Notch3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Notch3
Entrez Gene ID	56761
Full Name	notch 3
General protein information	Preferred Names notch 3 Names neurogenic locus notch homolog protein 3 Notch gene homolog 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_020087.2	NP_064472.2	neurogenic locus notch homolog protein 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NOTCH3	XP_003316212.1
	NOTCH3	XP_002808222.1
Bos taurus (cattle)	NOTCH3	XP_003586294.1
Canis lupus familiaris (dog)	NOTCH3	XP_005633258.1
Mus musculus (house mouse)	Notch3	NP_032742.1
Xenopus tropicalis (tropical clawed frog)	notch2	XP_002941531.2
Homo sapiens (human)	NOTCH3	NP_000426.2
Rattus norvegicus (Norway rat)	Notch3	NP_064472.2

Gene Ontology
Bibliography

Related articles in PubMed

mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.
Ivanovska J, Shah S, Wong MJ, Kantores C, Jain A, Post M, Yeganeh B, Jankov RP
Pediatric pulmonology52(11)1443-1454(2017 Nov)

Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL.
Mui?o E, Gallego-Fabrega C, Cullell N, Carrera C, Torres N, Krupinski J, Roquer J, Montaner J, Fern?ndez-Cadenas I
International journal of molecular sciences18(9)(2017 Sep)

Notch3 drives development and progression of cholangiocarcinoma.
Guest RV, Boulter L, Dwyer BJ, Kendall TJ, Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, Wojtacha D, Morton JP, Komuta M, Roskams T, Wigmore SJ, Sansom OJ, Forbes SJ
Proceedings of the National Academy of Sciences of the United States of America113(43)12250-12255(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Notch3 signaling activation stimulated pulmonary vascular cells proliferation.
Title: Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.

Notch3, Jagged1, Hes1 and alpha-SMA were downregulated. This downregulation was accompanied by improved hepatic fibrosis after the inhibition of Notch3 in vivo.
Title: Recombinant adeno-associated virus-mediated transfer of shRNA against Notch3 ameliorates hepatic fibrosis in rats.

Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury.
Title: Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury.

These findings imply that Notch3 may not only be a regulator of fetal liver stem/progenitor cells differentiation into hepatocytes, but also be a potential marker of fetal liver stem/progenitor cells.
Title: Notch is the key factor in the process of fetal liver stem/progenitor cells differentiation into hepatocytes.

Jaggged1 can inhibit neointima formation after balloon injury by decreasing smooth muscle cell proliferation and migration through interference with Notch1/3-Herp2 signaling.
Title: Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling.

The following Notch3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Notch3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04658	NM_020087.2 Latest version!	Rattus norvegicus notch receptor 3 (Notch3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$1984.50 $2835.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Notch3 ( NM_020087.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_064472.2 Rattus norvegicus notch receptor 3 (Notch3), mRNA.

