Gsk3a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gsk3a
Entrez Gene ID	50686
Full Name	glycogen synthase kinase 3 alpha
General protein information	Preferred Names glycogen synthase kinase 3 alpha Names glycogen synthase kinase-3 alpha FA GSK-3 alpha factor A serine/threonine-protein kinase GSK3A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	protein-serine kinase; may mediate hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c-jun [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589607.1	XP_017445096.1	glycogen synthase kinase-3 alpha isoform X1
NM_017344.1	NP_059040.1	glycogen synthase kinase-3 alpha

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GSK3A	NP_001095662.1
Eremothecium gossypii	AGOS_ADR253W	NP_984349.2
Magnaporthe oryzae (rice blast fungus)	MGG_12122	XP_003719885.1
Neurospora crassa	NCU04185	XP_961145.1
Arabidopsis thaliana (thale cress)	ATSK12	NP_187235.1
Oryza sativa (rice)	Os01g0252100	NP_001042602.1
Pan troglodytes (chimpanzee)	GSK3A	XP_530044.2
	GSK3A	XP_001104964.1
Mus musculus (house mouse)	Gsk3a	NP_001026837.1
Arabidopsis thaliana (thale cress)	SK 11	NP_568486.1
Homo sapiens (human)	GSK3A	NP_063937.2
Rattus norvegicus (Norway rat)	Gsk3a	NP_059040.1
Danio rerio (zebrafish)	gsk3aa	NP_001038386.2
Danio rerio (zebrafish)	gsk3ab	NP_571465.1
Kluyveromyces lactis	KLLA0F17006g	XP_455844.1
Schizosaccharomyces pombe (fission yeast)	gsk3	NP_593134.1
Xenopus tropicalis (tropical clawed frog)	gsk3a	XP_002936450.1
Canis lupus familiaris (dog)	GSK3A	XP_005616585.1
Saccharomyces cerevisiae (baker's yeast)	RIM11	NP_013859.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats.
Xiao H, Deng M, Yang B, Tang J, Hu Z
Journal of neurochemistry142(2)194-203(2017 Jul)

Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.
Oh J, Kim Y, Che L, Kim JB, Chang GE, Cheong E, Kang SG, Ha Y
PloS one12(11)e0178881(2017)

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/?-TrCP.
Cuadrado A
Free radical biology & medicine88(Pt B)147-157(2015 Nov)

Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.
Kobayashi S, Nakamura TY, Wakabayashi S
Journal of molecular and cellular cardiology84133-42(2015 Jul)

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
Koo J, Wu X, Mao Z, Khuri FR, Sun SY
The Journal of biological chemistry290(22)14120-9(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

found that ovariectomized female rats exhibited increased mRNA levels of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), and increased protein levels of GSK3beta but not GSK3alpha in brain cortical area
Title: Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats.

he combined action of CHIR99021 and forskolin markedly delayed neurological deficits and significantly reduced the tumor volume. We suggest that reprogramming technology may be a potential treatment strategy replacing the therapeutic paradigm of traditional treatment of malignant glioma, and a combination molecule comprising a GSK3 inhibitor and a cAMP inducer could be the next generation of anticancer drugs.
Title: Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.

CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation.
Title: Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.

In addition, PNS significantly increased the levels of GSK-3alpha, beta and NR2B, but reduced hippocampal cell proliferation during fear extinction.
Title: Effects of prenatal chronic mild stress exposure on hippocampal cell proliferation, expression of GSK-3?, ? and NR2B in adult offspring during fear extinction in rats.

brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3.
Title: Control of synaptic vesicle endocytosis by an extracellular signalling molecule.

The following Gsk3a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gsk3a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12766	NM_017344.1 Latest version!	Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$286.30 $409.00
ORa56800	XM_017589607.1 Latest version!	Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gsk3a ( NM_017344.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059040.1 Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), mRNA.

