Rftn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rftn1
Entrez Gene ID	501095
Full Name	raftlin lipid raft linker 1
Synonyms	2310015n21rik,RGD1310777,RGD1563347
General protein information	Preferred Names raftlin lipid raft linker 1 Names raftlin raft-linking protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135011.1	NP_001128483.1	raftlin

Pathways from BioSystems

Homologies

Homo sapiens (human)	RFTN1	NP_055965.1
Canis lupus familiaris (dog)	RFTN1	XP_542773.4
Mus musculus (house mouse)	Rftn1	NP_852062.1
Xenopus tropicalis (tropical clawed frog)	rftn1	NP_001106555.1
	RFTN1	XP_001083771.2
Rattus norvegicus (Norway rat)	Rftn1	NP_001128483.1
Pan troglodytes (chimpanzee)	RFTN1	XP_516313.3
Gallus gallus (chicken)	RFTN1	NP_989789.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.
Tidwell JA, Schmidt C, Heaton P, Wilson V, Tucker PW
Molecular immunology49(1-2)260-72(2011 Oct)

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M
The Journal of biological chemistry286(12)10702-11(2011 Mar)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.
Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A
Journal of immunology (Baltimore, Md. : 1950)182(10)5929-37(2009 May)

The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.
Saeki K, Miura Y, Aki D, Kurosaki T, Yoshimura A
The EMBO journal22(12)3015-26(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rftn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rftn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13929	NM_001135011.1 Latest version!	Rattus norvegicus raftlin lipid raft linker 1 (Rftn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rftn1 ( NM_001135011.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128483.1 Rattus norvegicus raftlin lipid raft linker 1 (Rftn1), mRNA.