Price & Availability↑

CloneID	ORa04658
Clone ID Related Accession (Same CDS sequence)	NM_020087.2
Accession Version	NM_020087.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	neurogenic locus notch homolog protein 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF164486.2. On Sep 5, 2000 this sequence version replaced NM_020087.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF164486.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCCGG GGGCCCGGGG CCGCCGCCGC CGTCGTCGCC TGATGGCCCT GCCACCGCCA 
CCACCGCCCA TGCGGGCGCT GCCCCTGCTG CTGCTGCTGC TAGCGGGGCT GGGGGCTGCA 
GCACCCCCTT GTCTGGATGG AAGCCCATGT GCAAATGGAG GTCGTTGCAC CCACCAGCAG 
CCCTCCCGGG AGGCTGCTTG CCTGTGCCTG CCAGGCTGGG TGGGTGAGCG GTGCCAGCTG 
GAAGACCCTT GCCACTCTGG CCCCTGTGCC GGCCGAGGCG TTTGCCAGAG TTCAGTGGTG 
GCGGGCGTCG CCCGGTTCTC CTGTCGTTGT CTCCGTGGCT TCCGAGGCCC AGACTGCTCC 
CTGCCAGACC CCTGCTTCAG CAGCCCCTGT GCTCACGGTG CCCCCTGCTC AGTTGGGTCG 
GATGGCCGAT ATGCCTGTGC CTGCCCACCT GGCTACCAGG GTCGCAACTG CCGAAGCGAC 
ATAGATGAGT GCCGAGCTGG TGCGTCTTGC CGTCACGGTG GTACCTGCAT CAATACACCC 
GGATCCTTCC ACTGCCTGTG TCCACTTGGC TATACAGGGC TGCTGTGTGA AAACCCCATA 
GTGCCCTGCG CCCCTTCCCC ATGCCGTAAT GGTGGCACCT GTAGGCAGAG TAGTGATGTC 
ACATATGACT GTGCTTGTCT TCCTGGCTTC GAGGGCCAGA ACTGTGAAGT CAATGTGGAT 
GACTGTCCTG GACATCGGTG TCTCAATGGG GGAACGTGTG TGGATGGTGT CAATACTTAT 
AACTGCCAGT GCCCTCCTGA GTGGACAGGC CAGTTCTGCA CAGAAGATGT GGATGAGTGC 
CAGTTGCAGC CCAACGCTTG CCACAATGGG GGCACCTGCT TCAACCTACT GGGCGGCCAC 
AGCTGCGTAT GCGTCAACGG CTGGACGGGC GAGAGCTGCA GTCAGAATAT TGATGACTGT 
GCTACAGCCG TTTGCTTCCA TGGGGCCACT TGCCATGACC GTGTGGCCTC TTTCTATTGT 
GCCTGCCCTA TGGGGAAGAC CGGCCTCTTG TGTCATCTGG ATGATGCATG TGTCAGCAAC 
CCCTGCCATG AAGATGCTAT CTGTGACACA AACCCTGTGA GTGGTCGGGC CATCTGCACC 
TGTCCACCCG GCTTCACCGG AGGGGCGTGT GACCAGGATG TGGATGAGTG CTCTATTGGT 
GCTAACCCCT GTGAACATTT GGGTCGGTGT GTGAACACAC AGGGCTCATT CTTGTGCCAG 
TGTGGCCGTG GCTATACTGG ACCTCGCTGT GAGACTGATG TCAATGAGTG TCTGTCTGGG 
CCCTGCCGCA ACCAGGCCAC GTGTCTTGAC CGAATTGGCC AGTTCACTTG CATCTGCATG 
GCAGGCTTCA CAGGAACCTT CTGTGAGGTG GACATTGATG AATGTCAGAG CAGCCCATGT 
GTCAATGGTG GTGTCTGCAA GGATAGAGTC AATGGCTTCA GCTGCACCTG CCCATCAGGA 
TTCAGTGGGT CCACGTGTCA GCTGGATGTG GATGAATGTG CAAGCACTCC TTGCCGGAAC 
GGTGCCAAGT GTGTGGACCA GCCTGACGGC TATGAGTGTC GCTGTGCAGA GGGCTTTGAG 
GGCACCCTGT GTGAGCGAAA CGTGGACGAC TGCTCTCCGG ATCCCTGTCA CCACGGGCGC 
TGTGTCGACG GCATTGCTAG CTTCTCATGC GCTTGTGCGC CAGGCTACAC GGGCATACGC 
TGCGAGAGCC AGGTGGATGA GTGCCGCAGC CAGCCCTGCC GATACGGGGG CAAATGTCTA 
GACTTGGTGG ACAAGTACCT CTGCCGCTGT CCTCCCGGAA CCACAGGTGT GAACTGCGAA 
GTCAACATCG ATGATTGCGC CAGCAACCCC TGTACCTTTG GAGTTTGCCG TGATGGCATC 
