Cngb3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cngb3
Entrez Gene ID	500418
Full Name	cyclic nucleotide gated channel beta 3
Synonyms	Cng6,RGD1565364
General protein information	Preferred Names cyclic nucleotide gated channel beta 3 Names cyclic nucleotide-gated cation channel beta-3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q13

mRNA and Protein(s)

mRNA	Protein	Name
XM_017593570.1	XP_017449059.1	cyclic nucleotide-gated cation channel beta-3 isoform X1
NM_001271238.1	NP_001258167.1	cyclic nucleotide-gated cation channel beta-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CNGB3	XP_519846.2
Homo sapiens (human)	CNGB3	NP_061971.3
	CNGB3	XP_001083646.1
Bos taurus (cattle)	CNGB3	XP_002692873.2
Danio rerio (zebrafish)	cngb3	XP_691142.4
Canis lupus familiaris (dog)	CNGB3	NP_001003030.1
Rattus norvegicus (Norway rat)	Cngb3	NP_001258167.1
Danio rerio (zebrafish)	LOC562466	XP_690937.4
Xenopus tropicalis (tropical clawed frog)	cngb3	XP_002939202.2
Mus musculus (house mouse)	Cngb3	NP_038955.1
Gallus gallus (chicken)	CNGB3	XP_425928.4

Gene Ontology
Bibliography

Related articles in PubMed

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.
Meighan SE, Meighan PC, Rich ED, Brown RL, Varnum MD
Biochemistry52(46)8352-62(2013 Nov)

Calcium signalling remodelling and disease.
Berridge MJ
Biochemical Society transactions40(2)297-309(2012 Apr)

Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy.
Carvalho LS, Xu J, Pearson RA, Smith AJ, Bainbridge JW, Morris LM, Fliesler SJ, Ding XQ, Ali RR
Human molecular genetics20(16)3161-75(2011 Aug)

Achromatopsia: the CNGB3 p.T383fsX mutation results from a founder effect and is responsible for the visual phenotype in the original report of uniparental disomy 14.
Wiszniewski W, Lewis RA, Lupski JR
Human genetics121(3-4)433-9(2007 May)

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.
H?ttl S, Michalakis S, Seeliger M, Luo DG, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, Moser M, Pfeifer A, Gerstner A, Yau KW, Biel M
The Journal of neuroscience : the official journal of the Society for Neuroscience25(1)130-8(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cngb3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cngb3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10701	NM_001271238.1 Latest version!	Rattus norvegicus cyclic nucleotide gated channel subunit beta 3 (Cngb3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa61348	XM_017593570.1 Latest version!	Rattus norvegicus cyclic nucleotide gated channel beta 3 (Cngb3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cngb3 ( NM_001271238.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258167.1 Rattus norvegicus cyclic nucleotide gated channel subunit beta 3 (Cngb3), mRNA.

