Mapk6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mapk6
Entrez Gene ID	58840
Full Name	mitogen-activated protein kinase 6
Synonyms	ERK3
General protein information	Preferred Names mitogen-activated protein kinase 6 Names mitogen-activated protein kinase 6 ERK-3 MAP kinase 6 MAPK 6 extracellular signal-regulated kinase 3 p55-MAPK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	kinase that is activated following insulin and Ngf treatment [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031622.2	NP_113810.2	mitogen-activated protein kinase 6
XM_006243409.3	XP_006243471.1	mitogen-activated protein kinase 6 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAPK6	XP_510409.2
	MAPK6	XP_001083937.2
Bos taurus (cattle)	MAPK6	XP_002691011.2
Mus musculus (house mouse)	Mapk6	NP_081694.1
Canis lupus familiaris (dog)	MAPK6	XP_005638475.1
Rattus norvegicus (Norway rat)	Mapk6	NP_113810.2
Gallus gallus (chicken)	MAPK6	NP_001025720.1
Danio rerio (zebrafish)	mapk6	NP_001039017.1
Homo sapiens (human)	MAPK6	NP_002739.1
Xenopus tropicalis (tropical clawed frog)	mapk6	XP_002936385.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia.
Tan J, Yang L, Liu C, Yan Z
Scientific reports746602(2017 Apr)

Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury.
Walder RY, Wattiez AS, White SR, Marquez de Prado B, Hamity MV, Hammond DL
Molecular pain1055(2014 Sep)

Role of ERK1, 2, and 5 in dopamine neuron survival during aging.
Parmar MS, Jaumotte JD, Wyrostek SL, Zigmond MJ, Cavanaugh JE
Neurobiology of aging35(3)669-79(2014 Mar)

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.
Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A
Molecular and cellular biology32(13)2467-78(2012 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thsi study validated the Hprt1, Actb, Mapk6 or B2m and showed that any one or combination of two of them are good reference genes for normalization of mRNA expression in qPCR experiments in the spinal cord and RVM in the CFA model of inflammatory injury.
Title: Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury.

It plays distinct role in proliferation, differentiation, and neuronal viability.
Title: Role of ERK1, 2, and 5 in dopamine neuron survival during aging.

MAP2 is involved in ERK3 mediated insulin secretion
Title: ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion.

These data suggest a novel mechanism for the localization of an MAPK family member, ERK3, in which cell cycle-regulated, site-specific proteolysis generates the nuclear form of the protein.
Title: A novel mechanism for mitogen-activated protein kinase localization.

ERK3 biological activity is regulated by its cellular abundance through the control of protein stability
Title: Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.

The following Mapk6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mapk6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08289	NM_031622.2 Latest version!	Rattus norvegicus mitogen-activated protein kinase 6 (Mapk6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
ORa08289	XM_006243409.3 Latest version!	Rattus norvegicus mitogen-activated protein kinase 6 (Mapk6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mapk6 ( NM_031622.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113810.2 Rattus norvegicus mitogen-activated protein kinase 6 (Mapk6), mRNA.