AACCGCTATG ATTGTGTCTG TCAGCCTGGA TTCACAGGGC CCCTCTGCAA CGTGGAGATC 
AATGAGTGTG CATCCAGCCC ATGTGGAGAG GGTGGCTCCT GTGTGGACGG GGAAAATGGC 
TTCCACTGCC TCTGCCCACC TGGCTCCCTG CCTCCACTCT GCCTACCTGC GAACCACCCC 
TGTGCCCACA AGCCCTGTAG TCATGGAGTC TGCCACGATG CACCAGGCGG GTTTCAATGT 
GTGTGCGATC CCGGTTGGAG TGGCCCTCGT TGCAGCCAGA GCCTGGCTCC AGATGCCTGT 
GAGTCCCAGC CCTGCCAGGC TGGTGGCACC TGCACCAGTG ATGGAATAGG CTTCCACTGT 
ACCTGTGCCC CTGGATTCCA GGGTCATCAA TGTGAGGTGC TGTCCCCCTG CACTCCAAGT 
CTCTGTGAGC ACGGAGGCCA CTGTGAGTCT GACCCTGACC AGCTGACTGT CTGTTCCTGT 
CCTCCAGGCT GGCAAGGCCC TCGATGCCAG CAGGATGTGG ATGAATGTGC TGGTGCCTCA 
CCTTGTGGCC CCCATGGTAC CTGCACCAAC CTGCCAGGGA GCTTCAGGTG CATCTGCCAT 
GGAGGATACA CTGGCCCTTT CTGTGATCAG GACATTGACG ACTGTGACCC CAACCCGTGC 
CTCAATGGTG GCTCCTGCCA GGATGGTGTG GGCTCCTTTT CCTGTTCTTG CCTCAGTGGC 
TTTGCTGGTC CTCGCTGTGC TCGGGATGTG GATGAATGTC TGAGCAGTCC CTGTGGCCCT 
GGCACCTGCA CTGATCATGT AGCCTCTTTC ACCTGTACCT GTCCACCTGG CTATGGAGGC 
TTCCACTGTG AGACTGACTT GCTGGACTGC AGCCCCAGTT CCTGTTTCAA TGGAGGGACC 
TGTGTGGATG GCGTGAACTC CTTCAGCTGT CTGTGTCGTC CTGGCTACAC AGGCACACAT 
TGCCAATATA AGGTTGACCC CTGCTTCTCC CGGCCCTGTC TACATGGGGG CATCTGCAAC 
CCCACCCACT CAGGATTTGA ATGCACCTGC CGGGAGGGCT TCACTGGGAA TCAGTGTCAG 
AACCCAGTGG ACTGGTGCAG CCAGGCACCC TGTCAGAATG GGGGTCGCTG TGTCCAGACT 
GGGGCTTACT GCATCTGTCC GCCTGAATGG AGTGGCCCCC TGTGCGACAT ACCAAGCCTA 
CCCTGCACGG AGGCTGCAGC CCACATGGGG GTGCGGTTGG AGCAGCTGTG TCAGGCGGGT 
GGCCAGTGCA TAGACAAGGA CCACTCCCAC TACTGTGTGT GTCCGGAGGG CCGTATGGGT 
AGTCACTGCG AACAGGAGGT GGATCCCTGC ACAGCCCAGC CTTGCCAGCA TGGGGGCACC 
TGCCGTGGTT ACATGGGCGG CTATGTGTGT GAGTGTCCAA CCGGCTACTC TGGTGACAGT 
TGTGAGGATG ATGTGGATGA GTGCGCTTCC CAGCCCTGCC AGAATGGAGG CTCCTGTATT 
GATCTTGTGG CTCACTATCT CTGCTCCTGT CCCCCTGGCA CACTGGGAGT TCTCTGTGAG 
ATCAATGAGG ATGACTGTGG CCCAGGCCCA TCCTTGGACT CAGGCCTCCG GTGCCTACAC 
AACGGCACCT GTGTGGACCT GGTGGGTGGC TTCCGCTGTA ACTGTCCCCC AGGGTACACA 
GGTCTGCACT GTGAGGCGGA CATCAATGAG TGCCGACCCG GCACCTGTCA TGCAGCACAT 
ACCCGGGACT GCCTACAAGA TCCAGGTGGG CACTTCCGCT GCATCTGTCT CCCTGGCTTC 
ACAGGGCCTC GATGTCAGAC TGCTCTGTTC CCCTGTGAGT CCCAACCGTG TCAGCATGGA 
GGCCAGTGCC GTCCCAGCCT AGGCCGTGGA GGTGGGCTGA CCTTCACCTG TCACTGTGTC 
CAGCCATTCT GGGGTCTGCG TTGCGAGCGG GTGGCACGCT CCTGCCGGGA GCTGCAGTGC 
CCAGTGGGTA TCCCATGCCA GCAGACAGCC CGTGGGCCGC GCTGTGCTTG TCCTCCCGGG 
CTGTCTGGGC CCTCCTGCCG GGTTTCTAGG GCGTCACCCT CTGGAGCTAC TAACACCAGC 
TGCGCTGCTA CTCCTTGTCT GCATGGGGGC TCCTGCCTAC CTGTACAGAG TGTCCCTTTC 
TTCCGCTGTG TATGCGCTCC GGGCTGGGGT GGCCCGCGTT GCGAGACCCC TTCCGCAGCC 
CCTGAGGTCC CTGAGGAGCC ACGGTGCCCG CGAGCCGCCT GTCAGGCCAA GCGAGGGGAC 
CAGAACTGCG ACCGTGAGTG CAACAGCCCA GGCTGTGGCT GGGACGGCGG TGACTGCTCG 
