Nptn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nptn
Entrez Gene ID	56064
Full Name	neuroplastin
Synonyms	Sdfr1
General protein information	Preferred Names neuroplastin Names neuroplastin SDR-1 glycoprotein 55 glycoprotein 55/65 glycoprotein 65 gp55/65 stromal cell derived factor receptor 1 stromal cell-derived receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	synaptic membrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243172.3	XP_006243234.1	neuroplastin isoform X1
XM_006243174.3	XP_006243236.1	neuroplastin isoform X2
NM_019380.1	NP_062253.1	neuroplastin precursor
XM_008766330.2	XP_008764552.1	neuroplastin isoform X3

Pathways from BioSystems

Homologies

Homo sapiens (human)	NPTN	NP_036560.1
Pan troglodytes (chimpanzee)	NPTN	XP_510661.2
Gallus gallus (chicken)	NPTN	XP_413703.3
Danio rerio (zebrafish)	nptnb	NP_991268.1
	NPTN	XP_001093380.1
Rattus norvegicus (Norway rat)	Nptn	NP_062253.1
Canis lupus familiaris (dog)	NPTN	XP_005638771.1

Gene Ontology
Bibliography

Related articles in PubMed

A complex of Neuroplastin and Plasma Membrane Ca
Korthals M, Langnaese K, Smalla KH, K?hne T, Herrera-Molina R, Handschuh J, Lehmann AC, Mamula D, Naumann M, Seidenbecher C, Zuschratter W, Tedford K, Gundelfinger ED, Montag D, Fischer KD, Thomas U
Scientific reports7(1)8358(2017 Aug)

Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65.
Herrera-Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D
The Journal of biological chemistry289(13)8973-88(2014 Mar)

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Boyken J, Gr?nborg M, Riedel D, Urlaub H, Jahn R, Chua JJ
Neuron78(2)285-97(2013 Apr)

The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.
Wilson MC, Kraus M, Marzban H, Sarna JR, Wang Y, Hawkes R, Halestrap AP, Beesley PW
PloS one8(11)e78654(2013)

The cell adhesion molecule neuroplastin-65 is a novel interaction partner of ?-aminobutyric acid type A receptors.
Sarto-Jackson I, Milenkovic I, Smalla KH, Gundelfinger ED, Kaehne T, Herrera-Molina R, Thomas S, Kiebler MA, Sieghart W
The Journal of biological chemistry287(17)14201-14(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

neuroplastins act as key ancillary proteins for MCT2 cell surface localisation and activity in some neuronal populations, thus playing an important role in facilitating the uptake of lactate for use as a respiratory fuel.
Title: The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.

neuroplastin-65 can co-localize with a subset of GABA(A) receptor subtypes and might contribute to anchoring and/or confining GABA(A) receptors to particular synaptic or extra-synaptic sites, thus affecting receptor mobility and synaptic strength
Title: The cell adhesion molecule neuroplastin-65 is a novel interaction partner of ?-aminobutyric acid type A receptors.

Identified the homophilic binding site in Np65 and demonstrated the importance of homophilic interactions in biological responses such as neurite extension and calcium transients in vitro and in an animal model of learning and memory.
Title: Neuroplastin-65 and a mimetic peptide derived from its homophilic binding site modulate neuritogenesis and neuronal plasticity.

both Np55 and the narpin peptide induce neurite outgrowth through FGFR1 activation and that Np55 increases synaptic calcium concentration in an FGFR1-dependent manner.
Title: Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor.

