Ctss cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctss
Entrez Gene ID	50654
Full Name	cathepsin S
General protein information	Preferred Names cathepsin S Names cathepsin S
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	lysosomal cysteine proteases; may mediate matrix degradation, and thyroglobulin hydrolysis; may play a role in thyroid hormone biosynthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017320.1	NP_059016.1	cathepsin S preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTSS	XP_001171268.1
Mus musculus (house mouse)	Ctss	NP_067256.4
Gallus gallus (chicken)	CTSS	NP_001026516.1
Danio rerio (zebrafish)	ctssb.1	NP_001019580.2
Arabidopsis thaliana (thale cress)	AT4G11320	NP_567377.1
Homo sapiens (human)	CTSS	NP_004070.3
Canis lupus familiaris (dog)	CTSS	NP_001002938.2
Arabidopsis thaliana (thale cress)	AT4G11310	NP_567376.1
Bos taurus (cattle)	CTSS	NP_001028787.1
Rattus norvegicus (Norway rat)	Ctss	NP_059016.1
Danio rerio (zebrafish)	ctssb.2	NP_001017661.1
Xenopus tropicalis (tropical clawed frog)	ctss	NP_001005695.1
	LOC708080	XP_002801809.1
Arabidopsis thaliana (thale cress)	AT4G23520	NP_567686.2

Gene Ontology
Bibliography

Related articles in PubMed

Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats.
Ye L, Xiao L, Yang SY, Duan JJ, Chen Y, Cui Y, Chen Y
Neuroscience344265-275(2017 Mar)

Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S.
Samouillan V, Revuelta-L?pez E, Dandurand J, Nasarre L, Badimon L, Lacabanne C, Llorente-Cort?s V
The international journal of biochemistry & cell biology55209-19(2014 Oct)

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners.
Sage J, Leblanc-Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, Kurfurst R, Br?mme D, Lalmanach G, Lecaille F
PloS one7(8)e43494(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings demonstrate that neuronal reactive oxygen species promote maturation of microglial CatS which facilitates activation of NMDA in the spinal dorsal horn.
Title: Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats.

Data show that LDL-receptor related protein 1 (LRP1)-mediated cardiomyocyte intracellular cholesteryl ester accumulation alters the structural and physical characteristics of secreted tropoelastin through an increase in cathepsin S mature protein levels.
Title: Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S.

Cysteine cathepsins may be putative leptin activity regulators in white adipose tissue.
Title: Cysteine cathepsin S processes leptin, inactivating its biological activity.

Inhibition of cathepsin S release is one mechanism that is responsible for purinergic P2X7 antagonist efficacy in neuropathic pain.
Title: Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor.

under neuropathic conditions, noxious stimulation of primary afferent fibers induces release of CatS from microglia, which liberates FKN from dorsal horn neurons, thereby contributing to the amplification and maintenance of chronic pain
Title: The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

The following Ctss gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctss cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03638	NM_017320.1 Latest version!	Rattus norvegicus cathepsin S (Ctss), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctss ( NM_017320.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059016.1 Rattus norvegicus cathepsin S (Ctss), mRNA.

Price & Availability↑

CloneID	ORa03638
Clone ID Related Accession (Same CDS sequence)	NM_017320.1
Accession Version	NM_017320.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Rattus norvegicus(Norway rat)
Product	cathepsin S preproprotein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L03201.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L03201.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGTTT TGGGTGCCCC TGGTGTGCTC TGTGACAATG GAGCAACTGC AGAGAGACCT 
ACCCTGGACC ACCACTGGGA TCTCTGGAAG AAAACTCGCA TGAGAAGGAA TACAGATCAG 
AATGAAGAAG ACGTACGACG TCTCATCTGG GAAAAGAATC TCAAGTTTAT AATGCTTCAC 
AATCTGGAAC ATTCTATGGG AATGCATTCA TACAGTGTGG GCATGAACCA CATGGGAGAC 
ATGACACCTG AAGAAGTCAT AGGTTATATG GGCTCTCTGA GAATTCCCAG GCCCTGGAAT 
AGAAGTGGCA CTCTCAAGTC AAGCTCTAAT CAGACATTGC CCGACTCTGT GGACTGGCGA 
GAAAAGGGCT GCGTCACTAA TGTGAAATAC CAGGGCTCTT GTGGTTCCTG CTGGGCTTTC 
AGCGCCGAGG GGGCCCTTGA AGGGCAGCTG AAGCTGAAAA CGGGGAAGCT GGTGTCTCTC 
AGTGCTCAGA ACCTGGTGGA TTGCTCAACC GAAGAAAAGT ACGGGAATAA AGGCTGCGGG 
GGTGGCTTCA TGACCGAAGC TTTCCAGTAC ATCATCGATA CGAGCATCGA CTCAGAAGCT 
TCCTATCCCT ACAAAGCCAT GGATGAAAAG TGTCTCTATG ACCCAAAAAA TCGAGCTGCC 
ACGTGTTCAA GGTACATTGA GCTCCCCTTC GGCGATGAAG AAGCTCTGAA AGAAGCAGTG 
GCCACTAAAG GGCCTGTCTC TGTGGGCATC GACGACGCCA GCCATTCCTC CTTCTTCCTC 
TACCAAAGTG GTGTCTATGA TGACCCCTCC TGTACCGAGA ATATGAATCA TGGTGTTCTC 
GTGGTTGGCT ATGGGACTCT TGATGGGAAA GACTACTGGC TTGTGAAAAA CAGTTGGGGC 
CTTCACTTTG GTGATCAAGG ATATATTCGG ATGGCGAGAA ATAACAAAAA TCACTGCGGG 
ATTGCTAGCT ATTGCTCTTA CCCAGAAATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059016.1
CDS	28..1020
Translation	MAVLGAPGVLCDNGATAERPTLDHHWDLWKKTRMRRNTDQNEEDVRRLIWEKNLKFIMLHNLEHSMGMHSYSVGMNHMGDMTPEEVIGYMGSLRIPRPWNRSGTLKSSSNQTLPDSVDWREKGCVTNVKYQGSCGSCWAFSAEGALEGQLKLKTGKLVSLSAQNLVDCSTEEKYGNKGCGGGFMTEAFQYIIDTSIDSEASYPYKAMDEKCLYDPKNRAATCSRYIELPFGDEEALKEAVATKGPVSVGIDDASHSSFFLYQSGVYDDPSCTENMNHGVLVVGYGTLDGKDYWLVKNSWGLHFGDQGYIRMARNNKNHCGIASYCSYPEI