CTGAATGTGG ACGACCCCTG GAGGCAGTGT GAGGCACTGC AGTGCTGGCG TCTCTTCAAC 
AACAGCCGGT GCGATCCAGC CTGCAGCTCT CCTGCCTGCC TCTATGACAA CTTTGACTGC 
TACTCTGGTG GCCGCGACCG CACCTGCAAC CCGGTTTATA AGAAGTACTG CGCCGACCAC 
TTTGCAGATG GCCGTTGTGA CCAGGGCTGT AACACCGAGG AGTGTGGCTG GGATGGGCTG 
GACTGTGCCA GTGAGGTCCC GGCCCTTTTG GCCCGGGGGG TTCTGGTCCT CACAGTTCTT 
CTGCCTCCTG AAGAGTTGCT TCGCTCTAGT GCTGACTTCC TGCAGCGACT CAGCGCTATT 
CTGCGCACCT CGCTGCGCTT CCGCCTGGAT GCACGTGGCC AAGCCATGGT CTTTCCCTAC 
CACCGGCCAA GTCCTGGCTC CGAATCCCGG GTTCGTCGTG AGCTTGGCCC AGAGGTGATC 
GGCTCTGTAG TGATGCTGGA GATTGACAAC CGGCTCTGTC TGAAGTCAGC GGAGAACGAC 
CACTGCTTCC CTGACGCCCA GAGTGCTGCC GACTACCTGG GAGCCTTGTC GGCAGTGGAG 
CGGCTTGATT TCCCATACCC ACTACGGGAT GTGCGAGGAG AGCCCTTGGA GCCTCCAGAG 
CAGAGCGTGC CACTGCTGCC GCTGCTGGTG GCAGGGGCTG TCTTTCTGCT GGTCATCTTC 
GTCCTGGGTG TCATGGTTGC CAGGCGCAAG CGAGAGCACA GCACCCTCTG GTTTCCTGAG 
GGTTTTGCAT TACACAAGGA CATAGCTGCT GGCCACAAGG GCCGGAGGGA GCCCGTGGGA 
CAAGACGCAC TGGGCATGAA GAACATGACC AAGGGTGAGA GTCTGATGGG GGAGGTGGCC 
ACAGACTGGA ATGACTCAGA ATGCCCAGAG GCCAAGAGAC TGAAGGTAGA GGAGCCAGGC 
ATGGGGGCCG AGGAGCCCGT GGACTGTCGC CAGTGGACCC AACACCACCT GGTTGCTGCC 
GATATCCGTG TGGCACCAGC CATGGCACTG ACTCCACCTC AGGGAGATGC AGATGCCGAT 
GGCATGGATG TCAACGTACG AGGGCCTGAT GGCTTCACCC CACTTATGCT GGCCTCGTTC 
TGTGGGGGAG CCCTGGAGCC GATGCCAGCT GAGGAGGATG AGGCCGATGA CACGTCAGCC 
AGCATTATAT CAGATCTGAT CTGCCAAGGA GCCCAGCTCG GGGCACGAAC TGACCGAACT 
GGCGAGACCG CCCTGCATTT GGCCGCCCGA TATGCTCGAG CCGATGCGGC CAAGCGGCTA 
CTGGATGCTG GGGCAGACAC CAACGCCCAG GATCATTCCG GCCGCACCCC TCTGCACACC 
GCAGTGACAG CTGATGCCCA GGGTGTCTTC CAGATTCTCA TCAGGAACCG CTCCACTGAC 
CTGGATGCCC GAATGGCAGA TGGCTCTACT GCATTGATCC TGGCAGCCCG CCTGGCGGTG 
GAGGGAATGG TGGAAGAGCT CATCGCCAGC CACGCAGATG TCAATGCAGT GGATGAGCTC 
GGGAAATCGG CCTTACACTG GGCTGCAGCC GTGAACAATG TGGAGGCTAC CTTGGCTCTG 
CTGAAAAATG GAGCCAACAA GGACATGCAG GACAGCAAGG AGGAGACTCC ACTGTTCTTG 
GCCGCCCGTG AGGGCAGCTA TGAGGCTGCC AAGCTGCTGC TGGATCATTT TGCCAACCGG 
GAGATCACAG ATCACTTGGA CAGGCTGCCC CGGGATGTGG CCCAGGAGCG GCTGCACCAG 
GACATTGTGC GGTTGCTGGA CCAGCCCAGT GGCCCCCGAA GTCCCTCTGG TCCCCATGGC 
TTGGGGCCAT TGCTCTGCCC ACCAGGAGCC TTCCTTCCTG GCCTCAAAGC GGTGCAGTCT 
GGGACCAAGA AGAGCAGGAG GCCACCTGGC AAGACTGGGC TGGGGCCCCA GGGAACTCGG 
GGTCGGGGCA AGAAGCTGAC ACTGGCCTGT CCAGGCCCTC TGGCAGACAG CTCTGTCACA 
CTGTCACCAG TAGACTCGCT GGACTCACCA CGGCCTTTCG GTGGGCCCCC TGCTTCCCCT 
GGAGGCTTCC CCTTGGAGGG TCCCTATGCC ACCACAGCCA CCACGGTGTC CTTGGCACAG 
CTGGGTGCAA GTCGGGCGGG TCCTCTGGGG CGCCAGCCTC CTGGGGGCTG TGTGCTCAGC 
CTTGGTTTGC TCAACCCTGT GGCTGTTCCC CTTGACTGGG CCCGGCTGCC TCCACCTGCC 
CCTCCAGGGC CCTCATTCCT GCTGCCCCTG GCTCCGGGAT CCCAGCTGCT CAACCCGGCA 
