Srf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srf
Entrez Gene ID	501099
Full Name	serum response factor
Synonyms	RGD1559787
General protein information	Preferred Names serum response factor Names serum response factor serum response factor (c-fos serum response element-binding transcription factor)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109302.1	NP_001102772.1	serum response factor
XM_006244557.3	XP_006244619.1	serum response factor isoform X1
XM_006244558.3	XP_006244620.1	serum response factor isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SRF	NP_003122.1
Pan troglodytes (chimpanzee)	SRF	XP_518487.4
Bos taurus (cattle)	SRF	NP_001192945.1
Mus musculus (house mouse)	Srf	NP_065239.1
Danio rerio (zebrafish)	srfa	NP_001103996.1
Xenopus tropicalis (tropical clawed frog)	srf	XP_002942523.2
Gallus gallus (chicken)	SRF	NP_001239070.1
	SRF	XP_001093365.2
Canis lupus familiaris (dog)	SRF	XP_852302.1
Rattus norvegicus (Norway rat)	Srf	NP_001102772.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypoxia-induced microRNA-26b inhibition contributes to hypoxic pulmonary hypertension via CTGF.
Zhou S, Sun L, Cao C, Wu P, Li M, Sun G, Fei G, Ding X, Wang R
Journal of cellular biochemistry119(2)1942-1952(2018 Feb)

Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy.
Cheng XY, Li SY, Mao CJ, Wang MX, Chen J, Wang F, Wang GH, Deng WB, Li XK, Liu CF
Neuroscience371288-295(2017 Nov)

Upregulation of SRF Is Associated With Hypoxic Pulmonary Hypertension by Promoting Viability of Smooth Muscle Cells via Increasing Expression of Bcl-2.
Ding X, Zhou S, Li M, Cao C, Wu P, Sun L, Fei G, Wang R
Journal of cellular biochemistry118(9)2731-2738(2017 Sep)

Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis.
Fan Y, Zhang J, Chen CY, Xiao YB, Asico LD, Jose PA, Xu JC, Qian GS, Zeng CY
Cardiovascular research113(5)519-530(2017 Apr)

An Alternative Promoter in Intron1 of the Renin Gene is Regulated by Glucose Starvation via Serum Response Factor.
Lutze P, Wanka H, B?umgen I, Staar D, Grunow B, Peters J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1447-1457(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data validated that SRF responded to hypoxia, which subsequently was involved in pulmonary hypertension by abnormally promoting viability of PASMCs via modulating expression of Bcl-2.
Title: Upregulation of SRF Is Associated With Hypoxic Pulmonary Hypertension by Promoting Viability of Smooth Muscle Cells via Increasing Expression of Bcl-2.

MIF triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor signaling axis.
Title: Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis.

Olfactomedin 2 regulates vascular smooth muscle phenotype and vascular remodeling by regulating Runx2/serum response factor interaction.
Title: Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor.

SRF/myocardin pathway acts as a pivotal mediator of aortic vascular smooth muscle cells mechanical properties and plays a central role in the pathological aortic stiffening in hypertension.
Title: Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension.

An alternative promoter in intron1 of the renin gene is regulated by glucose starvation via SRF.
Title: An Alternative Promoter in Intron1 of the Renin Gene is Regulated by Glucose Starvation via Serum Response Factor.

The following Srf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12284	NM_001109302.1 Latest version!	Rattus norvegicus serum response factor (Srf), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa12284	XM_006244557.3 Latest version!	Rattus norvegicus serum response factor (Srf), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa32030	XM_006244558.3 Latest version!	Rattus norvegicus serum response factor (Srf), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srf ( NM_001109302.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102772.1 Rattus norvegicus serum response factor (Srf), mRNA.

