Ccnd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccnd1
Entrez Gene ID	58919
Full Name	cyclin D1
General protein information	Preferred Names cyclin D1 Names G1/S-specific cyclin-D1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q42
Summary	regulatory subunit of CDK4 or CDK6; involved in regulation of the G1/S transition of the cell cycle [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_171992.4	NP_741989.3	G1/S-specific cyclin-D1
XM_008760168.1	XP_008758390.1	G1/S-specific cyclin-D1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CCND1	NP_444284.1
Bos taurus (cattle)	CCND1	NP_001039738.1
Mus musculus (house mouse)	Ccnd1	NP_031657.1
Gallus gallus (chicken)	CCND1	NP_990712.1
Pan troglodytes (chimpanzee)	CCND1	XP_003952008.1
	CCND1	XP_001101029.1
Canis lupus familiaris (dog)	CCND1	NP_001005757.1
Rattus norvegicus (Norway rat)	Ccnd1	NP_741989.3
Danio rerio (zebrafish)	ccnd1	NP_571100.1
Xenopus tropicalis (tropical clawed frog)	ccnd1	NP_001005452.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system.
Wu SY, Lan SH, Wu SR, Chiu YC, Lin XZ, Su IJ, Tsai TF, Yen CJ, Lu TH, Liang FW, Li CY, Su HJ, Su CL, Liu HS
Hepatology (Baltimore, Md.)(2018 Jan)

Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients.
Zhang T, Nanney LB, Luongo C, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD
Cancer research57(1)169-75(1997 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells.
Title: HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.

These results highlight the essential role of NF-kappaB-dependent transcriptional upregulation of cyclin D1 in EGFR-mediated cytoprotective effects under hypoxic preconditioning.
Title: NF-?B-dependent transcriptional upregulation of cyclin D1 exerts cytoprotection against hypoxic injury upon EGFR activation.

these data demonstrated that Dixdc1 might participate in Schwann cell proliferation by targeting CyclinD1 and p21 at least partially through the PI3K/AKT activation.
Title: Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to promote Schwann cell proliferation after sciatic nerve crush.

The robust increase in the expression of cyclin D1 and CDK4 at day 2 suggests that Muller glia may be in G1 phase of the cell cycle at this stage.
Title: DNA Damage Response in Proliferating M?ller Glia in the Mammalian Retina.

AGO1 and AGO2 play non-equivalent roles of in mRNA turnover and translation of Ccnd1 mRNA.
Title: Non-equivalent Roles of AGO1 and AGO2 in mRNA Turnover and Translation of Cyclin D1 mRNA.

The following Ccnd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccnd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12615	NM_171992.4 Latest version!	Rattus norvegicus cyclin D1 (Ccnd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa43463	XM_008760168.1 Latest version!	Rattus norvegicus cyclin D1 (Ccnd1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccnd1 ( NM_171992.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_741989.3 Rattus norvegicus cyclin D1 (Ccnd1), mRNA.

Price & Availability↑

CloneID	ORa12615
Clone ID Related Accession (Same CDS sequence)	NM_171992.4
Accession Version	NM_171992.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	G1/S-specific cyclin-D1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA510842.1, EV775485.1 and AC095937.7. On Feb 21, 2008 this sequence version replaced NM_171992.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AM258963.2, FQ226502.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906352, SAMN01906358 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAGACCATCC GCCGCGCGTA CCCTGACACC 
AATCTCCTCA ACGACCGGGT GCTGCGAGCC ATGCTTAAGA CTGAGGAGAC CTGCGCGCCC 
TCCGTTTCTT ACTTCAAGTG CGTGCAGAGG GAGATTGTGC CATCCATGCG GAAAATCGTG 
GCCACCTGGA TGCTAGAGGT CTGCGAGGAG CAGAAGTGCG AAGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG TTTCTTGTCT CTGGAGCCCC TGAAGAAGAG CCGCCTGCAG 
CTTCTGGGGG CCACCTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT TCCCCTGACT 
GCCGAGAAGT TGTGCATCTA CACTGACAAC TCTATCCGCC CCGAGGAGTT GCTGCAAATG 
GAACTGCTTC TGGTGAACAA GCTCAAATGG AACCTGGCCG CCATGACTCC CCACGATTTC 
ATCGAACACT TCCTCTCCAA AATGCCAGAG GCGGATGAGA ACAAGCAGAT CATCCGCAAA 
CATGCACAGA CCTTTGTGGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAACCCACCC 
TCCATGGTGG CTGCTGGGAG TGTGGTGGCC GCGATGCAGG GCCTGAACCT GGGCAGCCCC 
AACAACTTCC TCTCCTGCTA CCGCACAACG CACTTTCTTT CCAGAGTCAT CAAGTGTGAC 
CCGGACTGCC TCCGTGCCTG CCAGGAACAG ATTGAAGCCC TTCTGGAGTC AAGCCTGCGC 
CAGGCCCAGC AGAACATCGA TCCCAAGGCC ACCGAGGAGG AAGGGGAAGT GGAGGAAGAA 
GCTGGTCTGG CTTGCACACC CACCGACGTC CGAGATGTGG ACATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_741989.3
CDS	126..1013
Translation	MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQREIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNIDPKATEEEGEVEEEAGLACTPTDVRDVDI