ACCCCAGTTT CTCCCCATGA GCGGCCCCCA CCCTACCTGG CTGCTCCAGG ACATGGAGAG 
GAATACCCTG CAGCAGGGAC CCACAGCAGC CCCACAAAGG CCCGCTTCCT GCGGGTTCCC 
AGCGAGCATC CTTATTTGAC CCCATCTCCT GAGTCCCCAG AGCACTGGGC CAGCCCGTCC 
CCTCCCTCCC TCTCAGACTG GTCCGACTCA ACGCCTAGTC CAGCAACTGC TACCAGTGCC 
ACAGCCGCTG GAGCCCTGCC TGCTCAACCA CACCCCATAT CTGTTCCCTC CCTCCCTCAG 
TCCCAGACTC AGCTGGGGCC CCAGCCAGAA GTAACCCCCA AGAGGCAGGT GATGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064472.2
CDS	94..7053
Translation	MGPGARGRRRRRRLMALPPPPPPMRALPLLLLLLAGLGAAAPPCLDGSPCANGGRCTHQQPSREAACLCLPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGVARFSCRCLRGFRGPDCSLPDPCFSSPCAHGAPCSVGSDGRYACACPPGYQGRNCRSDIDECRAGASCRHGGTCINTPGSFHCLCPLGYTGLLCENPIVPCAPSPCRNGGTCRQSSDVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNLLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVSGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTFCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCERNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGIRCESQVDECRSQPCRYGGKCLDLVDKYLCRCPPGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFHCLCPPGSLPPLCLPANHPCAHKPCSHGVCHDAPGGFQCVCDPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIGFHCTCAPGFQGHQCEVLSPCTPSLCEHGGHCESDPDQLTVCSCPPGWQGPRCQQDVDECAGASPCGPHGTCTNLPGSFRCICHGGYTGPFCDQDIDDCDPNPCLNGGSCQDGVGSFSCSCLSGFAGPRCARDVDECLSSPCGPGTCTDHVASFTCTCPPGYGGFHCETDLLDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQYKVDPCFSRPCLHGGICNPTHSGFECTCREGFTGNQCQNPVDWCSQAPCQNGGRCVQTGAYCICPPEWSGPLCDIPSLPCTEAAAHMGVRLEQLCQAGGQCIDKDHSHYCVCPEGRMGSHCEQEVDPCTAQPCQHGGTCRGYMGGYVCECPTGYSGDSCEDDVDECASQPCQNGGSCIDLVAHYLCSCPPGTLGVLCEINEDDCGPGPSLDSGLRCLHNGTCVDLVGGFRCNCPPGYTGLHCEADINECRPGTCHAAHTRDCLQDPGGHFRCICLPGFTGPRCQTALFPCESQPCQHGGQCRPSLGRGGGLTFTCHCVQPFWGLRCERVARSCRELQCPVGIPCQQTARGPRCACPPGLSGPSCRVSRASPSGATNTSCAATPCLHGGSCLPVQSVPFFRCVCAPGWGGPRCETPSAAPEVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDCSLNVDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCYSGGRDRTCNPVYKKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHRPSPGSESRVRRELGPEVIGSVVMLEIDNRLCLKSAENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPEGFALHKDIAAGHKGRREPVGQDALGMKNMTKGESLMGEVATDWNDSECPEAKRLKVEEPGMGAEEPVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPAEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPSGPHGLGPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGLGPQGTRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYATTATTVSLAQLGASRAGPLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGSQLLNPATPVSPHERPPPYLAAPGHGEEYPAAGTHSSPTKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSDSTPSPATATSATAAGALPAQPHPISVPSLPQSQTQLGPQPEVTPKRQVMA