Price & Availability↑

CloneID	ORa10701
Clone ID Related Accession (Same CDS sequence)	NM_001271238.1
Accession Version	NM_001271238.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2073bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Rattus norvegicus(Norway rat)
Product	cyclic nucleotide-gated cation channel beta-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07047458.1, AABR07047466.1, AABR07047471.1 and AABR07047477.1. On Sep 8, 2012 this sequence version replaced XM_001057513.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTTAAAAT CTCTGACAGT AAAATGCAAC AAAGTGAAGC CCATGGAAGG GAGGACCGAG 
AAGCAACCCT GCCCCCACCT GAGCAGTGGG TCTCAGCCAT CCATAGCACA GGGAGAAAAC 
CAAAGTGAAA ACGAATCTCT GATGAGCAGG ACACCAGCCA CAGTTGAAAA ATCACACAGC 
AAAGAAGACA ACAGCACTGG GGAGAACTCC CTCAGGGGTT CTACCACAAA TCCTGACACT 
GAATGTCCTG CAGAACTCAC GGGAACAATA TCGGAGATGG AGCAAACTAG GACTAGGAAA 
GAAAAGCCAG CCAGCATTAA GACCAAAGTA TTTGAAACTT CAATTATAAA TGAATATACT 
GATGCCCATC TACACAACCT AGTGGAGAGA ATGCGTGAAA GGACTGCTTT CTACAAGAGA 
ACACTGACAG AGGGAGAGAA CTCCCCCGAA TTAGAAGCCA GCTCTCATAC TGCAACGTCT 
ACAGATATAT CACCAAGACA AGAGATCAAT TCTAAGCCAA AAGAACACCA CCACAAACTC 
CAGAGAGTAC CTGTGAAAGA GTACCTAAGA AGCATGAGAC TTCCGAGAAG CATAGATTCC 
TACACAGATC GGATTTATCT CCTGTGGCTC CTGCTTGTCA CCATTGCCTA CAACTGGAAC 
TGTTGGCTGC TACCGGTACG CCTTGTCTTT CCATGCCAAA CACCAGACAA CAGGAACTAC 
TGGATCATTA CTGACATCAT ATGTGATATC ATCTACCTTG GTGATATATT ATTGATCCAA 
CCAAGACTTC AATTCGTAAG AGGAGGAGAA ATTATCGTAG ATTCAAATGA GCTGAAGAGG 
CACTACAGGA GTTCTACAAA ATTTCAGATG GATGTGGCAT CTCTACTGCC ATTTGAAGTT 
CTCTACATCT TCTTCGGAGT CAATCCAATA TTCAGAACAA ATCGGATATT AAAGTACACT 
TCATTCTTTG AGTTTAACCA TCACCTGGAG TCTATAATGG ACAGAGCATA TGTCTACAGG 
ATAATCCGAA CAACTGGCTA CTTGCTGTTT CTTCTGCACA TTAACGCCTG TGTTTATTAC 
TGGGCTTCAG ACTATGAAGG AATTGGCTCA ACTAAATGGG TCTATAATGG GGAAGGAAAC 
AAGTATCTGC GATGTTTTTA TTGGGCAGTT CGAACTTTAA TTACAATTGG GGGCCTTCCA 
GAGCCACAGA CTTCATTTGA AATTGTTTTT CAACTCTTGA ATTTCTTTTC GGGAGTTTTT 
GTGTTCTCCA GCTTAATTGG TCAGATGCGT GATGTAATTG GGGCAGCAAC AGCCAATCAG 
AACAACTTCC ATGTCTGCAT GGACCATATC ATTGCCTACA TGAACAAATA CTCCATTCCT 
CAGAGTACGC AGCATCGAGT TCGGACTTGG CTGGAATATA CGTGGCATTC TCAGAGAATC 
CTAGATGAGT CCAACTTGCT TGAGACCCTC CCAACAGCAA TGCAGTTGTC TGTTGCCATT 
GACATAAACT TCAATATCAT CGACAAAGTG GAGCTGTTCA AGGGCTGTGA CACCCAGATG 
ATTTATGACC TGCTACTAAG ACTGAAATCC ACTATTTATT TACCTGGTGA CTTTGTCTGC 
AAAAAGGGAG AAATTGGAAA AGAAATGTAC ATCATCAAGC ATGGAGAAGT CCAAGTTCTT 
GGAGGCCCTG ATGGTGCTCA AGTTCTGGTT ACTCTGAAAG CTGGGGCAGT GTTTGGAGAA 
ATAAGCCTTC TGGCAAAAGG AGGAGGAAAC CGCCGGACAG CGGATGTGGT GGCCCACGGG 
TTTGCCAATC TTTTAACTCT GGACAAAAAG ACTCTCCAGG AAATTTTGCT GCATTATCCA 
ACTTCTAAAA AGCTTCTCAT GAAGAAAGCC AAAGTTCTTT TAAGCCAGAA GGGAAAGAAC 
ACACAGGCAA TCCCTCCAAG AACAAGACCT GCCTTTCTTT TCCCACCAAA AGAAGAGACA 
CCACGAATGC TTAAAGTCCT CCTGGGAAAC ACAGGAAAGG TGGACCTTGG AAGACTCCTT 
AAAGGAAAGA GAAAACAAAC CACTCAGAAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258167.1
CDS	1..2073
Translation	MLKSLTVKCNKVKPMEGRTEKQPCPHLSSGSQPSIAQGENQSENESLMSRTPATVEKSHSKEDNSTGENSLRGSTTNPDTECPAELTGTISEMEQTRTRKEKPASIKTKVFETSIINEYTDAHLHNLVERMRERTAFYKRTLTEGENSPELEASSHTATSTDISPRQEINSKPKEHHHKLQRVPVKEYLRSMRLPRSIDSYTDRIYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNRNYWIITDIICDIIYLGDILLIQPRLQFVRGGEIIVDSNELKRHYRSSTKFQMDVASLLPFEVLYIFFGVNPIFRTNRILKYTSFFEFNHHLESIMDRAYVYRIIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYWAVRTLITIGGLPEPQTSFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNNFHVCMDHIIAYMNKYSIPQSTQHRVRTWLEYTWHSQRILDESNLLETLPTAMQLSVAIDINFNIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGAVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKVLLSQKGKNTQAIPPRTRPAFLFPPKEETPRMLKVLLGNTGKVDLGRLLKGKRKQTTQK

