Cacna1i cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cacna1i
Entrez Gene ID	56827
Full Name	calcium voltage-gated channel subunit alpha1 I
General protein information	Preferred Names calcium voltage-gated channel subunit alpha1 I Names voltage-dependent T-type calcium channel subunit alpha-1I caVT.3 calcium channel, voltage-dependent, T type, alpha 1I subunit calcium channel, voltage-dependent, alpha 1I subunit hypothetical gene supported by NM_020084 low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I) voltage-dependent calcium channel voltage-gated calcium channel subunit alpha Cav3.3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	low voltage-activated calcium channel subunit; important for calcium ion transport into nerve, muscle and endocrine cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020084.3	NP_064469.3	voltage-dependent T-type calcium channel subunit alpha-1I

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CACNA1I	XP_425474.3
Pan troglodytes (chimpanzee)	CACNA1I	XP_515143.4
Canis lupus familiaris (dog)	CACNA1I	XP_538364.4
Homo sapiens (human)	CACNA1I	NP_001003406.1
Bos taurus (cattle)	CACNA1I	XP_002687981.2
Mus musculus (house mouse)	Cacna1i	NP_001037773.2
Xenopus tropicalis (tropical clawed frog)	cacna1i	XP_002933803.2
Rattus norvegicus (Norway rat)	Cacna1i	NP_064469.3
Danio rerio (zebrafish)	cacna1i	XP_694715.5

Gene Ontology
Bibliography

Related articles in PubMed

In vitro neurotoxicity by ropivacaine is reduced by silencing Cav3.3 T-type calcium subunits in neonatal rat sensory neurons.
Wen X, Liang H, Li H, Ou W, Wang HB, Liu H, Li S
Artificial cells, nanomedicine, and biotechnology1-8(2017 Oct)

Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex.
Gonz?lez B, Rivero-Echeto C, Mu?iz JA, Cadet JL, Garc?a-Rill E, Urbano FJ, Bisagno V
Addiction biology21(3)589-602(2016 May)

Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-?.
Basson MD, Zeng B, Downey C, Sirivelu MP, Tepe JJ
Molecular oncology9(2)513-26(2015 Feb)

Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
Yue J, Liu L, Liu Z, Shu B, Zhang Y
Spine38(6)463-70(2013 Mar)

The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus.
Astori S, Wimmer RD, Prosser HM, Corti C, Corsi M, Liaudet N, Volterra A, Franken P, Adelman JP, L?thi A
Proceedings of the National Academy of Sciences of the United States of America108(33)13823-8(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation
Title: Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-?.

Results suggest that T-type Ca channels Cav3.1, Cav3.2 and Cav3.3 are potential therapeutic targets for the treatment of spinal nerve ligation-induced neuropathic pain.
Title: Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.

Important link between pressure-mediated exacerbation of infarct size and T-type Ca2+ channel activity.
Title: Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel.

T-type Ca2+ channels appear to be essential for the initiation of the spontaneous activity in mammalian bipolar cells.
Title: Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels.

alternative splicing produces channels with distinct properties
Title: Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1).

The following Cacna1i gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cacna1i cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04769	NM_020084.3 Latest version!	Rattus norvegicus calcium voltage-gated channel subunit alpha1 I (Cacna1i), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	30	$1945.30 $2779.00

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cacna1i ( NM_020084.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064469.3 Rattus norvegicus calcium voltage-gated channel subunit alpha1 I (Cacna1i), mRNA.