Target ORF information:

RefSeq Version	NM_020087.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus notch receptor 3 (Notch3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020087.2

ORF Insert Sequence:

ATGGGGCCGG GGGCCCGGGG CCGCCGCCGC CGTCGTCGCC TGATGGCCCT GCCACCGCCA 
CCACCGCCCA TGCGGGCGCT GCCCCTGCTG CTGCTGCTGC TAGCGGGGCT GGGGGCTGCA 
GCACCCCCTT GTCTGGATGG AAGCCCATGT GCAAATGGAG GTCGTTGCAC CCACCAGCAG 
CCCTCCCGGG AGGCTGCTTG CCTGTGCCTG CCAGGCTGGG TGGGTGAGCG GTGCCAGCTG 
GAAGACCCTT GCCACTCTGG CCCCTGTGCC GGCCGAGGCG TTTGCCAGAG TTCAGTGGTG 
GCGGGCGTCG CCCGGTTCTC CTGTCGTTGT CTCCGTGGCT TCCGAGGCCC AGACTGCTCC 
CTGCCAGACC CCTGCTTCAG CAGCCCCTGT GCTCACGGTG CCCCCTGCTC AGTTGGGTCG 
GATGGCCGAT ATGCCTGTGC CTGCCCACCT GGCTACCAGG GTCGCAACTG CCGAAGCGAC 
ATAGATGAGT GCCGAGCTGG TGCGTCTTGC CGTCACGGTG GTACCTGCAT CAATACACCC 
GGATCCTTCC ACTGCCTGTG TCCACTTGGC TATACAGGGC TGCTGTGTGA AAACCCCATA 
GTGCCCTGCG CCCCTTCCCC ATGCCGTAAT GGTGGCACCT GTAGGCAGAG TAGTGATGTC 
ACATATGACT GTGCTTGTCT TCCTGGCTTC GAGGGCCAGA ACTGTGAAGT CAATGTGGAT 
GACTGTCCTG GACATCGGTG TCTCAATGGG GGAACGTGTG TGGATGGTGT CAATACTTAT 
AACTGCCAGT GCCCTCCTGA GTGGACAGGC CAGTTCTGCA CAGAAGATGT GGATGAGTGC 
CAGTTGCAGC CCAACGCTTG CCACAATGGG GGCACCTGCT TCAACCTACT GGGCGGCCAC 
AGCTGCGTAT GCGTCAACGG CTGGACGGGC GAGAGCTGCA GTCAGAATAT TGATGACTGT 
GCTACAGCCG TTTGCTTCCA TGGGGCCACT TGCCATGACC GTGTGGCCTC TTTCTATTGT 
GCCTGCCCTA TGGGGAAGAC CGGCCTCTTG TGTCATCTGG ATGATGCATG TGTCAGCAAC 
CCCTGCCATG AAGATGCTAT CTGTGACACA AACCCTGTGA GTGGTCGGGC CATCTGCACC 
TGTCCACCCG GCTTCACCGG AGGGGCGTGT GACCAGGATG TGGATGAGTG CTCTATTGGT 
GCTAACCCCT GTGAACATTT GGGTCGGTGT GTGAACACAC AGGGCTCATT CTTGTGCCAG 
TGTGGCCGTG GCTATACTGG ACCTCGCTGT GAGACTGATG TCAATGAGTG TCTGTCTGGG 
CCCTGCCGCA ACCAGGCCAC GTGTCTTGAC CGAATTGGCC AGTTCACTTG CATCTGCATG 
GCAGGCTTCA CAGGAACCTT CTGTGAGGTG GACATTGATG AATGTCAGAG CAGCCCATGT 
GTCAATGGTG GTGTCTGCAA GGATAGAGTC AATGGCTTCA GCTGCACCTG CCCATCAGGA 
TTCAGTGGGT CCACGTGTCA GCTGGATGTG GATGAATGTG CAAGCACTCC TTGCCGGAAC 
GGTGCCAAGT GTGTGGACCA GCCTGACGGC TATGAGTGTC GCTGTGCAGA GGGCTTTGAG 
GGCACCCTGT GTGAGCGAAA CGTGGACGAC TGCTCTCCGG ATCCCTGTCA CCACGGGCGC 
TGTGTCGACG GCATTGCTAG CTTCTCATGC GCTTGTGCGC CAGGCTACAC GGGCATACGC 
TGCGAGAGCC AGGTGGATGA GTGCCGCAGC CAGCCCTGCC GATACGGGGG CAAATGTCTA 
GACTTGGTGG ACAAGTACCT CTGCCGCTGT CCTCCCGGAA CCACAGGTGT GAACTGCGAA 
GTCAACATCG ATGATTGCGC CAGCAACCCC TGTACCTTTG GAGTTTGCCG TGATGGCATC 
AACCGCTATG ATTGTGTCTG TCAGCCTGGA TTCACAGGGC CCCTCTGCAA CGTGGAGATC 
AATGAGTGTG CATCCAGCCC ATGTGGAGAG GGTGGCTCCT GTGTGGACGG GGAAAATGGC 
TTCCACTGCC TCTGCCCACC TGGCTCCCTG CCTCCACTCT GCCTACCTGC GAACCACCCC 
TGTGCCCACA AGCCCTGTAG TCATGGAGTC TGCCACGATG CACCAGGCGG GTTTCAATGT 
GTGTGCGATC CCGGTTGGAG TGGCCCTCGT TGCAGCCAGA GCCTGGCTCC AGATGCCTGT 
GAGTCCCAGC CCTGCCAGGC TGGTGGCACC TGCACCAGTG ATGGAATAGG CTTCCACTGT 
ACCTGTGCCC CTGGATTCCA GGGTCATCAA TGTGAGGTGC TGTCCCCCTG CACTCCAAGT 
CTCTGTGAGC ACGGAGGCCA CTGTGAGTCT GACCCTGACC AGCTGACTGT CTGTTCCTGT 
CCTCCAGGCT GGCAAGGCCC TCGATGCCAG CAGGATGTGG ATGAATGTGC TGGTGCCTCA 