Price & Availability↑

CloneID	ORa08289
Clone ID Related Accession (Same CDS sequence)	NM_031622.2 , XM_006243409.3
Accession Version	NM_031622.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2163bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB742965.1, BC109380.1 and BE104187.1. On Nov 29, 2005 this sequence version replaced NM_031622.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC109380.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGCT TTGATCTGGG TTCCAGGTAC 
ATGGACTTAA AACCATTGGG CTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 
GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTCA CCGATCCCCA GAGTGTCAAA 
CATGCCCTCC GTGAAATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTGAAAGTG 
TTTGAAATTC TTGGTCCCAG TGGAAGCCAG CTGACAGACG ATGTGGGCTC TCTAACAGAG 
CTGAATAGCG TCTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCGAA CGTGCTGGAG 
CAGGGCCCTT TACTGGAGGA GCATGCCAGG CTCTTCATGT ACCAGCTGCT GCGTGGGCTC 
AAGTACATCC ACTCTGCAAA CGTGCTGCAC AGGGATCTCA AGCCGGCCAA CCTTTTCATT 
AACACTGAAG ACTTGGTGCT GAAGATTGGT GACTTTGGCC TGGCCCGGAT CATGGATCCT 
CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CCAAATGGTA CAGATCTCCA 
CGGCTTTTAC TTTCTCCTAA TAACTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 
ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 
ATGCAGCTGA TCTTGGAGTC TATCCCTGTT GTGCACGAGG AAGATCGGCA GGAGCTTCTC 
AGCGTGATTC CAGTTTACAT TAGAAACGAC ATGACTGAGC CACACAAACC GCTGACTCAG 
CTGCTTCCGG GGATTAGTCG GGAAGCACTG GATTTCCTGG AACAGATTCT GACGTTCAGT 
CCCATGGACC GGCTGACAGC CGAGGAAGCA CTTTCCCATC CTTACATGAG CATCTACTCT 
TTCCCAACGG ACGAGCCTAT TTCCAGCCAT CCTTTCCACA TAGAAGACGA AGTGGACGAC 
ATTTTGCTAA TGGATGAAAC ACACAGTCAC ATTTATAACT GGGAAAGGTA CCACGATTGT 
CAGTTCTCGG AGCATGACTG GCCTATTCAT AACAACTTTG ATATCGATGA GGTTCAGCTT 
GACCCGAGAG CTCTGTCTGA TGTCACCGAT GAAGAAGAAG TTCAAGTTGA TCCTCGAAAG 
TACTTGGATG GAGACCGAGA GAAGTATCTG GAGGATCCCG CCTTCGACAC CAGCTACTCT 
GCTGAGCCTT GCTGGCAGTA CCCAGATCAC CACGAGAACA AGTACTGTGA TCTGGAGTGT 
AGCCACACCT GTAACTACAA AACAAGGTCG CCATCATACT TAGATAACCT GGTGTGGAGG 
GAGAGCGAGG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTTTC CAACTGGAAA 
GAGCAAAGTA AGGACAAATC CGACAAGAGA GGCAAGTCCA AGTGTGAGAG GAACGGGTTG 
GTCAAGGCGC AGATTGCGCT TGAGGAAGCG TCCCAGCAGC TGGCTGAGAG GGAGAGGGGC 
CAAGGCTTTG ACTTTGATGC CTTCATCGCA GGCACCGTTC AGCTCAGTGC CCAGCGTGAG 
TCTGCTGACG TAGTTGACAA GTTAAACGAC TTGAATAGCT CAGTGTCCCA GCTAGAAATG 
AAAAGCCTGA TATCCAAGTC AGTCAGCCGA GAAAAGCAAG AAAAGGGAAG GGCTAACCTG 
GCCCAGCTGG GAGCCTTGTA CCAGCCCTCC TGGGAGAGCC AGTTTGTGAG TGGCGGGGAG 
GAGTGCTTCC TTATCAGTCA GTTTTGTTGT GAGGTCAGGA AGGACGAACA CGTGGAGAAG 
GAGAACACTT ACACCAGCTA TTTGGACAAG TTTTTTAGCA GGAAGGAGGA TTCTGAAATG 
CTAGAAACTG AGCCAGTGGA AGAAGGGAAG CGTGGGGAGA GAGGCCGTGA GGCAGGGCTT 
CTGAGCAGCG GTGGGGAGTT TCTCCTGAGC AGGCAGCTAG AGTCCATAGG CACCCCGCAG 
TTCCACAGTC CAGGGGGATC CCCACTCAAG TCCATCCAGG CCACGTTAAC ACCTTCCGCT 
ATGAAATCTT CCCCTCAAAT CCCTCACAAG ACATACAGCA ACATTCTGAA ACATCTGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113810.2
CDS	762..2924
Translation	MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSPSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKDKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDAFIAGTVQLSAQRESADVVDKLNDLNSSVSQLEMKSLISKSVSREKQEKGRANLAQLGALYQPSWESQFVSGGEECFLISQFCCEVRKDEHVEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSSGGEFLLSRQLESIGTPQFHSPGGSPLKSIQATLTPSAMKSSPQIPHKTYSNILKHLN