The following Nptn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nptn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa43438	XM_008766330.2 Latest version!	Rattus norvegicus neuroplastin (Nptn), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa31233	XM_006243172.3 Latest version!	Rattus norvegicus neuroplastin (Nptn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa31235	XM_006243174.3 Latest version!	Rattus norvegicus neuroplastin (Nptn), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa04614	NM_019380.1 Latest version!	Rattus norvegicus neuroplastin (Nptn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nptn ( XM_008766330.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008764552.1 Rattus norvegicus neuroplastin (Nptn), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa43438
Clone ID Related Accession (Same CDS sequence)	XM_008766330.2
Accession Version	XM_008766330.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neuroplastin isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008766330.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GAACCAAGAA TTGTCACCAG CGAAGAGGTC 
ATTATTCGAG ACAGCCTCCT TCCTGTCACC CTGCAGTGTA ACCTCACTTC CAGCTCTCAC 
ACCCTTATGT ACAGCTACTG GACAAAGAAT GGGGTAGAAC TCACTGCCAC CCGTAAGAAT 
GCCAGCAACA TGGAATACAG GATCAATAAG CCAAGAGCTG AGGATTCAGG CGAATACCAC 
TGTGTATATC ATTTTGTCAG CGCTCCTAAA GCAAATGCCA CCATTGAAGT GAAAGCTGCT 
CCTGACATCA CTGGCCATAA ACGCAGTGAA AACAAAAATG AAGGGCAGGA TGCTATGATG 
TATTGCAAGT CTGTTGGCTA CCCCCACCCG GAATGGATGT GGCGCAAGAA GGAGAATGGT 
GTGTTTGAGG AGATTTCCAA TAGCTCTGGT CGCTTCTTCA TCATCAACAA GGAGAATTAC 
ACTGAATTGA ATATTGTGAA TCTCCAAATC ACAGAAGATC CTGGAGAGTA TGAATGTAAT 
GCCACCAACT CCATTGGCTC TGCCTCCGTT TCCACAGTCC TCAGGGTACG GAGCCACCTT 
GCCCCACTTT GGCCTTTCTT GGGAATTCTG GCTGAAATCA TCATCCTTGT GGTGATCATT 
GTTGTGTATG AGAAGAGGAA GAGGCCAGAT GAGGTTCCTG ATGCCGGGCC AATGAAAACC 
AACTCTACCA ACAATCACAA AGATAAAAAC TTGCGCCAGA GAAACACAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008764552.1
CDS	164..997
Translation	MSGSSLPGALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSLLPVTLQCNLTSSSHTLMYSYWTKNGVELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRKKENGVFEEISNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDAGPMKTNSTNNHKDKNLRQRNTN

Target ORF information:

RefSeq Version	XM_008766330.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuroplastin (Nptn), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008766330.2

ORF Insert Sequence:

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GAACCAAGAA TTGTCACCAG CGAAGAGGTC 
ATTATTCGAG ACAGCCTCCT TCCTGTCACC CTGCAGTGTA ACCTCACTTC CAGCTCTCAC 
ACCCTTATGT ACAGCTACTG GACAAAGAAT GGGGTAGAAC TCACTGCCAC CCGTAAGAAT 
GCCAGCAACA TGGAATACAG GATCAATAAG CCAAGAGCTG AGGATTCAGG CGAATACCAC 
TGTGTATATC ATTTTGTCAG CGCTCCTAAA GCAAATGCCA CCATTGAAGT GAAAGCTGCT 
CCTGACATCA CTGGCCATAA ACGCAGTGAA AACAAAAATG AAGGGCAGGA TGCTATGATG 
TATTGCAAGT CTGTTGGCTA CCCCCACCCG GAATGGATGT GGCGCAAGAA GGAGAATGGT 
GTGTTTGAGG AGATTTCCAA TAGCTCTGGT CGCTTCTTCA TCATCAACAA GGAGAATTAC 
ACTGAATTGA ATATTGTGAA TCTCCAAATC ACAGAAGATC CTGGAGAGTA TGAATGTAAT 
GCCACCAACT CCATTGGCTC TGCCTCCGTT TCCACAGTCC TCAGGGTACG GAGCCACCTT 
GCCCCACTTT GGCCTTTCTT GGGAATTCTG GCTGAAATCA TCATCCTTGT GGTGATCATT 
GTTGTGTATG AGAAGAGGAA GAGGCCAGAT GAGGTTCCTG ATGCCGGGCC AATGAAAACC 
AACTCTACCA ACAATCACAA AGATAAAAAC TTGCGCCAGA GAAACACAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nptn ( XM_006243172.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243234.1 Rattus norvegicus neuroplastin (Nptn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31233
Clone ID Related Accession (Same CDS sequence)	XM_006243172.3
Accession Version	XM_006243172.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neuroplastin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243172.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GCTGGGTTTG TCAAGTCGCC CATGTCAGAA 
ACTAAGCTCA CAGGGGACGC CTTTGAGCTG TACTGTGATG TGGTCGGGAG TCCCACGCCA 
GAGATCCAGT GGTGGTACGC AGAAGTCAAC CGGGCAGAGT CTTTCAGACA GCTGTGGGAC 
GGTGCTCGGA AGCGCCGTGT CACCGTAAAC ACCGCCTACG GGTCAAACGG CGTGAGTGTG 
CTGAGAATAA CCCGGCTCAC CTTGGAGGAC TCTGGGACTT ACGAGTGCAG GGCAAGCAAC 
GACCCCAAAC GGAATGACTT GAGGCAAAAC CCTTCCATAA CATGGATTCG AGCCCAGGCC 
ACCATAAGCG TCCTTCAGAA ACCAAGAATT GTCACCAGCG AAGAGGTCAT TATTCGAGAC 
AGCCTCCTTC CTGTCACCCT GCAGTGTAAC CTCACTTCCA GCTCTCACAC CCTTATGTAC 
AGCTACTGGA CAAAGAATGG GGTAGAACTC ACTGCCACCC GTAAGAATGC CAGCAACATG 
GAATACAGGA TCAATAAGCC AAGAGCTGAG GATTCAGGCG AATACCACTG TGTATATCAT 
TTTGTCAGCG CTCCTAAAGC AAATGCCACC ATTGAAGTGA AAGCTGCTCC TGACATCACT 
GGCCATAAAC GCAGTGAAAA CAAAAATGAA GGGCAGGATG CTATGATGTA TTGCAAGTCT 
GTTGGCTACC CCCACCCGGA ATGGATGTGG CGCAAGAAGG AGAATGGTGT GTTTGAGGAG 
ATTTCCAATA GCTCTGGTCG CTTCTTCATC ATCAACAAGG AGAATTACAC TGAATTGAAT 
ATTGTGAATC TCCAAATCAC AGAAGATCCT GGAGAGTATG AATGTAATGC CACCAACTCC 
ATTGGCTCTG CCTCCGTTTC CACAGTCCTC AGGGTACGGA GCCACCTTGC CCCACTTTGG 
CCTTTCTTGG GAATTCTGGC TGAAATCATC ATCCTTGTGG TGATCATTGT TGTGTATGAG 
AAGAGGAAGA GGCCAGATGA GGTTCCTGAT GATGATGAAC CAGCCGGGCC AATGAAAACC 
AACTCTACCA ACAATCACAA AGATAAAAAC TTGCGCCAGA GAAACACAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243234.1
CDS	164..1357
Translation	MSGSSLPGALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSLLPVTLQCNLTSSSHTLMYSYWTKNGVELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRKKENGVFEEISNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN

Target ORF information:

RefSeq Version	XM_006243172.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuroplastin (Nptn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243172.3

ORF Insert Sequence:

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GCTGGGTTTG TCAAGTCGCC CATGTCAGAA 
ACTAAGCTCA CAGGGGACGC CTTTGAGCTG TACTGTGATG TGGTCGGGAG TCCCACGCCA 
GAGATCCAGT GGTGGTACGC AGAAGTCAAC CGGGCAGAGT CTTTCAGACA GCTGTGGGAC 
GGTGCTCGGA AGCGCCGTGT CACCGTAAAC ACCGCCTACG GGTCAAACGG CGTGAGTGTG 
CTGAGAATAA CCCGGCTCAC CTTGGAGGAC TCTGGGACTT ACGAGTGCAG GGCAAGCAAC 
GACCCCAAAC GGAATGACTT GAGGCAAAAC CCTTCCATAA CATGGATTCG AGCCCAGGCC 
ACCATAAGCG TCCTTCAGAA ACCAAGAATT GTCACCAGCG AAGAGGTCAT TATTCGAGAC 
AGCCTCCTTC CTGTCACCCT GCAGTGTAAC CTCACTTCCA GCTCTCACAC CCTTATGTAC 
AGCTACTGGA CAAAGAATGG GGTAGAACTC ACTGCCACCC GTAAGAATGC CAGCAACATG 
GAATACAGGA TCAATAAGCC AAGAGCTGAG GATTCAGGCG AATACCACTG TGTATATCAT 
TTTGTCAGCG CTCCTAAAGC AAATGCCACC ATTGAAGTGA AAGCTGCTCC TGACATCACT 
GGCCATAAAC GCAGTGAAAA CAAAAATGAA GGGCAGGATG CTATGATGTA TTGCAAGTCT 
GTTGGCTACC CCCACCCGGA ATGGATGTGG CGCAAGAAGG AGAATGGTGT GTTTGAGGAG 
ATTTCCAATA GCTCTGGTCG CTTCTTCATC ATCAACAAGG AGAATTACAC TGAATTGAAT 
ATTGTGAATC TCCAAATCAC AGAAGATCCT GGAGAGTATG AATGTAATGC CACCAACTCC 
ATTGGCTCTG CCTCCGTTTC CACAGTCCTC AGGGTACGGA GCCACCTTGC CCCACTTTGG 
CCTTTCTTGG GAATTCTGGC TGAAATCATC ATCCTTGTGG TGATCATTGT TGTGTATGAG 
AAGAGGAAGA GGCCAGATGA GGTTCCTGAT GATGATGAAC CAGCCGGGCC AATGAAAACC 
AACTCTACCA ACAATCACAA AGATAAAAAC TTGCGCCAGA GAAACACAAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nptn ( XM_006243174.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243236.1 Rattus norvegicus neuroplastin (Nptn), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa31235
Clone ID Related Accession (Same CDS sequence)	XM_006243174.3
Accession Version	XM_006243174.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neuroplastin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243174.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GAACCAAGAA TTGTCACCAG CGAAGAGGTC 
ATTATTCGAG ACAGCCTCCT TCCTGTCACC CTGCAGTGTA ACCTCACTTC CAGCTCTCAC 
ACCCTTATGT ACAGCTACTG GACAAAGAAT GGGGTAGAAC TCACTGCCAC CCGTAAGAAT 
GCCAGCAACA TGGAATACAG GATCAATAAG CCAAGAGCTG AGGATTCAGG CGAATACCAC 
TGTGTATATC ATTTTGTCAG CGCTCCTAAA GCAAATGCCA CCATTGAAGT GAAAGCTGCT 
CCTGACATCA CTGGCCATAA ACGCAGTGAA AACAAAAATG AAGGGCAGGA TGCTATGATG 
TATTGCAAGT CTGTTGGCTA CCCCCACCCG GAATGGATGT GGCGCAAGAA GGAGAATGGT 
GTGTTTGAGG AGATTTCCAA TAGCTCTGGT CGCTTCTTCA TCATCAACAA GGAGAATTAC 
ACTGAATTGA ATATTGTGAA TCTCCAAATC ACAGAAGATC CTGGAGAGTA TGAATGTAAT 
GCCACCAACT CCATTGGCTC TGCCTCCGTT TCCACAGTCC TCAGGGTACG GAGCCACCTT 
GCCCCACTTT GGCCTTTCTT GGGAATTCTG GCTGAAATCA TCATCCTTGT GGTGATCATT 
GTTGTGTATG AGAAGAGGAA GAGGCCAGAT GAGGTTCCTG ATGATGATGA ACCAGCCGGG 
CCAATGAAAA CCAACTCTAC CAACAATCAC AAAGATAAAA ACTTGCGCCA GAGAAACACA 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243236.1
CDS	164..1009
Translation	MSGSSLPGALALSLLLVSGSLLPGPGAAQNEPRIVTSEEVIIRDSLLPVTLQCNLTSSSHTLMYSYWTKNGVELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRKKENGVFEEISNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN

Target ORF information:

RefSeq Version	XM_006243174.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuroplastin (Nptn), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243174.3

ORF Insert Sequence:

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GAACCAAGAA TTGTCACCAG CGAAGAGGTC 
ATTATTCGAG ACAGCCTCCT TCCTGTCACC CTGCAGTGTA ACCTCACTTC CAGCTCTCAC 
ACCCTTATGT ACAGCTACTG GACAAAGAAT GGGGTAGAAC TCACTGCCAC CCGTAAGAAT 
GCCAGCAACA TGGAATACAG GATCAATAAG CCAAGAGCTG AGGATTCAGG CGAATACCAC 
TGTGTATATC ATTTTGTCAG CGCTCCTAAA GCAAATGCCA CCATTGAAGT GAAAGCTGCT 
CCTGACATCA CTGGCCATAA ACGCAGTGAA AACAAAAATG AAGGGCAGGA TGCTATGATG 
TATTGCAAGT CTGTTGGCTA CCCCCACCCG GAATGGATGT GGCGCAAGAA GGAGAATGGT 
GTGTTTGAGG AGATTTCCAA TAGCTCTGGT CGCTTCTTCA TCATCAACAA GGAGAATTAC 
ACTGAATTGA ATATTGTGAA TCTCCAAATC ACAGAAGATC CTGGAGAGTA TGAATGTAAT 
GCCACCAACT CCATTGGCTC TGCCTCCGTT TCCACAGTCC TCAGGGTACG GAGCCACCTT 
GCCCCACTTT GGCCTTTCTT GGGAATTCTG GCTGAAATCA TCATCCTTGT GGTGATCATT 
GTTGTGTATG AGAAGAGGAA GAGGCCAGAT GAGGTTCCTG ATGATGATGA ACCAGCCGGG 
CCAATGAAAA CCAACTCTAC CAACAATCAC AAAGATAAAA ACTTGCGCCA GAGAAACACA 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nptn ( NM_019380.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062253.1 Rattus norvegicus neuroplastin (Nptn), mRNA.

Price & Availability↑

CloneID	ORa04614
Clone ID Related Accession (Same CDS sequence)	NM_019380.1
Accession Version	NM_019380.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	neuroplastin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X99338.1. On Dec 17, 2003 this sequence version replaced XM_346826.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X99338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GCTGGGTTTG TCAAGTCGCC CATGTCAGAA 
ACTAAGCTCA CAGGGGACGC CTTTGAGCTG TACTGTGATG TGGTCGGGAG TCCCACGCCA 
GAGATCCAGT GGTGGTACGC AGAAGTCAAC CGGGCAGAGT CTTTCAGACA GCTGTGGGAC 
GGTGCTCGGA AGCGCCGTGT CACCGTAAAC ACCGCCTACG GGTCAAACGG CGTGAGTGTG 
CTGAGAATAA CCCGGCTCAC CTTGGAGGAC TCTGGGACTT ACGAGTGCAG GGCAAGCAAC 
GACCCCAAAC GGAATGACTT GAGGCAAAAC CCTTCCATAA CATGGATTCG AGCCCAGGCC 
ACCATAAGCG TCCTTCAGAA ACCAAGAATT GTCACCAGCG AAGAGGTCAT TATTCGAGAC 
AGCCTCCTTC CTGTCACCCT GCAGTGTAAC CTCACTTCCA GCTCTCACAC CCTTATGTAC 
AGCTACTGGA CAAAGAATGG GGTAGAACTC ACTGCCACCC GTAAGAATGC CAGCAACATG 
GAATACAGGA TCAATAAGCC AAGAGCTGAG GATTCAGGCG AATACCACTG TGTATATCAT 
TTTGTCAGCG CTCCTAAAGC AAATGCCACC ATTGAAGTGA AAGCTGCTCC TGACATCACT 
GGCCATAAAC GCAGTGAAAA CAAAAATGAA GGGCAGGATG CTATGATGTA TTGCAAGTCT 
GTTGGCTACC CCCACCCGGA ATGGATGTGG CGCAAGAAGG AGAATGGTGT GTTTGAGGAG 
ATTTCCAATA GCTCTGGTCG CTTCTTCATC ATCAACAAGG AGAATTACAC TGAATTGAAT 
ATTGTGAATC TCCAAATCAC AGAAGATCCT GGAGAGTATG AATGTAATGC CACCAACTCC 
ATTGGCTCTG CCTCCGTTTC CACAGTCCTC AGGGTACGGA GCCACCTTGC CCCACTTTGG 
CCTTTCTTGG GAATTCTGGC TGAAATCATC ATCCTTGTGG TGATCATTGT TGTGTATGAG 
AAGAGGAAGA GGCCAGATGA GGTTCCTGAT GCCGGGCCAA TGAAAACCAA CTCTACCAAC 
AATCACAAAG ATAAAAACTT GCGCCAGAGA AACACAAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062253.1
CDS	142..1323
Translation	MSGSSLPGALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSLLPVTLQCNLTSSSHTLMYSYWTKNGVELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRKKENGVFEEISNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDAGPMKTNSTNNHKDKNLRQRNTN

Target ORF information:

RefSeq Version	NM_019380.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuroplastin (Nptn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019380.1

