Gjd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gjd2
Entrez Gene ID	50564
Full Name	gap junction protein, delta 2
Synonyms	Cx36,Gja9
General protein information	Preferred Names gap junction protein, delta 2 Names gap junction delta-2 protein connexin-36 gap junction alpha-9 protein gap junction membrane channel protein alpha 9
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35
Summary	component of gap junctions that may mediate cell-cell signaling that contributes to insulin cell function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019281.2	NP_062154.1	gap junction delta-2 protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GJD2	NP_065711.1
Mus musculus (house mouse)	Gjd2	NP_034420.2
Gallus gallus (chicken)	GJD2	NP_989913.1
Bos taurus (cattle)	GJD2	NP_777108.1
Rattus norvegicus (Norway rat)	Gjd2	NP_062154.1
Danio rerio (zebrafish)	cx35b	NP_919401.1
Canis lupus familiaris (dog)	GJD2	XP_544602.2
Pan troglodytes (chimpanzee)	GJD2	XP_510284.1
Xenopus tropicalis (tropical clawed frog)	gjd2	XP_002932880.1

Gene Ontology
Bibliography

Related articles in PubMed

Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia.
Nagy JI, Rash JE
The European journal of neuroscience46(2)1790-1804(2017 Jul)

Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.
Corsini S, Tortora M, Rauti R, Nistri A
Cell death & disease8(6)e2881(2017 Jun)

Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy.
Motaghi S, Sayyah M, Babapour V, Mahdian R
Iranian biomedical journal21(3)167-73(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of the present study revealed that during memory consolidation in a passive avoidance paradigm, a rapid upregulation of Cx36 mRNA level occurs in the hippocampus, which declines to the control level by 24 h after training.
Title: Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation.

Neuronal Cx36 plays a role in rhythmic firing in substantia gelatinosa of rat neonatal dorsal horn in vitro.
Title: The role of Cx36 and Cx43 in 4-aminopyridine-induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in?vitro.

The results suggest that electrical synapses formed by Cx36-containing gap junctions occur in most of the widely distributed centers of the auditory system.
Title: Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses.

Cx 32 and Cx 43 associated with oligodendrocytes and astrocytes had an important role in the first stages of seizures induced by 4-AP, whereas Cx36 localized to neurons could be associated with later stages.
Title: Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus.

This study showed that hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36.
Title: Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation.

The following Gjd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gjd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04260	NM_019281.2 Latest version!	Rattus norvegicus gap junction protein, delta 2 (Gjd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gjd2 ( NM_019281.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062154.1 Rattus norvegicus gap junction protein, delta 2 (Gjd2), mRNA.

Price & Availability↑

CloneID	ORa04260
Clone ID Related Accession (Same CDS sequence)	NM_019281.2
Accession Version	NM_019281.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	gap junction delta-2 protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y16898.1. On Feb 21, 2013 this sequence version replaced NM_019281.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y16898.1, AJ296282.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAAT GGACCATCTT GGAGAGGCTG CTGGAAGCCG CGGTGCAGCA GCACTCCACT 
ATGATTGGGA GGATCCTGTT GACTGTGGTG GTGATCTTCC GGATACTCAT TGTGGCCATT 
GTAGGGGAGA CGGTGTACGA TGATGAGCAG ACCATGTTTG TGTGCAACAC CCTGCAGCCC 
GGCTGTAACC AGGCCTGCTA TGACCGCGCC TTTCCCATCT CCCATATACG TTACTGGGTC 
TTCCAGATCA TAATGGTGTG CACCCCCAGT CTCTGTTTCA TCACCTATTC TGTGCATCAA 
TCTGCCAAGC AGAGAGAACG CCGGTACTCG ACTGTCTTCC TAGCCCTGGA CAGAGACCCT 
GCTGAGTCTA TAGGGGGACC TGGAGGAACG GGGGGTGGTG GCAGTGGTGG GAGCAAGCGA 
GAAGATAAGA AGTTGCAAAA TGCCATTGTC AATGGGGTGC TCCAGAACAC AGAGACCACC 
AGTAAGGAGA CAGAACCAGA TTGCTTAGAG GTTAAAGAGC TGGCTCCACA TCCATCTGGG 
CTGCGCACAG CAGCAAGGTC CAAGCTTCGA AGACAGGAAG GTATTTCCCG CTTCTACATC 
ATCCAAGTGG TGTTTCGAAA TGCTCTGGAG ATTGGGTTTC TGGTGGGCCA GTACTTTCTA 
TATGGCTTCA GTGTCCCAGG GTTGTATGAG TGCAACCGCT ACCCCTGCAT CAAGGAGGTA 
GAATGTTATG TGTCTAGACC TACGGAGAAG ACGGTCTTTC TGGTGTTCAT GTTTGCTGTG 
AGCGGCATTT GTGTGGTGCT CAATCTGGCT GAACTTAACC ATCTGGGATG GCGGAAGATC 
AAACTGGCTG TCCGGGGAGC CCAGGCCAAG AGGAAGTCAG TCTATGAGAT TCGTAACAAA 
GACCTGCCAA GAGTCAGTGT TCCCAATTTC GGCAGGACTC AGTCCAGTGA CTCCGCCTAT 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062154.1
CDS	116..1081
Translation	MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETTSKETEPDCLEVKELAPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV

Target ORF information:

RefSeq Version	NM_019281.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gap junction protein, delta 2 (Gjd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019281.2

ORF Insert Sequence:

ATGGGGGAAT GGACCATCTT GGAGAGGCTG CTGGAAGCCG CGGTGCAGCA GCACTCCACT 
ATGATTGGGA GGATCCTGTT GACTGTGGTG GTGATCTTCC GGATACTCAT TGTGGCCATT 
GTAGGGGAGA CGGTGTACGA TGATGAGCAG ACCATGTTTG TGTGCAACAC CCTGCAGCCC 
GGCTGTAACC AGGCCTGCTA TGACCGCGCC TTTCCCATCT CCCATATACG TTACTGGGTC 
TTCCAGATCA TAATGGTGTG CACCCCCAGT CTCTGTTTCA TCACCTATTC TGTGCATCAA 
TCTGCCAAGC AGAGAGAACG CCGGTACTCG ACTGTCTTCC TAGCCCTGGA CAGAGACCCT 
GCTGAGTCTA TAGGGGGACC TGGAGGAACG GGGGGTGGTG GCAGTGGTGG GAGCAAGCGA 
GAAGATAAGA AGTTGCAAAA TGCCATTGTC AATGGGGTGC TCCAGAACAC AGAGACCACC 
AGTAAGGAGA CAGAACCAGA TTGCTTAGAG GTTAAAGAGC TGGCTCCACA TCCATCTGGG 
CTGCGCACAG CAGCAAGGTC CAAGCTTCGA AGACAGGAAG GTATTTCCCG CTTCTACATC 
ATCCAAGTGG TGTTTCGAAA TGCTCTGGAG ATTGGGTTTC TGGTGGGCCA GTACTTTCTA 
TATGGCTTCA GTGTCCCAGG GTTGTATGAG TGCAACCGCT ACCCCTGCAT CAAGGAGGTA 
GAATGTTATG TGTCTAGACC TACGGAGAAG ACGGTCTTTC TGGTGTTCAT GTTTGCTGTG 
AGCGGCATTT GTGTGGTGCT CAATCTGGCT GAACTTAACC ATCTGGGATG GCGGAAGATC 
AAACTGGCTG TCCGGGGAGC CCAGGCCAAG AGGAAGTCAG TCTATGAGAT TCGTAACAAA 
GACCTGCCAA GAGTCAGTGT TCCCAATTTC GGCAGGACTC AGTCCAGTGA CTCCGCCTAT 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia.
The European journal of neuroscience46(2)1790-1804(2017 Jul)
Nagy JI,Rash JE

Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.
Cell death & disease8(6)e2881(2017 Jun)
Corsini S,Tortora M,Rauti R,Nistri A

Hippocampal Expression of Connexin36 and Connexin43 during Epileptogenesis in Pilocarpine Model of Epilepsy.
ian biomedical journal21(3)167-73(2017 05)
Motaghi S,Sayyah M,Babapour V,Mahdian R

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Gjd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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