CCTTGTGGCC CCCATGGTAC CTGCACCAAC CTGCCAGGGA GCTTCAGGTG CATCTGCCAT 
GGAGGATACA CTGGCCCTTT CTGTGATCAG GACATTGACG ACTGTGACCC CAACCCGTGC 
CTCAATGGTG GCTCCTGCCA GGATGGTGTG GGCTCCTTTT CCTGTTCTTG CCTCAGTGGC 
TTTGCTGGTC CTCGCTGTGC TCGGGATGTG GATGAATGTC TGAGCAGTCC CTGTGGCCCT 
GGCACCTGCA CTGATCATGT AGCCTCTTTC ACCTGTACCT GTCCACCTGG CTATGGAGGC 
TTCCACTGTG AGACTGACTT GCTGGACTGC AGCCCCAGTT CCTGTTTCAA TGGAGGGACC 
TGTGTGGATG GCGTGAACTC CTTCAGCTGT CTGTGTCGTC CTGGCTACAC AGGCACACAT 
TGCCAATATA AGGTTGACCC CTGCTTCTCC CGGCCCTGTC TACATGGGGG CATCTGCAAC 
CCCACCCACT CAGGATTTGA ATGCACCTGC CGGGAGGGCT TCACTGGGAA TCAGTGTCAG 
AACCCAGTGG ACTGGTGCAG CCAGGCACCC TGTCAGAATG GGGGTCGCTG TGTCCAGACT 
GGGGCTTACT GCATCTGTCC GCCTGAATGG AGTGGCCCCC TGTGCGACAT ACCAAGCCTA 
CCCTGCACGG AGGCTGCAGC CCACATGGGG GTGCGGTTGG AGCAGCTGTG TCAGGCGGGT 
GGCCAGTGCA TAGACAAGGA CCACTCCCAC TACTGTGTGT GTCCGGAGGG CCGTATGGGT 
AGTCACTGCG AACAGGAGGT GGATCCCTGC ACAGCCCAGC CTTGCCAGCA TGGGGGCACC 
TGCCGTGGTT ACATGGGCGG CTATGTGTGT GAGTGTCCAA CCGGCTACTC TGGTGACAGT 
TGTGAGGATG ATGTGGATGA GTGCGCTTCC CAGCCCTGCC AGAATGGAGG CTCCTGTATT 
GATCTTGTGG CTCACTATCT CTGCTCCTGT CCCCCTGGCA CACTGGGAGT TCTCTGTGAG 
ATCAATGAGG ATGACTGTGG CCCAGGCCCA TCCTTGGACT CAGGCCTCCG GTGCCTACAC 
AACGGCACCT GTGTGGACCT GGTGGGTGGC TTCCGCTGTA ACTGTCCCCC AGGGTACACA 
GGTCTGCACT GTGAGGCGGA CATCAATGAG TGCCGACCCG GCACCTGTCA TGCAGCACAT 
ACCCGGGACT GCCTACAAGA TCCAGGTGGG CACTTCCGCT GCATCTGTCT CCCTGGCTTC 
ACAGGGCCTC GATGTCAGAC TGCTCTGTTC CCCTGTGAGT CCCAACCGTG TCAGCATGGA 
GGCCAGTGCC GTCCCAGCCT AGGCCGTGGA GGTGGGCTGA CCTTCACCTG TCACTGTGTC 
CAGCCATTCT GGGGTCTGCG TTGCGAGCGG GTGGCACGCT CCTGCCGGGA GCTGCAGTGC 
CCAGTGGGTA TCCCATGCCA GCAGACAGCC CGTGGGCCGC GCTGTGCTTG TCCTCCCGGG 
CTGTCTGGGC CCTCCTGCCG GGTTTCTAGG GCGTCACCCT CTGGAGCTAC TAACACCAGC 
TGCGCTGCTA CTCCTTGTCT GCATGGGGGC TCCTGCCTAC CTGTACAGAG TGTCCCTTTC 
TTCCGCTGTG TATGCGCTCC GGGCTGGGGT GGCCCGCGTT GCGAGACCCC TTCCGCAGCC 
CCTGAGGTCC CTGAGGAGCC ACGGTGCCCG CGAGCCGCCT GTCAGGCCAA GCGAGGGGAC 
CAGAACTGCG ACCGTGAGTG CAACAGCCCA GGCTGTGGCT GGGACGGCGG TGACTGCTCG 
CTGAATGTGG ACGACCCCTG GAGGCAGTGT GAGGCACTGC AGTGCTGGCG TCTCTTCAAC 
AACAGCCGGT GCGATCCAGC CTGCAGCTCT CCTGCCTGCC TCTATGACAA CTTTGACTGC 
TACTCTGGTG GCCGCGACCG CACCTGCAAC CCGGTTTATA AGAAGTACTG CGCCGACCAC 
TTTGCAGATG GCCGTTGTGA CCAGGGCTGT AACACCGAGG AGTGTGGCTG GGATGGGCTG 
GACTGTGCCA GTGAGGTCCC GGCCCTTTTG GCCCGGGGGG TTCTGGTCCT CACAGTTCTT 
CTGCCTCCTG AAGAGTTGCT TCGCTCTAGT GCTGACTTCC TGCAGCGACT CAGCGCTATT 
CTGCGCACCT CGCTGCGCTT CCGCCTGGAT GCACGTGGCC AAGCCATGGT CTTTCCCTAC 
CACCGGCCAA GTCCTGGCTC CGAATCCCGG GTTCGTCGTG AGCTTGGCCC AGAGGTGATC 
GGCTCTGTAG TGATGCTGGA GATTGACAAC CGGCTCTGTC TGAAGTCAGC GGAGAACGAC 
CACTGCTTCC CTGACGCCCA GAGTGCTGCC GACTACCTGG GAGCCTTGTC GGCAGTGGAG 
CGGCTTGATT TCCCATACCC ACTACGGGAT GTGCGAGGAG AGCCCTTGGA GCCTCCAGAG 
CAGAGCGTGC CACTGCTGCC GCTGCTGGTG GCAGGGGCTG TCTTTCTGCT GGTCATCTTC 
GTCCTGGGTG TCATGGTTGC CAGGCGCAAG CGAGAGCACA GCACCCTCTG GTTTCCTGAG 
GGTTTTGCAT TACACAAGGA CATAGCTGCT GGCCACAAGG GCCGGAGGGA GCCCGTGGGA 
