Gata4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gata4
Entrez Gene ID	54254
Full Name	GATA binding protein 4
General protein information	Preferred Names GATA binding protein 4 Names transcription factor GATA-4 DNA-binding protein GATA-GT2 GATA-binding factor 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p12
Summary	plays a role in regulation of cardiac-myocyte specific gene expression; interacts with dHAND (HAND2) to activate transcription of several cardiac-specific genes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017599788.1	XP_017455277.1	transcription factor GATA-4 isoform X1
XM_006252189.3	XP_006252251.1	transcription factor GATA-4 isoform X1
NM_144730.1	NP_653331.1	transcription factor GATA-4
XM_017599789.1	XP_017455278.1	transcription factor GATA-4 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GATA4	NP_001041577.1
Danio rerio (zebrafish)	gata4	XP_005160990.1
Rattus norvegicus (Norway rat)	Gata4	NP_653331.1
Homo sapiens (human)	GATA4	NP_002043.2
Pan troglodytes (chimpanzee)	GATA4	XP_528070.3
Mus musculus (house mouse)	Gata4	NP_032118.2
Xenopus tropicalis (tropical clawed frog)	gata4	NP_001016949.1
	GATA4	XP_001087008.2
Bos taurus (cattle)	GATA4	NP_001179806.1
Gallus gallus (chicken)	GATA4	XP_420041.1

Gene Ontology
Bibliography

Related articles in PubMed

GATA4 Loss-of-Function Mutation and the Congenitally Bicuspid Aortic Valve.
Li RG, Xu YJ, Wang J, Liu XY, Yuan F, Huang RT, Xue S, Li L, Liu H, Li YJ, Qu XK, Shi HY, Zhang M, Qiu XB, Yang YQ
The American journal of cardiology(2017 Nov)

Downregulation of miR-200c protects cardiomyocytes from hypoxia-induced apoptosis by targeting GATA-4.
Chen Z, Zhang S, Guo C, Li J, Sang W
International journal of molecular medicine39(6)1589-1596(2017 Jun)

Downregulation of miR-122 attenuates hypoxia/reoxygenation (H/R)-induced myocardial cell apoptosis by upregulating GATA-4.
Liang W, Guo J, Li J, Bai C, Dong Y
Biochemical and biophysical research communications478(3)1416-22(2016 09)

MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes.
Liu Y, Wang Z, Xiao W
Molecular medicine reports14(3)2860-6(2016 Sep)

MicroRNA-208b Alleviates Post-Infarction Myocardial Fibrosis in a Rat Model by Inhibiting GATA4.
Zhou C, Cui Q, Su G, Guo X, Liu X, Zhang J
Medical science monitor : international medical journal of experimental and clinical research221808-16(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

downregulation of miR-122 alleviates cardiomyocyte hypoxia/reoxygenation injury through upregulation of GATA-4 expression.
Title: Downregulation of miR-122 attenuates hypoxia/reoxygenation (H/R)-induced myocardial cell apoptosis by upregulating GATA-4.

the present study has identified a protective role of miR-26a via suppression of GATA4, and, in turn, further downstream factors in cardiac hypertrophy.
Title: MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes.

The inhibition of LOX-1 by RNA interference LOX-1 lentivirus resulted in the loss of PI3K/Akt activation and GATA4 protein expression. GATA4 may play an important role in the LOX-1 and PI3K/Akt regulation of cardiac fibroblast proliferation.
Title: Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces cardiac fibroblast proliferation by suppressing GATA Binding Protein 4.

This study demonstrates the protective function of miR-208b via GATA4 in post-infarction myocardial fibrosis. Luciferase reporter assay proved Gata4 to be the direct target of miR-208b, with the target sequence in the 3'UTR.
Title: MicroRNA-208b Alleviates Post-Infarction Myocardial Fibrosis in a Rat Model by Inhibiting GATA4.