Price & Availability↑

CloneID	ORa12284
Clone ID Related Accession (Same CDS sequence)	NM_001109302.1 , XM_006244557.3
Accession Version	NM_001109302.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	serum response factor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473987.2. On or before Oct 4, 2007 this sequence version replaced XM_001063545.1, XM_576514.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTTACCGA GCCAAGCTGG GGCCGCGGCG GCTCTGGGCC GGGGCTCGGC CCTGGGGGGC 
AGCCTGAACA GGACCCCGAC GGGGCGGCCG GGCGGCAGCG GTGGGACTCG CGGGGCGAAC 
GGGGGCCGGG TCCCCGGGAA CGGCGCGGGG CTCGGCCCGG GTCGTCTGGA GCGGGAGGCT 
GCAGCAGCAG CAGCGCCCAC CGCCGGGGCC CTCTACAGCG GCAGCGAGGG CGACTCTGAG 
TCCGGCGAGG AGGAGGAGCT GGGCGCCGAG CGGCGCGGCC TCAAGCGGAG TCTGAGCGAG 
ATGGAGCTCG GTGTGGTGGT CGGTGGGCCT GAGGCGGCGG CGGCGGCCGC CGGAGGCTAC 
GGACCGGTGA GCGGCGCGGT GAGCGGGGCC AAGCCGGGGA AGAAGACCCG GGGCCGCGTG 
AAGATCAAGA TGGAGTTCAT CGACAACAAG CTGCGGCGTT ACACGACCTT CAGCAAGAGG 
AAGACGGGCA TCATGAAGAA GGCTTATGAG CTGTCCACGC TGACAGGGAC ACAGGTGCTG 
TTGCTGGTGG CCAGTGAGAC AGGCCATGTG TATACCTTTG CCACCCGCAA ACTGCAGCCC 
ATGATCACCA GTGAGACCGG CAAGGCGCTG ATTCAGACCT GCCTCAACTC GCCAGACTCT 
CCACCCCGCT CAGACCCCAG CACAGACCAG AGAATGAGTG CCACTGGCTT TGAAGAGCCA 
GATCTCACCT ACCAGGTGTC GGAATCTGAC AGCAGTGGGG AAACCAAGGA CACACTGAAG 
CCAGCATTCA CAGTCACCAA CCTGCCGGGT ACCACCTCCA CAATCCAAAC AGCACCCAGC 
ACCTCTACCA CCATGCAAGT CAGCAGCGGC CCCTCCTTCC CCATCACCAA CTACCTGGCA 
CCAGTGTCTG CTAGTGTCAG CCCCAGTGCT GTCAGCAGTG CCAACGGGAC TGTGCTCAAG 
AGTACAGGCA GCGGCCCTGT CTCCTCTGGG GGCCTTATGC AGCTGCCTAC CAGCTTCACT 
CTCATGCCTG GTGGGGCAGT GGCCCAGCAG GTCCCTGTGC AGGCCATTCA TGTGCACCAG 
GCCCCACAGC AAGCGTCTCC CTCTCGTGAC AGCAGCACAG ACCTCACGCA GACCTCCTCC 
AGCGGGACAG TGACGTTGCC CGCCACCATC ATGACGTCGT CTGTACCCAC AACTGTGGGT 
GGCCACATGA TGTACCCTAG TCCCCATGCA GTGATGTATG CCCCCACCTC GGGCCTGGCT 
GATGGCAGCC TCACCGTGCT CAATGCCTTC TCTCAGGCAC CATCCACCAT GCAGGTGTCC 
CACAGCCAGG TCCAGGAGCC AGGTGGTGTC CCTCAGGTGT TCCTCACAGC ACCGTCTGGG 
ACCGTGCAGA TCCCTGTCTC TGCCGTTCAG CTTCACCAGA TGGCTGTGAT AGGACAGCAA 
GCTGGGAGCA GCAGCAACCT CACCGAGCTA CAGGTGGTGA ACTTGGACGC CACCCACAGC 
ACCAAGAGTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102772.1
CDS	329..1843
Translation	MLPSQAGAAAALGRGSALGGSLNRTPTGRPGGSGGTRGANGGRVPGNGAGLGPGRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPSTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE

Target ORF information:

RefSeq Version	NM_001109302.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serum response factor (Srf), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109302.1

ORF Insert Sequence:

ATGTTACCGA GCCAAGCTGG GGCCGCGGCG GCTCTGGGCC GGGGCTCGGC CCTGGGGGGC 
AGCCTGAACA GGACCCCGAC GGGGCGGCCG GGCGGCAGCG GTGGGACTCG CGGGGCGAAC 
GGGGGCCGGG TCCCCGGGAA CGGCGCGGGG CTCGGCCCGG GTCGTCTGGA GCGGGAGGCT 
GCAGCAGCAG CAGCGCCCAC CGCCGGGGCC CTCTACAGCG GCAGCGAGGG CGACTCTGAG 
TCCGGCGAGG AGGAGGAGCT GGGCGCCGAG CGGCGCGGCC TCAAGCGGAG TCTGAGCGAG 
ATGGAGCTCG GTGTGGTGGT CGGTGGGCCT GAGGCGGCGG CGGCGGCCGC CGGAGGCTAC 
GGACCGGTGA GCGGCGCGGT GAGCGGGGCC AAGCCGGGGA AGAAGACCCG GGGCCGCGTG 
AAGATCAAGA TGGAGTTCAT CGACAACAAG CTGCGGCGTT ACACGACCTT CAGCAAGAGG 
AAGACGGGCA TCATGAAGAA GGCTTATGAG CTGTCCACGC TGACAGGGAC ACAGGTGCTG 
TTGCTGGTGG CCAGTGAGAC AGGCCATGTG TATACCTTTG CCACCCGCAA ACTGCAGCCC 
ATGATCACCA GTGAGACCGG CAAGGCGCTG ATTCAGACCT GCCTCAACTC GCCAGACTCT 
CCACCCCGCT CAGACCCCAG CACAGACCAG AGAATGAGTG CCACTGGCTT TGAAGAGCCA 
GATCTCACCT ACCAGGTGTC GGAATCTGAC AGCAGTGGGG AAACCAAGGA CACACTGAAG 
CCAGCATTCA CAGTCACCAA CCTGCCGGGT ACCACCTCCA CAATCCAAAC AGCACCCAGC 
ACCTCTACCA CCATGCAAGT CAGCAGCGGC CCCTCCTTCC CCATCACCAA CTACCTGGCA 
CCAGTGTCTG CTAGTGTCAG CCCCAGTGCT GTCAGCAGTG CCAACGGGAC TGTGCTCAAG 
AGTACAGGCA GCGGCCCTGT CTCCTCTGGG GGCCTTATGC AGCTGCCTAC CAGCTTCACT 
CTCATGCCTG GTGGGGCAGT GGCCCAGCAG GTCCCTGTGC AGGCCATTCA TGTGCACCAG 
GCCCCACAGC AAGCGTCTCC CTCTCGTGAC AGCAGCACAG ACCTCACGCA GACCTCCTCC 
AGCGGGACAG TGACGTTGCC CGCCACCATC ATGACGTCGT CTGTACCCAC AACTGTGGGT 
GGCCACATGA TGTACCCTAG TCCCCATGCA GTGATGTATG CCCCCACCTC GGGCCTGGCT 
GATGGCAGCC TCACCGTGCT CAATGCCTTC TCTCAGGCAC CATCCACCAT GCAGGTGTCC 
CACAGCCAGG TCCAGGAGCC AGGTGGTGTC CCTCAGGTGT TCCTCACAGC ACCGTCTGGG 
ACCGTGCAGA TCCCTGTCTC TGCCGTTCAG CTTCACCAGA TGGCTGTGAT AGGACAGCAA 
GCTGGGAGCA GCAGCAACCT CACCGAGCTA CAGGTGGTGA ACTTGGACGC CACCCACAGC 
ACCAAGAGTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srf ( XM_006244557.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006244619.1 Rattus norvegicus serum response factor (Srf), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12284
Clone ID Related Accession (Same CDS sequence)	NM_001109302.1 , XM_006244557.3
