Acox1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acox1
Entrez Gene ID	50681
Full Name	acyl-CoA oxidase 1
Synonyms	RATACOA1,aCoA
General protein information	Preferred Names acyl-CoA oxidase 1 Names peroxisomal acyl-coenzyme A oxidase 1 AOX acyl-CoA oxidase 1, palmitoyl acyl-Coenzyme A oxidase 1, palmitoyl palmitoyl-CoA oxidase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	catalyzes the oxidation of fatty acyl CoA to trans-2-enoyl-CoA and peroxide [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017340.2	NP_059036.1	peroxisomal acyl-coenzyme A oxidase 1

Pathways from BioSystems

Homologies

	ACOX1	XP_001102134.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011798	XP_320718.4
Caenorhabditis elegans (roundworm)	F08A8.3	NP_493263.1
Arabidopsis thaliana (thale cress)	ACX5	NP_181112.1
Bos taurus (cattle)	ACOX1	NP_001030366.1
Mus musculus (house mouse)	Acox1	NP_056544.2
Rattus norvegicus (Norway rat)	Acox1	NP_059036.1
Caenorhabditis elegans (roundworm)	F59F4.1	NP_510603.1
Arabidopsis thaliana (thale cress)	ACX1	NP_567513.4
Homo sapiens (human)	ACOX1	NP_009223.2
Pan troglodytes (chimpanzee)	ACOX1	XP_001149084.1
Gallus gallus (chicken)	ACOX1	NP_001006205.1
Oryza sativa (rice)	Os06g0103500	NP_001056542.1
Canis lupus familiaris (dog)	ACOX1	XP_003435209.1
Caenorhabditis elegans (roundworm)	acox-1	NP_001021089.1
Danio rerio (zebrafish)	acox1	NP_001005933.1
Drosophila melanogaster (fruit fly)	CG5009	NP_611264.2
Caenorhabditis elegans (roundworm)	F08A8.2	NP_493262.2
Caenorhabditis elegans (roundworm)	F08A8.4	NP_493264.1
Caenorhabditis elegans (roundworm)	C48B4.1	NP_499119.1
Xenopus tropicalis (tropical clawed frog)	acox1	NP_001015762.1

Gene Ontology
Bibliography

Related articles in PubMed

Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.
Zeng J, Deng S, Wang Y, Li P, Tang L, Pang Y
The Journal of biological chemistry292(9)3800-3809(2017 03)

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
Sang?esa G, Shaligram S, Akther F, Roglans N, Laguna JC, Rahimian R, Alegret M
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)

Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.
Bonfleur ML, Borck PC, Ribeiro RA, Caetano LC, Soares GM, Carneiro EM, Balbo SL
Life sciences13515-21(2015 Aug)

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)

Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].
Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK, Cherkaoui-Malki M
Laboratory investigation; a journal of technical methods and pathology90(5)696-708(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of ACOX1 is a novel and effective approach for the treatment of high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism
Title: Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.

Tau supplementation prevented obesity and hepatic TG deposition by upregulating MTP mRNA, ameliorating hepatic lipid efflux, and consequently enhancing PPAR-alpha which increases lipid oxidation through ACO and CPT-1a gene expressions.
Title: Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.

In comparison with the control group, while ACO mRNA was markedly decreased in the obese group.
Title: [Study on SOCS-3, PPARgamma and ACO mRNA expression of adipose tissues in obese rats with leptin resistance].

The isomerase activity of the enzyme was characterized through studies of kinetics, pH dependence, and enzyme inhibition.
Title: Intrinsic enoyl-CoA isomerase activity of rat acyl-CoA oxidase I.

The following Acox1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acox1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03693	NM_017340.2 Latest version!	Rattus norvegicus acyl-CoA oxidase 1 (Acox1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acox1 ( NM_017340.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059036.1 Rattus norvegicus acyl-CoA oxidase 1 (Acox1), mRNA.

