Ldlrap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ldlrap1
Entrez Gene ID	500564
Full Name	low density lipoprotein receptor adaptor protein 1
Synonyms	RGD1563417
General protein information	Preferred Names low density lipoprotein receptor adaptor protein 1 Names low density lipoprotein receptor adapter protein 1 autosomal recessive hypercholesterolemia protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109271.1	NP_001102741.1	low density lipoprotein receptor adapter protein 1

Pathways from BioSystems

Homologies

	LOC713032	XP_001107620.1
Homo sapiens (human)	LDLRAP1	NP_056442.2
Pan troglodytes (chimpanzee)	LDLRAP1	XP_001145086.2
Bos taurus (cattle)	LDLRAP1	NP_001077137.1
Mus musculus (house mouse)	Ldlrap1	NP_663529.2
Rattus norvegicus (Norway rat)	Ldlrap1	NP_001102741.1
Gallus gallus (chicken)	LDLRAP1	XP_417736.2
Canis lupus familiaris (dog)	LDLRAP1	XP_855049.1
Danio rerio (zebrafish)	ldlrap1b	NP_001074104.1
Xenopus tropicalis (tropical clawed frog)	ldlrap1	NP_001017114.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.
Gabunia K, Herman AB, Ray M, Kelemen SE, England RN, DeLa Cadena R, Foster WJ, Elliott KJ, Eguchi S, Autieri MV
Journal of molecular and cellular cardiology10538-48(2017 Apr)

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Shah M, Baterina OY Jr, Taupin V, Farquhar MG
The Journal of cell biology202(1)113-27(2013 Jul)

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
Dvir H, Shah M, Girardi E, Guo L, Farquhar MG, Zajonc DM
Proceedings of the National Academy of Sciences of the United States of America109(18)6916-21(2012 May)

The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.
Lehtonen S, Shah M, Nielsen R, Iino N, Ryan JJ, Zhou H, Farquhar MG
Molecular biology of the cell19(7)2949-61(2008 Jul)

Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.
Mameza MG, Lockard JM, Zamora E, Hillefors M, Lavina ZS, Kaplan BB
Journal of neurochemistry103(3)927-41(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ARH knockdown leads to fast recycling of megalin via a Rab35 pathway.
Title: ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.

the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis
Title: The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.

The following Ldlrap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ldlrap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09496	NM_001109271.1 Latest version!	Rattus norvegicus low density lipoprotein receptor adaptor protein 1 (Ldlrap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ldlrap1 ( NM_001109271.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102741.1 Rattus norvegicus low density lipoprotein receptor adaptor protein 1 (Ldlrap1), mRNA.

Price & Availability↑

CloneID	ORa09496
Clone ID Related Accession (Same CDS sequence)	NM_001109271.1
Accession Version	NM_001109271.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Rattus norvegicus(Norway rat)
Product	low density lipoprotein receptor adapter protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473968.1. On or before Oct 4, 2007 this sequence version replaced XM_575931.2, XM_001067557.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGACGCGC TCAAGTCGGC GGGGCGCGCG CTAATCCGGA GCCCCAGTCT GGCCAAGCAG 
AGCTGGGCGG GCGGCCGGCA CCGCAAGTTG CCAGAGAACT GGACGGACAC TCGGGAGACA 
CTGCTGGAGG GCATGGTTTT TAGCCTCAAG TACCTTGGTA TGACATTGGT GGAGAGGCCC 
AAGGGTGAGG AGCTGTCTGC AGCTGCTGTC AAAAGAATCG TGGCTACGGC CAAGGCGAGC 
GGGAAGAAGC TGCAGAAGGT GACACTGAAG GTGTCACCCC GGGGGATCAT CCTGACTGAC 
AGCCTCACTA GCCAACTCAT TGAGAACGTG TCCATTTACA GGATCTCCTA CTGCACCGCA 
GACAAGATGC ATGACAAGGT GTTCGCGTAC ATCGCCCAGA GCCAGCAGAA CGAGAGCCTG 
GAGTGTCATG CGTTCCTCTG CACCAAGCGG AAAGTGGCAC AAGCTGTCAC CCTCACTGTA 
GCCCAAGCCT TCAAAGTTGC CTTTGAGTTT TGGCAGGTGT CCAAGGAAGA GAAAGAGAAG 
AGAGAGAAAG CCAACCAGGA GGGAGGAGAC GTCCCAGGGA CCCGACGTGA CAGCACCCCC 
TCGTTGAAAA CCTCGGTCGC TACTGGGAAC CTGCTGGATC TGGAAGAGCT GGCTAAGGCC 
CCGTTGTCCA CAGTCAGCGC TAATACTAAG AACATGGACG ACGCACTGCG GCCTCAAGTC 
TTGGGCAACA ACAGCGTCGT CTGGGAGCTG GATGACGGTC TGGATGAAGC GTTTTCAAGG 
CTGGCGCAGT CACGGACAAA CCCTCAAGTC CTGGACACTG GACTGACAGC ACAGGATATC 
CATTACGCAC AGTGCTTATC GCCCACTGAC TGGGACAAGC CTGACAGCAG TGGCTTTGAT 
CAAGACGACG TCTTCAGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102741.1
CDS	76..999
Translation	MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTSVATGNLLDLEELAKAPLSTVSANTKNMDDALRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDIHYAQCLSPTDWDKPDSSGFDQDDVFSF