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CloneID	ORa04769
Clone ID Related Accession (Same CDS sequence)	NM_020084.3
Accession Version	NM_020084.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	voltage-dependent T-type calcium channel subunit alpha-1I
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF290214.4. On Aug 24, 2006 this sequence version replaced NM_020084.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF290214.4 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGACA GCAACTTACC GCCCTCATCT GCAGCAGCCC CGGCCCCTGA GCCGGGAATC 
ACTGAGCAGC CGGGGCCCCG GAGTCCCCCT CCATCCCCTC CAGGCCTGGA GGAGCCATTG 
GAAGGAACCA ACCCTGACGT CCCACATCCA GACCTGGCTC CTGTTGCTTT CTTCTGCCTG 
CGCCAGACCA CGAGCCCACG GAACTGGTGC ATCAAGATGG TTTGTAACCC GTGGTTCGAG 
TGTGTGAGCA TGCTGGTTAT TCTGCTGAAC TGTGTGACCC TGGGCATGTA CCAGCCATGT 
GATGACATGG AGTGCCTGTC GGACCGTTGC AAGATCCTGC AGGTCTTCGA TGACTTCATC 
TTCATCTTCT TTGCCATGGA GATGGTGCTT AAGATGGTGG CCCTGGGCAT TTTTGGCAAG 
AAGTGCTACC TCGGAGACAC ATGGAACCGC CTGGATTTCT TCATTGTCAT GGCAGGGATG 
GTTGAGTACT CTCTGGACCT ACAGAACATC AACCTGTCAG CCATCCGCAC TGTGCGTGTC 
CTGAGGCCTC TCAAAGCCAT CAACCGTGTA CCCAGCATGC GGATCCTGGT GAACCTGCTG 
CTCGACACGC TGCCCATGCT GGGGAACGTG CTCCTGCTCT GTTTCTTCGT CTTCTTCATC 
TTCGGCATCA TTGGCGTGCA GCTCTGGGCA GGCCTGCTAC GGAACCGCTG CTTCCTGGAA 
GAGAACTTCA CCATACAAGG GGATGTGGCC CTGCCCCCTT ATTACCAACC AGAGGAGGAT 
GACGAGATGC CCTTTATCTG CTCCCTGACT GGGGACAATG GCATCATGGG CTGCCACGAG 
ATCCCCCCAC TGAAGGAGCA GGGCCGGGAA TGCTGCCTGT CCAAAGATGA TGTGTATGAC 
TTCGGGGCGG GGCGCCAGGA CCTCAACGCC AGCGGTCTGT GCGTCAACTG GAACCGCTAC 
TACAACGTCT GCCGCACGGG CAACGCCAAC CCTCACAAGG GCGCCATCAA CTTTGACAAC 
ATTGGCTATG CCTGGATTGT GATTTTCCAG GTGATCACTC TGGAAGGCTG GGTGGAGATC 
ATGTACTATG TGATGGACGC ACATTCTTTC TACAACTTCA TCTACTTCAT TCTGCTCATC 
ATAGTGGGCT CCTTCTTCAT GATCAACTTG TGCCTCGTTG TCATAGCAAC CCAGTTCTCT 
GAGACCAAGC AACGGGAGCA CCGGCTGATG CTGGAGCAAC GCCAGCGCTA CCTGTCCTCC 
AGCACGGTGG CCAGTTACGC TGAGCCCGGT GATTGCTATG AGGAGATCTT CCAATATGTC 
TGTCACATCC TTCGCAAAGC CAAGCGCCGT GCCCTAGGCC TCTACCAGGC CCTGCAGAAC 
CGGCGCCAGG CCATGGGCCC GGGGACACCA GCCCCTGCCA AGCCTGGGCC CCATGCCAAG 
GAGCCCAGCC ACTGCAAGCT GTGCCCACGA CACAGCCCCC TGGACCCCAC TCCCCACACA 
CTGGTGCAGC CCATCTCTGC CATTCTGGCC TCTGACCCCA GCAGCTGCCC TCACTGCCAG 
