Adam2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam2
Entrez Gene ID	56806
Full Name	ADAM metallopeptidase domain 2
Synonyms	Ftnb,PH-30
General protein information	Preferred Names ADAM metallopeptidase domain 2 Names disintegrin and metalloproteinase domain-containing protein 2 A disintegrin and metalloprotease domain 2 (Fertilin beta) ADAM 2 PH30 PH30-beta a disintegrin and metallopeptidase domain 2 a disintegrin and metalloprotease domain 2 a disintegrin and metalloprotease domain (ADAM) 2 fertilin beta fertilin subunit beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p12
Summary	may play a role in sperm-oocyte binding and fusion [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020077.1	NP_064462.1	disintegrin and metalloproteinase domain-containing protein 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADAM2	NP_001455.3
Bos taurus (cattle)	ADAM2	NP_776653.1
Mus musculus (house mouse)	Adam2	NP_033748.2
	ADAM2	XP_001095726.1
Rattus norvegicus (Norway rat)	Adam2	NP_064462.1
Pan troglodytes (chimpanzee)	ADAM2	XP_519722.2
Canis lupus familiaris (dog)	ADAM2	XP_005629892.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins.
Nishimura H, Gupta S, Myles DG, Primakoff P
Reproduction (Cambridge, England)141(4)437-51(2011 Apr)

ADAM2 interactions with mouse eggs and cell lines expressing ?4/?9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization.
Desiderio UV, Zhu X, Evans JP
PloS one5(10)e13744(2010 Oct)

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H, Cho C
Biology of reproduction80(5)1001-8(2009 May)

Deficits in spatial learning and motor coordination in ADAM11-deficient mice.
Takahashi E, Sagane K, Oki T, Yamazaki K, Nagasu T, Kuromitsu J
BMC neuroscience719(2006 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Adam2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04708	NM_020077.1 Latest version!	Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam2 ( NM_020077.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064462.1 Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA.

