGGTGGTC CTGGCAGTTG AGAATGTTGC CCTGGCCCTG 
ATGGAAATCA AGGTGTGCGA CAGCCAGGAA CACACTGTCA CTGTCTCCCT GCGGGATGGC 
GAGGCCACCC TGGAAGTGGA TGGTACCAAG GGCCAGAGCG AAGTGAGCAC CGCACAGCTG 
CAGGAGCGAC TGGACCTGCT TAAGACACGT CTGCAAGGCT CCGTGCTCAC CTTTGTGGGG 
GGCCTGCCAG ATGTACAAGT GACTTCCACA CCCGTCACGG CGTTCTACCG TGGATGCATG 
ACTCTGGAGG TAAACGGGAA GACCCTGGAC CTGGATACGG CCTCCTACAA GCACAGTGAC 
ATCACCTCCC ACTCCTGCCC GCCTGTGGAG CACGTCACAG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gas6 ( XM_017600238.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455727.1 Rattus norvegicus growth arrest specific 6 (Gas6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58898
Clone ID Related Accession (Same CDS sequence)	XM_017600238.1
Accession Version	XM_017600238.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1725bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	growth arrest-specific protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCCAC CGCCCGGGCC CACCGCCGCC CTGGGCACTG CGCTTCTGCT GCTCCTGCTG 
GCCTCCGAGT CTTCGCACAC TGTGCTGTTG CGGGCGCGTG AGGCGGCGCA GTTCCTGCGG 
CCCAGGCAGC GCCGCGCCTA CCAAGTCTTC GAGGAGGCCA AGCAGGGCCA CCTGGAACGG 
GAGTGCGTGG AGGAGGTGTG CAGCAAGGAG GAGGCTAGAG AGGTGTTCGA GAACGACCCC 
GAGACGGACT ATTTCTATCC AAGATATCAA GAGTGCATGA GGAAATATGG CCGGCCCGAA 
GATAAAAACC CAAATTTCGC CACCTGTGTT AAGAACTTAC CTGACCAATG CACCCCAAAC 
CCCTGTGATA AGAAGGGCAC TCAACTCTGC CAAGACCTCA TGGGCAACTT CTTCTGCTTG 
TGCAAAGATG GCTGGGGAGG CCGGCTCTGT GACAAAGATG TCAACGAGTG TAGTCAGAAG 
AATGGGGGCT GCAGCCAGGT CTGCCATAAC AAACCAGGAA GCTTCCAATG TGCCTGCCAC 
AGTGGCTTCT CACTTCAATC AGACAACAAG AGCTGCCAAG ATATAGATGA ATGCACAGAC 
TCAGACACCT GTGGGGATGC GCGTTGCAAG AACCTTCCGG GCTCCTACTC CTGCCTCTGC 
GACAAGGGGT ACACTTACAG CTCCAAGGAG AAGACCTGCC AAGATGTGGA TGAGTGCCAG 
CAGGACCGTT GTGAGCAGAC CTGTGTCAAC TCCCCAGGCA GCTATACCTG CCACTGTAAT 
GGGCGCGGGG GCCTAAAACT GTCCCCAGAC ATGGATACCT GTGAGGACAT CTTACCGTGT 
GTGCCCTTCA GCATGGCCAA GAGCGTCAAG TCCTTGTACC TGGGCCGCAT GTTCAGCGGG 
ACCCCCGTGA TTAGACTACG CTTCAAGAGG CTCCAGCCTA CCAGGCTGCT GGCCGAATTT 
GACTTCCGTA CTTTTGACCC TGAGGGAGTC CTCTTCTTCG CCGGAGGTCG CTCGGATAGC 
ACCTGGATCG TCCTGGGCCT CAGGGCTGGG CGACTTGAGT TGCAGCTACG GTACAATGGC 
GTTGGACGCA TCACCAGCAG TGGGCCAACC ATCAACCACG GCATGTGGCA AACGATCTCT 
GTGGAAGAAC TGGACCGCAA CCTTGTCATC AAGGTCAACA AAGATGCCGT GATGAAGATT 
GCGGTGGCTG GGGGGCTGTT CCAGCTAGAG AGAGGCCTGT ACCACCTGAA TCTCACTGTG 
GGGGGCATTC CCTTCAAGGA GAGTGACCTC GTCCAGCCGA TTAACCCTCG CCTGGACGGG 
TGCATGAGGA GCTGGAACTG GCTGAATGGG GAAGACAGTG CCATTCAGGA AACGGTCAAG 
GCCAATACAA AAATGCAGTG CTTCTCTGTG ACAGAGAGGG GCTCCTTCTT CCCGGGGAAT 
GGATTTGCCT TCTATAGCCT CAACTACACC CGGACATCGC TGGATGTCGG CACGGAAACC 
ACCTGGGAAG TAGAAGTCGT GGCTCGCATT CGCCCTGCCA CTGACACGGG GGTGCTGATG 
GCACTGGTGG GGGACAAAGA CGTCGTCCTC CTCTCTGTGG CCCTGGTCGA CTACCACTCC 
ACAAAGAAGC TCAAGAAGCA GCTGGGTGGT CCCCTCTGGC TTTGGGGACA AGGTTGCCAT 
GCGGTCACAC AGCCACAACT GCACAGTACG GGCCAAGGTG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455727.1
CDS	198..1922
Translation	MPPPPGPTAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETDYFYPRYQECMRKYGRPEDKNPNFATCVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQKNGGCSQVCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKNLPGSYSCLCDKGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELDRNLVIKVNKDAVMKIAVAGGLFQLERGLYHLNLTVGGIPFKESDLVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEVEVVARIRPATDTGVLMALVGDKDVVLLSVALVDYHSTKKLKKQLGGPLWLWGQGCHAVTQPQLHSTGQGG