CACGAGGCAG GCAGGCGGCC CTCTGGCCTG GGCAGCACTG ACTCAGGCCA GGAAGGCTCA 
GGTTCTGGTG GCTCTGCAGA GGCCGAAGCC AATGGGGATG GACCCCAGAG CAGTGAGGAT 
GGGGTCTCCT CGGACCTGGG GAAGGAGGAG GAACAGGAGG ACGGGGCAGC CCGACTGTGT 
GGGGATGTGT GGCGCGAGAC ACGAGAAAAG CTGCGGGGCA TCGTGGACAG CAAGTACTTC 
AACAGAGGTA TCATGATGGC TATCCTGGTG AACACAGTCA GCATGGGCAT CGAGCACCAC 
GAACAGCCCG AGGAGCTGAC CAACATCCTG GAGATCTGCA ATGTGGTCTT CACCAGTATG 
TTTGCCCTGG AGATGATCCT GAAACTGGCC GCCTTTGGGC TCTTCGACTA CCTGCGGAAC 
CCTTACAACA TCTTTGACAG CATCATCGTC ATCATCAGCA TCTGGGAAAT CGTGGGGCAG 
GCAGACGGTG GCCTGTCTGT GCTGCGCACC TTCCGGTTGC TGCGGGTGCT GAAGCTGGTG 
CGCTTCATGC CGGCGCTGCG GCGCCAGCTC GTGGTGCTCA TGAAGACCAT GGACAACGTG 
GCCACCTTCT GCATGCTACT CATGCTGTTC ATCTTCATCT TCAGCATCCT TGGGATGCAT 
ATCTTTGGCT GCAAATTCAG CCTCCGCACG GACACGGGAG ACACCGTTCC TGACAGGAAG 
AACTTCGATT CCTTACTGTG GGCCATCGTC ACAGTGTTCC AGATCCTCAC TCAGGAGGAC 
TGGAACGTTG TCCTGTACAA TGGCATGGCC TCCACCACCC CCTGGGCCTC CCTCTATTTT 
GTTGCCCTCA TGACCTTTGG CAACTACGTT CTCTTCAATC TCCTGGTGGC TATCCTGGTA 
GAGGGTTTCC AGGCTGAGGG TGATGCTAAT CGTTCCTACT CTGATGAGGA CCAGAGCTCA 
TCCAATTTGG AGGAGTTTGA CAAGCTCCCA GAGGGCCTGG ACAACAGTAG AGATCTCAAG 
CTCTGCCCAA TACCCATGAC ACCCAATGGA CACCTGGACC CTAGCCTCCC TCTGGGTGCG 
CATCTGGGTC CTGCTGGTAC CATGGGTACT GCCCCCCGCC TCTCACTGCA GCCAGACCCG 
GTACTGGTGG CCCTAGACTC TCGGAAAAGC AGTGTCATGT CCCTGGGCAG GATGAGCTAT 
GATCAGCGAT CCTTGTCCAG CTCCCGGAGC TCCTACTACG GGCCCTGGGG CCGCAGTGGG 
ACCTGGGCTA GCCGCCGCTC CAGCTGGAAC AGCCTGAAAC ACAAGCCGCC CTCAGCTGAG 
CATGAGTCCT TACTGTCTGG GGAGGGTGGA GGTAGCTGCG TCAGGGCCTG TGAAGGCGCC 
CGGGAGGAGG CGCCAACTCG CACCGCACCC CTGCATGCTC CACACGCGCA CCACGCGCAC 
CATGGACCCC ACCTGGCACA CCGTCACCGA CACCACCGCC GGACTCTGTC CCTTGATACC 
AGGGACTCTG TTGACCTGGG AGAGCTGGTG CCCGTGGTGG GTGCCCACTC ACGGGCCGCT 
TGGAGGGGGG CGGGTCAGGC CCCTGGGCAC GAGGACTGCA ATGGCAGAAT GCCCAACATA 
GCCAAGGATG TCTTCACCAA GATGGATGAC TGCCGCGACC GCGGGGAGGA CGAGGAGGAG 
ATCGACTATA CCCTGTGTTT CCGGGTCCGC AAGATGATTG ATGTGTACAA GCCGGACTGG 
TGCGAAGTCC GCGAGGACTG GTCGGTCTAC CTCTTCTCCC CCGAGAACAA GTTCCGGATC 
CTGTGTCAGA CTATCATTGC TCACAAGCTT TTTGACTACG TGGTCTTGGC CTTTATCTTC 
CTCAACTGTA TCACCATTGC TCTGGAGAGA CCCCAGATTG AAGCTGGTAG CACTGAGCGC 
ATCTTCCTCA CGGTGTCTAA CTACATCTTC ACAGCCATCT TCGTGGGCGA GATGACACTG 
AAGGTGGTTT CTCTGGGCCT GTACTTTGGT GAGCAGGCGT ACCTGCGTAG CAGCTGGAAT 