Target ORF information:

RefSeq Version	NM_031622.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase 6 (Mapk6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031622.2

ORF Insert Sequence:

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGCT TTGATCTGGG TTCCAGGTAC 
ATGGACTTAA AACCATTGGG CTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 
GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTCA CCGATCCCCA GAGTGTCAAA 
CATGCCCTCC GTGAAATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTGAAAGTG 
TTTGAAATTC TTGGTCCCAG TGGAAGCCAG CTGACAGACG ATGTGGGCTC TCTAACAGAG 
CTGAATAGCG TCTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCGAA CGTGCTGGAG 
CAGGGCCCTT TACTGGAGGA GCATGCCAGG CTCTTCATGT ACCAGCTGCT GCGTGGGCTC 
AAGTACATCC ACTCTGCAAA CGTGCTGCAC AGGGATCTCA AGCCGGCCAA CCTTTTCATT 
AACACTGAAG ACTTGGTGCT GAAGATTGGT GACTTTGGCC TGGCCCGGAT CATGGATCCT 
CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CCAAATGGTA CAGATCTCCA 
CGGCTTTTAC TTTCTCCTAA TAACTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 
ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 
ATGCAGCTGA TCTTGGAGTC TATCCCTGTT GTGCACGAGG AAGATCGGCA GGAGCTTCTC 
AGCGTGATTC CAGTTTACAT TAGAAACGAC ATGACTGAGC CACACAAACC GCTGACTCAG 
CTGCTTCCGG GGATTAGTCG GGAAGCACTG GATTTCCTGG AACAGATTCT GACGTTCAGT 
CCCATGGACC GGCTGACAGC CGAGGAAGCA CTTTCCCATC CTTACATGAG CATCTACTCT 
TTCCCAACGG ACGAGCCTAT TTCCAGCCAT CCTTTCCACA TAGAAGACGA AGTGGACGAC 
ATTTTGCTAA TGGATGAAAC ACACAGTCAC ATTTATAACT GGGAAAGGTA CCACGATTGT 
CAGTTCTCGG AGCATGACTG GCCTATTCAT AACAACTTTG ATATCGATGA GGTTCAGCTT 
GACCCGAGAG CTCTGTCTGA TGTCACCGAT GAAGAAGAAG TTCAAGTTGA TCCTCGAAAG 
TACTTGGATG GAGACCGAGA GAAGTATCTG GAGGATCCCG CCTTCGACAC CAGCTACTCT 
GCTGAGCCTT GCTGGCAGTA CCCAGATCAC CACGAGAACA AGTACTGTGA TCTGGAGTGT 
AGCCACACCT GTAACTACAA AACAAGGTCG CCATCATACT TAGATAACCT GGTGTGGAGG 
GAGAGCGAGG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTTTC CAACTGGAAA 
GAGCAAAGTA AGGACAAATC CGACAAGAGA GGCAAGTCCA AGTGTGAGAG GAACGGGTTG 
GTCAAGGCGC AGATTGCGCT TGAGGAAGCG TCCCAGCAGC TGGCTGAGAG GGAGAGGGGC 
