Adam17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam17
Entrez Gene ID	57027
Full Name	ADAM metallopeptidase domain 17
Synonyms	TACE
General protein information	Preferred Names ADAM metallopeptidase domain 17 Names disintegrin and metalloproteinase domain-containing protein 17 ADAM 17 TNF-alpha convertase TNF-alpha-converting enzyme a disintegrin and metallopeptidase domain 17 a disintegrin and metalloprotease domain 17 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q16
Summary	expression occurs in response to oxygen glucose deprivation, may play a role in inhibition of apoptosis via induction of TNF-alpha release [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020306.2	NP_064702.1	disintegrin and metalloproteinase domain-containing protein 17 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ADAM17	NP_001008682.1
Pan troglodytes (chimpanzee)	ADAM17	XP_515293.2
	ADAM17	XP_002799185.1
Bos taurus (cattle)	ADAM17	XP_002691532.1
Mus musculus (house mouse)	Adam17	NP_033745.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002381	XP_312572.5
Homo sapiens (human)	ADAM17	NP_003174.3
Rattus norvegicus (Norway rat)	Adam17	NP_064702.1
Danio rerio (zebrafish)	adam17a	NP_955967.1
Caenorhabditis elegans (roundworm)	adm-4	NP_509318.1
Xenopus tropicalis (tropical clawed frog)	adam17	NP_001182159.1
Canis lupus familiaris (dog)	ADAM17	XP_005630166.1
Drosophila melanogaster (fruit fly)	Tace	NP_733334.1
Danio rerio (zebrafish)	adam17b	XP_689147.3

Gene Ontology
Bibliography

Related articles in PubMed

Enhanced ADAM17 expression is associated with cardiac remodeling in rats with acute myocardial infarction.
Zheng DY, Zhao J, Yang JM, Wang M, Zhang XT
Life sciences15161-69(2016 Apr)

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
van Erp S, van den Heuvel DM, Fujita Y, Robinson RA, Hellemons AJ, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Developmental cell35(5)537-52(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Enhanced ADAM17 expression, along with decreased TIMP-3 and increased TNF-alpha expression, especially within one week after acute myocardial infarction
Title: Enhanced ADAM17 expression is associated with cardiac remodeling in rats with acute myocardial infarction.

high glucose-induced HIF-1alpha activation and ADAM17 up-regulation.
Title: High Glucose Up-regulates ADAM17 through HIF-1? in Mesangial Cells.

Angiotensin II induces ADAM17 expression in the vasculatures through a hypoxia inducible factor 1alpha-dependent transcriptional upregulation, potentially contributing to end-organ damage in the cardiovascular system.
Title: Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1?.

We conclude that adenosine-stimulated exocytosis requires PKC- and ADAM17-dependent EGFR transactivation and that the function of ADAM17 in this pathway depends on the phosphorylation state of Ser-811 in its cytoplasmic domain.
Title: A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.

TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
Title: Canonical transforming growth factor-? signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.

The following Adam17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04790	NM_020306.2 Latest version!	Rattus norvegicus ADAM metallopeptidase domain 17 (Adam17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$489.30 $699.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam17 ( NM_020306.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064702.1 Rattus norvegicus ADAM metallopeptidase domain 17 (Adam17), mRNA.