GTACTGGATG GTTTCCTGGT CTTTGTGTCC ATCATCGATA TCGTAGTGTC CGTGGCCTCT 
GCTGGGGGAG CCAAGATTCT GGGGGTCCTC CGGGTCCTGC GGCTCCTGCG TACCTTACGT 
CCTTTGAGGG TTATCAGCCG GGCCCCTGGG CTGAAGCTGG TGGTAGAGAC GCTCATCTCC 
TCCCTCAAGC CCATTGGGAA CATCGTCCTC ATCTGCTGTG CCTTCTTCAT CATCTTCGGC 
ATCCTGGGGG TGCAGCTTTT CAAAGGCAAG TTCTACCATT GTTTGGGAGT GGACACCCGA 
AACATCACCA ACCGATCTGA CTGCGTGGCG GCCAACTACC GCTGGGTGCA TCACAAATAC 
AACTTTGACA ACCTGGGCCA GGCATTGATG TCCCTCTTTG TCTTGGCCTC CAAGGACGGC 
TGGGTGAACA TCATGTATAA TGGATTAGAT GCTGTTGCTG TGGACCAGCA GCCAGTGACG 
AACCACAACC CCTGGATGCT ACTGTACTTC ATTTCGTTCC TGCTCATCGT CAGCTTCTTT 
GTGCTCAACA TGTTTGTGGG CGTGGTCGTG GAGAACTTCC ACAAGTGCCG GCAGCACCAG 
GAGGCTGAGG AGGCGCGGAG GCGTGAGGAG AAACGGCTGC GGCGCCTGGA AAAGAAGCGC 
CGTAAGGCTC AGAGGCTGCC CTACTATGCT ACCTACTGTC CCACAAGGCT GCTCATCCAC 
TCCATGTGCA CCAGCCACTA CCTGGACATC TTCATTACCT TCATCATCTG CCTCAATGTT 
GTCACCATGT CCCTGGAGCA CTACAACCAG CCTACATCCC TAGAGACAGC CCTTAAGTAC 
TGCAACTACA TGTTCACCAC TGTCTTTGTG CTGGAGGCTG TGCTGAAGCT GGTGGCATTT 
GGCCTGAGGC GTTTCTTCAA GGACCGATGG AACCAGCTGG ACCTGGCCAT TGTGCTGCTG 
TCCGTCATGG GCATCACACT GGAGGAGATC GAGATCAATG CCGCCCTTCC CATCAACCCC 
ACCATCATCC GTATCATGCG TGTTCTGCGT ATCGCCCGGG TGTTGAAGCT ATTGAAGATG 
GCCACAGGAA TGCGGGCCCT GCTGGACACA GTGGTACAGG CTCTGCCCCA GGTGGGCAAC 
CTGGGCCTGC TCTTCATGCT GCTCTTCTTC ATCTATGCTG CTCTGGGAGT GGAGCTCTTC 
GGAAAGCTGG TCTGCAATGA CGAGAACCCG TGTGAGGGCA TGAGCCGGCA CGCCACCTTT 
GAAAACTTCG GCATGGCCTT CCTCACGCTC TTCCAGGTCT CCACAGGCGA TAACTGGAAT 
GGAATTATGA AGGACACCCT GCGAGACTGT ACCCATGATG AGCGCAGCTG CCTAAGCAGC 
CTGCAGTTTG TGTCACCGCT CTACTTTGTG AGCTTCGTGC TCACAGCTCA GTTCGTGCTC 
ATCAACGTGG TGGTGGCCGT GCTGATGAAA CATCTGGATG ACAGCAACAA GGAGGCCCAG 
GAGGATGCAG AGATGGATGC TGAGATCGAG CTGGAGATGG CCCATGGCCT CGGCCCCTGC 
CCTGGCCCCT GCCCTGGTCC CTGCCCCTGC CCCTGGCCCC TAGCCCCTGT CCTGGCCCGA 
GGCTGCCCGC TAGTTCTCCT AGGGGCTACC GGGGCGAGGA TCGGGAGGGG CAGGTGCTGG 
AGGCGACACC GAGAGTCACC TGTGCCGAGC ACTCGCTATT CTCCAGCCCA GGAGACCCTG 
TGGCTGGACA GCGTCTCTTT AATCATCAAG GACTCCTTGG AGGGGGAGCT GACCATCATT 
GACAACCTGT CTGGGTCCGT CTTCCACCAC TACGCCTCAC CTGACGGCTG TGGCAAGTGT 
CACCATGACA AGCAAGAGGT GCAGCTGGCT GAGACAGAGG CCTTCTCCCT GAACTCAGAC 
AGGTCTTCAT CCATCCTGCT GGGGGATGAC CTGAGTCTTG AGGACCCCAC GGCCTGCCCA 
CCTGGCCGCA AAGACAGCAA GGGTGAGCTG GACCCACCTG AGCCCATGCG TGTGGGAGAC 