CAAGGCTTTG ACTTTGATGC CTTCATCGCA GGCACCGTTC AGCTCAGTGC CCAGCGTGAG 
TCTGCTGACG TAGTTGACAA GTTAAACGAC TTGAATAGCT CAGTGTCCCA GCTAGAAATG 
AAAAGCCTGA TATCCAAGTC AGTCAGCCGA GAAAAGCAAG AAAAGGGAAG GGCTAACCTG 
GCCCAGCTGG GAGCCTTGTA CCAGCCCTCC TGGGAGAGCC AGTTTGTGAG TGGCGGGGAG 
GAGTGCTTCC TTATCAGTCA GTTTTGTTGT GAGGTCAGGA AGGACGAACA CGTGGAGAAG 
GAGAACACTT ACACCAGCTA TTTGGACAAG TTTTTTAGCA GGAAGGAGGA TTCTGAAATG 
CTAGAAACTG AGCCAGTGGA AGAAGGGAAG CGTGGGGAGA GAGGCCGTGA GGCAGGGCTT 
CTGAGCAGCG GTGGGGAGTT TCTCCTGAGC AGGCAGCTAG AGTCCATAGG CACCCCGCAG 
TTCCACAGTC CAGGGGGATC CCCACTCAAG TCCATCCAGG CCACGTTAAC ACCTTCCGCT 
ATGAAATCTT CCCCTCAAAT CCCTCACAAG ACATACAGCA ACATTCTGAA ACATCTGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mapk6 ( XM_006243409.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243471.1 Rattus norvegicus mitogen-activated protein kinase 6 (Mapk6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08289
Clone ID Related Accession (Same CDS sequence)	NM_031622.2 , XM_006243409.3
Accession Version	XM_006243409.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2163bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243409.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGCT TTGATCTGGG TTCCAGGTAC 
ATGGACTTAA AACCATTGGG CTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 
GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTCA CCGATCCCCA GAGTGTCAAA 
CATGCCCTCC GTGAAATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTGAAAGTG 
TTTGAAATTC TTGGTCCCAG TGGAAGCCAG CTGACAGACG ATGTGGGCTC TCTAACAGAG 
CTGAATAGCG TCTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCGAA CGTGCTGGAG 
CAGGGCCCTT TACTGGAGGA GCATGCCAGG CTCTTCATGT ACCAGCTGCT GCGTGGGCTC 
AAGTACATCC ACTCTGCAAA CGTGCTGCAC AGGGATCTCA AGCCGGCCAA CCTTTTCATT 
AACACTGAAG ACTTGGTGCT GAAGATTGGT GACTTTGGCC TGGCCCGGAT CATGGATCCT 
CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CCAAATGGTA CAGATCTCCA 
CGGCTTTTAC TTTCTCCTAA TAACTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 
ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 
