Ccnk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccnk
Entrez Gene ID	500715
Full Name	cyclin K
General protein information	Preferred Names cyclin K Names cyclin-K
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32

mRNA and Protein(s)

mRNA	Protein	Name
XM_006240551.3	XP_006240613.1	cyclin-K isoform X1
NM_001109672.1	NP_001103142.1	cyclin-K
XM_006240549.3	XP_006240611.1	cyclin-K isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CCNK	NP_001192910.1
Danio rerio (zebrafish)	ccnk	NP_001157251.1
Gallus gallus (chicken)	CCNK	NP_001026380.1
Homo sapiens (human)	CCNK	NP_001092872.1
Schizosaccharomyces pombe (fission yeast)	pch1	NP_596149.1
Pan troglodytes (chimpanzee)	CCNK	XP_529650.3
Mus musculus (house mouse)	Ccnk	NP_033962.2
Rattus norvegicus (Norway rat)	Ccnk	NP_001103142.1
Xenopus tropicalis (tropical clawed frog)	ccnk	NP_001072323.1
	LOC716572	XP_001107367.2

Gene Ontology
Bibliography

Related articles in PubMed

Control of transcriptional elongation.
Kwak H, Lis JT
Annual review of genetics47483-508(2013)

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.
Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB
Molecular and cellular biology32(22)4691-704(2012 Nov)

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.
Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang S, Song X, Li L, Li Q
The Journal of biological chemistry287(30)25344-52(2012 Jul)

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM
Genes & development25(20)2158-72(2011 Oct)

Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
Khan SZ, Mitra D
The Journal of biological chemistry286(26)22943-54(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ccnk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccnk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa10800	NM_001109672.1 Latest version!	Rattus norvegicus cyclin K (Ccnk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa10800	XM_006240551.3 Latest version!	Rattus norvegicus cyclin K (Ccnk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa10800	XM_006240549.3 Latest version!	Rattus norvegicus cyclin K (Ccnk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccnk ( NM_001109672.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103142.1 Rattus norvegicus cyclin K (Ccnk), mRNA.