Target ORF information:

RefSeq Version	NM_001271238.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclic nucleotide gated channel subunit beta 3 (Cngb3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271238.1

ORF Insert Sequence:

ATGTTAAAAT CTCTGACAGT AAAATGCAAC AAAGTGAAGC CCATGGAAGG GAGGACCGAG 
AAGCAACCCT GCCCCCACCT GAGCAGTGGG TCTCAGCCAT CCATAGCACA GGGAGAAAAC 
CAAAGTGAAA ACGAATCTCT GATGAGCAGG ACACCAGCCA CAGTTGAAAA ATCACACAGC 
AAAGAAGACA ACAGCACTGG GGAGAACTCC CTCAGGGGTT CTACCACAAA TCCTGACACT 
GAATGTCCTG CAGAACTCAC GGGAACAATA TCGGAGATGG AGCAAACTAG GACTAGGAAA 
GAAAAGCCAG CCAGCATTAA GACCAAAGTA TTTGAAACTT CAATTATAAA TGAATATACT 
GATGCCCATC TACACAACCT AGTGGAGAGA ATGCGTGAAA GGACTGCTTT CTACAAGAGA 
ACACTGACAG AGGGAGAGAA CTCCCCCGAA TTAGAAGCCA GCTCTCATAC TGCAACGTCT 
ACAGATATAT CACCAAGACA AGAGATCAAT TCTAAGCCAA AAGAACACCA CCACAAACTC 
CAGAGAGTAC CTGTGAAAGA GTACCTAAGA AGCATGAGAC TTCCGAGAAG CATAGATTCC 
TACACAGATC GGATTTATCT CCTGTGGCTC CTGCTTGTCA CCATTGCCTA CAACTGGAAC 
TGTTGGCTGC TACCGGTACG CCTTGTCTTT CCATGCCAAA CACCAGACAA CAGGAACTAC 
TGGATCATTA CTGACATCAT ATGTGATATC ATCTACCTTG GTGATATATT ATTGATCCAA 
CCAAGACTTC AATTCGTAAG AGGAGGAGAA ATTATCGTAG ATTCAAATGA GCTGAAGAGG 
CACTACAGGA GTTCTACAAA ATTTCAGATG GATGTGGCAT CTCTACTGCC ATTTGAAGTT 
CTCTACATCT TCTTCGGAGT CAATCCAATA TTCAGAACAA ATCGGATATT AAAGTACACT 
TCATTCTTTG AGTTTAACCA TCACCTGGAG TCTATAATGG ACAGAGCATA TGTCTACAGG 
ATAATCCGAA CAACTGGCTA CTTGCTGTTT CTTCTGCACA TTAACGCCTG TGTTTATTAC 
TGGGCTTCAG ACTATGAAGG AATTGGCTCA ACTAAATGGG TCTATAATGG GGAAGGAAAC 
AAGTATCTGC GATGTTTTTA TTGGGCAGTT CGAACTTTAA TTACAATTGG GGGCCTTCCA 
GAGCCACAGA CTTCATTTGA AATTGTTTTT CAACTCTTGA ATTTCTTTTC GGGAGTTTTT 
GTGTTCTCCA GCTTAATTGG TCAGATGCGT GATGTAATTG GGGCAGCAAC AGCCAATCAG 
AACAACTTCC ATGTCTGCAT GGACCATATC ATTGCCTACA TGAACAAATA CTCCATTCCT 
CAGAGTACGC AGCATCGAGT TCGGACTTGG CTGGAATATA CGTGGCATTC TCAGAGAATC 
CTAGATGAGT CCAACTTGCT TGAGACCCTC CCAACAGCAA TGCAGTTGTC TGTTGCCATT 
GACATAAACT TCAATATCAT CGACAAAGTG GAGCTGTTCA AGGGCTGTGA CACCCAGATG 
ATTTATGACC TGCTACTAAG ACTGAAATCC ACTATTTATT TACCTGGTGA CTTTGTCTGC 