Price & Availability↑

CloneID	ORa13929
Clone ID Related Accession (Same CDS sequence)	NM_001135011.1
Accession Version	NM_001135011.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1665bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	raftlin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07066725.1 and AABR07066726.1. On or before Sep 17, 2008 this sequence version replaced XM_001062448.1, XM_576510.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGTTGCA GTTTGAACAA GCTGGAGAAA CGTGAAGAGA AGCGGCCTGG TAACATTTAC 
TCTACTCTGA AGAGACCTCA GGTGGAGACC AAGATAGATG TGACCTATGA ATACTGCTTT 
CTAGAGTTCA CCACCCTGAC TGCCGCGGAG CTGCCGAGAT CCTCAGCCAC AAGGTTAGCT 
TCTCTGCGGG ATCTGCCTGA CCAGCTGCTG GAGCTGTACC AGCAGGGCTT CTCGCTGGCC 
GCCCTGCACC CGTTTGTGCA GCCGACGCGC AGGCAAGAGA AGATACCCCT GGAGCACATC 
TTCAGGGCCA TCCTGGTCAA GAAAACCAGC AGGTCCCAGA AGGCAGAGCT TCCCAATGAA 
GGGTACATCT TGGAACTGGA TCACTGCTCC TCCTTAGAAC ACCTGGCAGA CCAGAAGCTC 
GTCCCGGAGT TCATTAAGAA GGTACAGGAG GCTGCGAGTC GTGGCTTGAA GTTCGTTAGT 
GTGGTGCCTC AGTACCAGAC CTCTGTGAGC TCGGCAGGCA GCACGCGCTT CCTGCCTGTC 
ACCAACAGTG ACGAAGGTGC CAGGGATGGG AAGAACACCT TTGGGGACCG GCCATCTTTG 
GAAAGTGATA CCCCAAAGGC TGCGGATGTG GACGATGCCA CTGCGGGAGT GAACCAGAGA 
CCAGAGCCCA ACCCGGGATC CGCAGGGGAG GCGCCCGGTG CCCAGCAGCC TGGCATTCCC 
TCTCCCTCAG AAGAGAATGA GGCTGTCGAG TTTCCACTGC GGGGTTTGAG GCCAGCACTG 
GGTGGCTTGG AGGGTGACCC CTCCAATGGG CCTGAAGAGC TGCCTTCCAG GAAAATGGAG 
ATCTTCGCCT TTTTCAACAG ACCAAGGAGC CAGCAGAAAT GTCTGCAATA CTACCCCGTC 
ACCATCCCCC TCCAGGTCTC CAAGAACGGC CAGACAGTGA GCAGTCTGGA CGCCAGCTGG 
CTGGAGCACA TGAGTGACCA CTTCCGGAAA GGCGGTGTGC TGGTGAACGC CGTCTTCCAG 
CTTGGCATGG CCAACGATTC CTTCTATGGC CTGACAGATG GAGTATTCAT CTTTGAAGCT 
GTTTCCACAG AAGATAGCAA AACCACACAG GGCTATGACG CCATTGTTGT GGAACAATGG 
ACAGTCCTGG AAGGTACAGA GGTGCAGACC GACTACATGC CCCTGCTGAA CTCGCTGGCA 
GCCTATGGGT GGCAGCTCAC CTGTGTGCTG CCAACACCCA TACTCAAGAC TAACAGGGAA 
GGGAACGTGT GCACCAAGCA GATTGTGTTT CTCCAGAGAC CATGTCTACC TCAGAAAACC 
AAGAAGAGGG AGTCCAAGTT CCAGTGGCGG TTCTCCCGGA ACGACATCCA CAGCAGGCAG 
ACAAGGAAAT CCAAAGGGAA ACCCAGCGCC GGAGACAAGC AGCAAGCGGA AGAGAACGAG 
AAGAATCTAG ACGACCAGTT CTCCAGGGCT GGAGATGCGG GAAACTGTGT GCTGGGGGCA 
CAGCAGTGGG GCAGAGCCTC TGAGGTCAGG GAGCAAAGGC CGGGCTCAGC CGCCGTGCAG 
AACGGCCCCG CTGGCCACAA CAGGGACTCG GTGACCCTTA GGCACTCGAA TCCCAGAGCA 
GAGGCTGAGC TGGTTCCAGG CCCCGCTCCA ACAGAAGCAA ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128483.1
CDS	158..1822
Translation	MGCSLNKLEKREEKRPGNIYSTLKRPQVETKIDVTYEYCFLEFTTLTAAELPRSSATRLASLRDLPDQLLELYQQGFSLAALHPFVQPTRRQEKIPLEHIFRAILVKKTSRSQKAELPNEGYILELDHCSSLEHLADQKLVPEFIKKVQEAASRGLKFVSVVPQYQTSVSSAGSTRFLPVTNSDEGARDGKNTFGDRPSLESDTPKAADVDDATAGVNQRPEPNPGSAGEAPGAQQPGIPSPSEENEAVEFPLRGLRPALGGLEGDPSNGPEELPSRKMEIFAFFNRPRSQQKCLQYYPVTIPLQVSKNGQTVSSLDASWLEHMSDHFRKGGVLVNAVFQLGMANDSFYGLTDGVFIFEAVSTEDSKTTQGYDAIVVEQWTVLEGTEVQTDYMPLLNSLAAYGWQLTCVLPTPILKTNREGNVCTKQIVFLQRPCLPQKTKKRESKFQWRFSRNDIHSRQTRKSKGKPSAGDKQQAEENEKNLDDQFSRAGDAGNCVLGAQQWGRASEVREQRPGSAAVQNGPAGHNRDSVTLRHSNPRAEAELVPGPAPTEAN

Target ORF information:

RefSeq Version	NM_001135011.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus raftlin lipid raft linker 1 (Rftn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135011.1

ORF Insert Sequence:

ATGGGTTGCA GTTTGAACAA GCTGGAGAAA CGTGAAGAGA AGCGGCCTGG TAACATTTAC 
TCTACTCTGA AGAGACCTCA GGTGGAGACC AAGATAGATG TGACCTATGA ATACTGCTTT 
CTAGAGTTCA CCACCCTGAC TGCCGCGGAG CTGCCGAGAT CCTCAGCCAC AAGGTTAGCT 
TCTCTGCGGG ATCTGCCTGA CCAGCTGCTG GAGCTGTACC AGCAGGGCTT CTCGCTGGCC 
GCCCTGCACC CGTTTGTGCA GCCGACGCGC AGGCAAGAGA AGATACCCCT GGAGCACATC 
TTCAGGGCCA TCCTGGTCAA GAAAACCAGC AGGTCCCAGA AGGCAGAGCT TCCCAATGAA 
GGGTACATCT TGGAACTGGA TCACTGCTCC TCCTTAGAAC ACCTGGCAGA CCAGAAGCTC 
GTCCCGGAGT TCATTAAGAA GGTACAGGAG GCTGCGAGTC GTGGCTTGAA GTTCGTTAGT 
GTGGTGCCTC AGTACCAGAC CTCTGTGAGC TCGGCAGGCA GCACGCGCTT CCTGCCTGTC 
ACCAACAGTG ACGAAGGTGC CAGGGATGGG AAGAACACCT TTGGGGACCG GCCATCTTTG 
GAAAGTGATA CCCCAAAGGC TGCGGATGTG GACGATGCCA CTGCGGGAGT GAACCAGAGA 
CCAGAGCCCA ACCCGGGATC CGCAGGGGAG GCGCCCGGTG CCCAGCAGCC TGGCATTCCC 
TCTCCCTCAG AAGAGAATGA GGCTGTCGAG TTTCCACTGC GGGGTTTGAG GCCAGCACTG 
GGTGGCTTGG AGGGTGACCC CTCCAATGGG CCTGAAGAGC TGCCTTCCAG GAAAATGGAG 
ATCTTCGCCT TTTTCAACAG ACCAAGGAGC CAGCAGAAAT GTCTGCAATA CTACCCCGTC 
ACCATCCCCC TCCAGGTCTC CAAGAACGGC CAGACAGTGA GCAGTCTGGA CGCCAGCTGG 
CTGGAGCACA TGAGTGACCA CTTCCGGAAA GGCGGTGTGC TGGTGAACGC CGTCTTCCAG 
CTTGGCATGG CCAACGATTC CTTCTATGGC CTGACAGATG GAGTATTCAT CTTTGAAGCT 
GTTTCCACAG AAGATAGCAA AACCACACAG GGCTATGACG CCATTGTTGT GGAACAATGG 
ACAGTCCTGG AAGGTACAGA GGTGCAGACC GACTACATGC CCCTGCTGAA CTCGCTGGCA 
GCCTATGGGT GGCAGCTCAC CTGTGTGCTG CCAACACCCA TACTCAAGAC TAACAGGGAA 
GGGAACGTGT GCACCAAGCA GATTGTGTTT CTCCAGAGAC CATGTCTACC TCAGAAAACC 
AAGAAGAGGG AGTCCAAGTT CCAGTGGCGG TTCTCCCGGA ACGACATCCA CAGCAGGCAG 
ACAAGGAAAT CCAAAGGGAA ACCCAGCGCC GGAGACAAGC AGCAAGCGGA AGAGAACGAG 
AAGAATCTAG ACGACCAGTT CTCCAGGGCT GGAGATGCGG GAAACTGTGT GCTGGGGGCA 
CAGCAGTGGG GCAGAGCCTC TGAGGTCAGG GAGCAAAGGC CGGGCTCAGC CGCCGTGCAG 
AACGGCCCCG CTGGCCACAA CAGGGACTCG GTGACCCTTA GGCACTCGAA TCCCAGAGCA 
GAGGCTGAGC TGGTTCCAGG CCCCGCTCCA ACAGAAGCAA ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.
Molecular immunology49(1-2)260-72(2011 Oct)
Tidwell JA,Schmidt C,Heaton P,Wilson V,Tucker PW

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
The Journal of biological chemistry286(12)10702-11(2011 Mar)
Watanabe A,Tatematsu M,Saeki K,Shibata S,Shime H,Yoshimura A,Obuse C,Seya T,Matsumoto M

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.
Journal of immunology (Baltimore, Md. : 1950)182(10)5929-37(2009 May)
Saeki K,Fukuyama S,Ayada T,Nakaya M,Aki D,Takaesu G,Hanada T,Matsumura Y,Kobayashi T,Nakagawa R,Yoshimura A

The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.
The EMBO journal22(12)3015-26(2003 Jun)
Saeki K,Miura Y,Aki D,Kurosaki T,Yoshimura A

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Rftn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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