CTGGGCGAAT GCTTCTTCCC CTTGTCCTCT ACGGCCGTCT CGCCGGATCC AGAGAACTTC 
CTGTGTGAGA TGGAGGAGAT CCCATTCAAC CCTGTCCAGT CCTGGCTCAA ACATGACAGC 
AGTCAAGCAC CCCCGAGCCC TTTCTCCCCG GATGGCTCCA GCCCTCTCCT GCAGATGCCT 
GCTGAGTTCT TCCACCCTGC TGTGTCTGCC AGCCAGAAAG GCCCAGAAAA GGGCACTGGC 
ACTGGAACCC TGCCCAAGAT TGCACTTCAG GGGTCCTGGG CATCGCTGAG GTCACCGAGT 
GTCAACTGCA CCCTCCTCCG GCAGGCCACC GGGAGCGACA CGTCGCTGGA CGCCAGCCCC 
AGCAGCTCAG CGGGCAGCCT ACAGACCACA CTGGAAGACA GTCTGACTCT GAGTGACAGT 
CCCCGGCGTG CCCTGGGGCC GCCGGTCCAG GTGCCTGGGC CACGGGCTAG CCTGTCACCG 
GCCACCCGGC GCCGCCTCAG CCTGCGGGGC CGTGGCCTGT TTAGTCTGCG TGGGCTGCGG 
GCCCATCAGC GTAGCCACAG CAGTGGCGGC TCCACCAGCC CTGGCTGCAC TCACCACGAC 
TCCATGGACC CCTCTGATGA GGAGGGCCGC GGGGGCGCAG GTGGCGGGGG TGCAGGCAGT 
GAGCACTCGG AGACCCTCAG CAGCCTGTCA CTCACATCTC TCTTCTGCCT ACCACCCACG 
CTGCCACCAC CCGGCCTCAC CCCAGCCAGG AAGTTCAACA GTACCAGCAG CCTGGCCGCT 
GGACCTGGCC GTCCTGGCTC CACTGTCTCA GCCCGTGGTC TGGTCAGAAG CCCCTCATGG 
GCTGCAGACC GCAGCAAGGA CCCACCAGGC CAAGCTCAGC TGGTCTCAGG CTTGGGCTCC 
TCAGCACCCG GGCCACAGCC ACCTCCCGGG GAGTCAACTG ATGCTGCGAG CAAAAGGAAG 
AGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064469.3
CDS	1..6606
Translation	MADSNLPPSSAAAPAPEPGITEQPGPRSPPPSPPGLEEPLEGTNPDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLTGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQAMGPGTPAPAKPGPHAKEPSHCKLCPRHSPLDPTPHTLVQPISAILASDPSSCPHCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANGDGPQSSEDGVSSDLGKEEEQEDGAARLCGDVWRETREKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEEFDKLPEGLDNSRDLKLCPIPMTPNGHLDPSLPLGAHLGPAGTMGTAPRLSLQPDPVLVALDSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGEGGGSCVRACEGAREEAPTRTAPLHAPHAHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLGELVPVVGAHSRAAWRGAGQAPGHEDCNGRMPNIAKDVFTKMDDCRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPCPGPCPGPCPCPWPLAPVLARGCPLVLLGATGARIGRGRCWRRHRESPVPSTRYSPAQETLWLDSVSLIIKDSLEGELTIIDNLSGSVFHHYASPDGCGKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVQSWLKHDSSQAPPSPFSPDGSSPLLQMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPSVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPVQVPGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCLPPTLPPPGLTPARKFNSTSSLAAGPGRPGSTVSARGLVRSPSWAADRSKDPPGQAQLVSGLGSSAPGPQPPPGESTDAASKRKR

