Gpc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpc1
Entrez Gene ID	58920
Full Name	glypican 1
Synonyms	HSPG M12,HSPGM12
General protein information	Preferred Names glypican 1 Names glypican-1 GPI-anchored cell surface heparan sulfate proteoglycan
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q36
Summary	glycosylphosphatidylinositol-linked heparan sulfate proteoglycan that may play a role in cell adhesion and growth factor response in the nervous system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030828.1	NP_110455.1	glypican-1 precursor

Pathways from BioSystems

Homologies

	GPC1	XP_001089255.1
Xenopus tropicalis (tropical clawed frog)	gpc1	NP_001072316.1
Homo sapiens (human)	GPC1	NP_002072.2
Pan troglodytes (chimpanzee)	GPC1	XP_001156197.2
Danio rerio (zebrafish)	gpc1a	NP_001032450.1
Canis lupus familiaris (dog)	GPC1	XP_005636000.1
Gallus gallus (chicken)	GPC1	XP_422590.2
Danio rerio (zebrafish)	gpc1b	NP_957314.1
Bos taurus (cattle)	GPC1	NP_001039701.1
Mus musculus (house mouse)	Gpc1	NP_057905.1
Rattus norvegicus (Norway rat)	Gpc1	NP_110455.1

Gene Ontology
Bibliography

Related articles in PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.
Zeng Y, Waters M, Andrews A, Honarmandi P, Ebong EE, Rizzo V, Tarbell JM
American journal of physiology. Heart and circulatory physiology305(6)H811-20(2013 Sep)

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Hill JJ, Jin K, Mao XO, Xie L, Greenberg DA
Proceedings of the National Academy of Sciences of the United States of America109(23)9155-60(2012 Jun)

Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
Strunz CM, Matsuda M, Salemi VM, Nogueira A, Mansur AP, Cestari IN, Marquezini MV
Cardiovascular diabetology1035(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that fluid shear stress induced the cell junctional clustering of lipid rafts with their anchored glypican-1 and associated HS.
Title: Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.

Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Title: Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.

Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Title: Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.

conclusion, gpc-1 expression in odontoblast-like cells is associated with the early differentiation but not with the formation of reparative dentine.
Title: Effect of glypican-1 gene on the pulp cells during the reparative dentine process.

Data suggest that glypican-1 acts as a positive regulator of muscle differentiation by sequestering FGF-2 in lipid rafts and preventing its binding and dependent signaling.
Title: A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.

The following Gpc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07111	NM_030828.1 Latest version!	Rattus norvegicus glypican 1 (Gpc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpc1 ( NM_030828.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110455.1 Rattus norvegicus glypican 1 (Gpc1), mRNA.