Accession Version	XM_006244557.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serum response factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006244557.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTACCGA GCCAAGCTGG GGCCGCGGCG GCTCTGGGCC GGGGCTCGGC CCTGGGGGGC 
AGCCTGAACA GGACCCCGAC GGGGCGGCCG GGCGGCAGCG GTGGGACTCG CGGGGCGAAC 
GGGGGCCGGG TCCCCGGGAA CGGCGCGGGG CTCGGCCCGG GTCGTCTGGA GCGGGAGGCT 
GCAGCAGCAG CAGCGCCCAC CGCCGGGGCC CTCTACAGCG GCAGCGAGGG CGACTCTGAG 
TCCGGCGAGG AGGAGGAGCT GGGCGCCGAG CGGCGCGGCC TCAAGCGGAG TCTGAGCGAG 
ATGGAGCTCG GTGTGGTGGT CGGTGGGCCT GAGGCGGCGG CGGCGGCCGC CGGAGGCTAC 
GGACCGGTGA GCGGCGCGGT GAGCGGGGCC AAGCCGGGGA AGAAGACCCG GGGCCGCGTG 
AAGATCAAGA TGGAGTTCAT CGACAACAAG CTGCGGCGTT ACACGACCTT CAGCAAGAGG 
AAGACGGGCA TCATGAAGAA GGCTTATGAG CTGTCCACGC TGACAGGGAC ACAGGTGCTG 
TTGCTGGTGG CCAGTGAGAC AGGCCATGTG TATACCTTTG CCACCCGCAA ACTGCAGCCC 
ATGATCACCA GTGAGACCGG CAAGGCGCTG ATTCAGACCT GCCTCAACTC GCCAGACTCT 
CCACCCCGCT CAGACCCCAG CACAGACCAG AGAATGAGTG CCACTGGCTT TGAAGAGCCA 
GATCTCACCT ACCAGGTGTC GGAATCTGAC AGCAGTGGGG AAACCAAGGA CACACTGAAG 
CCAGCATTCA CAGTCACCAA CCTGCCGGGT ACCACCTCCA CAATCCAAAC AGCACCCAGC 
ACCTCTACCA CCATGCAAGT CAGCAGCGGC CCCTCCTTCC CCATCACCAA CTACCTGGCA 
CCAGTGTCTG CTAGTGTCAG CCCCAGTGCT GTCAGCAGTG CCAACGGGAC TGTGCTCAAG 
AGTACAGGCA GCGGCCCTGT CTCCTCTGGG GGCCTTATGC AGCTGCCTAC CAGCTTCACT 
CTCATGCCTG GTGGGGCAGT GGCCCAGCAG GTCCCTGTGC AGGCCATTCA TGTGCACCAG 
GCCCCACAGC AAGCGTCTCC CTCTCGTGAC AGCAGCACAG ACCTCACGCA GACCTCCTCC 
AGCGGGACAG TGACGTTGCC CGCCACCATC ATGACGTCGT CTGTACCCAC AACTGTGGGT 
GGCCACATGA TGTACCCTAG TCCCCATGCA GTGATGTATG CCCCCACCTC GGGCCTGGCT 
GATGGCAGCC TCACCGTGCT CAATGCCTTC TCTCAGGCAC CATCCACCAT GCAGGTGTCC 
CACAGCCAGG TCCAGGAGCC AGGTGGTGTC CCTCAGGTGT TCCTCACAGC ACCGTCTGGG 
ACCGTGCAGA TCCCTGTCTC TGCCGTTCAG CTTCACCAGA TGGCTGTGAT AGGACAGCAA 
GCTGGGAGCA GCAGCAACCT CACCGAGCTA CAGGTGGTGA ACTTGGACGC CACCCACAGC 
ACCAAGAGTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006244619.1
CDS	334..1848
Translation	MLPSQAGAAAALGRGSALGGSLNRTPTGRPGGSGGTRGANGGRVPGNGAGLGPGRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPSTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE

Target ORF information:

RefSeq Version	XM_006244557.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serum response factor (Srf), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244557.3

ORF Insert Sequence:

ATGTTACCGA GCCAAGCTGG GGCCGCGGCG GCTCTGGGCC GGGGCTCGGC CCTGGGGGGC 
AGCCTGAACA GGACCCCGAC GGGGCGGCCG GGCGGCAGCG GTGGGACTCG CGGGGCGAAC 
GGGGGCCGGG TCCCCGGGAA CGGCGCGGGG CTCGGCCCGG GTCGTCTGGA GCGGGAGGCT 
GCAGCAGCAG CAGCGCCCAC CGCCGGGGCC CTCTACAGCG GCAGCGAGGG CGACTCTGAG 
TCCGGCGAGG AGGAGGAGCT GGGCGCCGAG CGGCGCGGCC TCAAGCGGAG TCTGAGCGAG 
ATGGAGCTCG GTGTGGTGGT CGGTGGGCCT GAGGCGGCGG CGGCGGCCGC CGGAGGCTAC 
GGACCGGTGA GCGGCGCGGT GAGCGGGGCC AAGCCGGGGA AGAAGACCCG GGGCCGCGTG 
AAGATCAAGA TGGAGTTCAT CGACAACAAG CTGCGGCGTT ACACGACCTT CAGCAAGAGG 
AAGACGGGCA TCATGAAGAA GGCTTATGAG CTGTCCACGC TGACAGGGAC ACAGGTGCTG 
TTGCTGGTGG CCAGTGAGAC AGGCCATGTG TATACCTTTG CCACCCGCAA ACTGCAGCCC 
ATGATCACCA GTGAGACCGG CAAGGCGCTG ATTCAGACCT GCCTCAACTC GCCAGACTCT 
CCACCCCGCT CAGACCCCAG CACAGACCAG AGAATGAGTG CCACTGGCTT TGAAGAGCCA 
GATCTCACCT ACCAGGTGTC GGAATCTGAC AGCAGTGGGG AAACCAAGGA CACACTGAAG 
CCAGCATTCA CAGTCACCAA CCTGCCGGGT ACCACCTCCA CAATCCAAAC AGCACCCAGC 
ACCTCTACCA CCATGCAAGT CAGCAGCGGC CCCTCCTTCC CCATCACCAA CTACCTGGCA 
CCAGTGTCTG CTAGTGTCAG CCCCAGTGCT GTCAGCAGTG CCAACGGGAC TGTGCTCAAG 
AGTACAGGCA GCGGCCCTGT CTCCTCTGGG GGCCTTATGC AGCTGCCTAC CAGCTTCACT 
CTCATGCCTG GTGGGGCAGT GGCCCAGCAG GTCCCTGTGC AGGCCATTCA TGTGCACCAG 
GCCCCACAGC AAGCGTCTCC CTCTCGTGAC AGCAGCACAG ACCTCACGCA GACCTCCTCC 
AGCGGGACAG TGACGTTGCC CGCCACCATC ATGACGTCGT CTGTACCCAC AACTGTGGGT 
GGCCACATGA TGTACCCTAG TCCCCATGCA GTGATGTATG CCCCCACCTC GGGCCTGGCT 
GATGGCAGCC TCACCGTGCT CAATGCCTTC TCTCAGGCAC CATCCACCAT GCAGGTGTCC 
CACAGCCAGG TCCAGGAGCC AGGTGGTGTC CCTCAGGTGT TCCTCACAGC ACCGTCTGGG 
ACCGTGCAGA TCCCTGTCTC TGCCGTTCAG CTTCACCAGA TGGCTGTGAT AGGACAGCAA 
GCTGGGAGCA GCAGCAACCT CACCGAGCTA CAGGTGGTGA ACTTGGACGC CACCCACAGC 
ACCAAGAGTG AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srf ( XM_006244558.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006244620.1 Rattus norvegicus serum response factor (Srf), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa32030