Target ORF information:

RefSeq Version	NM_171992.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin D1 (Ccnd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_171992.4

ORF Insert Sequence:

ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAGACCATCC GCCGCGCGTA CCCTGACACC 
AATCTCCTCA ACGACCGGGT GCTGCGAGCC ATGCTTAAGA CTGAGGAGAC CTGCGCGCCC 
TCCGTTTCTT ACTTCAAGTG CGTGCAGAGG GAGATTGTGC CATCCATGCG GAAAATCGTG 
GCCACCTGGA TGCTAGAGGT CTGCGAGGAG CAGAAGTGCG AAGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG TTTCTTGTCT CTGGAGCCCC TGAAGAAGAG CCGCCTGCAG 
CTTCTGGGGG CCACCTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT TCCCCTGACT 
GCCGAGAAGT TGTGCATCTA CACTGACAAC TCTATCCGCC CCGAGGAGTT GCTGCAAATG 
GAACTGCTTC TGGTGAACAA GCTCAAATGG AACCTGGCCG CCATGACTCC CCACGATTTC 
ATCGAACACT TCCTCTCCAA AATGCCAGAG GCGGATGAGA ACAAGCAGAT CATCCGCAAA 
CATGCACAGA CCTTTGTGGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAACCCACCC 
TCCATGGTGG CTGCTGGGAG TGTGGTGGCC GCGATGCAGG GCCTGAACCT GGGCAGCCCC 
AACAACTTCC TCTCCTGCTA CCGCACAACG CACTTTCTTT CCAGAGTCAT CAAGTGTGAC 
CCGGACTGCC TCCGTGCCTG CCAGGAACAG ATTGAAGCCC TTCTGGAGTC AAGCCTGCGC 
CAGGCCCAGC AGAACATCGA TCCCAAGGCC ACCGAGGAGG AAGGGGAAGT GGAGGAAGAA 
GCTGGTCTGG CTTGCACACC CACCGACGTC CGAGATGTGG ACATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ccnd1 ( XM_008760168.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758390.1 Rattus norvegicus cyclin D1 (Ccnd1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43463
Clone ID Related Accession (Same CDS sequence)	XM_008760168.1
Accession Version	XM_008760168.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	G1/S-specific cyclin-D1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAGACCATCC GCCGCGCGTA CCCTGACACC 
AATCTCCTCA ACGACCGGGT GCTGCGAGCC ATGCTTAAGA CTGAGGAGAC CTGCGCGCCC 
TCCGTTTCTT ACTTCAAGTG CGTGCAGAGG GAGATTGTGC CATCCATGCG GAAAATCGTG 
GCCACCTGGA TGCTAGAGGT CTGCGAGGAG CAGAAGTGCG AAGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG TTTCTTGTCT CTGGAGCCCC TGAAGAAGAG CCGCCTGCAG 
CTTCTGGGGG CCACCTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT TCCCCTGACT 
GCCGAGAAGT TGTGCATCTA CACTGACAAC TCTATCCGCC CCGAGGAGTT GCTGCAAATG 
GAACTGCTTC TGGTGAACAA GCTCAAATGG AACCTGGCCG CCATGACTCC CCACGATTTC 
ATCGAACACT TCCTCTCCAA AATGCCAGAG GCGGATGAGA ACAAGCAGAT CATCCGCAAA 
CATGCACAGA CCTTTGTGGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAACCCACCC 
TCCATGGTGG CTGCTGGGAG TGTGGTGGCC GCGATGCAGG GCCTGAACCT GGGCAGCCCC 
AACAACTTCC TCTCCTGCTA CCGCACAACG CACTTTCTTT CCAGAGTCAT CAAGTGTGAC 
CCGGTCAAGG CCCTGGCCAC CGGCCTCTGG CTAAACAAGG ACTCCCTCCA TCTCCGCCCG 
CCTCTCCAGG ACTGCCTCCG TGCCTGCCAG GAACAGATTG AAGCCCTTCT GGAGTCAAGC 
CTGCGCCAGG CCCAGCAGAA CATCGATCCC AAGGCCACCG AGGAGGAAGG GGAAGTGGAG 
GAAGAAGCTG GTCTGGCTTG CACACCCACC GACGTCCGAG ATGTGGACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758390.1
CDS	301..1254
Translation	MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQREIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPVKALATGLWLNKDSLHLRPPLQDCLRACQEQIEALLESSLRQAQQNIDPKATEEEGEVEEEAGLACTPTDVRDVDI