Price & Availability↑

CloneID	ORa10800
Clone ID Related Accession (Same CDS sequence)	XM_006240551.3 , NM_001109672.1 , XM_006240549.3
Accession Version	NM_001109672.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-K
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC129121.1. On or before Sep 7, 2008 this sequence version replaced XR_008600.1, XM_580110.2. ##Evidence-Data-START## Transcript exon combination :: BC129121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGAGA ACAAAGAAAA TTCAAGCCCG TCAGTCACAT CAGCAAACCT GGACCACACA 
AAACCATGTT GGTACTGGGA TAAGAAGGAC TTGGCGCATA CACCCTCACA ACTTGAAGGA 
CTCGATCCAG CCACTGAGGC CCGGTACCGC CGAGAGGGGG CTCGCTTCAT CTTTGATGTG 
GGCACACGTT TGGGGTTACA CTATGACACC CTGGCAACTG GAATCATTTA TTTTCACCGA 
TTCTATATGT TCCATTCCTT CAAACAATTC CCAAGATACG TGACAGGAGC CTGTTGTCTC 
TTTCTGGCTG GGAAAGTAGA GGAAACACCA AAAAAGTGTA AAGATATCAT CAAAACGGCT 
CGTAGTTTAT TAAATGATGT CCAGTTTGGC CAGTTTGGAG ATGACCCAAA GGAAGAAGTC 
ATGGTGCTGG AGAGGATCCT ACTGCAGACC ATAAAGTTCG ACTTACAAGT AGAGCATCCG 
TACCAGTTCC TGCTCAAATA CGCCAAGCAG CTGAAAGGTG ATAAAAACAA AATTCAGAAG 
TTGGTTCAAA TGGCATGGAC ATTTGTAAAT GACAGTCTCT GCACCACCCT GTCACTGCAG 
TGGGAGCCAG AAATCATAGC TGTTGCAGTA ATGTATCTTG CGGGACGTTT GTGCAAATTT 
GAAATACAAG AGTGGACCTC CAAGCCCATG TACAGGAGAT GGTGGGAACA ATTTGTTCAA 
GATGTCCCTG TTGACGTTCT GGAAGACATC TGCCACCAAA TCCTGGACCT TTATTCACAA 
GGGAAACAAC AGATGCCTCA CCACACCCCT CATCAGCTGC AGCAGCCCCC ATCTCTTCAG 
CCCACACCAC AAGTGCCCCC GGTGCCACAG GCACAGCCAT CCCAAGGTTC TGAAGCAGCG 
CAGCCGCAGC AGAAGGATGC ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AAGCACAACA GCCCAAGAAA CCATCCCCTC AGCCCAGTCC TCCGCGACAG 
GCCAAGCGTG CCGTGGTGGT GTCTCCCAAG GAAGAGAACA AAGCCACAGA ACCACCACCA 
CCACCTAAAA TTCCCAAACT TGAGGCTGCT CACCCACCAT TGCCTCCAGC ACACCCGCCT 
CCAGACCGGA AGCTTCCCCT TGCTCCTGCC TTAGGTGAGG CTGAACCGAC TGGCCCTGTG 
GAAACAAGTG ACCTCCCTAA AGTCCAGATT CCTCCCCCAG CCCACCCGGC CCCTGTGCAC 
CAGCCCCCAC CACTGCCACA TCGGCCTCCA CCCCCGCCGC CCTCCAGCTA CATGACTGGG 
ATGTCTACCA CCAGCTCCTA CATGTCAGGA GAGGGCTACC AGAGCCTGCA GTCCATGATG 
AAAACAGAGG GGCCCTCCTA TGGCGCCCTT CCCCCAGCCT ATGGCCCACC TGCTCACCTA 
ACATACCATC CCCATGTCTA CCCCCCCAAC CCACCTCCAC CTCCTGTTCC TCCACCCCCA 
GCCTCCTTCC CTCCACCAAC CATCCCTCCC CCTACCCCAG GCTACCCTCC ACCTCCCCCT 
ACCTACAACC CCAATTTTCC ACCCCCGCCC CCACGCCTTC CTCCAACTCA TGCAGTCCCT 
CCTCACCCTC CTCCAGGCTT GGGTTTGCCA CCAGCCAGCT ACCCACCTCC AGCTGTCCCT 
CCTGGGGGGC AACCCCCTGT TCCCCCACCC ATCCCTCCAC CTGGCATGCC GCCTGTTGGG 
GGACTAGGGC GGGCAGCCTG GATGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103142.1
CDS	113..1882
Translation	MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR

Target ORF information:

RefSeq Version	NM_001109672.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin K (Ccnk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109672.1

ORF Insert Sequence:

ATGAAGGAGA ACAAAGAAAA TTCAAGCCCG TCAGTCACAT CAGCAAACCT GGACCACACA 
AAACCATGTT GGTACTGGGA TAAGAAGGAC TTGGCGCATA CACCCTCACA ACTTGAAGGA 
CTCGATCCAG CCACTGAGGC CCGGTACCGC CGAGAGGGGG CTCGCTTCAT CTTTGATGTG 
GGCACACGTT TGGGGTTACA CTATGACACC CTGGCAACTG GAATCATTTA TTTTCACCGA 
TTCTATATGT TCCATTCCTT CAAACAATTC CCAAGATACG TGACAGGAGC CTGTTGTCTC 
TTTCTGGCTG GGAAAGTAGA GGAAACACCA AAAAAGTGTA AAGATATCAT CAAAACGGCT 
CGTAGTTTAT TAAATGATGT CCAGTTTGGC CAGTTTGGAG ATGACCCAAA GGAAGAAGTC 
ATGGTGCTGG AGAGGATCCT ACTGCAGACC ATAAAGTTCG ACTTACAAGT AGAGCATCCG 
TACCAGTTCC TGCTCAAATA CGCCAAGCAG CTGAAAGGTG ATAAAAACAA AATTCAGAAG 
TTGGTTCAAA TGGCATGGAC ATTTGTAAAT GACAGTCTCT GCACCACCCT GTCACTGCAG 
TGGGAGCCAG AAATCATAGC TGTTGCAGTA ATGTATCTTG CGGGACGTTT GTGCAAATTT 
GAAATACAAG AGTGGACCTC CAAGCCCATG TACAGGAGAT GGTGGGAACA ATTTGTTCAA 
GATGTCCCTG TTGACGTTCT GGAAGACATC TGCCACCAAA TCCTGGACCT TTATTCACAA 
GGGAAACAAC AGATGCCTCA CCACACCCCT CATCAGCTGC AGCAGCCCCC ATCTCTTCAG 
CCCACACCAC AAGTGCCCCC GGTGCCACAG GCACAGCCAT CCCAAGGTTC TGAAGCAGCG 
CAGCCGCAGC AGAAGGATGC ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AAGCACAACA GCCCAAGAAA CCATCCCCTC AGCCCAGTCC TCCGCGACAG 
GCCAAGCGTG CCGTGGTGGT GTCTCCCAAG GAAGAGAACA AAGCCACAGA ACCACCACCA 
CCACCTAAAA TTCCCAAACT TGAGGCTGCT CACCCACCAT TGCCTCCAGC ACACCCGCCT 
CCAGACCGGA AGCTTCCCCT TGCTCCTGCC TTAGGTGAGG CTGAACCGAC TGGCCCTGTG 
GAAACAAGTG ACCTCCCTAA AGTCCAGATT CCTCCCCCAG CCCACCCGGC CCCTGTGCAC 
CAGCCCCCAC CACTGCCACA TCGGCCTCCA CCCCCGCCGC CCTCCAGCTA CATGACTGGG 
ATGTCTACCA CCAGCTCCTA CATGTCAGGA GAGGGCTACC AGAGCCTGCA GTCCATGATG 
AAAACAGAGG GGCCCTCCTA TGGCGCCCTT CCCCCAGCCT ATGGCCCACC TGCTCACCTA 
ACATACCATC CCCATGTCTA CCCCCCCAAC CCACCTCCAC CTCCTGTTCC TCCACCCCCA 
GCCTCCTTCC CTCCACCAAC CATCCCTCCC CCTACCCCAG GCTACCCTCC ACCTCCCCCT 
ACCTACAACC CCAATTTTCC ACCCCCGCCC CCACGCCTTC CTCCAACTCA TGCAGTCCCT 
CCTCACCCTC CTCCAGGCTT GGGTTTGCCA CCAGCCAGCT ACCCACCTCC AGCTGTCCCT 
CCTGGGGGGC AACCCCCTGT TCCCCCACCC ATCCCTCCAC CTGGCATGCC GCCTGTTGGG 
GGACTAGGGC GGGCAGCCTG GATGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ccnk ( XM_006240551.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240613.1 Rattus norvegicus cyclin K (Ccnk), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa10800
Clone ID Related Accession (Same CDS sequence)	XM_006240551.3 , NM_001109672.1 , XM_006240549.3