Price & Availability↑

CloneID	ORa03693
Clone ID Related Accession (Same CDS sequence)	NM_017340.2
Accession Version	NM_017340.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1986bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	peroxisomal acyl-coenzyme A oxidase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085743.1. On Jun 10, 2007 this sequence version replaced NM_017340.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085743.1, J02752.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAACCCCG ACCTGCGCAA GGAGCGGGCC TCCGCCACCT TCAATCCGGA GTTGATCACG 
CACATCTTGG ATGGCAGTCC GGAGAATACC CGGCGCCGTC GAGAAATTGA GAACTTGATT 
CTGAACGACC CAGACTTCCA GCATGAGGAC TATAACTTCC TCACTCGAAG CCAGCGTTAT 
GAGGTGGCTG TTAAGAAGAG TGCCACCATG GTGAAGAAGA TGAGGGAATA TGGCATCTCG 
GACCCTGAAG AAATCATGTG GTTTAAAAAA CTATATTTGG CCAATTTTGT GGAACCTGTT 
GGCCTCAATT ACTCCATGTT TATTCCTACC TTGCTGAATC AGGGCACCAC TGCTCAGCAG 
GAGAAATGGA TGCGCCCGTC CCAAGAACTC CAGATAATTG GCACCTACGC CCAGACGGAG 
ATGGGCCACG GAACTCATCT TCGAGGCTTG GAAACCACTG CCACATATGA CCCCAAGACC 
CAAGAGTTCA TTCTCAACAG CCCTACTGTG ACTTCCATTA AGTGGTGGCC TGGGGGACTT 
GGGAAAACTT CCAATCACGC AATAGTTCTG GCTCAGCTCA TCACTCAAGG AGAGTGCTAC 
GGGTTACATG CCTTTGTTGT CCCTATCCGT GAAATTGGGA CCCACAAGCC CTTGCCAGGC 
ATCACTGTCG GGGATATCGG TCCCAAATTT GGTTATGAAG AGATGGATAA CGGCTACCTG 
AAGATGGACA ATTACCGTAT TCCCAGAGAG AACATGCTGA TGAAATACGC CCAGGTGAAG 
CCTGATGGCA CATATGTAAA GCCTTTGAGT AACAAGCTGA CGTATGGGAC CATGGTTTTT 
GTGAGGTCCT TCCTCGTGGG AAATGCAGCT CAGAGTCTGT CCAAGGCTTG CACAATCGCC 
ATACGATACA GCGCTGTGAG GCGCCAGTCT GAAATCAAGC AAAGCGAACC AGAACCACAG 
ATTTTGGATT TTCAAACCCA GCAGTATAAA CTCTTCCCGC TCCTGGCCAC TGCCTATGCC 
TTCCACTTCG TAGGAAGGTA CATGAAGGAG ACCTACCTTC GAATTAATGA GAGCATTGGC 
CAAGGGGACC TGAGTGAACT GCCTGAGCTT CACGCCCTCA CTGCTGGGCT GAAGGCTTTT 
ACTACTTGGA CAGCCAATGC TGGCATCGAA GAATGTCGAA TGGCCTGCGG CGGGCACGGC 
TATTCTCACA GCAGTGGGAT TCCAAATATT TACGTCACTT TTACCCCGGC CTGCACCTTC 
GAGGGAGAGA ACACTGTTAT GATGCTGCAG ACAGCCAGGT TCTTGATGAA AATCTACGAC 
CAGGTGCGGT CGGGGAAGTT GGTGGGTGGT ATGGTGTCAT ACCTGAATGA CCTGCCGAGT 
CAGCGGATCC AGCCACAGCA GGTGGCAGTC TGGCCAACTA TGGTGGACAT CAACAGCCTG 
GAGGGCCTGA CAGAAGCCTA CAAGCTTCGT GCAGCCAGAT TGGTAGAAAT CGCTGCAAAA 
AACCTTCAGA CTCACGTGAG TCACAGGAAG AGCAAGGAAG TAGCATGGAA CCTAACCTCT 
GTCGACCTTG TTCGGGCAAG TGAGGCGCAT TGCCACTACG TGGTCGTTAA GGTCTTCTCA 
GACAAACTCC CCAAGATTCA AGACAAAGCC GTCCAAGCTG TGCTGAGGAA CCTGTGTCTC 
TTGTATTCTC TCTATGGGAT CAGCCAGAAA GGAGGGGACT TTCTTGAGGG GAGCATCATC 
ACAGGGGCTC AGCTGTCACA AGTAAACGCT CGGATCCTGG AGCTGCTCAC CCTGATCCGC 
CCCAATGCTG TTGCTCTGGT GGATGCCTTT GACTTTAAGG ACATGACACT TGGCTCTGTT 
CTTGGCCGCT ATGATGGAAA TGTGTATGAA AACTTGTTTG AGTGGGCCAA GAAATCCCCA 
CTGAACAAAA CAGAGGTCCA TGAATCTTAC CACAAGCACT TGAAGCCCCT GCAGTCCAAG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059036.1
CDS	91..2076
Translation	MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRYEVAVKKSATMVKKMREYGISDPEEIMWFKKLYLANFVEPVGLNYSMFIPTLLNQGTTAQQEKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACTIAIRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVRSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTMVDINSLEGLTEAYKLRAARLVEIAAKNLQTHVSHRKSKEVAWNLTSVDLVRASEAHCHYVVVKVFSDKLPKIQDKAVQAVLRNLCLLYSLYGISQKGGDFLEGSIITGAQLSQVNARILELLTLIRPNAVALVDAFDFKDMTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSKL

Target ORF information:

RefSeq Version	NM_017340.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus acyl-CoA oxidase 1 (Acox1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017340.2

ORF Insert Sequence:

ATGAACCCCG ACCTGCGCAA GGAGCGGGCC TCCGCCACCT TCAATCCGGA GTTGATCACG 
CACATCTTGG ATGGCAGTCC GGAGAATACC CGGCGCCGTC GAGAAATTGA GAACTTGATT 
CTGAACGACC CAGACTTCCA GCATGAGGAC TATAACTTCC TCACTCGAAG CCAGCGTTAT 
GAGGTGGCTG TTAAGAAGAG TGCCACCATG GTGAAGAAGA TGAGGGAATA TGGCATCTCG 
GACCCTGAAG AAATCATGTG GTTTAAAAAA CTATATTTGG CCAATTTTGT GGAACCTGTT 
GGCCTCAATT ACTCCATGTT TATTCCTACC TTGCTGAATC AGGGCACCAC TGCTCAGCAG 
GAGAAATGGA TGCGCCCGTC CCAAGAACTC CAGATAATTG GCACCTACGC CCAGACGGAG 
ATGGGCCACG GAACTCATCT TCGAGGCTTG GAAACCACTG CCACATATGA CCCCAAGACC 
CAAGAGTTCA TTCTCAACAG CCCTACTGTG ACTTCCATTA AGTGGTGGCC TGGGGGACTT 
GGGAAAACTT CCAATCACGC AATAGTTCTG GCTCAGCTCA TCACTCAAGG AGAGTGCTAC 
GGGTTACATG CCTTTGTTGT CCCTATCCGT GAAATTGGGA CCCACAAGCC CTTGCCAGGC 
ATCACTGTCG GGGATATCGG TCCCAAATTT GGTTATGAAG AGATGGATAA CGGCTACCTG 
AAGATGGACA ATTACCGTAT TCCCAGAGAG AACATGCTGA TGAAATACGC CCAGGTGAAG 
CCTGATGGCA CATATGTAAA GCCTTTGAGT AACAAGCTGA CGTATGGGAC CATGGTTTTT 
GTGAGGTCCT TCCTCGTGGG AAATGCAGCT CAGAGTCTGT CCAAGGCTTG CACAATCGCC 
ATACGATACA GCGCTGTGAG GCGCCAGTCT GAAATCAAGC AAAGCGAACC AGAACCACAG 
ATTTTGGATT TTCAAACCCA GCAGTATAAA CTCTTCCCGC TCCTGGCCAC TGCCTATGCC 
TTCCACTTCG TAGGAAGGTA CATGAAGGAG ACCTACCTTC GAATTAATGA GAGCATTGGC 
CAAGGGGACC TGAGTGAACT GCCTGAGCTT CACGCCCTCA CTGCTGGGCT GAAGGCTTTT 
ACTACTTGGA CAGCCAATGC TGGCATCGAA GAATGTCGAA TGGCCTGCGG CGGGCACGGC 
TATTCTCACA GCAGTGGGAT TCCAAATATT TACGTCACTT TTACCCCGGC CTGCACCTTC 
GAGGGAGAGA ACACTGTTAT GATGCTGCAG ACAGCCAGGT TCTTGATGAA AATCTACGAC 
CAGGTGCGGT CGGGGAAGTT GGTGGGTGGT ATGGTGTCAT ACCTGAATGA CCTGCCGAGT 
CAGCGGATCC AGCCACAGCA GGTGGCAGTC TGGCCAACTA TGGTGGACAT CAACAGCCTG 
GAGGGCCTGA CAGAAGCCTA CAAGCTTCGT GCAGCCAGAT TGGTAGAAAT CGCTGCAAAA 
AACCTTCAGA CTCACGTGAG TCACAGGAAG AGCAAGGAAG TAGCATGGAA CCTAACCTCT 
GTCGACCTTG TTCGGGCAAG TGAGGCGCAT TGCCACTACG TGGTCGTTAA GGTCTTCTCA 
GACAAACTCC CCAAGATTCA AGACAAAGCC GTCCAAGCTG TGCTGAGGAA CCTGTGTCTC 
TTGTATTCTC TCTATGGGAT CAGCCAGAAA GGAGGGGACT TTCTTGAGGG GAGCATCATC 
ACAGGGGCTC AGCTGTCACA AGTAAACGCT CGGATCCTGG AGCTGCTCAC CCTGATCCGC 
CCCAATGCTG TTGCTCTGGT GGATGCCTTT GACTTTAAGG ACATGACACT TGGCTCTGTT 
CTTGGCCGCT ATGATGGAAA TGTGTATGAA AACTTGTTTG AGTGGGCCAA GAAATCCCCA 
CTGAACAAAA CAGAGGTCCA TGAATCTTAC CACAAGCACT TGAAGCCCCT GCAGTCCAAG 
CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.
The Journal of biological chemistry292(9)3800-3809(2017 03)
Zeng J,Deng S,Wang Y,Li P,Tang L,Pang Y

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)
Sang?esa G,Shaligram S,Akther F,Roglans N,Laguna JC,Rahimian R,Alegret M

Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.
Life sciences13515-21(2015 Aug)
Bonfleur ML,Borck PC,Ribeiro RA,Caetano LC,Soares GM,Carneiro EM,Balbo SL

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
The Journal of cell biology199(6)951-67(2012 Dec)
Ahmed SM,Th?riault BL,Uppalapati M,Chiu CW,Gallie BL,Sidhu SS,Angers S

Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].
Laboratory investigation; a journal of technical methods and pathology90(5)696-708(2010 May)
Vluggens A,Andreoletti P,Viswakarma N,Jia Y,Matsumoto K,Kulik W,Khan M,Huang J,Guo D,Yu S,Sarkar J,Singh I,Rao MS,Wanders RJ,Reddy JK,Cherkaoui-Malki M

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Acox1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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