ATGCAGCTGA TCTTGGAGTC TATCCCTGTT GTGCACGAGG AAGATCGGCA GGAGCTTCTC 
AGCGTGATTC CAGTTTACAT TAGAAACGAC ATGACTGAGC CACACAAACC GCTGACTCAG 
CTGCTTCCGG GGATTAGTCG GGAAGCACTG GATTTCCTGG AACAGATTCT GACGTTCAGT 
CCCATGGACC GGCTGACAGC CGAGGAAGCA CTTTCCCATC CTTACATGAG CATCTACTCT 
TTCCCAACGG ACGAGCCTAT TTCCAGCCAT CCTTTCCACA TAGAAGACGA AGTGGACGAC 
ATTTTGCTAA TGGATGAAAC ACACAGTCAC ATTTATAACT GGGAAAGGTA CCACGATTGT 
CAGTTCTCGG AGCATGACTG GCCTATTCAT AACAACTTTG ATATCGATGA GGTTCAGCTT 
GACCCGAGAG CTCTGTCTGA TGTCACCGAT GAAGAAGAAG TTCAAGTTGA TCCTCGAAAG 
TACTTGGATG GAGACCGAGA GAAGTATCTG GAGGATCCCG CCTTCGACAC CAGCTACTCT 
GCTGAGCCTT GCTGGCAGTA CCCAGATCAC CACGAGAACA AGTACTGTGA TCTGGAGTGT 
AGCCACACCT GTAACTACAA AACAAGGTCG CCATCATACT TAGATAACCT GGTGTGGAGG 
GAGAGCGAGG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTTTC CAACTGGAAA 
GAGCAAAGTA AGGACAAATC CGACAAGAGA GGCAAGTCCA AGTGTGAGAG GAACGGGTTG 
GTCAAGGCGC AGATTGCGCT TGAGGAAGCG TCCCAGCAGC TGGCTGAGAG GGAGAGGGGC 
CAAGGCTTTG ACTTTGATGC CTTCATCGCA GGCACCGTTC AGCTCAGTGC CCAGCGTGAG 
TCTGCTGACG TAGTTGACAA GTTAAACGAC TTGAATAGCT CAGTGTCCCA GCTAGAAATG 
AAAAGCCTGA TATCCAAGTC AGTCAGCCGA GAAAAGCAAG AAAAGGGAAG GGCTAACCTG 
GCCCAGCTGG GAGCCTTGTA CCAGCCCTCC TGGGAGAGCC AGTTTGTGAG TGGCGGGGAG 
GAGTGCTTCC TTATCAGTCA GTTTTGTTGT GAGGTCAGGA AGGACGAACA CGTGGAGAAG 
GAGAACACTT ACACCAGCTA TTTGGACAAG TTTTTTAGCA GGAAGGAGGA TTCTGAAATG 
CTAGAAACTG AGCCAGTGGA AGAAGGGAAG CGTGGGGAGA GAGGCCGTGA GGCAGGGCTT 
CTGAGCAGCG GTGGGGAGTT TCTCCTGAGC AGGCAGCTAG AGTCCATAGG CACCCCGCAG 
TTCCACAGTC CAGGGGGATC CCCACTCAAG TCCATCCAGG CCACGTTAAC ACCTTCCGCT 
ATGAAATCTT CCCCTCAAAT CCCTCACAAG ACATACAGCA ACATTCTGAA ACATCTGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243471.1
CDS	1076..3238
Translation	MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSPSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKDKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDAFIAGTVQLSAQRESADVVDKLNDLNSSVSQLEMKSLISKSVSREKQEKGRANLAQLGALYQPSWESQFVSGGEECFLISQFCCEVRKDEHVEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSSGGEFLLSRQLESIGTPQFHSPGGSPLKSIQATLTPSAMKSSPQIPHKTYSNILKHLN