Target ORF information:

RefSeq Version	XM_008760168.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin D1 (Ccnd1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760168.1

ORF Insert Sequence:

ATGGAACACC AGCTCCTGTG CTGCGAAGTG GAGACCATCC GCCGCGCGTA CCCTGACACC 
AATCTCCTCA ACGACCGGGT GCTGCGAGCC ATGCTTAAGA CTGAGGAGAC CTGCGCGCCC 
TCCGTTTCTT ACTTCAAGTG CGTGCAGAGG GAGATTGTGC CATCCATGCG GAAAATCGTG 
GCCACCTGGA TGCTAGAGGT CTGCGAGGAG CAGAAGTGCG AAGAGGAGGT CTTCCCGCTG 
GCCATGAACT ACCTGGACCG TTTCTTGTCT CTGGAGCCCC TGAAGAAGAG CCGCCTGCAG 
CTTCTGGGGG CCACCTGCAT GTTCGTGGCC TCTAAGATGA AGGAGACCAT TCCCCTGACT 
GCCGAGAAGT TGTGCATCTA CACTGACAAC TCTATCCGCC CCGAGGAGTT GCTGCAAATG 
GAACTGCTTC TGGTGAACAA GCTCAAATGG AACCTGGCCG CCATGACTCC CCACGATTTC 
ATCGAACACT TCCTCTCCAA AATGCCAGAG GCGGATGAGA ACAAGCAGAT CATCCGCAAA 
CATGCACAGA CCTTTGTGGC CCTCTGTGCC ACAGATGTGA AGTTCATTTC CAACCCACCC 
TCCATGGTGG CTGCTGGGAG TGTGGTGGCC GCGATGCAGG GCCTGAACCT GGGCAGCCCC 
AACAACTTCC TCTCCTGCTA CCGCACAACG CACTTTCTTT CCAGAGTCAT CAAGTGTGAC 
CCGGTCAAGG CCCTGGCCAC CGGCCTCTGG CTAAACAAGG ACTCCCTCCA TCTCCGCCCG 
CCTCTCCAGG ACTGCCTCCG TGCCTGCCAG GAACAGATTG AAGCCCTTCT GGAGTCAAGC 
CTGCGCCAGG CCCAGCAGAA CATCGATCCC AAGGCCACCG AGGAGGAAGG GGAAGTGGAG 
GAAGAAGCTG GTCTGGCTTG CACACCCACC GACGTCCGAG ATGTGGACAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system.
Hepatology (Baltimore, Md.)(2018 Jan)
Wu SY,Lan SH,Wu SR,Chiu YC,Lin XZ,Su IJ,Tsai TF,Yen CJ,Lu TH,Liang FW,Li CY,Su HJ,Su CL,Liu HS

Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients.
Cancer research57(1)169-75(1997 Jan)
Zhang T,Nanney LB,Luongo C,Lamps L,Heppner KJ,DuBois RN,Beauchamp RD

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Ccnd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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