Price & Availability↑

CloneID	ORa12766
Clone ID Related Accession (Same CDS sequence)	NM_017344.1
Accession Version	NM_017344.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Rattus norvegicus(Norway rat)
Product	glycogen synthase kinase-3 alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X53427.1. On Dec 17, 2003 this sequence version replaced XM_346536.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X53427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCGGCG GCGGGCCTTC GGGAGGTGGC CCTGGGGGCT CGGGCCGGGC GCGGACCAGC 
TCGTTCGCGG AGCCAGGCGG CGGAGGCGGA GGCGGTGGCG GCGGCCCCGG GGGCTCGGCC 
TCCGGCCCAG GAGGCACTGG CGGCGGGAAG GCGTCAGTCG GGGCTATGGG TGGGGGCGTG 
GGAGCCTCGA GCTCTGGGGG TGGCCCCAGC GGCAGCGGCG GAGGAGGCAG CGGTGGCCCC 
GGCGCGGGCA CTAGCTTCCC GCCGCCCGGA GTGAAGCTGG GCCGTGACAG CGGGAAGGTG 
ACCACAGTGG TAGCCACTCT AGGCCAAGGC CCAGAGCGTT CCCAAGAGGT GGCTTACACC 
GACATCAAAG TGATTGGCAA TGGCTCATTC GGAGTAGTGT ACCAGGCACG GCTGGCAGAA 
ACGAGGGAAC TGGTGGCCAT CAAGAAGGTT CTTCAGGACA AAAGGTTCAA GAACCGAGAG 
CTGCAGATTA TGCGTAAGCT GGACCACTGC AATATCGTGA GGCTGCGGTA CTTTTTCTAC 
TCCAGTGGGG AGAAGAAAGA TGAGCTGTAT TTAAATCTGG TGCTGGAATA TGTGCCCGAG 
ACCGTGTACC GAGTGGCCCG TCACTTTACC AAGGCCAAGT TGATCATCCC TATCATCTAT 
GTCAAGGTGT ACATGTACCA GCTCTTCCGG AGCTTGGCCT ACATCCACTC CCAAGGTGTG 
TGTCACCGTG ACATCAAGCC CCAGAATTTG CTTGTGGACC CTGACACTGC TGTCCTCAAG 
CTCTGCGACT TTGGCAGTGC AAAGCAGTTG GTTCGGGGGG AGCCCAACGT GTCCTACATC 
TGTTCTCGGT ACTACCGTGC TCCGGAGCTC ATCTTTGGAG CCACAGATTA CACCTCGTCC 
ATCGATGTGT GGTCAGCTGG CTGTGTACTG GCTGAGCTGC TTCTTGGCCA GCCCATCTTC 
CCTGGGGACA GTGGGGTAGA CCAGCTTGTG GAGATCATCA AGGTACTAGG GACGCCAACC 
AGGGAGCAAA TCCGAGAGAT GAACCCTAAC TACACAGAAT TCAAGTTCCC CCAGATCAAA 
GCTCACCCCT GGACAAAGGT GTTCAAATCT CGGACACCAC CTGAGGCCAT CGCACTCTGC 
TCTAGCCTGC TGGAGTACAC TCCATCCTCA AGGCTCTCCC CACTAGAGGC CTGTGCCCAC 
AGTTTCTTTG ATGAACTGCG GAGTCTCGGA ACCCAGCTCC CCAACAACCG CCCGCTTCCC 
CCCCTCTTCA ACTTCAGTCC TGGTGAACTT TCCATCCAAC CGTCTCTCAA TGCCATTCTC 
ATCCCTCCTC ACTTGAGGTC CCCATCAGGC CCTGCTACCC TCACCTCGTC CTCACAAGCT 
TTAACTGAGA CTCAGACTGG CCAAGACTGG CAGGCACCTG ATGCCACACC TACCCTCACT 
AACTCTTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059040.1
CDS	127..1578
Translation	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRSLGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPSGPATLTSSSQALTETQTGQDWQAPDATPTLTNSS

Target ORF information:

RefSeq Version	NM_017344.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017344.1

ORF Insert Sequence:

ATGAGCGGCG GCGGGCCTTC GGGAGGTGGC CCTGGGGGCT CGGGCCGGGC GCGGACCAGC 
TCGTTCGCGG AGCCAGGCGG CGGAGGCGGA GGCGGTGGCG GCGGCCCCGG GGGCTCGGCC 
TCCGGCCCAG GAGGCACTGG CGGCGGGAAG GCGTCAGTCG GGGCTATGGG TGGGGGCGTG 
GGAGCCTCGA GCTCTGGGGG TGGCCCCAGC GGCAGCGGCG GAGGAGGCAG CGGTGGCCCC 
GGCGCGGGCA CTAGCTTCCC GCCGCCCGGA GTGAAGCTGG GCCGTGACAG CGGGAAGGTG 
ACCACAGTGG TAGCCACTCT AGGCCAAGGC CCAGAGCGTT CCCAAGAGGT GGCTTACACC 
GACATCAAAG TGATTGGCAA TGGCTCATTC GGAGTAGTGT ACCAGGCACG GCTGGCAGAA 
ACGAGGGAAC TGGTGGCCAT CAAGAAGGTT CTTCAGGACA AAAGGTTCAA GAACCGAGAG 
CTGCAGATTA TGCGTAAGCT GGACCACTGC AATATCGTGA GGCTGCGGTA CTTTTTCTAC 
TCCAGTGGGG AGAAGAAAGA TGAGCTGTAT TTAAATCTGG TGCTGGAATA TGTGCCCGAG 
ACCGTGTACC GAGTGGCCCG TCACTTTACC AAGGCCAAGT TGATCATCCC TATCATCTAT 
GTCAAGGTGT ACATGTACCA GCTCTTCCGG AGCTTGGCCT ACATCCACTC CCAAGGTGTG 
TGTCACCGTG ACATCAAGCC CCAGAATTTG CTTGTGGACC CTGACACTGC TGTCCTCAAG 
CTCTGCGACT TTGGCAGTGC AAAGCAGTTG GTTCGGGGGG AGCCCAACGT GTCCTACATC 
TGTTCTCGGT ACTACCGTGC TCCGGAGCTC ATCTTTGGAG CCACAGATTA CACCTCGTCC 
ATCGATGTGT GGTCAGCTGG CTGTGTACTG GCTGAGCTGC TTCTTGGCCA GCCCATCTTC 
CCTGGGGACA GTGGGGTAGA CCAGCTTGTG GAGATCATCA AGGTACTAGG GACGCCAACC 
AGGGAGCAAA TCCGAGAGAT GAACCCTAAC TACACAGAAT TCAAGTTCCC CCAGATCAAA 
GCTCACCCCT GGACAAAGGT GTTCAAATCT CGGACACCAC CTGAGGCCAT CGCACTCTGC 
TCTAGCCTGC TGGAGTACAC TCCATCCTCA AGGCTCTCCC CACTAGAGGC CTGTGCCCAC 
AGTTTCTTTG ATGAACTGCG GAGTCTCGGA ACCCAGCTCC CCAACAACCG CCCGCTTCCC 
CCCCTCTTCA ACTTCAGTCC TGGTGAACTT TCCATCCAAC CGTCTCTCAA TGCCATTCTC 
ATCCCTCCTC ACTTGAGGTC CCCATCAGGC CCTGCTACCC TCACCTCGTC CTCACAAGCT 
TTAACTGAGA CTCAGACTGG CCAAGACTGG CAGGCACCTG ATGCCACACC TACCCTCACT 
AACTCTTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gsk3a ( XM_017589607.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445096.1 Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56800
Clone ID Related Accession (Same CDS sequence)	XM_017589607.1
Accession Version	XM_017589607.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	glycogen synthase kinase-3 alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCGGCG GCGGGCCTTC GGGAGGTGGC CCTGGGGGCT CGGGCCGGGC GCGGACCAGC 