Target ORF information:

RefSeq Version	NM_020084.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcium voltage-gated channel subunit alpha1 I (Cacna1i), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020084.3

ORF Insert Sequence:

ATGGCTGACA GCAACTTACC GCCCTCATCT GCAGCAGCCC CGGCCCCTGA GCCGGGAATC 
ACTGAGCAGC CGGGGCCCCG GAGTCCCCCT CCATCCCCTC CAGGCCTGGA GGAGCCATTG 
GAAGGAACCA ACCCTGACGT CCCACATCCA GACCTGGCTC CTGTTGCTTT CTTCTGCCTG 
CGCCAGACCA CGAGCCCACG GAACTGGTGC ATCAAGATGG TTTGTAACCC GTGGTTCGAG 
TGTGTGAGCA TGCTGGTTAT TCTGCTGAAC TGTGTGACCC TGGGCATGTA CCAGCCATGT 
GATGACATGG AGTGCCTGTC GGACCGTTGC AAGATCCTGC AGGTCTTCGA TGACTTCATC 
TTCATCTTCT TTGCCATGGA GATGGTGCTT AAGATGGTGG CCCTGGGCAT TTTTGGCAAG 
AAGTGCTACC TCGGAGACAC ATGGAACCGC CTGGATTTCT TCATTGTCAT GGCAGGGATG 
GTTGAGTACT CTCTGGACCT ACAGAACATC AACCTGTCAG CCATCCGCAC TGTGCGTGTC 
CTGAGGCCTC TCAAAGCCAT CAACCGTGTA CCCAGCATGC GGATCCTGGT GAACCTGCTG 
CTCGACACGC TGCCCATGCT GGGGAACGTG CTCCTGCTCT GTTTCTTCGT CTTCTTCATC 
TTCGGCATCA TTGGCGTGCA GCTCTGGGCA GGCCTGCTAC GGAACCGCTG CTTCCTGGAA 
GAGAACTTCA CCATACAAGG GGATGTGGCC CTGCCCCCTT ATTACCAACC AGAGGAGGAT 
GACGAGATGC CCTTTATCTG CTCCCTGACT GGGGACAATG GCATCATGGG CTGCCACGAG 
ATCCCCCCAC TGAAGGAGCA GGGCCGGGAA TGCTGCCTGT CCAAAGATGA TGTGTATGAC 
TTCGGGGCGG GGCGCCAGGA CCTCAACGCC AGCGGTCTGT GCGTCAACTG GAACCGCTAC 
TACAACGTCT GCCGCACGGG CAACGCCAAC CCTCACAAGG GCGCCATCAA CTTTGACAAC 
ATTGGCTATG CCTGGATTGT GATTTTCCAG GTGATCACTC TGGAAGGCTG GGTGGAGATC 
ATGTACTATG TGATGGACGC ACATTCTTTC TACAACTTCA TCTACTTCAT TCTGCTCATC 
ATAGTGGGCT CCTTCTTCAT GATCAACTTG TGCCTCGTTG TCATAGCAAC CCAGTTCTCT 
GAGACCAAGC AACGGGAGCA CCGGCTGATG CTGGAGCAAC GCCAGCGCTA CCTGTCCTCC 
AGCACGGTGG CCAGTTACGC TGAGCCCGGT GATTGCTATG AGGAGATCTT CCAATATGTC 
TGTCACATCC TTCGCAAAGC CAAGCGCCGT GCCCTAGGCC TCTACCAGGC CCTGCAGAAC 
CGGCGCCAGG CCATGGGCCC GGGGACACCA GCCCCTGCCA AGCCTGGGCC CCATGCCAAG 
GAGCCCAGCC ACTGCAAGCT GTGCCCACGA CACAGCCCCC TGGACCCCAC TCCCCACACA 
CTGGTGCAGC CCATCTCTGC CATTCTGGCC TCTGACCCCA GCAGCTGCCC TCACTGCCAG 
CACGAGGCAG GCAGGCGGCC CTCTGGCCTG GGCAGCACTG ACTCAGGCCA GGAAGGCTCA 
GGTTCTGGTG GCTCTGCAGA GGCCGAAGCC AATGGGGATG GACCCCAGAG CAGTGAGGAT 
GGGGTCTCCT CGGACCTGGG GAAGGAGGAG GAACAGGAGG ACGGGGCAGC CCGACTGTGT 
GGGGATGTGT GGCGCGAGAC ACGAGAAAAG CTGCGGGGCA TCGTGGACAG CAAGTACTTC 
AACAGAGGTA TCATGATGGC TATCCTGGTG AACACAGTCA GCATGGGCAT CGAGCACCAC 
GAACAGCCCG AGGAGCTGAC CAACATCCTG GAGATCTGCA ATGTGGTCTT CACCAGTATG 
TTTGCCCTGG AGATGATCCT GAAACTGGCC GCCTTTGGGC TCTTCGACTA CCTGCGGAAC 
CCTTACAACA TCTTTGACAG CATCATCGTC ATCATCAGCA TCTGGGAAAT CGTGGGGCAG 
GCAGACGGTG GCCTGTCTGT GCTGCGCACC TTCCGGTTGC TGCGGGTGCT GAAGCTGGTG 
CGCTTCATGC CGGCGCTGCG GCGCCAGCTC GTGGTGCTCA TGAAGACCAT GGACAACGTG 
GCCACCTTCT GCATGCTACT CATGCTGTTC ATCTTCATCT TCAGCATCCT TGGGATGCAT 
ATCTTTGGCT GCAAATTCAG CCTCCGCACG GACACGGGAG ACACCGTTCC TGACAGGAAG 
AACTTCGATT CCTTACTGTG GGCCATCGTC ACAGTGTTCC AGATCCTCAC TCAGGAGGAC 
TGGAACGTTG TCCTGTACAA TGGCATGGCC TCCACCACCC CCTGGGCCTC CCTCTATTTT 