AAAAAGGGAG AAATTGGAAA AGAAATGTAC ATCATCAAGC ATGGAGAAGT CCAAGTTCTT 
GGAGGCCCTG ATGGTGCTCA AGTTCTGGTT ACTCTGAAAG CTGGGGCAGT GTTTGGAGAA 
ATAAGCCTTC TGGCAAAAGG AGGAGGAAAC CGCCGGACAG CGGATGTGGT GGCCCACGGG 
TTTGCCAATC TTTTAACTCT GGACAAAAAG ACTCTCCAGG AAATTTTGCT GCATTATCCA 
ACTTCTAAAA AGCTTCTCAT GAAGAAAGCC AAAGTTCTTT TAAGCCAGAA GGGAAAGAAC 
ACACAGGCAA TCCCTCCAAG AACAAGACCT GCCTTTCTTT TCCCACCAAA AGAAGAGACA 
CCACGAATGC TTAAAGTCCT CCTGGGAAAC ACAGGAAAGG TGGACCTTGG AAGACTCCTT 
AAAGGAAAGA GAAAACAAAC CACTCAGAAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cngb3 ( XM_017593570.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449059.1 Rattus norvegicus cyclic nucleotide gated channel beta 3 (Cngb3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61348
Clone ID Related Accession (Same CDS sequence)	XM_017593570.1
Accession Version	XM_017593570.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2085bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclic nucleotide-gated cation channel beta-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTAAAAT CTCTGACAGT AAAATGCAAC AAAGTGAAGC CCATGGAAGG GAGGACCGAG 
AAGCAACCCT GCCCCCACCT GAGCAGTGGG TCTCAGCCAT CCATAGCACA GGGAGAAAAC 
CAAAGTGAAA ACGAATCTCT GATGAGCAGG ACACCAGCCA CAGTTGAAAA ATCACACAGC 
AAAGAAGACA ACAGCACTGG GGAGAACTCC CTCAGGGGTT CTACCACAAA TCCTGACACT 
GAATGTCCTG CAGAACTCAC GGGAACAATA TCGGAGATGG AGCAAACTAG GACTAGGAAA 
GAAAAGCCAG CCAGCATTAA GACCAAAGTA TTTGAAACTT CAATTATAAA TGAATATACT 
GATGCCCATC TACACAACCT AGTGGAGAGA ATGCGTGAAA GGACTGCTTT CTACAAGAGA 
ACACTGACAG AGGGAGAGAA CTCCCCCGAA TTAGAAGCCA GCTCTCATAC TGCAACGTCT 
ACAGATATAT CACCAAGACA AGAGATCAAT TCTAAGCCAA AAGAACACCA CCACAAACTC 
CAGAGAGTAC CTGTGAAAGA GTACCTAAGA AGCATGAGAC TTCCGAGAAG CATAGATTCC 
TACACAGATC GGATTTATCT CCTGTGGCTC CTGCTTGTCA CCATTGCCTA CAACTGGAAC 
TGTTGGCTGC TACCGGTACG CCTTGTCTTT CCATGCCAAA CACCAGACAA CAGGAACTAC 
TGGATCATTA CTGACATCAT ATGTGATATC ATCTACCTTG GTGATATATT ATTGATCCAA 
CCAAGACTTC AATTCGTAAG AGGAGGAGAA ATTATCGTAG ATTCAAATGA GCTGAAGAGG 
CACTACAGGA GTTCTACAAA ATTTCAGATG GATGTGGCAT CTCTACTGCC ATTTGAAGTT 
CTCTACATCT TCTTCGGAGT CAATCCAATA TTCAGAACAA ATCGGATATT AAAGTACACT 