CAAGACGCAC TGGGCATGAA GAACATGACC AAGGGTGAGA GTCTGATGGG GGAGGTGGCC 
ACAGACTGGA ATGACTCAGA ATGCCCAGAG GCCAAGAGAC TGAAGGTAGA GGAGCCAGGC 
ATGGGGGCCG AGGAGCCCGT GGACTGTCGC CAGTGGACCC AACACCACCT GGTTGCTGCC 
GATATCCGTG TGGCACCAGC CATGGCACTG ACTCCACCTC AGGGAGATGC AGATGCCGAT 
GGCATGGATG TCAACGTACG AGGGCCTGAT GGCTTCACCC CACTTATGCT GGCCTCGTTC 
TGTGGGGGAG CCCTGGAGCC GATGCCAGCT GAGGAGGATG AGGCCGATGA CACGTCAGCC 
AGCATTATAT CAGATCTGAT CTGCCAAGGA GCCCAGCTCG GGGCACGAAC TGACCGAACT 
GGCGAGACCG CCCTGCATTT GGCCGCCCGA TATGCTCGAG CCGATGCGGC CAAGCGGCTA 
CTGGATGCTG GGGCAGACAC CAACGCCCAG GATCATTCCG GCCGCACCCC TCTGCACACC 
GCAGTGACAG CTGATGCCCA GGGTGTCTTC CAGATTCTCA TCAGGAACCG CTCCACTGAC 
CTGGATGCCC GAATGGCAGA TGGCTCTACT GCATTGATCC TGGCAGCCCG CCTGGCGGTG 
GAGGGAATGG TGGAAGAGCT CATCGCCAGC CACGCAGATG TCAATGCAGT GGATGAGCTC 
GGGAAATCGG CCTTACACTG GGCTGCAGCC GTGAACAATG TGGAGGCTAC CTTGGCTCTG 
CTGAAAAATG GAGCCAACAA GGACATGCAG GACAGCAAGG AGGAGACTCC ACTGTTCTTG 
GCCGCCCGTG AGGGCAGCTA TGAGGCTGCC AAGCTGCTGC TGGATCATTT TGCCAACCGG 
GAGATCACAG ATCACTTGGA CAGGCTGCCC CGGGATGTGG CCCAGGAGCG GCTGCACCAG 
GACATTGTGC GGTTGCTGGA CCAGCCCAGT GGCCCCCGAA GTCCCTCTGG TCCCCATGGC 
TTGGGGCCAT TGCTCTGCCC ACCAGGAGCC TTCCTTCCTG GCCTCAAAGC GGTGCAGTCT 
GGGACCAAGA AGAGCAGGAG GCCACCTGGC AAGACTGGGC TGGGGCCCCA GGGAACTCGG 
GGTCGGGGCA AGAAGCTGAC ACTGGCCTGT CCAGGCCCTC TGGCAGACAG CTCTGTCACA 
CTGTCACCAG TAGACTCGCT GGACTCACCA CGGCCTTTCG GTGGGCCCCC TGCTTCCCCT 
GGAGGCTTCC CCTTGGAGGG TCCCTATGCC ACCACAGCCA CCACGGTGTC CTTGGCACAG 
CTGGGTGCAA GTCGGGCGGG TCCTCTGGGG CGCCAGCCTC CTGGGGGCTG TGTGCTCAGC 
CTTGGTTTGC TCAACCCTGT GGCTGTTCCC CTTGACTGGG CCCGGCTGCC TCCACCTGCC 
CCTCCAGGGC CCTCATTCCT GCTGCCCCTG GCTCCGGGAT CCCAGCTGCT CAACCCGGCA 
ACCCCAGTTT CTCCCCATGA GCGGCCCCCA CCCTACCTGG CTGCTCCAGG ACATGGAGAG 
GAATACCCTG CAGCAGGGAC CCACAGCAGC CCCACAAAGG CCCGCTTCCT GCGGGTTCCC 
AGCGAGCATC CTTATTTGAC CCCATCTCCT GAGTCCCCAG AGCACTGGGC CAGCCCGTCC 
CCTCCCTCCC TCTCAGACTG GTCCGACTCA ACGCCTAGTC CAGCAACTGC TACCAGTGCC 
ACAGCCGCTG GAGCCCTGCC TGCTCAACCA CACCCCATAT CTGTTCCCTC CCTCCCTCAG 
TCCCAGACTC AGCTGGGGCC CCAGCCAGAA GTAACCCCCA AGAGGCAGGT GATGGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.
Pediatric pulmonology52(11)1443-1454(2017 Nov)
Ivanovska J,Shah S,Wong MJ,Kantores C,Jain A,Post M,Yeganeh B,Jankov RP

Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL.
International journal of molecular sciences18(9)(2017 Sep)
Mui?o E,Gallego-Fabrega C,Cullell N,Carrera C,Torres N,Krupinski J,Roquer J,Montaner J,Fern?ndez-Cadenas I

Notch3 drives development and progression of cholangiocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America113(43)12250-12255(2016 Oct)
Guest RV,Boulter L,Dwyer BJ,Kendall TJ,Man TY,Minnis-Lyons SE,Lu WY,Robson AJ,Gonzalez SF,Raven A,Wojtacha D,Morton JP,Komuta M,Roskams T,Wigmore SJ,Sansom OJ,Forbes SJ

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Notch3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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