Price & Availability↑

CloneID	ORa04708
Clone ID Related Accession (Same CDS sequence)	NM_020077.1
Accession Version	NM_020077.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	disintegrin and metalloproteinase domain-containing protein 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X99794.1. ##Evidence-Data-START## Transcript exon combination :: X99794.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCATGT GGCTCCTCTT GCTTCTGCTG AGTGGGCTGA GTAGACTTGG AGGGCTTAGC 
GAGCCCCAAA CAGAAGGCAC TCGTGAGAAA TTACACGTGC AAGTCACGGT GCCAGAGAAA 
ATCCGGTCCA TCACAAGTGA AGGCTACGAA ACACAGGTGA CCTACAGTCT CAAAATCGAA 
GGGAAAACAT ACATCCTGAA CCTAATGCAA AAAGCGTTCT TGCCTCCCAA CTTTAGAGTC 
TACAGCTATG ACAGCACAGG GATCATGAGG CCTCTTGAGC AGAAGTTTCA GAATATCTGC 
TACTTCCAAG GATACATTGA AGGTTATCCA AATTCTATGG TGATTGTTAG CACATGTACT 
GGACTCAGGG GAGTACTTCA GTTTGGAAAC GTTAGCTACG GAATTGAACC CCTGGAATCT 
TCCAGTGGTT TTGAACATGT AATCTACCAA GTGGAACCTA AGAAAGGAGA CACATTACTC 
TATGCCGAGA AGGATATGGA TTTAAGAGAC CCGCAGTATA AGATACGAAG TATCAAGCCT 
CAGCGAACCG TCTCGCACTA TCTGGAAATA CACATTGTAG TTGAAAAGCA GATGTTTGAG 
CATATTGGGG CTGATACAGC TGTTGTCACT CAAAAGATTT TCCAGTTGAT TGGACTGACA 
AATGCTATCT TTGCCCCCTT TAATCTTACA GTAATTCTGT CTTCCCTGGA ATTTTGGATG 
GACGAAAACA AAATCTCGAC CACGGGTGAT GCTAACAAGT TGCTGTACAG GTTCCTGAAG 
TGGAAACAGT CGTACCTCGT TCTGCGACCA CATGACATGG CGTTTTTACT CGTCTACAGG 
GACACCACTG ATTATGTTGG CGCCACCTAT CAAGGGAAGA TGTGTGACAA GAACTATGCA 
GGAGGCGTTG CTCTGCACCC CAAAGCCGTA ACTCTGGAAT CACTTGCAAT TATTTTAGTT 
CAGCTGCTGA GCCTCAGCAT GGGGGTCGCA TATGACGATG TGAACACGTG CCAGTGCGGA 
GTACCCATCT GCGTGATGAA CCCCGAAGCA CTTCATTCCA GCGGTGTGAG GTCCTTCAGT 
AACTGCAGCA TGGAGGACTT CTCCAAGTTT ATCGTAAGTC AAAGCTCCCA CTGTCTTCAG 
AACCAGCCAC ACCTACAGCC GTCGTACAAG ATGGCAGTCT GTGGGAATGG AGAGTTGGAA 
GAAGGAGAAG TTTGCGACTG TGGACAGGAG GGCTGTGACG ATAAGCCTCC TCCATGCTGT 
AATCCCACCA CCTGTCAGCT GTCAGAGGGC TCCACTTGCT CCACCGGAAG TTGCTGCGAC 
GCTTCGTGCA ATCTGAAGGC AAAAGGGGAA CTTTGCAGGC CTGCCAATCA GGAATGTGAC 
GTCACAGAGT ACTGCAACGG CACTTCCGAA GTGTGTGAAG AAGACTTCTT TGTTCAAGAC 
GGTCACCCAT GTGCAGAACA GAAGTGGATC TGTATTAATG GCACCTGTCA GAGTGGAGCA 
CAGCAGTGCC GGGATCTGTT TGGCACTGAT GCAGACTATG GTACAAAAGA ATGTTACTCG 
GAGCTGAATT CCAAAAGTGA CATATCTGGG AGCTGCGGTA TCACTCCTAC GGGGTACAAG 
GACTGCGCAC CTAATGACCG GATGTGTGGA AAACTAATAT GTATATACCA AAGTGAAGAC 
ATACTTAAAA TGAGGTCTGC CATTGTTATC TATGCCAATA TAAGCGGGCA AATCTGCATC 
TCCCTGGAAT ACCCCCCAGG TCACAAAGAG AGCAAGAAGA TGTGTGTGAG AGATGGAACT 
GTCTGCGGGT CAGGGAAGGT TTGCTTGAAT CAAGAGTGTG TAGAAGATAC TTTCTTGAAC 
TATGATTGCA CCCCAGAAAA ATGCAACCAC CATGGGGTAT GTAATAACAA GAAGCATTGC 
CACTGTGAGC CCACATACTT ACCTCCGGAT TGTAAAAATA CGGAGGATAC ATGGCCTGGT 
GGGAGCGTTG ACAGTGGCAA CCAGCAACGG GCTGAATCCA TCCCTGCACG GTCCTATGTT 
GCAAGTGCCT ACCGCTCCAA GTCTGCAAGG TGGCCATTTT TCCTGATCAT CCCTTTCTAC 
GTGGTGATCC TTGTCCTGAT CGGCATGCTG GTAAAAGTCT ATTCCCAAAG AAAAAAATGG 
AGAATGGATG ACTTCTCAAG TGAAGAACAA TTTGAAAGTG AAAGTGAATC CAAAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064462.1
CDS	9..2228
Translation	MAMWLLLLLLSGLSRLGGLSEPQTEGTREKLHVQVTVPEKIRSITSEGYETQVTYSLKIEGKTYILNLMQKAFLPPNFRVYSYDSTGIMRPLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGVLQFGNVSYGIEPLESSSGFEHVIYQVEPKKGDTLLYAEKDMDLRDPQYKIRSIKPQRTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLTNAIFAPFNLTVILSSLEFWMDENKISTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLVYRDTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGVAYDDVNTCQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKFIVSQSSHCLQNQPHLQPSYKMAVCGNGELEEGEVCDCGQEGCDDKPPPCCNPTTCQLSEGSTCSTGSCCDASCNLKAKGELCRPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQSGAQQCRDLFGTDADYGTKECYSELNSKSDISGSCGITPTGYKDCAPNDRMCGKLICIYQSEDILKMRSAIVIYANISGQICISLEYPPGHKESKKMCVRDGTVCGSGKVCLNQECVEDTFLNYDCTPEKCNHHGVCNNKKHCHCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSYVASAYRSKSARWPFFLIIPFYVVILVLIGMLVKVYSQRKKWRMDDFSSEEQFESESESKD

Target ORF information:

RefSeq Version	NM_020077.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020077.1

ORF Insert Sequence:

ATGGCCATGT GGCTCCTCTT GCTTCTGCTG AGTGGGCTGA GTAGACTTGG AGGGCTTAGC 
GAGCCCCAAA CAGAAGGCAC TCGTGAGAAA TTACACGTGC AAGTCACGGT GCCAGAGAAA 
ATCCGGTCCA TCACAAGTGA AGGCTACGAA ACACAGGTGA CCTACAGTCT CAAAATCGAA 
GGGAAAACAT ACATCCTGAA CCTAATGCAA AAAGCGTTCT TGCCTCCCAA CTTTAGAGTC 
TACAGCTATG ACAGCACAGG GATCATGAGG CCTCTTGAGC AGAAGTTTCA GAATATCTGC 
TACTTCCAAG GATACATTGA AGGTTATCCA AATTCTATGG TGATTGTTAG CACATGTACT 
GGACTCAGGG GAGTACTTCA GTTTGGAAAC GTTAGCTACG GAATTGAACC CCTGGAATCT 
TCCAGTGGTT TTGAACATGT AATCTACCAA GTGGAACCTA AGAAAGGAGA CACATTACTC 
TATGCCGAGA AGGATATGGA TTTAAGAGAC CCGCAGTATA AGATACGAAG TATCAAGCCT 
CAGCGAACCG TCTCGCACTA TCTGGAAATA CACATTGTAG TTGAAAAGCA GATGTTTGAG 
CATATTGGGG CTGATACAGC TGTTGTCACT CAAAAGATTT TCCAGTTGAT TGGACTGACA 
AATGCTATCT TTGCCCCCTT TAATCTTACA GTAATTCTGT CTTCCCTGGA ATTTTGGATG 
GACGAAAACA AAATCTCGAC CACGGGTGAT GCTAACAAGT TGCTGTACAG GTTCCTGAAG 
TGGAAACAGT CGTACCTCGT TCTGCGACCA CATGACATGG CGTTTTTACT CGTCTACAGG 
GACACCACTG ATTATGTTGG CGCCACCTAT CAAGGGAAGA TGTGTGACAA GAACTATGCA 
GGAGGCGTTG CTCTGCACCC CAAAGCCGTA ACTCTGGAAT CACTTGCAAT TATTTTAGTT 
CAGCTGCTGA GCCTCAGCAT GGGGGTCGCA TATGACGATG TGAACACGTG CCAGTGCGGA 
GTACCCATCT GCGTGATGAA CCCCGAAGCA CTTCATTCCA GCGGTGTGAG GTCCTTCAGT 
AACTGCAGCA TGGAGGACTT CTCCAAGTTT ATCGTAAGTC AAAGCTCCCA CTGTCTTCAG 
AACCAGCCAC ACCTACAGCC GTCGTACAAG ATGGCAGTCT GTGGGAATGG AGAGTTGGAA 
GAAGGAGAAG TTTGCGACTG TGGACAGGAG GGCTGTGACG ATAAGCCTCC TCCATGCTGT 
AATCCCACCA CCTGTCAGCT GTCAGAGGGC TCCACTTGCT CCACCGGAAG TTGCTGCGAC 
GCTTCGTGCA ATCTGAAGGC AAAAGGGGAA CTTTGCAGGC CTGCCAATCA GGAATGTGAC 
GTCACAGAGT ACTGCAACGG CACTTCCGAA GTGTGTGAAG AAGACTTCTT TGTTCAAGAC 
GGTCACCCAT GTGCAGAACA GAAGTGGATC TGTATTAATG GCACCTGTCA GAGTGGAGCA 
CAGCAGTGCC GGGATCTGTT TGGCACTGAT GCAGACTATG GTACAAAAGA ATGTTACTCG 
GAGCTGAATT CCAAAAGTGA CATATCTGGG AGCTGCGGTA TCACTCCTAC GGGGTACAAG 
GACTGCGCAC CTAATGACCG GATGTGTGGA AAACTAATAT GTATATACCA AAGTGAAGAC 
ATACTTAAAA TGAGGTCTGC CATTGTTATC TATGCCAATA TAAGCGGGCA AATCTGCATC 
TCCCTGGAAT ACCCCCCAGG TCACAAAGAG AGCAAGAAGA TGTGTGTGAG AGATGGAACT 
GTCTGCGGGT CAGGGAAGGT TTGCTTGAAT CAAGAGTGTG TAGAAGATAC TTTCTTGAAC 
TATGATTGCA CCCCAGAAAA ATGCAACCAC CATGGGGTAT GTAATAACAA GAAGCATTGC 
CACTGTGAGC CCACATACTT ACCTCCGGAT TGTAAAAATA CGGAGGATAC ATGGCCTGGT 
GGGAGCGTTG ACAGTGGCAA CCAGCAACGG GCTGAATCCA TCCCTGCACG GTCCTATGTT 
GCAAGTGCCT ACCGCTCCAA GTCTGCAAGG TGGCCATTTT TCCTGATCAT CCCTTTCTAC 
GTGGTGATCC TTGTCCTGAT CGGCATGCTG GTAAAAGTCT ATTCCCAAAG AAAAAAATGG 
AGAATGGATG ACTTCTCAAG TGAAGAACAA TTTGAAAGTG AAAGTGAATC CAAAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins.
Reproduction (Cambridge, England)141(4)437-51(2011 Apr)
Nishimura H,Gupta S,Myles DG,Primakoff P

ADAM2 interactions with mouse eggs and cell lines expressing ?4/?9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization.
PloS one5(10)e13744(2010 Oct)
Desiderio UV,Zhu X,Evans JP

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Biology of reproduction80(5)1001-8(2009 May)
Han C,Choi E,Park I,Lee B,Jin S,Kim DH,Nishimura H,Cho C

Deficits in spatial learning and motor coordination in ADAM11-deficient mice.
BMC neuroscience719(2006 Feb)
Takahashi E,Sagane K,Oki T,Yamazaki K,Nagasu T,Kuromitsu J

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Adam2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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