TCGTTCGCGG AGCCAGGCGG CGGAGGCGGA GGCGGTGGCG GCGGCCCCGG GGGCTCGGCC 
TCCGGCCCAG GAGGCACTGG CGGCGGGAAG GCGTCAGTCG GGGCTATGGG TGGGGGCGTG 
GGAGCCTCGA GCTCTGGGGG TGGCCCCAGC GGCAGCGGCG GAGGAGGCAG CGGTGGCCCC 
GGCGCGGGCA CTAGCTTCCC GCCGCCCGGA GTGAAGCTGG GCCGTGACAG CGGGAAGGTG 
ACCACAGTGG TAGCCACTCT AGGCCAAGGC CCAGAGCGTT CCCAAGAGGT GGCTTACACC 
GACATCAAAG TGATTGGCAA TGGCTCATTC GGAGTAGTGT ACCAGGCACG GCTGGCAGAA 
ACGAGGGAAC TGGTGGCCAT CAAGAAGGTT CTTCAGGACA AAAGGTTCAA GAACCGAGAG 
CTGCAGATTA TGCGTAAGCT GGACCACTGC AATATCGTGA GGCTACGGTA CTTTTTCTAC 
TCCAGTGGGG AGAAGAAAGA TGAGCTGTAT TTAAATCTGG TGCTGGAATA TGTGCCCGAG 
ACGGTGTACC GAGTGGCCCG TCACTTTACC AAGGCCAAGT TGATCATCCC TATCATCTAT 
GTCAAGGTGT ACATGTACCA GCTCTTCCGG AGCTTGGCCT ACATCCACTC CCAAGGTGTG 
TGTCACCGTG ACATCAAGCC CCAGAATTTG CTTGTGGACC CTGACACTGC TGTCCTCAAG 
CTCTGCGACT TTGGCAGTGC AAAGCAGTTG GTTCGGGGGG AGCCCAACGT GTCCTACATC 
TGTTCTCGGT ACTACCGTGC TCCGGAGCTC ATCTTTGGAG CCACAGATTA CACCTCGTCC 
ATCGATGTGT GGTCAGCTGG CTGTGTACTG GCTGAGCTGC TTCTTGGCCA GCCCATCTTC 
CCTGGGGACA GTGGGGTAGA CCAGCTTGTG GAGATCATCA AGGTACTAGG GACGCCAACC 
AGGGAGCAAA TCCGAGAGAT GAACCCTAAC TACACAGAAT TCAAGTTCCC CCAGATCAAA 
GCTCACCCCT GGACAAAGGT GTTCAAATCT CGGACACCAC CTGAGGCCAT CGCACTCTGC 
TCTAGCCTGC TGGAGTACAC TCCATCCTCA AGGCTCTCCC CACTAGAGGC CTGTGCCCAC 
AGTTTCTTTG ATGAACTGCG GAGTCTCGGA ACCCAGCTCC CCAACAACCG CCCGCTTCCC 
CCCCTCTTCA ACTTCAGTCC TGGTGAACTT TCCATCCAAC CGTCTCTCAA TGCCATTCTC 
ATCCCTCCTC ACTTGAGGTC CCCATCAGGC CCTGCTACCC TCACCTCGTC CTCACAAGCT 
TTAACTGAGA CTCAGACTGG CCAAGACTGG CAGGCACCTG ATGCCACACC TACCCTCACT 
AACTCTTCCT GGAGGGCCCT ACCGACTACC CCTCCACGTC CATCTGTGGT TAAGCAAAAT 
GGGCTCAAGT GGGGCTGGGG TAAGGCGGGG CCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445096.1
CDS	156..1691
Translation	MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRSLGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPSGPATLTSSSQALTETQTGQDWQAPDATPTLTNSSWRALPTTPPRPSVVKQNGLKWGWGKAGP