TCATTCTTTG AGTTTAACCA TCACCTGGAG TCTATAATGG ACAGAGCATA TGTCTACAGG 
ATAATCCGAA CAACTGGCTA CTTGCTGTTT CTTCTGCACA TTAACGCCTG TGTTTATTAC 
TGGGCTTCAG ACTATGAAGG AATTGGCTCA ACTAAATGGG TCTATAATGG GGAAGGAAAC 
AAGTATCTGC GATGTTTTTA TTGGGCAGTT CGAACTTTAA TTACAATTGG GGGCCTTCCA 
GAGCCACAGA CTTCATTTGA AATTGTTTTT CAACTCTTGA ATTTCTTTTC GGGAGTTTTT 
GTGTTCTCCA GCTTAATTGG TCAGATGCGT GATGTAATTG GGGCAGCAAC AGCCAATCAG 
AACAACTTCC ATGTCTGCAT GGACCATATC ATTGCCTACA TGAACAAATA CTCCATTCCT 
CAGAGTACGC AGCATCGAGT TCGGACTTGG CTGGAATATA CGTGGCATTC TCAGAGAATC 
CTAGATGAGT CCAACTTGCT TGAGACCCTC CCAACAGCAA TGCAGTTGTC TGTTGCCATT 
GACATAAACT TCAATATCAT CGACAAAGTG GAGCTGTTCA AGGGCTGTGA CACCCAGATG 
ATTTATGACC TGCTACTAAG ACTGAAATCC ACTATTTATT TACCTGGTGA CTTTGTCTGC 
AAAAAGGGAG AAATTGGAAA AGAAATGTAC ATCATCAAGC ATGGAGAAGT CCAAGTTCTT 
GGAGGCCCTG ATGGTGCTCA AGTTCTGGTT ACTCTGAAAG CTGGGGCAGT GTTTGGAGAA 
ATAAGCCTTC TGGCAAAAGG AGGAGGAAAC CGCCGGACAG CGGATGTGGT GGCCCACGGG 
TTTGCCAATC TTTTAACTCT GGACAAAAAG ACTCTCCAGG AAATTTTGCT GCATTATCCA 
ACTTCTAAAA AGCTTCTCAT GAAGAAAGCC AAAGTTCTTT TAAGCCAGAA GGGAAAGAAC 
ACACAGGCAA TCCCTCCAAG AACAAGACCT GCCTTTCTTT TCCCACCAAA AGAAGAGACA 
CCACGAATGC TTAAAGTCCT CCTGGGAAAC ACAGGAAAGG TGGACCTTGG AAGACTCCTT 
AAAGGAAAGA GAAAACAAAC CACTCAGGTA ACAAGGCTGA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449059.1
CDS	302..2386
Translation	MLKSLTVKCNKVKPMEGRTEKQPCPHLSSGSQPSIAQGENQSENESLMSRTPATVEKSHSKEDNSTGENSLRGSTTNPDTECPAELTGTISEMEQTRTRKEKPASIKTKVFETSIINEYTDAHLHNLVERMRERTAFYKRTLTEGENSPELEASSHTATSTDISPRQEINSKPKEHHHKLQRVPVKEYLRSMRLPRSIDSYTDRIYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNRNYWIITDIICDIIYLGDILLIQPRLQFVRGGEIIVDSNELKRHYRSSTKFQMDVASLLPFEVLYIFFGVNPIFRTNRILKYTSFFEFNHHLESIMDRAYVYRIIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYWAVRTLITIGGLPEPQTSFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNNFHVCMDHIIAYMNKYSIPQSTQHRVRTWLEYTWHSQRILDESNLLETLPTAMQLSVAIDINFNIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGAVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKVLLSQKGKNTQAIPPRTRPAFLFPPKEETPRMLKVLLGNTGKVDLGRLLKGKRKQTTQVTRLT