Price & Availability↑

CloneID	ORa04790
Clone ID Related Accession (Same CDS sequence)	NM_020306.2
Accession Version	NM_020306.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2484bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	disintegrin and metalloproteinase domain-containing protein 17 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ012603.1. On Aug 31, 2012 this sequence version replaced NM_020306.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ012603.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGGCAGC GTCTCCTCTT CCTGACCACT TTGGTGCCTT TCGTCCTGGC ACCCCGACCT 
CCGGAGGAAC CAGGCTCTGG CTCCCACCTG CGACTTGAGA AGCTTGATTC TTTGCTCTCA 
GACTACGATA TCCTCTCTTT ATCTAATATC CAGCAGCACT CCATAAGGAA AAGGGATCTA 
CAGTCTGCGA CACACTTAGA AACACTACTA ACTTTTTCAG CTTTGAAAAG GCATTTTAAA 
TTATACTTGA CATCAAGTAC AGAACGCTTT TCACAGAACT TGCGAGTCGT GGTGGTGGAT 
GGGAAAGAGG AAAGCGAGTA CAGTGTGAAG TGGCAGGACT TCTTCAGCGG ACATGTGGTT 
GGTGAGCCTG ACTCTAGGGT TCTAGCGCAC ATAGGAGATG ATGATGTCAC AGTAAGAATC 
AACACAGATG GGGCAGAATA TAACATAGAG CCACTTTGGA GGTTTGTTAA TGATACTAAA 
GATAAAAGGA TGCTGGTGTA TAAGTCTGAA GATATCAAGG ATTTTTCACG TTTGCAGTCT 
CCAAAAGTAT GTGGTTATTT AAATGCAGAT AGTGAAGAGT TGCTTCCAAA AGGGCTCATA 
GACAGAGAGC CATCTGAAGA GTTTGTCCGT CGAGTGAAGA GGCGAGCTGA ACCTAACCCA 
TTGAAGAATA CTTGTAAATT ACTGGTGGTG GCAGATCATC GATTTTATAA GTACATGGGC 
CGAGGAGAAG AGAGCACTAC TACAAATTAC TTAATAGAGT TAATTGACCG AGTTGATGAC 
ATATACCGGA ACACCTCGTG GGACAATGCA GGATTTAAAG GTTATGGAGT ACAGATAGAA 
CAGATTCGAA TTCTCAAGTC TCCACAAGAG GTAAAACCTG GTGAAAGACA CTTCAATATG 
GCAAAAAGTT TTCCAAATGA AGAAAAGGAT GCTTGGGATG TGAAGATGCT GCTGGAGCAA 
TTTAGCCTTG ATATAGCTGA AGAGGCCTCT AAAGTCTGCC TGGCTCATCT TTTCACCTAC 
CAAGATTTTG ATATGGGAAC TCTTGGATTA GCTTACGTTG GTTCTCCCAG AGCAAACAGT 
CATGGAGGGG TTTGTCCAAA AGCTTATTAC AACCCAGGTG TGAAGAAGAA CATCTATTTG 
AATAGTGGTC TGACAAGTAC AAAAAATTAT GGTAAAACCA TCCTTACAAA GGAGGCTGAC 
CTGGTTACAA CTCATGAATT GGGACACAAT TTTGGAGCAG AACATGATCC TGATGGGCTG 
GCAGAGTGTG CCCCAAATGA GGACCAAGGA GGAAAGTATG TTATGTACCC CATAGCTGTG 
AGTGGTGACC ATGAGAATAA TAAGATGTTT TCAAACTGCA GTAAACAGTC CATCTACAAG 
ACCATAGAAA GCAAGGCTCA AGAGTGCTTC CAGGAGCGCA GCAACAAGGT GTGCGGCAAC 
TCCAGGGTGG ACGAAGGAGA AGAGTGTGAC CCGGGCATCA TGTACCTGAA CAACGACACC 
TGCTGCAATA GTGACTGCAC ACTGAAGCCA GGTGTGCAGT GCAGTGATAG GAATAGTCCT 
TGCTGTAAAA ATTGTCAGTT TGAGACGGCC CAGAAGAAGT GCCAGGAGGC TATCAATGCT 
ACTTGCAAAG GAGTGTCTTA CTGCACAGGG AATAGCAGTG AGTGCCCCCC ACCAGGAGAT 
GCTGAAGATG ACACTGTGTG CTTGGACCTG GGCAAGTGCA AGGCTGGGAA ATGCATCCCT 
TTCTGCAAGA GGGAGCAGGA GCTGGAGTCC TGCGCATGTG CTGACACCGA CAACTCGTGC 
AAGGTATGCT GCAGGAACCT TTCTGGCCCA TGTGTGCCTT ACGTCGATGC AGAGCAAAAG 
AACTTATTTT TGAGGAAAGG GAAGCCCTGT ACAGTAGGGT TTTGTGACAT GAATGGCAAA 
TGTGAGAAAC GGGTACAGGA CGTAATTGAG CGGTTTTGGG ATTTCATTGA CCAGCTGAGC 
ATCAACACTT TTGGGAAGTT TCTGGCAGAC AACATCGTTG GGTCTGTTCT GGTTTTCTCC 
TTGATATTTT GGATTCCTTT CAGCATTCTT GTCCACTGTG TGGATAAGAA ACTGGACAAG 
CAGTATGAGT CCCTGTCTCT GTTTCATCAC AGTAACATTG AGATGTTGAG CAGCATGGAC 
TCAGCATCTG TTCGCATTAT CAAGCCGTTC CCTGCACCCC AGACTCCAGG TCGTCTGCAG 
GCCCTGCAGC CGGCTGCAAT GATGCCGCCA GTGTCTGCGG CTCCAAAACT GGATCACCAG 
AGGATGGACA CCATCCAGGA AGACCCCAGC ACAGATTCAC ATGTGGATGA TGATGGCTTT 
GAGAAGGACC CCTTCCCCAA CAGCAGTGCA GCCGCCAAGT CCTTTGAGGA CCTCACAGAC 
CACCCAGTCA CCAGGAGTGA GAAGGCCGCC TCCTTCAAGC TGCAGCGTCA GAGCCGAGTT 
GATAGCAAAG AGACAGAGTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064702.1
CDS	240..2723
Translation	MRQRLLFLTTLVPFVLAPRPPEEPGSGSHLRLEKLDSLLSDYDILSLSNIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC

Target ORF information:

RefSeq Version	NM_020306.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ADAM metallopeptidase domain 17 (Adam17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020306.2

ORF Insert Sequence:

ATGAGGCAGC GTCTCCTCTT CCTGACCACT TTGGTGCCTT TCGTCCTGGC ACCCCGACCT 
CCGGAGGAAC CAGGCTCTGG CTCCCACCTG CGACTTGAGA AGCTTGATTC TTTGCTCTCA 
GACTACGATA TCCTCTCTTT ATCTAATATC CAGCAGCACT CCATAAGGAA AAGGGATCTA 
CAGTCTGCGA CACACTTAGA AACACTACTA ACTTTTTCAG CTTTGAAAAG GCATTTTAAA 
TTATACTTGA CATCAAGTAC AGAACGCTTT TCACAGAACT TGCGAGTCGT GGTGGTGGAT 
GGGAAAGAGG AAAGCGAGTA CAGTGTGAAG TGGCAGGACT TCTTCAGCGG ACATGTGGTT 
GGTGAGCCTG ACTCTAGGGT TCTAGCGCAC ATAGGAGATG ATGATGTCAC AGTAAGAATC 
AACACAGATG GGGCAGAATA TAACATAGAG CCACTTTGGA GGTTTGTTAA TGATACTAAA 
GATAAAAGGA TGCTGGTGTA TAAGTCTGAA GATATCAAGG ATTTTTCACG TTTGCAGTCT 
CCAAAAGTAT GTGGTTATTT AAATGCAGAT AGTGAAGAGT TGCTTCCAAA AGGGCTCATA 
GACAGAGAGC CATCTGAAGA GTTTGTCCGT CGAGTGAAGA GGCGAGCTGA ACCTAACCCA 
TTGAAGAATA CTTGTAAATT ACTGGTGGTG GCAGATCATC GATTTTATAA GTACATGGGC 
CGAGGAGAAG AGAGCACTAC TACAAATTAC TTAATAGAGT TAATTGACCG AGTTGATGAC 
ATATACCGGA ACACCTCGTG GGACAATGCA GGATTTAAAG GTTATGGAGT ACAGATAGAA 
CAGATTCGAA TTCTCAAGTC TCCACAAGAG GTAAAACCTG GTGAAAGACA CTTCAATATG 
GCAAAAAGTT TTCCAAATGA AGAAAAGGAT GCTTGGGATG TGAAGATGCT GCTGGAGCAA 
TTTAGCCTTG ATATAGCTGA AGAGGCCTCT AAAGTCTGCC TGGCTCATCT TTTCACCTAC 
CAAGATTTTG ATATGGGAAC TCTTGGATTA GCTTACGTTG GTTCTCCCAG AGCAAACAGT 
CATGGAGGGG TTTGTCCAAA AGCTTATTAC AACCCAGGTG TGAAGAAGAA CATCTATTTG 
AATAGTGGTC TGACAAGTAC AAAAAATTAT GGTAAAACCA TCCTTACAAA GGAGGCTGAC 
CTGGTTACAA CTCATGAATT GGGACACAAT TTTGGAGCAG AACATGATCC TGATGGGCTG 
GCAGAGTGTG CCCCAAATGA GGACCAAGGA GGAAAGTATG TTATGTACCC CATAGCTGTG 
AGTGGTGACC ATGAGAATAA TAAGATGTTT TCAAACTGCA GTAAACAGTC CATCTACAAG 
ACCATAGAAA GCAAGGCTCA AGAGTGCTTC CAGGAGCGCA GCAACAAGGT GTGCGGCAAC 