ORF Insert Sequence:

ATGTCGGGCT CGTCGCTCCC CGGCGCCCTG GCCCTCTCGC TCTTGCTGGT CTCTGGCTCG 
CTCCTCCCAG GGCCAGGCGC TGCTCAGAAC GCTGGGTTTG TCAAGTCGCC CATGTCAGAA 
ACTAAGCTCA CAGGGGACGC CTTTGAGCTG TACTGTGATG TGGTCGGGAG TCCCACGCCA 
GAGATCCAGT GGTGGTACGC AGAAGTCAAC CGGGCAGAGT CTTTCAGACA GCTGTGGGAC 
GGTGCTCGGA AGCGCCGTGT CACCGTAAAC ACCGCCTACG GGTCAAACGG CGTGAGTGTG 
CTGAGAATAA CCCGGCTCAC CTTGGAGGAC TCTGGGACTT ACGAGTGCAG GGCAAGCAAC 
GACCCCAAAC GGAATGACTT GAGGCAAAAC CCTTCCATAA CATGGATTCG AGCCCAGGCC 
ACCATAAGCG TCCTTCAGAA ACCAAGAATT GTCACCAGCG AAGAGGTCAT TATTCGAGAC 
AGCCTCCTTC CTGTCACCCT GCAGTGTAAC CTCACTTCCA GCTCTCACAC CCTTATGTAC 
AGCTACTGGA CAAAGAATGG GGTAGAACTC ACTGCCACCC GTAAGAATGC CAGCAACATG 
GAATACAGGA TCAATAAGCC AAGAGCTGAG GATTCAGGCG AATACCACTG TGTATATCAT 
TTTGTCAGCG CTCCTAAAGC AAATGCCACC ATTGAAGTGA AAGCTGCTCC TGACATCACT 
GGCCATAAAC GCAGTGAAAA CAAAAATGAA GGGCAGGATG CTATGATGTA TTGCAAGTCT 
GTTGGCTACC CCCACCCGGA ATGGATGTGG CGCAAGAAGG AGAATGGTGT GTTTGAGGAG 
ATTTCCAATA GCTCTGGTCG CTTCTTCATC ATCAACAAGG AGAATTACAC TGAATTGAAT 
ATTGTGAATC TCCAAATCAC AGAAGATCCT GGAGAGTATG AATGTAATGC CACCAACTCC 
ATTGGCTCTG CCTCCGTTTC CACAGTCCTC AGGGTACGGA GCCACCTTGC CCCACTTTGG 
CCTTTCTTGG GAATTCTGGC TGAAATCATC ATCCTTGTGG TGATCATTGT TGTGTATGAG 
AAGAGGAAGA GGCCAGATGA GGTTCCTGAT GCCGGGCCAA TGAAAACCAA CTCTACCAAC 
AATCACAAAG ATAAAAACTT GCGCCAGAGA AACACAAATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A complex of Neuroplastin and Plasma Membrane Ca
Scientific reports7(1)8358(2017 Aug)
Korthals M,Langnaese K,Smalla KH,K?hne T,Herrera-Molina R,Handschuh J,Lehmann AC,Mamula D,Naumann M,Seidenbecher C,Zuschratter W,Tedford K,Gundelfinger ED,Montag D,Fischer KD,Thomas U

Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65.
The Journal of biological chemistry289(13)8973-88(2014 Mar)
Herrera-Molina R,Sarto-Jackson I,Montenegro-Venegas C,Heine M,Smalla KH,Seidenbecher CI,Beesley PW,Gundelfinger ED,Montag D

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Neuron78(2)285-97(2013 Apr)
Boyken J,Gr?nborg M,Riedel D,Urlaub H,Jahn R,Chua JJ

The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.
PloS one8(11)e78654(2013)
Wilson MC,Kraus M,Marzban H,Sarna JR,Wang Y,Hawkes R,Halestrap AP,Beesley PW

The cell adhesion molecule neuroplastin-65 is a novel interaction partner of ?-aminobutyric acid type A receptors.
The Journal of biological chemistry287(17)14201-14(2012 Apr)
Sarto-Jackson I,Milenkovic I,Smalla KH,Gundelfinger ED,Kaehne T,Herrera-Molina R,Thomas S,Kiebler MA,Sieghart W

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Nptn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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