Target ORF information:

RefSeq Version	NM_001109271.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus low density lipoprotein receptor adaptor protein 1 (Ldlrap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109271.1

ORF Insert Sequence:

ATGGACGCGC TCAAGTCGGC GGGGCGCGCG CTAATCCGGA GCCCCAGTCT GGCCAAGCAG 
AGCTGGGCGG GCGGCCGGCA CCGCAAGTTG CCAGAGAACT GGACGGACAC TCGGGAGACA 
CTGCTGGAGG GCATGGTTTT TAGCCTCAAG TACCTTGGTA TGACATTGGT GGAGAGGCCC 
AAGGGTGAGG AGCTGTCTGC AGCTGCTGTC AAAAGAATCG TGGCTACGGC CAAGGCGAGC 
GGGAAGAAGC TGCAGAAGGT GACACTGAAG GTGTCACCCC GGGGGATCAT CCTGACTGAC 
AGCCTCACTA GCCAACTCAT TGAGAACGTG TCCATTTACA GGATCTCCTA CTGCACCGCA 
GACAAGATGC ATGACAAGGT GTTCGCGTAC ATCGCCCAGA GCCAGCAGAA CGAGAGCCTG 
GAGTGTCATG CGTTCCTCTG CACCAAGCGG AAAGTGGCAC AAGCTGTCAC CCTCACTGTA 
GCCCAAGCCT TCAAAGTTGC CTTTGAGTTT TGGCAGGTGT CCAAGGAAGA GAAAGAGAAG 
AGAGAGAAAG CCAACCAGGA GGGAGGAGAC GTCCCAGGGA CCCGACGTGA CAGCACCCCC 
TCGTTGAAAA CCTCGGTCGC TACTGGGAAC CTGCTGGATC TGGAAGAGCT GGCTAAGGCC 
CCGTTGTCCA CAGTCAGCGC TAATACTAAG AACATGGACG ACGCACTGCG GCCTCAAGTC 
TTGGGCAACA ACAGCGTCGT CTGGGAGCTG GATGACGGTC TGGATGAAGC GTTTTCAAGG 
CTGGCGCAGT CACGGACAAA CCCTCAAGTC CTGGACACTG GACTGACAGC ACAGGATATC 
CATTACGCAC AGTGCTTATC GCCCACTGAC TGGGACAAGC CTGACAGCAG TGGCTTTGAT 
CAAGACGACG TCTTCAGCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.
Journal of molecular and cellular cardiology10538-48(2017 Apr)
Gabunia K,Herman AB,Ray M,Kelemen SE,England RN,DeLa Cadena R,Foster WJ,Elliott KJ,Eguchi S,Autieri MV

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
The Journal of cell biology202(1)113-27(2013 Jul)
Shah M,Baterina OY Jr,Taupin V,Farquhar MG

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
Proceedings of the National Academy of Sciences of the United States of America109(18)6916-21(2012 May)
Dvir H,Shah M,Girardi E,Guo L,Farquhar MG,Zajonc DM

The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.
Molecular biology of the cell19(7)2949-61(2008 Jul)
Lehtonen S,Shah M,Nielsen R,Iino N,Ryan JJ,Zhou H,Farquhar MG

Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.
Journal of neurochemistry103(3)927-41(2007 Nov)
Mameza MG,Lockard JM,Zamora E,Hillefors M,Lavina ZS,Kaplan BB

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Ldlrap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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