Target ORF information:

RefSeq Version	NM_017320.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cathepsin S (Ctss), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017320.1

ORF Insert Sequence:

ATGGCTGTTT TGGGTGCCCC TGGTGTGCTC TGTGACAATG GAGCAACTGC AGAGAGACCT 
ACCCTGGACC ACCACTGGGA TCTCTGGAAG AAAACTCGCA TGAGAAGGAA TACAGATCAG 
AATGAAGAAG ACGTACGACG TCTCATCTGG GAAAAGAATC TCAAGTTTAT AATGCTTCAC 
AATCTGGAAC ATTCTATGGG AATGCATTCA TACAGTGTGG GCATGAACCA CATGGGAGAC 
ATGACACCTG AAGAAGTCAT AGGTTATATG GGCTCTCTGA GAATTCCCAG GCCCTGGAAT 
AGAAGTGGCA CTCTCAAGTC AAGCTCTAAT CAGACATTGC CCGACTCTGT GGACTGGCGA 
GAAAAGGGCT GCGTCACTAA TGTGAAATAC CAGGGCTCTT GTGGTTCCTG CTGGGCTTTC 
AGCGCCGAGG GGGCCCTTGA AGGGCAGCTG AAGCTGAAAA CGGGGAAGCT GGTGTCTCTC 
AGTGCTCAGA ACCTGGTGGA TTGCTCAACC GAAGAAAAGT ACGGGAATAA AGGCTGCGGG 
GGTGGCTTCA TGACCGAAGC TTTCCAGTAC ATCATCGATA CGAGCATCGA CTCAGAAGCT 
TCCTATCCCT ACAAAGCCAT GGATGAAAAG TGTCTCTATG ACCCAAAAAA TCGAGCTGCC 
ACGTGTTCAA GGTACATTGA GCTCCCCTTC GGCGATGAAG AAGCTCTGAA AGAAGCAGTG 
GCCACTAAAG GGCCTGTCTC TGTGGGCATC GACGACGCCA GCCATTCCTC CTTCTTCCTC 
TACCAAAGTG GTGTCTATGA TGACCCCTCC TGTACCGAGA ATATGAATCA TGGTGTTCTC 
GTGGTTGGCT ATGGGACTCT TGATGGGAAA GACTACTGGC TTGTGAAAAA CAGTTGGGGC 
CTTCACTTTG GTGATCAAGG ATATATTCGG ATGGCGAGAA ATAACAAAAA TCACTGCGGG 
ATTGCTAGCT ATTGCTCTTA CCCAGAAATC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats.
Neuroscience344265-275(2017 Mar)
Ye L,Xiao L,Yang SY,Duan JJ,Chen Y,Cui Y,Chen Y

Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S.
The international journal of biochemistry & cell biology55209-19(2014 Oct)
Samouillan V,Revuelta-L?pez E,Dandurand J,Nasarre L,Badimon L,Lacabanne C,Llorente-Cort?s V

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners.
PloS one7(8)e43494(2012)
Sage J,Leblanc-Noblesse E,Nizard C,Sasaki T,Schnebert S,Perrier E,Kurfurst R,Br?mme D,Lalmanach G,Lecaille F

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Ctss cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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