Target ORF information:

RefSeq Version	XM_017600238.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus growth arrest specific 6 (Gas6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017600238.1

ORF Insert Sequence:

ATGCCGCCAC CGCCCGGGCC CACCGCCGCC CTGGGCACTG CGCTTCTGCT GCTCCTGCTG 
GCCTCCGAGT CTTCGCACAC TGTGCTGTTG CGGGCGCGTG AGGCGGCGCA GTTCCTGCGG 
CCCAGGCAGC GCCGCGCCTA CCAAGTCTTC GAGGAGGCCA AGCAGGGCCA CCTGGAACGG 
GAGTGCGTGG AGGAGGTGTG CAGCAAGGAG GAGGCTAGAG AGGTGTTCGA GAACGACCCC 
GAGACGGACT ATTTCTATCC AAGATATCAA GAGTGCATGA GGAAATATGG CCGGCCCGAA 
GATAAAAACC CAAATTTCGC CACCTGTGTT AAGAACTTAC CTGACCAATG CACCCCAAAC 
CCCTGTGATA AGAAGGGCAC TCAACTCTGC CAAGACCTCA TGGGCAACTT CTTCTGCTTG 
TGCAAAGATG GCTGGGGAGG CCGGCTCTGT GACAAAGATG TCAACGAGTG TAGTCAGAAG 
AATGGGGGCT GCAGCCAGGT CTGCCATAAC AAACCAGGAA GCTTCCAATG TGCCTGCCAC 
AGTGGCTTCT CACTTCAATC AGACAACAAG AGCTGCCAAG ATATAGATGA ATGCACAGAC 
TCAGACACCT GTGGGGATGC GCGTTGCAAG AACCTTCCGG GCTCCTACTC CTGCCTCTGC 
GACAAGGGGT ACACTTACAG CTCCAAGGAG AAGACCTGCC AAGATGTGGA TGAGTGCCAG 
CAGGACCGTT GTGAGCAGAC CTGTGTCAAC TCCCCAGGCA GCTATACCTG CCACTGTAAT 
GGGCGCGGGG GCCTAAAACT GTCCCCAGAC ATGGATACCT GTGAGGACAT CTTACCGTGT 
GTGCCCTTCA GCATGGCCAA GAGCGTCAAG TCCTTGTACC TGGGCCGCAT GTTCAGCGGG 
ACCCCCGTGA TTAGACTACG CTTCAAGAGG CTCCAGCCTA CCAGGCTGCT GGCCGAATTT 
GACTTCCGTA CTTTTGACCC TGAGGGAGTC CTCTTCTTCG CCGGAGGTCG CTCGGATAGC 
ACCTGGATCG TCCTGGGCCT CAGGGCTGGG CGACTTGAGT TGCAGCTACG GTACAATGGC 
GTTGGACGCA TCACCAGCAG TGGGCCAACC ATCAACCACG GCATGTGGCA AACGATCTCT 
GTGGAAGAAC TGGACCGCAA CCTTGTCATC AAGGTCAACA AAGATGCCGT GATGAAGATT 
GCGGTGGCTG GGGGGCTGTT CCAGCTAGAG AGAGGCCTGT ACCACCTGAA TCTCACTGTG 
GGGGGCATTC CCTTCAAGGA GAGTGACCTC GTCCAGCCGA TTAACCCTCG CCTGGACGGG 
TGCATGAGGA GCTGGAACTG GCTGAATGGG GAAGACAGTG CCATTCAGGA AACGGTCAAG 
GCCAATACAA AAATGCAGTG CTTCTCTGTG ACAGAGAGGG GCTCCTTCTT CCCGGGGAAT 
GGATTTGCCT TCTATAGCCT CAACTACACC CGGACATCGC TGGATGTCGG CACGGAAACC 
ACCTGGGAAG TAGAAGTCGT GGCTCGCATT CGCCCTGCCA CTGACACGGG GGTGCTGATG 
GCACTGGTGG GGGACAAAGA CGTCGTCCTC CTCTCTGTGG CCCTGGTCGA CTACCACTCC 
ACAAAGAAGC TCAAGAAGCA GCTGGGTGGT CCCCTCTGGC TTTGGGGACA AGGTTGCCAT 
GCGGTCACAC AGCCACAACT GCACAGTACG GGCCAAGGTG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-?B pathway after MCAO in rats.
Neurobiology of disease11059-67(2018 Feb)
Wu G,McBride DW,Zhang JH

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Molecular and cellular biochemistry433(1-2)149-159(2017 Sep)
Qiu C,Zheng H,Tao H,Yu W,Jiang X,Li A,Jin H,Lv A,Li H

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.
Diabetologia56(4)763-73(2013 Apr)
Haase TN,Rasmussen M,Jaksch CA,Gaarn LW,Petersen CK,Billestrup N,Nielsen JH

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Gas6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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