GTTGCCCTCA TGACCTTTGG CAACTACGTT CTCTTCAATC TCCTGGTGGC TATCCTGGTA 
GAGGGTTTCC AGGCTGAGGG TGATGCTAAT CGTTCCTACT CTGATGAGGA CCAGAGCTCA 
TCCAATTTGG AGGAGTTTGA CAAGCTCCCA GAGGGCCTGG ACAACAGTAG AGATCTCAAG 
CTCTGCCCAA TACCCATGAC ACCCAATGGA CACCTGGACC CTAGCCTCCC TCTGGGTGCG 
CATCTGGGTC CTGCTGGTAC CATGGGTACT GCCCCCCGCC TCTCACTGCA GCCAGACCCG 
GTACTGGTGG CCCTAGACTC TCGGAAAAGC AGTGTCATGT CCCTGGGCAG GATGAGCTAT 
GATCAGCGAT CCTTGTCCAG CTCCCGGAGC TCCTACTACG GGCCCTGGGG CCGCAGTGGG 
ACCTGGGCTA GCCGCCGCTC CAGCTGGAAC AGCCTGAAAC ACAAGCCGCC CTCAGCTGAG 
CATGAGTCCT TACTGTCTGG GGAGGGTGGA GGTAGCTGCG TCAGGGCCTG TGAAGGCGCC 
CGGGAGGAGG CGCCAACTCG CACCGCACCC CTGCATGCTC CACACGCGCA CCACGCGCAC 
CATGGACCCC ACCTGGCACA CCGTCACCGA CACCACCGCC GGACTCTGTC CCTTGATACC 
AGGGACTCTG TTGACCTGGG AGAGCTGGTG CCCGTGGTGG GTGCCCACTC ACGGGCCGCT 
TGGAGGGGGG CGGGTCAGGC CCCTGGGCAC GAGGACTGCA ATGGCAGAAT GCCCAACATA 
GCCAAGGATG TCTTCACCAA GATGGATGAC TGCCGCGACC GCGGGGAGGA CGAGGAGGAG 
ATCGACTATA CCCTGTGTTT CCGGGTCCGC AAGATGATTG ATGTGTACAA GCCGGACTGG 
TGCGAAGTCC GCGAGGACTG GTCGGTCTAC CTCTTCTCCC CCGAGAACAA GTTCCGGATC 
CTGTGTCAGA CTATCATTGC TCACAAGCTT TTTGACTACG TGGTCTTGGC CTTTATCTTC 
CTCAACTGTA TCACCATTGC TCTGGAGAGA CCCCAGATTG AAGCTGGTAG CACTGAGCGC 
ATCTTCCTCA CGGTGTCTAA CTACATCTTC ACAGCCATCT TCGTGGGCGA GATGACACTG 
AAGGTGGTTT CTCTGGGCCT GTACTTTGGT GAGCAGGCGT ACCTGCGTAG CAGCTGGAAT 
GTACTGGATG GTTTCCTGGT CTTTGTGTCC ATCATCGATA TCGTAGTGTC CGTGGCCTCT 
GCTGGGGGAG CCAAGATTCT GGGGGTCCTC CGGGTCCTGC GGCTCCTGCG TACCTTACGT 
CCTTTGAGGG TTATCAGCCG GGCCCCTGGG CTGAAGCTGG TGGTAGAGAC GCTCATCTCC 
TCCCTCAAGC CCATTGGGAA CATCGTCCTC ATCTGCTGTG CCTTCTTCAT CATCTTCGGC 
ATCCTGGGGG TGCAGCTTTT CAAAGGCAAG TTCTACCATT GTTTGGGAGT GGACACCCGA 
AACATCACCA ACCGATCTGA CTGCGTGGCG GCCAACTACC GCTGGGTGCA TCACAAATAC 
AACTTTGACA ACCTGGGCCA GGCATTGATG TCCCTCTTTG TCTTGGCCTC CAAGGACGGC 
TGGGTGAACA TCATGTATAA TGGATTAGAT GCTGTTGCTG TGGACCAGCA GCCAGTGACG 
AACCACAACC CCTGGATGCT ACTGTACTTC ATTTCGTTCC TGCTCATCGT CAGCTTCTTT 
GTGCTCAACA TGTTTGTGGG CGTGGTCGTG GAGAACTTCC ACAAGTGCCG GCAGCACCAG 
GAGGCTGAGG AGGCGCGGAG GCGTGAGGAG AAACGGCTGC GGCGCCTGGA AAAGAAGCGC 
CGTAAGGCTC AGAGGCTGCC CTACTATGCT ACCTACTGTC CCACAAGGCT GCTCATCCAC 
TCCATGTGCA CCAGCCACTA CCTGGACATC TTCATTACCT TCATCATCTG CCTCAATGTT 
GTCACCATGT CCCTGGAGCA CTACAACCAG CCTACATCCC TAGAGACAGC CCTTAAGTAC 
TGCAACTACA TGTTCACCAC TGTCTTTGTG CTGGAGGCTG TGCTGAAGCT GGTGGCATTT 
GGCCTGAGGC GTTTCTTCAA GGACCGATGG AACCAGCTGG ACCTGGCCAT TGTGCTGCTG 
TCCGTCATGG GCATCACACT GGAGGAGATC GAGATCAATG CCGCCCTTCC CATCAACCCC 
ACCATCATCC GTATCATGCG TGTTCTGCGT ATCGCCCGGG TGTTGAAGCT ATTGAAGATG 
GCCACAGGAA TGCGGGCCCT GCTGGACACA GTGGTACAGG CTCTGCCCCA GGTGGGCAAC 
CTGGGCCTGC TCTTCATGCT GCTCTTCTTC ATCTATGCTG CTCTGGGAGT GGAGCTCTTC 
GGAAAGCTGG TCTGCAATGA CGAGAACCCG TGTGAGGGCA TGAGCCGGCA CGCCACCTTT 
GAAAACTTCG GCATGGCCTT CCTCACGCTC TTCCAGGTCT CCACAGGCGA TAACTGGAAT 
GGAATTATGA AGGACACCCT GCGAGACTGT ACCCATGATG AGCGCAGCTG CCTAAGCAGC 
CTGCAGTTTG TGTCACCGCT CTACTTTGTG AGCTTCGTGC TCACAGCTCA GTTCGTGCTC 
