Pdpn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdpn
Entrez Gene ID	54320
Full Name	podoplanin
Synonyms	E11,Gp38,OTS-8,RTI40,T1-alpha
General protein information	Preferred Names podoplanin Names podoplanin E11 antigen epitope RTI140 T1A epithelial cell surface transmembrane protein antigen glycoprotein 38 pulmonary type I alveolar epithelial cell transmembrane differentiation marker type I cell 40 kDa protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	membrane glycoprotein that may function in lung development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019358.1	NP_062231.1	podoplanin precursor
XM_006239338.3	XP_006239400.1	podoplanin isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDPN	NP_001003220.1
Pan troglodytes (chimpanzee)	PDPN	XP_001148148.1
Rattus norvegicus (Norway rat)	Pdpn	NP_062231.1
Homo sapiens (human)	PDPN	NP_006465.3
	LOC716250	XP_001106933.2
Mus musculus (house mouse)	Pdpn	NP_034459.2

Gene Ontology
Bibliography

Related articles in PubMed

Inherent physical characteristics and gene expression differences between alveolar and basal bones.
Zakhary I, Alotibi F, Lewis J, ElSalanty M, Wenger K, Sharawy M, Messer RL
Oral surgery, oral medicine, oral pathology and oral radiology122(1)35-42(2016 Jul)

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.
Mart?n-Villar E, Borda-d'Agua B, Carrasco-Ramirez P, Renart J, Parsons M, Quintanilla M, Jones GE
Oncogene34(34)4531-44(2015 Aug)

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.
Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ
Nature immunology16(1)75-84(2015 Jan)

Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model.
Hirahara I, Sato H, Imai T, Onishi A, Morishita Y, Muto S, Kusano E, Nagata D
BioMed research international2015289751(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Four genes are expressed significantly higher in basal bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of the proteins (SOST, MEPE, and DMP-1) are associated with mature osteocytes, indicating that basal bone has more mature osteocyte phenotypes because the immature osteocyte converts to a mature osteocyte as a result of bone mineralization.
Title: Inherent physical characteristics and gene expression differences between alveolar and basal bones.

In rats treated with MGO, peritoneal fibrous thickening with the appearance of basophilic spindle cells with podoplanin, cytokeratin, and alpha-smooth muscle actin at the surface of the peritoneum was observed
Title: Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model.

There was a significant increase in the expression of both TTF-1 and T1alpha mRNA in the IGF-2 group, in comparison to the control group after 48 h of culture.
Title: Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model.

Decreased expression of podoplanin plays a role in the decrease of glomerular permselectivity.
Title: Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model.

Albuminuria in male and female rats is preceded by glomerular hypertrophy and accompanied by focal and segmental loss of podoplanin when focal segmental glomerulosclerosis is not yet present.
Title: Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Fr?mter rats.

The following Pdpn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdpn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04540	NM_019358.1 Latest version!	Rattus norvegicus podoplanin (Pdpn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa28866	XM_006239338.3 Latest version!	Rattus norvegicus podoplanin (Pdpn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdpn ( NM_019358.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062231.1 Rattus norvegicus podoplanin (Pdpn), mRNA.

Price & Availability↑

CloneID	ORa04540
Clone ID Related Accession (Same CDS sequence)	NM_019358.1
Accession Version	NM_019358.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	podoplanin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U07797.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U07797.1, BC072492.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTGGACCG CGCCAGTGTT GCTCTGGGTT TTGGGGAGCG TTTGGTTCTG GGACTCAGCG 
CAGGGAGGGG CCATCGGTGC GCTAGAAGAT GATCTTGTGA CCCCGGGTCC AGGAGATGAC 
ATGGTGAACC CAGGTCTAGA AGACAGAATA GAAACCACGG ACACTACAGG AGAACTGGAT 
AAGTCAACTG CCAAGGCGCC TCTGGTACCA ACACAGCCTC CCATTGAGGA ACTGCCGACC 
TCAGGAACCT CCGACCACGA TCACAAAGAA CATGAGAGTA CGACCACTGT CAAAGCGGTG 
ACCAGCCACT CCACGGACAA GAAAACAACT CACCCCAATA GAGATAACGC AGGCGGTGAA 
ACGCAGACCA CAGATAAGAA AGATGGCTTG GCTGTAGTGA CCCTGGTCGG AATCATAATT 
GGCGTCTTGT TAGCCATTGG CTTCATTGGA GGGATCATCA TTGTGGTTAT GAGGAAGATT 
TCTGGAAGGT TCTCGCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062231.1
CDS	237..737
Translation	MWTAPVLLWVLGSVWFWDSAQGGAIGALEDDLVTPGPGDDMVNPGLEDRIETTDTTGELDKSTAKAPLVPTQPPIEELPTSGTSDHDHKEHESTTTVKAVTSHSTDKKTTHPNRDNAGGETQTTDKKDGLAVVTLVGIIIGVLLAIGFIGGIIIVVMRKISGRFSP

Target ORF information:

RefSeq Version	NM_019358.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus podoplanin (Pdpn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019358.1

ORF Insert Sequence:

ATGTGGACCG CGCCAGTGTT GCTCTGGGTT TTGGGGAGCG TTTGGTTCTG GGACTCAGCG 
CAGGGAGGGG CCATCGGTGC GCTAGAAGAT GATCTTGTGA CCCCGGGTCC AGGAGATGAC 
ATGGTGAACC CAGGTCTAGA AGACAGAATA GAAACCACGG ACACTACAGG AGAACTGGAT 
AAGTCAACTG CCAAGGCGCC TCTGGTACCA ACACAGCCTC CCATTGAGGA ACTGCCGACC 
TCAGGAACCT CCGACCACGA TCACAAAGAA CATGAGAGTA CGACCACTGT CAAAGCGGTG 
ACCAGCCACT CCACGGACAA GAAAACAACT CACCCCAATA GAGATAACGC AGGCGGTGAA 
ACGCAGACCA CAGATAAGAA AGATGGCTTG GCTGTAGTGA CCCTGGTCGG AATCATAATT 
GGCGTCTTGT TAGCCATTGG CTTCATTGGA GGGATCATCA TTGTGGTTAT GAGGAAGATT 
TCTGGAAGGT TCTCGCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pdpn ( XM_006239338.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239400.1 Rattus norvegicus podoplanin (Pdpn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28866
Clone ID Related Accession (Same CDS sequence)	XM_006239338.3
Accession Version	XM_006239338.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	podoplanin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239338.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGACCG CGCCAGTGTT GCTCTGGGTT TTGGGGAGCG TTTGGTTCTG GGACTCAGCG 
CAGGGAGGGG CCATCGGTGC GCTAGAAGAT GATCTTGTGA CCCCGGGTCC AGGAGATGAC 
ATGGTGAACC CAGGTCTAGA AGACAGAATA GAAACCACGG ACACTACAGG AGAACTGGAT 
AAGTCAACTG CCAAGGCGCC TCTGGTACCA ACACAGCCTC CCATTGAGGA ACTGCCGACC 
TCAGGAACCT CCGACCACGA TCACAAAGAA CATGAGAGTA CAACCACTGT CAAAGCGGTG 
ACCAGCCACT CCACGGACAA GAAAACAACT CACTCCAATA GAGATAACGC AGGCGGTGAA 
ACGCAGACCA CAGATAAGAA AGATGGCTTG GCTGTAGTGA CCCTGGTCGG AATCATAATT 
GGCGTCTTGT TAGCCATTGG CTTCATTGGA GGGATCATCA TTGTGGTTAT GAGGAAGATT 
TCTGGAAGGT TCTCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239400.1
CDS	236..733
Translation	MWTAPVLLWVLGSVWFWDSAQGGAIGALEDDLVTPGPGDDMVNPGLEDRIETTDTTGELDKSTAKAPLVPTQPPIEELPTSGTSDHDHKEHESTTTVKAVTSHSTDKKTTHSNRDNAGGETQTTDKKDGLAVVTLVGIIIGVLLAIGFIGGIIIVVMRKISGRFS

Target ORF information:

RefSeq Version	XM_006239338.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus podoplanin (Pdpn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239338.3

ORF Insert Sequence:

ATGTGGACCG CGCCAGTGTT GCTCTGGGTT TTGGGGAGCG TTTGGTTCTG GGACTCAGCG 
CAGGGAGGGG CCATCGGTGC GCTAGAAGAT GATCTTGTGA CCCCGGGTCC AGGAGATGAC 
ATGGTGAACC CAGGTCTAGA AGACAGAATA GAAACCACGG ACACTACAGG AGAACTGGAT 
AAGTCAACTG CCAAGGCGCC TCTGGTACCA ACACAGCCTC CCATTGAGGA ACTGCCGACC 
TCAGGAACCT CCGACCACGA TCACAAAGAA CATGAGAGTA CAACCACTGT CAAAGCGGTG 
ACCAGCCACT CCACGGACAA GAAAACAACT CACTCCAATA GAGATAACGC AGGCGGTGAA 
ACGCAGACCA CAGATAAGAA AGATGGCTTG GCTGTAGTGA CCCTGGTCGG AATCATAATT 
GGCGTCTTGT TAGCCATTGG CTTCATTGGA GGGATCATCA TTGTGGTTAT GAGGAAGATT 
TCTGGAAGGT TCTCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inherent physical characteristics and gene expression differences between alveolar and basal bones.
Oral surgery, oral medicine, oral pathology and oral radiology122(1)35-42(2016 Jul)
Zakhary I,Alotibi F,Lewis J,ElSalanty M,Wenger K,Sharawy M,Messer RL

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.
Oncogene34(34)4531-44(2015 Aug)
Mart?n-Villar E,Borda-d'Agua B,Carrasco-Ramirez P,Renart J,Parsons M,Quintanilla M,Jones GE

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.
Nature immunology16(1)75-84(2015 Jan)
Astarita JL,Cremasco V,Fu J,Darnell MC,Peck JR,Nieves-Bonilla JM,Song K,Kondo Y,Woodruff MC,Gogineni A,Onder L,Ludewig B,Weimer RM,Carroll MC,Mooney DJ,Xia L,Turley SJ

Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model.
BioMed research international2015289751(2015)
Hirahara I,Sato H,Imai T,Onishi A,Morishita Y,Muto S,Kusano E,Nagata D

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Pdpn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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