Target ORF information:

RefSeq Version	XM_006243409.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase 6 (Mapk6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243409.3

ORF Insert Sequence:

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGCT TTGATCTGGG TTCCAGGTAC 
ATGGACTTAA AACCATTGGG CTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 
GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTCA CCGATCCCCA GAGTGTCAAA 
CATGCCCTCC GTGAAATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTGAAAGTG 
TTTGAAATTC TTGGTCCCAG TGGAAGCCAG CTGACAGACG ATGTGGGCTC TCTAACAGAG 
CTGAATAGCG TCTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCGAA CGTGCTGGAG 
CAGGGCCCTT TACTGGAGGA GCATGCCAGG CTCTTCATGT ACCAGCTGCT GCGTGGGCTC 
AAGTACATCC ACTCTGCAAA CGTGCTGCAC AGGGATCTCA AGCCGGCCAA CCTTTTCATT 
AACACTGAAG ACTTGGTGCT GAAGATTGGT GACTTTGGCC TGGCCCGGAT CATGGATCCT 
CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CCAAATGGTA CAGATCTCCA 
CGGCTTTTAC TTTCTCCTAA TAACTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 
ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 
ATGCAGCTGA TCTTGGAGTC TATCCCTGTT GTGCACGAGG AAGATCGGCA GGAGCTTCTC 
AGCGTGATTC CAGTTTACAT TAGAAACGAC ATGACTGAGC CACACAAACC GCTGACTCAG 
CTGCTTCCGG GGATTAGTCG GGAAGCACTG GATTTCCTGG AACAGATTCT GACGTTCAGT 
CCCATGGACC GGCTGACAGC CGAGGAAGCA CTTTCCCATC CTTACATGAG CATCTACTCT 
TTCCCAACGG ACGAGCCTAT TTCCAGCCAT CCTTTCCACA TAGAAGACGA AGTGGACGAC 
ATTTTGCTAA TGGATGAAAC ACACAGTCAC ATTTATAACT GGGAAAGGTA CCACGATTGT 
CAGTTCTCGG AGCATGACTG GCCTATTCAT AACAACTTTG ATATCGATGA GGTTCAGCTT 
GACCCGAGAG CTCTGTCTGA TGTCACCGAT GAAGAAGAAG TTCAAGTTGA TCCTCGAAAG 
TACTTGGATG GAGACCGAGA GAAGTATCTG GAGGATCCCG CCTTCGACAC CAGCTACTCT 
GCTGAGCCTT GCTGGCAGTA CCCAGATCAC CACGAGAACA AGTACTGTGA TCTGGAGTGT 
AGCCACACCT GTAACTACAA AACAAGGTCG CCATCATACT TAGATAACCT GGTGTGGAGG 
GAGAGCGAGG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTTTC CAACTGGAAA 
GAGCAAAGTA AGGACAAATC CGACAAGAGA GGCAAGTCCA AGTGTGAGAG GAACGGGTTG 
GTCAAGGCGC AGATTGCGCT TGAGGAAGCG TCCCAGCAGC TGGCTGAGAG GGAGAGGGGC 
CAAGGCTTTG ACTTTGATGC CTTCATCGCA GGCACCGTTC AGCTCAGTGC CCAGCGTGAG 
TCTGCTGACG TAGTTGACAA GTTAAACGAC TTGAATAGCT CAGTGTCCCA GCTAGAAATG 
AAAAGCCTGA TATCCAAGTC AGTCAGCCGA GAAAAGCAAG AAAAGGGAAG GGCTAACCTG 
GCCCAGCTGG GAGCCTTGTA CCAGCCCTCC TGGGAGAGCC AGTTTGTGAG TGGCGGGGAG 
GAGTGCTTCC TTATCAGTCA GTTTTGTTGT GAGGTCAGGA AGGACGAACA CGTGGAGAAG 
GAGAACACTT ACACCAGCTA TTTGGACAAG TTTTTTAGCA GGAAGGAGGA TTCTGAAATG 
CTAGAAACTG AGCCAGTGGA AGAAGGGAAG CGTGGGGAGA GAGGCCGTGA GGCAGGGCTT 
CTGAGCAGCG GTGGGGAGTT TCTCCTGAGC AGGCAGCTAG AGTCCATAGG CACCCCGCAG 
TTCCACAGTC CAGGGGGATC CCCACTCAAG TCCATCCAGG CCACGTTAAC ACCTTCCGCT 
ATGAAATCTT CCCCTCAAAT CCCTCACAAG ACATACAGCA ACATTCTGAA ACATCTGAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia.
Scientific reports746602(2017 Apr)
Tan J,Yang L,Liu C,Yan Z

Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury.
Molecular pain1055(2014 Sep)
Walder RY,Wattiez AS,White SR,Marquez de Prado B,Hamity MV,Hammond DL

Role of ERK1, 2, and 5 in dopamine neuron survival during aging.
Neurobiology of aging35(3)669-79(2014 Mar)
Parmar MS,Jaumotte JD,Wyrostek SL,Zigmond MJ,Cavanaugh JE

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.
Molecular and cellular biology32(13)2467-78(2012 Jul)
Brand F,Schumacher S,Kant S,Menon MB,Simon R,Turgeon B,Britsch S,Meloche S,Gaestel M,Kotlyarov A

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Mapk6 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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