Clusterin/Akt signaling pathway is involved in GATA-4 mediated cytoprotection against hypoxia stress.
Title: Clusterin/Akt Up-Regulation Is Critical for GATA-4 Mediated Cytoprotection of Mesenchymal Stem Cells against Ischemia Injury.

The following Gata4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gata4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa36802	XM_017599788.1 Latest version!	Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa36802	XM_017599789.1 Latest version!	Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa36802	XM_006252189.3 Latest version!	Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa12692	NM_144730.1 Latest version!	Rattus norvegicus GATA binding protein 4 (Gata4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gata4 ( XM_017599788.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455277.1 Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa36802
Clone ID Related Accession (Same CDS sequence)	XM_017599788.1 , XM_006252189.3 , XM_017599789.1
Accession Version	XM_017599788.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1326bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor GATA-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGTAGATAT GTTTGATGAC TTCTCAGAAG GCAGAGAGTG TGTCAACTGC 
GGGGCCATGT CCACCCCACT CTGGAGGCGA GATGGGACAG GACACTACCT ATGCAACGCC 
TGTGGCCTCT ACCACAAGAT GAATGGTATC AACCGGCCCC TCATCAAGCC TCAGCGCCGG 
CTGTCTGCCT CCCGCCGGGT AGGCCTCTCC TGTGCCAACT GCCAGACTAC CACCACCACA 
CTGTGGCGCC GTAACGCTGA GGGCGAGCCT GTTTGCAATG CCTGCGGCCT CTACATGAAG 
CTCCATGGGG TTCCCAGGCC TCTTGCAATG CGGAAGGAGG GGATTCAAAC CAGAAAACGG 
AAGCCCAAGA ATCTGAATAA ATCTAAGACA CCAGCAGGTC CTCCTGGCGA GAGCCTCCCT 
CCCTCCAGTG GTGCCTCCAG CAACTCCAGC AACGCCACCA GCAGCAGCAG CAGCAGTGAA 
GAGATGCGCC CCATCAAGAC AGAGCCCGGG CTGTCATCTC ACTATGGGCA CAGCAGCTCC 
ATGTCCCAGA CATTCAGTAC TGTGTCCGGC CATGGGTCCT CCATCCATCC AGTGCTGTCG 
GCTCTGAAGC TCTCCCCACA AGGCTATCCA TCTCCTGTCA CTCAGACATC ACAGGCCAGC 
TCCAAGCAGG ACTCTTGGAA CAGCCTGGTC CTGGCTGACA GTCATGGGGA CATAATCACC 
GCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455277.1
CDS	761..2086
Translation	MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSGAASGATSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSSGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPARHPNLVDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPPGESLPPSSGASSNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGSSIHPVLSALKLSPQGYPSPVTQTSQASSKQDSWNSLVLADSHGDIITA

Target ORF information:

RefSeq Version	XM_017599788.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599788.1

ORF Insert Sequence:

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGTAGATAT GTTTGATGAC TTCTCAGAAG GCAGAGAGTG TGTCAACTGC 
GGGGCCATGT CCACCCCACT CTGGAGGCGA GATGGGACAG GACACTACCT ATGCAACGCC 
TGTGGCCTCT ACCACAAGAT GAATGGTATC AACCGGCCCC TCATCAAGCC TCAGCGCCGG 
CTGTCTGCCT CCCGCCGGGT AGGCCTCTCC TGTGCCAACT GCCAGACTAC CACCACCACA 
CTGTGGCGCC GTAACGCTGA GGGCGAGCCT GTTTGCAATG CCTGCGGCCT CTACATGAAG 
CTCCATGGGG TTCCCAGGCC TCTTGCAATG CGGAAGGAGG GGATTCAAAC CAGAAAACGG 
AAGCCCAAGA ATCTGAATAA ATCTAAGACA CCAGCAGGTC CTCCTGGCGA GAGCCTCCCT 
CCCTCCAGTG GTGCCTCCAG CAACTCCAGC AACGCCACCA GCAGCAGCAG CAGCAGTGAA 
GAGATGCGCC CCATCAAGAC AGAGCCCGGG CTGTCATCTC ACTATGGGCA CAGCAGCTCC 
ATGTCCCAGA CATTCAGTAC TGTGTCCGGC CATGGGTCCT CCATCCATCC AGTGCTGTCG 
GCTCTGAAGC TCTCCCCACA AGGCTATCCA TCTCCTGTCA CTCAGACATC ACAGGCCAGC 
TCCAAGCAGG ACTCTTGGAA CAGCCTGGTC CTGGCTGACA GTCATGGGGA CATAATCACC 
GCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gata4 ( XM_006252189.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252251.1 Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36802
Clone ID Related Accession (Same CDS sequence)	XM_017599788.1 , XM_006252189.3 , XM_017599789.1
Accession Version	XM_006252189.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1326bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor GATA-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252189.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGTAGATAT GTTTGATGAC TTCTCAGAAG GCAGAGAGTG TGTCAACTGC 
GGGGCCATGT CCACCCCACT CTGGAGGCGA GATGGGACAG GACACTACCT ATGCAACGCC 
TGTGGCCTCT ACCACAAGAT GAATGGTATC AACCGGCCCC TCATCAAGCC TCAGCGCCGG 
CTGTCTGCCT CCCGCCGGGT AGGCCTCTCC TGTGCCAACT GCCAGACTAC CACCACCACA 
CTGTGGCGCC GTAACGCTGA GGGCGAGCCT GTTTGCAATG CCTGCGGCCT CTACATGAAG 
CTCCATGGGG TTCCCAGGCC TCTTGCAATG CGGAAGGAGG GGATTCAAAC CAGAAAACGG 
AAGCCCAAGA ATCTGAATAA ATCTAAGACA CCAGCAGGTC CTCCTGGCGA GAGCCTCCCT 
CCCTCCAGTG GTGCCTCCAG CAACTCCAGC AACGCCACCA GCAGCAGCAG CAGCAGTGAA 
GAGATGCGCC CCATCAAGAC AGAGCCCGGG CTGTCATCTC ACTATGGGCA CAGCAGCTCC 
ATGTCCCAGA CATTCAGTAC TGTGTCCGGC CATGGGTCCT CCATCCATCC AGTGCTGTCG 
GCTCTGAAGC TCTCCCCACA AGGCTATCCA TCTCCTGTCA CTCAGACATC ACAGGCCAGC 
TCCAAGCAGG ACTCTTGGAA CAGCCTGGTC CTGGCTGACA GTCATGGGGA CATAATCACC 
GCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252251.1
CDS	792..2117
Translation	MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSGAASGATSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSSGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPARHPNLVDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPPGESLPPSSGASSNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGSSIHPVLSALKLSPQGYPSPVTQTSQASSKQDSWNSLVLADSHGDIITA

Target ORF information:

RefSeq Version	XM_006252189.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252189.3

ORF Insert Sequence:

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGTAGATAT GTTTGATGAC TTCTCAGAAG GCAGAGAGTG TGTCAACTGC 
GGGGCCATGT CCACCCCACT CTGGAGGCGA GATGGGACAG GACACTACCT ATGCAACGCC 
TGTGGCCTCT ACCACAAGAT GAATGGTATC AACCGGCCCC TCATCAAGCC TCAGCGCCGG 
CTGTCTGCCT CCCGCCGGGT AGGCCTCTCC TGTGCCAACT GCCAGACTAC CACCACCACA 
CTGTGGCGCC GTAACGCTGA GGGCGAGCCT GTTTGCAATG CCTGCGGCCT CTACATGAAG 
CTCCATGGGG TTCCCAGGCC TCTTGCAATG CGGAAGGAGG GGATTCAAAC CAGAAAACGG 
AAGCCCAAGA ATCTGAATAA ATCTAAGACA CCAGCAGGTC CTCCTGGCGA GAGCCTCCCT 
CCCTCCAGTG GTGCCTCCAG CAACTCCAGC AACGCCACCA GCAGCAGCAG CAGCAGTGAA 
GAGATGCGCC CCATCAAGAC AGAGCCCGGG CTGTCATCTC ACTATGGGCA CAGCAGCTCC 
ATGTCCCAGA CATTCAGTAC TGTGTCCGGC CATGGGTCCT CCATCCATCC AGTGCTGTCG 
GCTCTGAAGC TCTCCCCACA AGGCTATCCA TCTCCTGTCA CTCAGACATC ACAGGCCAGC 
TCCAAGCAGG ACTCTTGGAA CAGCCTGGTC CTGGCTGACA GTCATGGGGA CATAATCACC 
GCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gata4 ( XM_017599789.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455278.1 Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa36802
Clone ID Related Accession (Same CDS sequence)	XM_017599788.1 , XM_006252189.3 , XM_017599789.1
Accession Version	XM_017599789.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1326bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor GATA-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGTAGATAT GTTTGATGAC TTCTCAGAAG GCAGAGAGTG TGTCAACTGC 
GGGGCCATGT CCACCCCACT CTGGAGGCGA GATGGGACAG GACACTACCT ATGCAACGCC 
TGTGGCCTCT ACCACAAGAT GAATGGTATC AACCGGCCCC TCATCAAGCC TCAGCGCCGG 
CTGTCTGCCT CCCGCCGGGT AGGCCTCTCC TGTGCCAACT GCCAGACTAC CACCACCACA 
CTGTGGCGCC GTAACGCTGA GGGCGAGCCT GTTTGCAATG CCTGCGGCCT CTACATGAAG 
CTCCATGGGG TTCCCAGGCC TCTTGCAATG CGGAAGGAGG GGATTCAAAC CAGAAAACGG 
AAGCCCAAGA ATCTGAATAA ATCTAAGACA CCAGCAGGTC CTCCTGGCGA GAGCCTCCCT 
CCCTCCAGTG GTGCCTCCAG CAACTCCAGC AACGCCACCA GCAGCAGCAG CAGCAGTGAA 
GAGATGCGCC CCATCAAGAC AGAGCCCGGG CTGTCATCTC ACTATGGGCA CAGCAGCTCC 
ATGTCCCAGA CATTCAGTAC TGTGTCCGGC CATGGGTCCT CCATCCATCC AGTGCTGTCG 
GCTCTGAAGC TCTCCCCACA AGGCTATCCA TCTCCTGTCA CTCAGACATC ACAGGCCAGC 
TCCAAGCAGG ACTCTTGGAA CAGCCTGGTC CTGGCTGACA GTCATGGGGA CATAATCACC 
GCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455278.1
CDS	595..1920
Translation	MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSGAASGATSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSSGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPARHPNLVDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPPGESLPPSSGASSNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGSSIHPVLSALKLSPQGYPSPVTQTSQASSKQDSWNSLVLADSHGDIITA

Target ORF information:

RefSeq Version	XM_017599789.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 4 (Gata4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599789.1

ORF Insert Sequence:

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGTAGATAT GTTTGATGAC TTCTCAGAAG GCAGAGAGTG TGTCAACTGC 
GGGGCCATGT CCACCCCACT CTGGAGGCGA GATGGGACAG GACACTACCT ATGCAACGCC 
TGTGGCCTCT ACCACAAGAT GAATGGTATC AACCGGCCCC TCATCAAGCC TCAGCGCCGG 
CTGTCTGCCT CCCGCCGGGT AGGCCTCTCC TGTGCCAACT GCCAGACTAC CACCACCACA 
CTGTGGCGCC GTAACGCTGA GGGCGAGCCT GTTTGCAATG CCTGCGGCCT CTACATGAAG 
CTCCATGGGG TTCCCAGGCC TCTTGCAATG CGGAAGGAGG GGATTCAAAC CAGAAAACGG 
AAGCCCAAGA ATCTGAATAA ATCTAAGACA CCAGCAGGTC CTCCTGGCGA GAGCCTCCCT 
CCCTCCAGTG GTGCCTCCAG CAACTCCAGC AACGCCACCA GCAGCAGCAG CAGCAGTGAA 
GAGATGCGCC CCATCAAGAC AGAGCCCGGG CTGTCATCTC ACTATGGGCA CAGCAGCTCC 
ATGTCCCAGA CATTCAGTAC TGTGTCCGGC CATGGGTCCT CCATCCATCC AGTGCTGTCG 
GCTCTGAAGC TCTCCCCACA AGGCTATCCA TCTCCTGTCA CTCAGACATC ACAGGCCAGC 
TCCAAGCAGG ACTCTTGGAA CAGCCTGGTC CTGGCTGACA GTCATGGGGA CATAATCACC 
GCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gata4 ( NM_144730.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_653331.1 Rattus norvegicus GATA binding protein 4 (Gata4), mRNA.

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CloneID	ORa12692
Clone ID Related Accession (Same CDS sequence)	NM_144730.1
Accession Version	NM_144730.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor GATA-4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L22761.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L22761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349, SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGATATGTT TGATGACTTC TCAGAAGGCA GAGAGTGTGT CAACTGCGGG 
GCCATGTCCA CCCCACTCTG GAGGCGAGAT GGGACAGGAC ACTACCTATG CAACGCCTGT 
GGCCTCTACC ACAAGATGAA TGGTATCAAC CGGCCCCTCA TCAAGCCTCA GCGCCGGCTG 
TCTGCCTCCC GCCGGGTAGG CCTCTCCTGT GCCAACTGCC AGACTACCAC CACCACACTG 
TGGCGCCGTA ACGCTGAGGG CGAGCCTGTT TGCAATGCCT GCGGCCTCTA CATGAAGCTC 
CATGGGGTTC CCAGGCCTCT TGCAATGCGG AAGGAGGGGA TTCAAACCAG AAAACGGAAG 
CCCAAGAATC TGAATAAATC TAAGACACCA GCAGGTCCTC CTGGCGAGAG CCTCCCTCCC 
TCCAGTGGTG CCTCCAGCAA CTCCAGCAAC GCCACCAGCA GCAGCAGCAG CAGTGAAGAG 
ATGCGCCCCA TCAAGACAGA GCCCGGGCTG TCATCTCACT ATGGGCACAG CAGCTCCATG 
TCCCAGACAT TCAGTACTGT GTCCGGCCAT GGGTCCTCCA TCCATCCAGT GCTGTCGGCT 
CTGAAGCTCT CCCCACAAGG CTATCCATCT CCTGTCACTC AGACATCACA GGCCAGCTCC 
AAGCAGGACT CTTGGAACAG CCTGGTCCTG GCTGACAGTC ATGGGGACAT AATCACCGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653331.1
CDS	562..1884
Translation	MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSGAASGATSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSSGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPARHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPPGESLPPSSGASSNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGSSIHPVLSALKLSPQGYPSPVTQTSQASSKQDSWNSLVLADSHGDIITA

Target ORF information:

RefSeq Version	NM_144730.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 4 (Gata4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144730.1

ORF Insert Sequence:

ATGTACCAAA GCCTGGCTAT GGCCGCCAAC CACGGGCCCC CGCCGGGCGC CTACGAAGCG 
GGTGGACCTG GCGCCTTCAT GCACAGTGCG GGCGCCGCGT CCTCGCCCGT CTACGTGCCC 
ACTCCGCGGG TGCCGTCCTC TGTGCTGGGC CTGTCCTACC TGCAGGGCGG AGGCAGTGGT 
GCTGCTTCTG GAGCCACCTC GGGTGGCAGC TCCGGGGCCG GCCCGTCGGG TGCTGGGCCT 
GGGACCCAGC AGGGTAGCCC GGGCTGGAGC CAGGCTGGAG CTGAGGGAGC CGCTTACACC 
CCACCGCCTG TGTCCCCGCG CTTCTCCTTC CCGGGGACTA CTGGGTCCCT GGCGGCCGCC 
GCCGCCGCTG CCGCAGCCCG GGAAGCTGCA GCCTACAGCA GTAGCGGCGG GGCAGCCGGC 
GCTGGCCTGG CTGGCCGAGA GCAGTACGGG CGTCCGGGCT TCGCAGGCTC CTACTCCAGC 
CCCTACCCAG CCTACATGGC CGATGTGGGC GCATCCTGGG CCGCAGCCGC TGCCGCCTCC 
GCCGGCCCCT TCGACAGCCC AGTCCTGCAC AGCCTACCTG GCCGGGCCAA CCCTGCGAGA 
CACCCCAATC TCGATATGTT TGATGACTTC TCAGAAGGCA GAGAGTGTGT CAACTGCGGG 
GCCATGTCCA CCCCACTCTG GAGGCGAGAT GGGACAGGAC ACTACCTATG CAACGCCTGT 
GGCCTCTACC ACAAGATGAA TGGTATCAAC CGGCCCCTCA TCAAGCCTCA GCGCCGGCTG 
TCTGCCTCCC GCCGGGTAGG CCTCTCCTGT GCCAACTGCC AGACTACCAC CACCACACTG 
TGGCGCCGTA ACGCTGAGGG CGAGCCTGTT TGCAATGCCT GCGGCCTCTA CATGAAGCTC 
CATGGGGTTC CCAGGCCTCT TGCAATGCGG AAGGAGGGGA TTCAAACCAG AAAACGGAAG 
CCCAAGAATC TGAATAAATC TAAGACACCA GCAGGTCCTC CTGGCGAGAG CCTCCCTCCC 
TCCAGTGGTG CCTCCAGCAA CTCCAGCAAC GCCACCAGCA GCAGCAGCAG CAGTGAAGAG 
ATGCGCCCCA TCAAGACAGA GCCCGGGCTG TCATCTCACT ATGGGCACAG CAGCTCCATG 
TCCCAGACAT TCAGTACTGT GTCCGGCCAT GGGTCCTCCA TCCATCCAGT GCTGTCGGCT 
CTGAAGCTCT CCCCACAAGG CTATCCATCT CCTGTCACTC AGACATCACA GGCCAGCTCC 
AAGCAGGACT CTTGGAACAG CCTGGTCCTG GCTGACAGTC ATGGGGACAT AATCACCGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GATA4 Loss-of-Function Mutation and the Congenitally Bicuspid Aortic Valve.
The American journal of cardiology(2017 Nov)
Li RG,Xu YJ,Wang J,Liu XY,Yuan F,Huang RT,Xue S,Li L,Liu H,Li YJ,Qu XK,Shi HY,Zhang M,Qiu XB,Yang YQ

Downregulation of miR-200c protects cardiomyocytes from hypoxia-induced apoptosis by targeting GATA-4.
International journal of molecular medicine39(6)1589-1596(2017 Jun)
Chen Z,Zhang S,Guo C,Li J,Sang W

Downregulation of miR-122 attenuates hypoxia/reoxygenation (H/R)-induced myocardial cell apoptosis by upregulating GATA-4.
Biochemical and biophysical research communications478(3)1416-22(2016 09)
Liang W,Guo J,Li J,Bai C,Dong Y

MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes.
Molecular medicine reports14(3)2860-6(2016 Sep)
Liu Y,Wang Z,Xiao W

MicroRNA-208b Alleviates Post-Infarction Myocardial Fibrosis in a Rat Model by Inhibiting GATA4.
Medical science monitor : international medical journal of experimental and clinical research221808-16(2016 May)
Zhou C,Cui Q,Su G,Guo X,Liu X,Zhang J

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Gata4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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