Target ORF information:

RefSeq Version	XM_017589607.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycogen synthase kinase 3 alpha (Gsk3a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589607.1

ORF Insert Sequence:

ATGAGCGGCG GCGGGCCTTC GGGAGGTGGC CCTGGGGGCT CGGGCCGGGC GCGGACCAGC 
TCGTTCGCGG AGCCAGGCGG CGGAGGCGGA GGCGGTGGCG GCGGCCCCGG GGGCTCGGCC 
TCCGGCCCAG GAGGCACTGG CGGCGGGAAG GCGTCAGTCG GGGCTATGGG TGGGGGCGTG 
GGAGCCTCGA GCTCTGGGGG TGGCCCCAGC GGCAGCGGCG GAGGAGGCAG CGGTGGCCCC 
GGCGCGGGCA CTAGCTTCCC GCCGCCCGGA GTGAAGCTGG GCCGTGACAG CGGGAAGGTG 
ACCACAGTGG TAGCCACTCT AGGCCAAGGC CCAGAGCGTT CCCAAGAGGT GGCTTACACC 
GACATCAAAG TGATTGGCAA TGGCTCATTC GGAGTAGTGT ACCAGGCACG GCTGGCAGAA 
ACGAGGGAAC TGGTGGCCAT CAAGAAGGTT CTTCAGGACA AAAGGTTCAA GAACCGAGAG 
CTGCAGATTA TGCGTAAGCT GGACCACTGC AATATCGTGA GGCTACGGTA CTTTTTCTAC 
TCCAGTGGGG AGAAGAAAGA TGAGCTGTAT TTAAATCTGG TGCTGGAATA TGTGCCCGAG 
ACGGTGTACC GAGTGGCCCG TCACTTTACC AAGGCCAAGT TGATCATCCC TATCATCTAT 
GTCAAGGTGT ACATGTACCA GCTCTTCCGG AGCTTGGCCT ACATCCACTC CCAAGGTGTG 
TGTCACCGTG ACATCAAGCC CCAGAATTTG CTTGTGGACC CTGACACTGC TGTCCTCAAG 
CTCTGCGACT TTGGCAGTGC AAAGCAGTTG GTTCGGGGGG AGCCCAACGT GTCCTACATC 
TGTTCTCGGT ACTACCGTGC TCCGGAGCTC ATCTTTGGAG CCACAGATTA CACCTCGTCC 
ATCGATGTGT GGTCAGCTGG CTGTGTACTG GCTGAGCTGC TTCTTGGCCA GCCCATCTTC 
CCTGGGGACA GTGGGGTAGA CCAGCTTGTG GAGATCATCA AGGTACTAGG GACGCCAACC 
AGGGAGCAAA TCCGAGAGAT GAACCCTAAC TACACAGAAT TCAAGTTCCC CCAGATCAAA 
GCTCACCCCT GGACAAAGGT GTTCAAATCT CGGACACCAC CTGAGGCCAT CGCACTCTGC 
TCTAGCCTGC TGGAGTACAC TCCATCCTCA AGGCTCTCCC CACTAGAGGC CTGTGCCCAC 
AGTTTCTTTG ATGAACTGCG GAGTCTCGGA ACCCAGCTCC CCAACAACCG CCCGCTTCCC 
CCCCTCTTCA ACTTCAGTCC TGGTGAACTT TCCATCCAAC CGTCTCTCAA TGCCATTCTC 
ATCCCTCCTC ACTTGAGGTC CCCATCAGGC CCTGCTACCC TCACCTCGTC CTCACAAGCT 
TTAACTGAGA CTCAGACTGG CCAAGACTGG CAGGCACCTG ATGCCACACC TACCCTCACT 
AACTCTTCCT GGAGGGCCCT ACCGACTACC CCTCCACGTC CATCTGTGGT TAAGCAAAAT 
GGGCTCAAGT GGGGCTGGGG TAAGGCGGGG CCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats.
Journal of neurochemistry142(2)194-203(2017 Jul)
Xiao H,Deng M,Yang B,Tang J,Hu Z

Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma.
PloS one12(11)e0178881(2017)
Oh J,Kim Y,Che L,Kim JB,Chang GE,Cheong E,Kang SG,Ha Y

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/?-TrCP.
Free radical biology & medicine88(Pt B)147-157(2015 Nov)
Cuadrado A

Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.
Journal of molecular and cellular cardiology84133-42(2015 Jul)
Kobayashi S,Nakamura TY,Wakabayashi S

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
The Journal of biological chemistry290(22)14120-9(2015 May)
Koo J,Wu X,Mao Z,Khuri FR,Sun SY

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Gsk3a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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