Price & Availability↑

CloneID	ORa07111
Clone ID Related Accession (Same CDS sequence)	NM_030828.1
Accession Version	NM_030828.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1677bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	glypican-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L02896.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L02896.1, BC061572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTCC GGGCCCGAGG CTGGTGGCTG CTGTGCGCGG CCGCCGCGCT AGTCGCCTGC 
ACCCGCGGGG ACCCCGCCAG CAAGAGCCGG AGCTGCAGCG AAGTCCGCCA GATCTACGGG 
GCTAAGGGCT TTAGCCTGAG CGACGTGCCC CAGGCAGAGA TCTCGGGAGA GCACCTGCGG 
ATCTGCCCCC AGGGCTACAC CTGCTGCACC AGTGAGATGG AGGAGAACCT GGCCAACCAC 
AGCCGGATGG AGCTGGAGAC CGCACTCCAC GACAGCAGCC GTGCCCTGCA GGCTACACTG 
GCCACCCAGC TGCATGGTAT CGATGACCAC TTCCAGCGCC TGCTGAATGA CTCGGAGCGT 
ACACTGCAGG ATGCTTTTCC CGGGGCCTTT GGGGACCTGT ACACGCAGAA CACTCGGGCC 
TTCCGGGACC TGTATGCTGA GCTGCGTCTC TACTACCGAG GGGCCAACCT ACACCTTGAG 
GAGACACTGG CCGAGTTCTG GGCACGGCTG CTGGAGCGTC TCTTCAAGCA GCTGCACCCC 
CAGCTGCTGC TGCCCGATGA CTATCTGGAC TGCCTGGGCA AGCAGGCGGA GGCACTGCGG 
CCGTTTGGGG ATGCCCCTCG AGAACTGCGC CTGAGGGCCA CCCGTGCTTT TGTGGCGGCA 
CGATCCTTTG TGCAGGGCCT GGGTGTGGCC AGTGACGTAG TCCGAAAGGT GGCCCAGGTT 
CCTCTGGCCC CAGAATGTTC TCGGGCTGTC ATGAAGTTGG TCTACTGTGC CCATTGCCGG 
GGAGTCCCTG GTGCCCGGCC CTGTCCCGAC TATTGCCGAA ATGTGCTCAA AGGCTGCCTT 
GCCAACCAGG CCGACCTGGA TGCCGAGTGG AGGAACCTCC TGGACTCCAT GGTGCTCATC 
ACTGACAAGT TCTGGGGCCC GTCGGGTGCG GAGTATGTCA TTGGCAGTGT GCATATGTGG 
CTGGCGGAGG CCATCAACGC CCTCCAGGAC AACAAGGACA CACTCACAGC TAAGGTCATC 
CAGGGCTGCG GAAACCCCAA GGTCAATCCC CATGGCTCTG GGCCTGAGGA GAAGCGTCGC 
CGTGCCAAAC TGGCACTGCA GGAGAAGTCC TCCACAGGTA CTCTGGAAAA GCTGGTCTCT 
GAGGCCAAGG CCCAGCTCCG AGACATTCAG GACTACTGGA TCAGCCTCCC AGGGACACTG 
TGTAGTGAGA AGATGGCCAT GAGTCCTGCC AGCGATGACC GCTGCTGGAA TGGGATTTCC 
AAGGGCCGGT ACCTACCTGA GGTGATGGGT GATGGGCTGG CCAACCAGAT CAACAACCCT 
GAAGTGGAGG TGGACATCAC CAAGCCGGAT ATGACCATCC GGCAGCAGAT CATGCAGCTC 
AAGATCATGA CCAACCGTTT ACGTGGCGCC TACGGTGGAA ATGATGTGGA CTTCCAGGAT 
GCCAGTGATG ACGGTAGTGG TTCCGGCAGC GGTGGCGGAT GCCCAGATGA CGCCTGTGGT 
CGGAGGGTCA GCAAGAAGAG CTCCAGCTCC CGGACCCCCT TGATCCATGC CCTCCCCGGC 
TTGTCAGAAC AGGAGGGACA GAAGACCTCG GCCGCCACTC GCCCAGAGCC TCACTACTTC 
TTTCTGCTCT TCCTGTTCAC CTTGGTCCTT GCTGCAGCCA GGCCCAGGTG GCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110455.1
CDS	222..1898
Translation	MELRARGWWLLCAAAALVACTRGDPASKSRSCSEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANHSRMELETALHDSSRALQATLATQLHGIDDHFQRLLNDSERTLQDAFPGAFGDLYTQNTRAFRDLYAELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGDAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLAPECSRAVMKLVYCAHCRGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGPSGAEYVIGSVHMWLAEAINALQDNKDTLTAKVIQGCGNPKVNPHGSGPEEKRRRAKLALQEKSSTGTLEKLVSEAKAQLRDIQDYWISLPGTLCSEKMAMSPASDDRCWNGISKGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYGGNDVDFQDASDDGSGSGSGGGCPDDACGRRVSKKSSSSRTPLIHALPGLSEQEGQKTSAATRPEPHYFFLLFLFTLVLAAARPRWR

Target ORF information:

RefSeq Version	NM_030828.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glypican 1 (Gpc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030828.1

ORF Insert Sequence:

ATGGAGCTCC GGGCCCGAGG CTGGTGGCTG CTGTGCGCGG CCGCCGCGCT AGTCGCCTGC 
ACCCGCGGGG ACCCCGCCAG CAAGAGCCGG AGCTGCAGCG AAGTCCGCCA GATCTACGGG 
GCTAAGGGCT TTAGCCTGAG CGACGTGCCC CAGGCAGAGA TCTCGGGAGA GCACCTGCGG 
ATCTGCCCCC AGGGCTACAC CTGCTGCACC AGTGAGATGG AGGAGAACCT GGCCAACCAC 
AGCCGGATGG AGCTGGAGAC CGCACTCCAC GACAGCAGCC GTGCCCTGCA GGCTACACTG 
GCCACCCAGC TGCATGGTAT CGATGACCAC TTCCAGCGCC TGCTGAATGA CTCGGAGCGT 
ACACTGCAGG ATGCTTTTCC CGGGGCCTTT GGGGACCTGT ACACGCAGAA CACTCGGGCC 
TTCCGGGACC TGTATGCTGA GCTGCGTCTC TACTACCGAG GGGCCAACCT ACACCTTGAG 
GAGACACTGG CCGAGTTCTG GGCACGGCTG CTGGAGCGTC TCTTCAAGCA GCTGCACCCC 
CAGCTGCTGC TGCCCGATGA CTATCTGGAC TGCCTGGGCA AGCAGGCGGA GGCACTGCGG 
CCGTTTGGGG ATGCCCCTCG AGAACTGCGC CTGAGGGCCA CCCGTGCTTT TGTGGCGGCA 
CGATCCTTTG TGCAGGGCCT GGGTGTGGCC AGTGACGTAG TCCGAAAGGT GGCCCAGGTT 
CCTCTGGCCC CAGAATGTTC TCGGGCTGTC ATGAAGTTGG TCTACTGTGC CCATTGCCGG 
GGAGTCCCTG GTGCCCGGCC CTGTCCCGAC TATTGCCGAA ATGTGCTCAA AGGCTGCCTT 
GCCAACCAGG CCGACCTGGA TGCCGAGTGG AGGAACCTCC TGGACTCCAT GGTGCTCATC 
ACTGACAAGT TCTGGGGCCC GTCGGGTGCG GAGTATGTCA TTGGCAGTGT GCATATGTGG 
CTGGCGGAGG CCATCAACGC CCTCCAGGAC AACAAGGACA CACTCACAGC TAAGGTCATC 
CAGGGCTGCG GAAACCCCAA GGTCAATCCC CATGGCTCTG GGCCTGAGGA GAAGCGTCGC 
CGTGCCAAAC TGGCACTGCA GGAGAAGTCC TCCACAGGTA CTCTGGAAAA GCTGGTCTCT 
GAGGCCAAGG CCCAGCTCCG AGACATTCAG GACTACTGGA TCAGCCTCCC AGGGACACTG 
TGTAGTGAGA AGATGGCCAT GAGTCCTGCC AGCGATGACC GCTGCTGGAA TGGGATTTCC 
AAGGGCCGGT ACCTACCTGA GGTGATGGGT GATGGGCTGG CCAACCAGAT CAACAACCCT 
GAAGTGGAGG TGGACATCAC CAAGCCGGAT ATGACCATCC GGCAGCAGAT CATGCAGCTC 
AAGATCATGA CCAACCGTTT ACGTGGCGCC TACGGTGGAA ATGATGTGGA CTTCCAGGAT 
GCCAGTGATG ACGGTAGTGG TTCCGGCAGC GGTGGCGGAT GCCCAGATGA CGCCTGTGGT 
CGGAGGGTCA GCAAGAAGAG CTCCAGCTCC CGGACCCCCT TGATCCATGC CCTCCCCGGC 
TTGTCAGAAC AGGAGGGACA GAAGACCTCG GCCGCCACTC GCCCAGAGCC TCACTACTTC 
TTTCTGCTCT TCCTGTTCAC CTTGGTCCTT GCTGCAGCCA GGCCCAGGTG GCGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.
American journal of physiology. Heart and circulatory physiology305(6)H811-20(2013 Sep)
Zeng Y,Waters M,Andrews A,Honarmandi P,Ebong EE,Rizzo V,Tarbell JM

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Proceedings of the National Academy of Sciences of the United States of America109(23)9155-60(2012 Jun)
Hill JJ,Jin K,Mao XO,Xie L,Greenberg DA

Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
Cardiovascular diabetology1035(2011 Apr)
Strunz CM,Matsuda M,Salemi VM,Nogueira A,Mansur AP,Cestari IN,Marquezini MV

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Gpc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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