Clone ID Related Accession (Same CDS sequence)	XM_006244558.3
Accession Version	XM_006244558.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serum response factor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006244558.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTACCGA GCCAAGCTGG GGCCGCGGCG GCTCTGGGCC GGGGCTCGGC CCTGGGGGGC 
AGCCTGAACA GGACCCCGAC GGGGCGGCCG GGCGGCAGCG GTGGGACTCG CGGGGCGAAC 
GGGGGCCGGG TCCCCGGGAA CGGCGCGGGG CTCGGCCCGG GTCGTCTGGA GCGGGAGGCT 
GCAGCAGCAG CAGCGCCCAC CGCCGGGGCC CTCTACAGCG GCAGCGAGGG CGACTCTGAG 
TCCGGCGAGG AGGAGGAGCT GGGCGCCGAG CGGCGCGGCC TCAAGCGGAG TCTGAGCGAG 
ATGGAGCTCG GTGTGGTGGT CGGTGGGCCT GAGGCGGCGG CGGCGGCCGC CGGAGGCTAC 
GGACCGGTGA GCGGCGCGGT GAGCGGGGCC AAGCCGGGGA AGAAGACCCG GGGCCGCGTG 
AAGATCAAGA TGGAGTTCAT CGACAACAAG CTGCGGCGTT ACACGACCTT CAGCAAGAGG 
AAGACGGGCA TCATGAAGAA GGCTTATGAG CTGTCCACGC TGACAGGGAC ACAGGTGCTG 
TTGCTGGTGG CCAGTGAGAC AGGCCATGTG TATACCTTTG CCACCCGCAA ACTGCAGCCC 
ATGATCACCA GTGAGACCGG CAAGGCGCTG ATTCAGACCT GCCTCAACTC GCCAGACTCT 
CCACCCCGCT CAGACCCCAG CACAGACCAG AGAATGAGTG CCACTGGCTT TGAAGAGCCA 
GATCTCACCT ACCAGGTGTC GGAATCTGAC AGCAGTGGGG AAACCAAGGA CACACTGAAG 
CCAGCATTCA CAGTCACCAA CCTGCCGGGT ACCACCTCCA CAATCCAAAC AGCACCCAGC 
ACCTCTACCA CCATGCAAGT CAGCAGCGGC CCCTCCTTCC CCATCACCAA CTACCTGGCA 
CCAGTGTCTG CTAGTGTCAG CCCCAGTGCT GTCAGCAGTG CCAACGGGAC TGTGCTCAAG 
AGTACAGGCA GCGGCCCTGT CTCCTCTGGG GGCCTTATGC AGCTGCCTAC CAGCTTCACT 
CTCATGCCTG GTGGGGCAGT GGCCCAGCAG GTCCCTGTGC AGGCCATTCA TGTGCACCAG 
GCCCCACAGC AAGCGTCTCC CTCTCGTGAC AGCAGCACAG ACCTCACGCA GACCTCCTCC 
AGCGGGACAG GTGGTGTCCC TCAGGTGTTC CTCACAGCAC CGTCTGGGAC CGTGCAGATC 
CCTGTCTCTG CCGTTCAGCT TCACCAGATG GCTGTGATAG GACAGCAAGC TGGGAGCAGC 
AGCAACCTCA CCGAGCTACA GGTGGTGAAC TTGGACGCCA CCCACAGCAC CAAGAGTGAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006244620.1
CDS	334..1656
Translation	MLPSQAGAAAALGRGSALGGSLNRTPTGRPGGSGGTRGANGGRVPGNGAGLGPGRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPSTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE

Target ORF information:

RefSeq Version	XM_006244558.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serum response factor (Srf), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244558.3

ORF Insert Sequence:

ATGTTACCGA GCCAAGCTGG GGCCGCGGCG GCTCTGGGCC GGGGCTCGGC CCTGGGGGGC 
AGCCTGAACA GGACCCCGAC GGGGCGGCCG GGCGGCAGCG GTGGGACTCG CGGGGCGAAC 
GGGGGCCGGG TCCCCGGGAA CGGCGCGGGG CTCGGCCCGG GTCGTCTGGA GCGGGAGGCT 
GCAGCAGCAG CAGCGCCCAC CGCCGGGGCC CTCTACAGCG GCAGCGAGGG CGACTCTGAG 
TCCGGCGAGG AGGAGGAGCT GGGCGCCGAG CGGCGCGGCC TCAAGCGGAG TCTGAGCGAG 
ATGGAGCTCG GTGTGGTGGT CGGTGGGCCT GAGGCGGCGG CGGCGGCCGC CGGAGGCTAC 
GGACCGGTGA GCGGCGCGGT GAGCGGGGCC AAGCCGGGGA AGAAGACCCG GGGCCGCGTG 
AAGATCAAGA TGGAGTTCAT CGACAACAAG CTGCGGCGTT ACACGACCTT CAGCAAGAGG 
AAGACGGGCA TCATGAAGAA GGCTTATGAG CTGTCCACGC TGACAGGGAC ACAGGTGCTG 
TTGCTGGTGG CCAGTGAGAC AGGCCATGTG TATACCTTTG CCACCCGCAA ACTGCAGCCC 
ATGATCACCA GTGAGACCGG CAAGGCGCTG ATTCAGACCT GCCTCAACTC GCCAGACTCT 
CCACCCCGCT CAGACCCCAG CACAGACCAG AGAATGAGTG CCACTGGCTT TGAAGAGCCA 
GATCTCACCT ACCAGGTGTC GGAATCTGAC AGCAGTGGGG AAACCAAGGA CACACTGAAG 
CCAGCATTCA CAGTCACCAA CCTGCCGGGT ACCACCTCCA CAATCCAAAC AGCACCCAGC 
ACCTCTACCA CCATGCAAGT CAGCAGCGGC CCCTCCTTCC CCATCACCAA CTACCTGGCA 
CCAGTGTCTG CTAGTGTCAG CCCCAGTGCT GTCAGCAGTG CCAACGGGAC TGTGCTCAAG 
AGTACAGGCA GCGGCCCTGT CTCCTCTGGG GGCCTTATGC AGCTGCCTAC CAGCTTCACT 
CTCATGCCTG GTGGGGCAGT GGCCCAGCAG GTCCCTGTGC AGGCCATTCA TGTGCACCAG 
GCCCCACAGC AAGCGTCTCC CTCTCGTGAC AGCAGCACAG ACCTCACGCA GACCTCCTCC 
AGCGGGACAG GTGGTGTCCC TCAGGTGTTC CTCACAGCAC CGTCTGGGAC CGTGCAGATC 
CCTGTCTCTG CCGTTCAGCT TCACCAGATG GCTGTGATAG GACAGCAAGC TGGGAGCAGC 
AGCAACCTCA CCGAGCTACA GGTGGTGAAC TTGGACGCCA CCCACAGCAC CAAGAGTGAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypoxia-induced microRNA-26b inhibition contributes to hypoxic pulmonary hypertension via CTGF.
Journal of cellular biochemistry119(2)1942-1952(2018 Feb)
Zhou S,Sun L,Cao C,Wu P,Li M,Sun G,Fei G,Ding X,Wang R

Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy.
Neuroscience371288-295(2017 Nov)
Cheng XY,Li SY,Mao CJ,Wang MX,Chen J,Wang F,Wang GH,Deng WB,Li XK,Liu CF

Upregulation of SRF Is Associated With Hypoxic Pulmonary Hypertension by Promoting Viability of Smooth Muscle Cells via Increasing Expression of Bcl-2.
Journal of cellular biochemistry118(9)2731-2738(2017 Sep)
Ding X,Zhou S,Li M,Cao C,Wu P,Sun L,Fei G,Wang R

Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis.
Cardiovascular research113(5)519-530(2017 Apr)
Fan Y,Zhang J,Chen CY,Xiao YB,Asico LD,Jose PA,Xu JC,Qian GS,Zeng CY

An Alternative Promoter in Intron1 of the Renin Gene is Regulated by Glucose Starvation via Serum Response Factor.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1447-1457(2017)
Lutze P,Wanka H,B?umgen I,Staar D,Grunow B,Peters J

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Srf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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