Accession Version	XM_006240551.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-K isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240551.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGAGA ACAAAGAAAA TTCAAGCCCG TCAGTCACAT CAGCAAACCT GGACCACACA 
AAACCATGTT GGTACTGGGA TAAGAAGGAC TTGGCGCATA CACCCTCACA ACTTGAAGGA 
CTCGATCCAG CCACTGAGGC CCGGTACCGC CGAGAGGGGG CTCGCTTCAT CTTTGATGTG 
GGCACACGTT TGGGGTTACA CTATGACACC CTGGCAACTG GAATCATTTA TTTTCACCGA 
TTCTATATGT TCCATTCCTT CAAACAATTC CCAAGATACG TGACAGGAGC CTGTTGTCTC 
TTTCTGGCTG GGAAAGTAGA GGAAACACCA AAAAAGTGTA AAGATATCAT CAAAACGGCT 
CGTAGTTTAT TAAATGATGT CCAGTTTGGC CAGTTTGGAG ATGACCCAAA GGAAGAAGTC 
ATGGTGCTGG AGAGGATCCT ACTGCAGACC ATAAAGTTCG ACTTACAAGT AGAGCATCCG 
TACCAGTTCC TGCTCAAATA CGCCAAGCAG CTGAAAGGTG ATAAAAACAA AATTCAGAAG 
TTGGTTCAAA TGGCATGGAC ATTTGTAAAT GACAGTCTCT GCACCACCCT GTCACTGCAG 
TGGGAGCCAG AAATCATAGC TGTTGCAGTA ATGTATCTTG CGGGACGTTT GTGCAAATTT 
GAAATACAAG AGTGGACCTC CAAGCCCATG TACAGGAGAT GGTGGGAACA ATTTGTTCAA 
GATGTCCCTG TTGACGTTCT GGAAGACATC TGCCACCAAA TCCTGGACCT TTATTCACAA 
GGGAAACAAC AGATGCCTCA CCACACCCCT CATCAGCTGC AGCAGCCCCC ATCTCTTCAG 
CCCACACCAC AAGTGCCCCC GGTGCCACAG GCACAGCCAT CCCAAGGTTC TGAAGCAGCG 
CAGCCGCAGC AGAAGGATGC ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AAGCACAACA GCCCAAGAAA CCATCCCCTC AGCCCAGTCC TCCGCGACAG 
GCCAAGCGTG CCGTGGTGGT GTCTCCCAAG GAAGAGAACA AAGCCACAGA ACCACCACCA 
CCACCTAAAA TTCCCAAACT TGAGGCTGCT CACCCACCAT TGCCTCCAGC ACACCCGCCT 
CCAGACCGGA AGCTTCCCCT TGCTCCTGCC TTAGGTGAGG CTGAACCGAC TGGCCCTGTG 
GAAACAAGTG ACCTCCCTAA AGTCCAGATT CCTCCCCCAG CCCACCCGGC CCCTGTGCAC 
CAGCCCCCAC CACTGCCACA TCGGCCTCCA CCCCCGCCGC CCTCCAGCTA CATGACTGGG 
ATGTCTACCA CCAGCTCCTA CATGTCAGGA GAGGGCTACC AGAGCCTGCA GTCCATGATG 
AAAACAGAGG GGCCCTCCTA TGGCGCCCTT CCCCCAGCCT ATGGCCCACC TGCTCACCTA 
ACATACCATC CCCATGTCTA CCCCCCCAAC CCACCTCCAC CTCCTGTTCC TCCACCCCCA 
GCCTCCTTCC CTCCACCAAC CATCCCTCCC CCTACCCCAG GCTACCCTCC ACCTCCCCCT 
ACCTACAACC CCAATTTTCC ACCCCCGCCC CCACGCCTTC CTCCAACTCA TGCAGTCCCT 
CCTCACCCTC CTCCAGGCTT GGGTTTGCCA CCAGCCAGCT ACCCACCTCC AGCTGTCCCT 
CCTGGGGGGC AACCCCCTGT TCCCCCACCC ATCCCTCCAC CTGGCATGCC GCCTGTTGGG 
GGACTAGGGC GGGCAGCCTG GATGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240613.1
CDS	353..2122
Translation	MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR

Target ORF information:

RefSeq Version	XM_006240551.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin K (Ccnk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240551.3

ORF Insert Sequence:

ATGAAGGAGA ACAAAGAAAA TTCAAGCCCG TCAGTCACAT CAGCAAACCT GGACCACACA 
AAACCATGTT GGTACTGGGA TAAGAAGGAC TTGGCGCATA CACCCTCACA ACTTGAAGGA 
CTCGATCCAG CCACTGAGGC CCGGTACCGC CGAGAGGGGG CTCGCTTCAT CTTTGATGTG 
GGCACACGTT TGGGGTTACA CTATGACACC CTGGCAACTG GAATCATTTA TTTTCACCGA 
TTCTATATGT TCCATTCCTT CAAACAATTC CCAAGATACG TGACAGGAGC CTGTTGTCTC 
TTTCTGGCTG GGAAAGTAGA GGAAACACCA AAAAAGTGTA AAGATATCAT CAAAACGGCT 
CGTAGTTTAT TAAATGATGT CCAGTTTGGC CAGTTTGGAG ATGACCCAAA GGAAGAAGTC 
ATGGTGCTGG AGAGGATCCT ACTGCAGACC ATAAAGTTCG ACTTACAAGT AGAGCATCCG 
TACCAGTTCC TGCTCAAATA CGCCAAGCAG CTGAAAGGTG ATAAAAACAA AATTCAGAAG 
TTGGTTCAAA TGGCATGGAC ATTTGTAAAT GACAGTCTCT GCACCACCCT GTCACTGCAG 
TGGGAGCCAG AAATCATAGC TGTTGCAGTA ATGTATCTTG CGGGACGTTT GTGCAAATTT 
GAAATACAAG AGTGGACCTC CAAGCCCATG TACAGGAGAT GGTGGGAACA ATTTGTTCAA 
GATGTCCCTG TTGACGTTCT GGAAGACATC TGCCACCAAA TCCTGGACCT TTATTCACAA 
GGGAAACAAC AGATGCCTCA CCACACCCCT CATCAGCTGC AGCAGCCCCC ATCTCTTCAG 
CCCACACCAC AAGTGCCCCC GGTGCCACAG GCACAGCCAT CCCAAGGTTC TGAAGCAGCG 
CAGCCGCAGC AGAAGGATGC ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AAGCACAACA GCCCAAGAAA CCATCCCCTC AGCCCAGTCC TCCGCGACAG 
GCCAAGCGTG CCGTGGTGGT GTCTCCCAAG GAAGAGAACA AAGCCACAGA ACCACCACCA 
CCACCTAAAA TTCCCAAACT TGAGGCTGCT CACCCACCAT TGCCTCCAGC ACACCCGCCT 
CCAGACCGGA AGCTTCCCCT TGCTCCTGCC TTAGGTGAGG CTGAACCGAC TGGCCCTGTG 
GAAACAAGTG ACCTCCCTAA AGTCCAGATT CCTCCCCCAG CCCACCCGGC CCCTGTGCAC 
CAGCCCCCAC CACTGCCACA TCGGCCTCCA CCCCCGCCGC CCTCCAGCTA CATGACTGGG 
ATGTCTACCA CCAGCTCCTA CATGTCAGGA GAGGGCTACC AGAGCCTGCA GTCCATGATG 
AAAACAGAGG GGCCCTCCTA TGGCGCCCTT CCCCCAGCCT ATGGCCCACC TGCTCACCTA 
ACATACCATC CCCATGTCTA CCCCCCCAAC CCACCTCCAC CTCCTGTTCC TCCACCCCCA 
GCCTCCTTCC CTCCACCAAC CATCCCTCCC CCTACCCCAG GCTACCCTCC ACCTCCCCCT 
ACCTACAACC CCAATTTTCC ACCCCCGCCC CCACGCCTTC CTCCAACTCA TGCAGTCCCT 
CCTCACCCTC CTCCAGGCTT GGGTTTGCCA CCAGCCAGCT ACCCACCTCC AGCTGTCCCT 
CCTGGGGGGC AACCCCCTGT TCCCCCACCC ATCCCTCCAC CTGGCATGCC GCCTGTTGGG 
GGACTAGGGC GGGCAGCCTG GATGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ccnk ( XM_006240549.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240611.1 Rattus norvegicus cyclin K (Ccnk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa10800