ATCAACGTGG TGGTGGCCGT GCTGATGAAA CATCTGGATG ACAGCAACAA GGAGGCCCAG 
GAGGATGCAG AGATGGATGC TGAGATCGAG CTGGAGATGG CCCATGGCCT CGGCCCCTGC 
CCTGGCCCCT GCCCTGGTCC CTGCCCCTGC CCCTGGCCCC TAGCCCCTGT CCTGGCCCGA 
GGCTGCCCGC TAGTTCTCCT AGGGGCTACC GGGGCGAGGA TCGGGAGGGG CAGGTGCTGG 
AGGCGACACC GAGAGTCACC TGTGCCGAGC ACTCGCTATT CTCCAGCCCA GGAGACCCTG 
TGGCTGGACA GCGTCTCTTT AATCATCAAG GACTCCTTGG AGGGGGAGCT GACCATCATT 
GACAACCTGT CTGGGTCCGT CTTCCACCAC TACGCCTCAC CTGACGGCTG TGGCAAGTGT 
CACCATGACA AGCAAGAGGT GCAGCTGGCT GAGACAGAGG CCTTCTCCCT GAACTCAGAC 
AGGTCTTCAT CCATCCTGCT GGGGGATGAC CTGAGTCTTG AGGACCCCAC GGCCTGCCCA 
CCTGGCCGCA AAGACAGCAA GGGTGAGCTG GACCCACCTG AGCCCATGCG TGTGGGAGAC 
CTGGGCGAAT GCTTCTTCCC CTTGTCCTCT ACGGCCGTCT CGCCGGATCC AGAGAACTTC 
CTGTGTGAGA TGGAGGAGAT CCCATTCAAC CCTGTCCAGT CCTGGCTCAA ACATGACAGC 
AGTCAAGCAC CCCCGAGCCC TTTCTCCCCG GATGGCTCCA GCCCTCTCCT GCAGATGCCT 
GCTGAGTTCT TCCACCCTGC TGTGTCTGCC AGCCAGAAAG GCCCAGAAAA GGGCACTGGC 
ACTGGAACCC TGCCCAAGAT TGCACTTCAG GGGTCCTGGG CATCGCTGAG GTCACCGAGT 
GTCAACTGCA CCCTCCTCCG GCAGGCCACC GGGAGCGACA CGTCGCTGGA CGCCAGCCCC 
AGCAGCTCAG CGGGCAGCCT ACAGACCACA CTGGAAGACA GTCTGACTCT GAGTGACAGT 
CCCCGGCGTG CCCTGGGGCC GCCGGTCCAG GTGCCTGGGC CACGGGCTAG CCTGTCACCG 
GCCACCCGGC GCCGCCTCAG CCTGCGGGGC CGTGGCCTGT TTAGTCTGCG TGGGCTGCGG 
GCCCATCAGC GTAGCCACAG CAGTGGCGGC TCCACCAGCC CTGGCTGCAC TCACCACGAC 
TCCATGGACC CCTCTGATGA GGAGGGCCGC GGGGGCGCAG GTGGCGGGGG TGCAGGCAGT 
GAGCACTCGG AGACCCTCAG CAGCCTGTCA CTCACATCTC TCTTCTGCCT ACCACCCACG 
CTGCCACCAC CCGGCCTCAC CCCAGCCAGG AAGTTCAACA GTACCAGCAG CCTGGCCGCT 
GGACCTGGCC GTCCTGGCTC CACTGTCTCA GCCCGTGGTC TGGTCAGAAG CCCCTCATGG 
GCTGCAGACC GCAGCAAGGA CCCACCAGGC CAAGCTCAGC TGGTCTCAGG CTTGGGCTCC 
TCAGCACCCG GGCCACAGCC ACCTCCCGGG GAGTCAACTG ATGCTGCGAG CAAAAGGAAG 
AGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In vitro neurotoxicity by ropivacaine is reduced by silencing Cav3.3 T-type calcium subunits in neonatal rat sensory neurons.
Artificial cells, nanomedicine, and biotechnology1-8(2017 Oct)
Wen X,Liang H,Li H,Ou W,Wang HB,Liu H,Li S

Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex.
Addiction biology21(3)589-602(2016 May)
Gonz?lez B,Rivero-Echeto C,Mu?iz JA,Cadet JL,Garc?a-Rill E,Urbano FJ,Bisagno V

Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-?.
Molecular oncology9(2)513-26(2015 Feb)
Basson MD,Zeng B,Downey C,Sirivelu MP,Tepe JJ

Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
Spine38(6)463-70(2013 Mar)
Yue J,Liu L,Liu Z,Shu B,Zhang Y

The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus.
Proceedings of the National Academy of Sciences of the United States of America108(33)13823-8(2011 Aug)
Astori S,Wimmer RD,Prosser HM,Corti C,Corsi M,Liaudet N,Volterra A,Franken P,Adelman JP,L?thi A

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Cacna1i cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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