TCCAGGGTGG ACGAAGGAGA AGAGTGTGAC CCGGGCATCA TGTACCTGAA CAACGACACC 
TGCTGCAATA GTGACTGCAC ACTGAAGCCA GGTGTGCAGT GCAGTGATAG GAATAGTCCT 
TGCTGTAAAA ATTGTCAGTT TGAGACGGCC CAGAAGAAGT GCCAGGAGGC TATCAATGCT 
ACTTGCAAAG GAGTGTCTTA CTGCACAGGG AATAGCAGTG AGTGCCCCCC ACCAGGAGAT 
GCTGAAGATG ACACTGTGTG CTTGGACCTG GGCAAGTGCA AGGCTGGGAA ATGCATCCCT 
TTCTGCAAGA GGGAGCAGGA GCTGGAGTCC TGCGCATGTG CTGACACCGA CAACTCGTGC 
AAGGTATGCT GCAGGAACCT TTCTGGCCCA TGTGTGCCTT ACGTCGATGC AGAGCAAAAG 
AACTTATTTT TGAGGAAAGG GAAGCCCTGT ACAGTAGGGT TTTGTGACAT GAATGGCAAA 
TGTGAGAAAC GGGTACAGGA CGTAATTGAG CGGTTTTGGG ATTTCATTGA CCAGCTGAGC 
ATCAACACTT TTGGGAAGTT TCTGGCAGAC AACATCGTTG GGTCTGTTCT GGTTTTCTCC 
TTGATATTTT GGATTCCTTT CAGCATTCTT GTCCACTGTG TGGATAAGAA ACTGGACAAG 
CAGTATGAGT CCCTGTCTCT GTTTCATCAC AGTAACATTG AGATGTTGAG CAGCATGGAC 
TCAGCATCTG TTCGCATTAT CAAGCCGTTC CCTGCACCCC AGACTCCAGG TCGTCTGCAG 
GCCCTGCAGC CGGCTGCAAT GATGCCGCCA GTGTCTGCGG CTCCAAAACT GGATCACCAG 
AGGATGGACA CCATCCAGGA AGACCCCAGC ACAGATTCAC ATGTGGATGA TGATGGCTTT 
GAGAAGGACC CCTTCCCCAA CAGCAGTGCA GCCGCCAAGT CCTTTGAGGA CCTCACAGAC 
CACCCAGTCA CCAGGAGTGA GAAGGCCGCC TCCTTCAAGC TGCAGCGTCA GAGCCGAGTT 
GATAGCAAAG AGACAGAGTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Enhanced ADAM17 expression is associated with cardiac remodeling in rats with acute myocardial infarction.
Life sciences15161-69(2016 Apr)
Zheng DY,Zhao J,Yang JM,Wang M,Zhang XT

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Developmental cell35(5)537-52(2015 Dec)
van Erp S,van den Heuvel DM,Fujita Y,Robinson RA,Hellemons AJ,Adolfs Y,Van Battum EY,Blokhuis AM,Kuijpers M,Demmers JA,Hedman H,Hoogenraad CC,Siebold C,Yamashita T,Pasterkamp RJ

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Adam17 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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