Target ORF information:

RefSeq Version	XM_017593570.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclic nucleotide gated channel beta 3 (Cngb3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017593570.1

ORF Insert Sequence:

ATGTTAAAAT CTCTGACAGT AAAATGCAAC AAAGTGAAGC CCATGGAAGG GAGGACCGAG 
AAGCAACCCT GCCCCCACCT GAGCAGTGGG TCTCAGCCAT CCATAGCACA GGGAGAAAAC 
CAAAGTGAAA ACGAATCTCT GATGAGCAGG ACACCAGCCA CAGTTGAAAA ATCACACAGC 
AAAGAAGACA ACAGCACTGG GGAGAACTCC CTCAGGGGTT CTACCACAAA TCCTGACACT 
GAATGTCCTG CAGAACTCAC GGGAACAATA TCGGAGATGG AGCAAACTAG GACTAGGAAA 
GAAAAGCCAG CCAGCATTAA GACCAAAGTA TTTGAAACTT CAATTATAAA TGAATATACT 
GATGCCCATC TACACAACCT AGTGGAGAGA ATGCGTGAAA GGACTGCTTT CTACAAGAGA 
ACACTGACAG AGGGAGAGAA CTCCCCCGAA TTAGAAGCCA GCTCTCATAC TGCAACGTCT 
ACAGATATAT CACCAAGACA AGAGATCAAT TCTAAGCCAA AAGAACACCA CCACAAACTC 
CAGAGAGTAC CTGTGAAAGA GTACCTAAGA AGCATGAGAC TTCCGAGAAG CATAGATTCC 
TACACAGATC GGATTTATCT CCTGTGGCTC CTGCTTGTCA CCATTGCCTA CAACTGGAAC 
TGTTGGCTGC TACCGGTACG CCTTGTCTTT CCATGCCAAA CACCAGACAA CAGGAACTAC 
TGGATCATTA CTGACATCAT ATGTGATATC ATCTACCTTG GTGATATATT ATTGATCCAA 
CCAAGACTTC AATTCGTAAG AGGAGGAGAA ATTATCGTAG ATTCAAATGA GCTGAAGAGG 
CACTACAGGA GTTCTACAAA ATTTCAGATG GATGTGGCAT CTCTACTGCC ATTTGAAGTT 
CTCTACATCT TCTTCGGAGT CAATCCAATA TTCAGAACAA ATCGGATATT AAAGTACACT 
TCATTCTTTG AGTTTAACCA TCACCTGGAG TCTATAATGG ACAGAGCATA TGTCTACAGG 
ATAATCCGAA CAACTGGCTA CTTGCTGTTT CTTCTGCACA TTAACGCCTG TGTTTATTAC 
TGGGCTTCAG ACTATGAAGG AATTGGCTCA ACTAAATGGG TCTATAATGG GGAAGGAAAC 
AAGTATCTGC GATGTTTTTA TTGGGCAGTT CGAACTTTAA TTACAATTGG GGGCCTTCCA 
GAGCCACAGA CTTCATTTGA AATTGTTTTT CAACTCTTGA ATTTCTTTTC GGGAGTTTTT 
GTGTTCTCCA GCTTAATTGG TCAGATGCGT GATGTAATTG GGGCAGCAAC AGCCAATCAG 
AACAACTTCC ATGTCTGCAT GGACCATATC ATTGCCTACA TGAACAAATA CTCCATTCCT 
CAGAGTACGC AGCATCGAGT TCGGACTTGG CTGGAATATA CGTGGCATTC TCAGAGAATC 
CTAGATGAGT CCAACTTGCT TGAGACCCTC CCAACAGCAA TGCAGTTGTC TGTTGCCATT 
GACATAAACT TCAATATCAT CGACAAAGTG GAGCTGTTCA AGGGCTGTGA CACCCAGATG 
ATTTATGACC TGCTACTAAG ACTGAAATCC ACTATTTATT TACCTGGTGA CTTTGTCTGC 
AAAAAGGGAG AAATTGGAAA AGAAATGTAC ATCATCAAGC ATGGAGAAGT CCAAGTTCTT 
GGAGGCCCTG ATGGTGCTCA AGTTCTGGTT ACTCTGAAAG CTGGGGCAGT GTTTGGAGAA 
ATAAGCCTTC TGGCAAAAGG AGGAGGAAAC CGCCGGACAG CGGATGTGGT GGCCCACGGG 
TTTGCCAATC TTTTAACTCT GGACAAAAAG ACTCTCCAGG AAATTTTGCT GCATTATCCA 
ACTTCTAAAA AGCTTCTCAT GAAGAAAGCC AAAGTTCTTT TAAGCCAGAA GGGAAAGAAC 
ACACAGGCAA TCCCTCCAAG AACAAGACCT GCCTTTCTTT TCCCACCAAA AGAAGAGACA 
CCACGAATGC TTAAAGTCCT CCTGGGAAAC ACAGGAAAGG TGGACCTTGG AAGACTCCTT 
AAAGGAAAGA GAAAACAAAC CACTCAGGTA ACAAGGCTGA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.
Biochemistry52(46)8352-62(2013 Nov)
Meighan SE,Meighan PC,Rich ED,Brown RL,Varnum MD

Calcium signalling remodelling and disease.
Biochemical Society transactions40(2)297-309(2012 Apr)
Berridge MJ

Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy.
Human molecular genetics20(16)3161-75(2011 Aug)
Carvalho LS,Xu J,Pearson RA,Smith AJ,Bainbridge JW,Morris LM,Fliesler SJ,Ding XQ,Ali RR

Achromatopsia: the CNGB3 p.T383fsX mutation results from a founder effect and is responsible for the visual phenotype in the original report of uniparental disomy 14.
Human genetics121(3-4)433-9(2007 May)
Wiszniewski W,Lewis RA,Lupski JR

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.
The Journal of neuroscience : the official journal of the Society for Neuroscience25(1)130-8(2005 Jan)
H?ttl S,Michalakis S,Seeliger M,Luo DG,Acar N,Geiger H,Hudl K,Mader R,Haverkamp S,Moser M,Pfeifer A,Gerstner A,Yau KW,Biel M

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Cngb3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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