Clone ID Related Accession (Same CDS sequence)	XM_006240551.3 , NM_001109672.1 , XM_006240549.3
Accession Version	XM_006240549.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-K isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240549.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGAGA ACAAAGAAAA TTCAAGCCCG TCAGTCACAT CAGCAAACCT GGACCACACA 
AAACCATGTT GGTACTGGGA TAAGAAGGAC TTGGCGCATA CACCCTCACA ACTTGAAGGA 
CTCGATCCAG CCACTGAGGC CCGGTACCGC CGAGAGGGGG CTCGCTTCAT CTTTGATGTG 
GGCACACGTT TGGGGTTACA CTATGACACC CTGGCAACTG GAATCATTTA TTTTCACCGA 
TTCTATATGT TCCATTCCTT CAAACAATTC CCAAGATACG TGACAGGAGC CTGTTGTCTC 
TTTCTGGCTG GGAAAGTAGA GGAAACACCA AAAAAGTGTA AAGATATCAT CAAAACGGCT 
CGTAGTTTAT TAAATGATGT CCAGTTTGGC CAGTTTGGAG ATGACCCAAA GGAAGAAGTC 
ATGGTGCTGG AGAGGATCCT ACTGCAGACC ATAAAGTTCG ACTTACAAGT AGAGCATCCG 
TACCAGTTCC TGCTCAAATA CGCCAAGCAG CTGAAAGGTG ATAAAAACAA AATTCAGAAG 
TTGGTTCAAA TGGCATGGAC ATTTGTAAAT GACAGTCTCT GCACCACCCT GTCACTGCAG 
TGGGAGCCAG AAATCATAGC TGTTGCAGTA ATGTATCTTG CGGGACGTTT GTGCAAATTT 
GAAATACAAG AGTGGACCTC CAAGCCCATG TACAGGAGAT GGTGGGAACA ATTTGTTCAA 
GATGTCCCTG TTGACGTTCT GGAAGACATC TGCCACCAAA TCCTGGACCT TTATTCACAA 
GGGAAACAAC AGATGCCTCA CCACACCCCT CATCAGCTGC AGCAGCCCCC ATCTCTTCAG 
CCCACACCAC AAGTGCCCCC GGTGCCACAG GCACAGCCAT CCCAAGGTTC TGAAGCAGCG 
CAGCCGCAGC AGAAGGATGC ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AAGCACAACA GCCCAAGAAA CCATCCCCTC AGCCCAGTCC TCCGCGACAG 
GCCAAGCGTG CCGTGGTGGT GTCTCCCAAG GAAGAGAACA AAGCCACAGA ACCACCACCA 
CCACCTAAAA TTCCCAAACT TGAGGCTGCT CACCCACCAT TGCCTCCAGC ACACCCGCCT 
CCAGACCGGA AGCTTCCCCT TGCTCCTGCC TTAGGTGAGG CTGAACCGAC TGGCCCTGTG 
GAAACAAGTG ACCTCCCTAA AGTCCAGATT CCTCCCCCAG CCCACCCGGC CCCTGTGCAC 
CAGCCCCCAC CACTGCCACA TCGGCCTCCA CCCCCGCCGC CCTCCAGCTA CATGACTGGG 
ATGTCTACCA CCAGCTCCTA CATGTCAGGA GAGGGCTACC AGAGCCTGCA GTCCATGATG 
AAAACAGAGG GGCCCTCCTA TGGCGCCCTT CCCCCAGCCT ATGGCCCACC TGCTCACCTA 
ACATACCATC CCCATGTCTA CCCCCCCAAC CCACCTCCAC CTCCTGTTCC TCCACCCCCA 
GCCTCCTTCC CTCCACCAAC CATCCCTCCC CCTACCCCAG GCTACCCTCC ACCTCCCCCT 
ACCTACAACC CCAATTTTCC ACCCCCGCCC CCACGCCTTC CTCCAACTCA TGCAGTCCCT 
CCTCACCCTC CTCCAGGCTT GGGTTTGCCA CCAGCCAGCT ACCCACCTCC AGCTGTCCCT 
CCTGGGGGGC AACCCCCTGT TCCCCCACCC ATCCCTCCAC CTGGCATGCC GCCTGTTGGG 
GGACTAGGGC GGGCAGCCTG GATGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240611.1
CDS	354..2123
Translation	MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR

Target ORF information:

RefSeq Version	XM_006240549.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin K (Ccnk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240549.3

ORF Insert Sequence:

ATGAAGGAGA ACAAAGAAAA TTCAAGCCCG TCAGTCACAT CAGCAAACCT GGACCACACA 
AAACCATGTT GGTACTGGGA TAAGAAGGAC TTGGCGCATA CACCCTCACA ACTTGAAGGA 
CTCGATCCAG CCACTGAGGC CCGGTACCGC CGAGAGGGGG CTCGCTTCAT CTTTGATGTG 
GGCACACGTT TGGGGTTACA CTATGACACC CTGGCAACTG GAATCATTTA TTTTCACCGA 
TTCTATATGT TCCATTCCTT CAAACAATTC CCAAGATACG TGACAGGAGC CTGTTGTCTC 
TTTCTGGCTG GGAAAGTAGA GGAAACACCA AAAAAGTGTA AAGATATCAT CAAAACGGCT 
CGTAGTTTAT TAAATGATGT CCAGTTTGGC CAGTTTGGAG ATGACCCAAA GGAAGAAGTC 
ATGGTGCTGG AGAGGATCCT ACTGCAGACC ATAAAGTTCG ACTTACAAGT AGAGCATCCG 
TACCAGTTCC TGCTCAAATA CGCCAAGCAG CTGAAAGGTG ATAAAAACAA AATTCAGAAG 
TTGGTTCAAA TGGCATGGAC ATTTGTAAAT GACAGTCTCT GCACCACCCT GTCACTGCAG 
TGGGAGCCAG AAATCATAGC TGTTGCAGTA ATGTATCTTG CGGGACGTTT GTGCAAATTT 
GAAATACAAG AGTGGACCTC CAAGCCCATG TACAGGAGAT GGTGGGAACA ATTTGTTCAA 
GATGTCCCTG TTGACGTTCT GGAAGACATC TGCCACCAAA TCCTGGACCT TTATTCACAA 
GGGAAACAAC AGATGCCTCA CCACACCCCT CATCAGCTGC AGCAGCCCCC ATCTCTTCAG 
CCCACACCAC AAGTGCCCCC GGTGCCACAG GCACAGCCAT CCCAAGGTTC TGAAGCAGCG 
CAGCCGCAGC AGAAGGATGC ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AAGCACAACA GCCCAAGAAA CCATCCCCTC AGCCCAGTCC TCCGCGACAG 
GCCAAGCGTG CCGTGGTGGT GTCTCCCAAG GAAGAGAACA AAGCCACAGA ACCACCACCA 
CCACCTAAAA TTCCCAAACT TGAGGCTGCT CACCCACCAT TGCCTCCAGC ACACCCGCCT 
CCAGACCGGA AGCTTCCCCT TGCTCCTGCC TTAGGTGAGG CTGAACCGAC TGGCCCTGTG 
GAAACAAGTG ACCTCCCTAA AGTCCAGATT CCTCCCCCAG CCCACCCGGC CCCTGTGCAC 
CAGCCCCCAC CACTGCCACA TCGGCCTCCA CCCCCGCCGC CCTCCAGCTA CATGACTGGG 
ATGTCTACCA CCAGCTCCTA CATGTCAGGA GAGGGCTACC AGAGCCTGCA GTCCATGATG 
AAAACAGAGG GGCCCTCCTA TGGCGCCCTT CCCCCAGCCT ATGGCCCACC TGCTCACCTA 
ACATACCATC CCCATGTCTA CCCCCCCAAC CCACCTCCAC CTCCTGTTCC TCCACCCCCA 
GCCTCCTTCC CTCCACCAAC CATCCCTCCC CCTACCCCAG GCTACCCTCC ACCTCCCCCT 
ACCTACAACC CCAATTTTCC ACCCCCGCCC CCACGCCTTC CTCCAACTCA TGCAGTCCCT 
CCTCACCCTC CTCCAGGCTT GGGTTTGCCA CCAGCCAGCT ACCCACCTCC AGCTGTCCCT 
CCTGGGGGGC AACCCCCTGT TCCCCCACCC ATCCCTCCAC CTGGCATGCC GCCTGTTGGG 
GGACTAGGGC GGGCAGCCTG GATGAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Control of transcriptional elongation.
Annual review of genetics47483-508(2013)
Kwak H,Lis JT

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.
Molecular and cellular biology32(22)4691-704(2012 Nov)
Cheng SW,Kuzyk MA,Moradian A,Ichu TA,Chang VC,Tien JF,Vollett SE,Griffith M,Marra MA,Morin GB

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.
The Journal of biological chemistry287(30)25344-52(2012 Jul)
Dai Q,Lei T,Zhao C,Zhong J,Tang YZ,Chen B,Yang J,Li C,Wang S,Song X,Li L,Li Q

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
Genes & development25(20)2158-72(2011 Oct)
Blazek D,Kohoutek J,Bartholomeeusen K,Johansen E,Hulinkova P,Luo Z,Cimermancic P,Ule J,Peterlin BM

Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
The Journal of biological chemistry286(26)22943-54(2011 Jul)
Khan SZ,Mitra D

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Ccnk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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