Gdf3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gdf3
Entrez Gene ID	500311
Full Name	growth differentiation factor 3
Synonyms	RGD1564178
General protein information	Preferred Names growth differentiation factor 3 Names growth/differentiation factor 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109671.1	NP_001103141.1	growth/differentiation factor 3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gdf3	NP_032134.2
Danio rerio (zebrafish)	dvr1	NP_571023.1
Bos taurus (cattle)	GDF3	XP_002687893.1
Xenopus tropicalis (tropical clawed frog)	gdf1	NP_001016819.1
	GDF3	XP_001112644.1
Gallus gallus (chicken)	GDF3	NP_990542.1
Xenopus tropicalis (tropical clawed frog)	gdf3	NP_001007905.1
Pan troglodytes (chimpanzee)	GDF3	XP_508988.2
Canis lupus familiaris (dog)	GDF3	XP_534896.1
Rattus norvegicus (Norway rat)	Gdf3	NP_001103141.1
Homo sapiens (human)	GDF3	NP_065685.1

Gene Ontology
Bibliography

Related articles in PubMed

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.
Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD, Chen J
PloS one8(7)e68068(2013)

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.
Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Br?ns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE
Cell death and differentiation19(6)1003-12(2012 Jun)

The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
Li Q, Liu X, Wu Y, An J, Hexige S, Ling Y, Zhang M, Yang X, Yu L
Molecular and cellular biochemistry359(1-2)115-23(2012 Jan)

Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.
Ye M, Berry-Wynne KM, Asai-Coakwell M, Sundaresan P, Footz T, French CR, Abitbol M, Fleisch VC, Corbett N, Allison WT, Drummond G, Walter MA, Underhill TM, Waskiewicz AJ, Lehmann OJ
Human molecular genetics19(2)287-98(2010 Jan)

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses.
Levine AJ, Levine ZJ, Brivanlou AH
Developmental biology325(1)43-8(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GDF3 is a potential target of miR-483-3p and is downregulated in low-protein diet rat offspring and low-birth-weight men.
Title: Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

The following Gdf3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gdf3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10797	NM_001109671.1 Latest version!	Rattus norvegicus growth differentiation factor 3 (Gdf3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gdf3 ( NM_001109671.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103141.1 Rattus norvegicus growth differentiation factor 3 (Gdf3), mRNA.

Price & Availability↑

CloneID	ORa10797
Clone ID Related Accession (Same CDS sequence)	NM_001109671.1
Accession Version	NM_001109671.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	growth/differentiation factor 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473964.2. On or before Oct 4, 2007 this sequence version replaced XM_575661.2, XM_001060448.1. ##Evidence-Data-START## Transcript exon combination :: DQ372084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGCAACCTT CCCAAAGGCT TCTGACTCTC GGCTTCCTTC TGTTAACCCT GGCCCGGGGC 
CAGACATCCG AGTTTCAAGA CTATGACTTT TTGCAATTTC TGGGCTTAAA GAAAGCGCCT 
TCACCCCACA GGTTCCAACC TGTGCCTCGC ATCTTAAGGA AAATCATACG GGCTCGAGAA 
ACCGCTGCAG CCAGCGGGGC CTCGCAGGAC TTATGCTACG TGAAGGAGCT GGGCGTCCGT 
GGGAACCTGC TTCGGCTTCT CCCAGACCAG GGTTTTTTCC TTAACACACA GAAACCTTCC 
CAAGATGGCT CCTGTCTACA GAAGGTCCTC TCTTTTAACT TGTCTGCCGT CAAAGAAAAG 
GGAAAGTTGA CCATGGCCCA GCTGATTCTA CACTTGGGGC CCAGGTCCTA CCATTACCTG 
CAGCTGGAGC TGGTGGTGGC TGTATCTGTG GTTCAGGATC GTGGTGTGTG GGGGCGATCC 
CACCCTAAGC TGGGCAGGTT GCTCGTTCAG AAGTCTGTCC TGGGACCTCA AGGTTCTCTT 
CAGTTCAACC TGCAGGGTGT GGTTAAGGAT TGGAACCGCC ACCAACTGAA GAATTTGGAC 
TTATACTTAG AGATTCTGGT CAAAGAGGAC AGATACTCCA GGGTAAATGC CCAGCTTGAT 
AACCCCTGTA ACCAGCTGAT GCACTCTCTT CATGCCTCCC TGCTGGTGGT GACCCTCAAC 
CTTAAACACT GTCACCCTTC TTCCAGAAAG AAGAGGGCAG CCATCCCTAT TCCCAAGGGT 
CTTTGTAGGA ACCTCTGCCA TCGTCACCAA CTGTTCGTCA ACTTCCAGGA CCTGGGTTGG 
CACAAGTGGG TCATTGCCCC TAAGGGTTTC ATGGCAAACT ACTGTCATGG AGATTGCCCC 
TTCACAATGA CCACGTATTT GAATAGCTCC AATTATGCCT TCATGCAGGC TCTGATGCAT 
ATGGCTGACC CCAGGGTCCC CAAGGCTGTC TGTATCCCCA CCAAGCTGTC TCCAATCTCC 
ATGCTCTATC AAGATAACGA GAAGAACGTC ATTCTCCGAC ATTATGAAGA CATGGTAGTG 
GATGAGTGTG GGTGTGGGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103141.1
CDS	116..1216
Translation	MQPSQRLLTLGFLLLTLARGQTSEFQDYDFLQFLGLKKAPSPHRFQPVPRILRKIIRARETAAASGASQDLCYVKELGVRGNLLRLLPDQGFFLNTQKPSQDGSCLQKVLSFNLSAVKEKGKLTMAQLILHLGPRSYHYLQLELVVAVSVVQDRGVWGRSHPKLGRLLVQKSVLGPQGSLQFNLQGVVKDWNRHQLKNLDLYLEILVKEDRYSRVNAQLDNPCNQLMHSLHASLLVVTLNLKHCHPSSRKKRAAIPIPKGLCRNLCHRHQLFVNFQDLGWHKWVIAPKGFMANYCHGDCPFTMTTYLNSSNYAFMQALMHMADPRVPKAVCIPTKLSPISMLYQDNEKNVILRHYEDMVVDECGCG

Target ORF information:

RefSeq Version	NM_001109671.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus growth differentiation factor 3 (Gdf3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109671.1

ORF Insert Sequence:

ATGCAACCTT CCCAAAGGCT TCTGACTCTC GGCTTCCTTC TGTTAACCCT GGCCCGGGGC 
CAGACATCCG AGTTTCAAGA CTATGACTTT TTGCAATTTC TGGGCTTAAA GAAAGCGCCT 
TCACCCCACA GGTTCCAACC TGTGCCTCGC ATCTTAAGGA AAATCATACG GGCTCGAGAA 
ACCGCTGCAG CCAGCGGGGC CTCGCAGGAC TTATGCTACG TGAAGGAGCT GGGCGTCCGT 
GGGAACCTGC TTCGGCTTCT CCCAGACCAG GGTTTTTTCC TTAACACACA GAAACCTTCC 
CAAGATGGCT CCTGTCTACA GAAGGTCCTC TCTTTTAACT TGTCTGCCGT CAAAGAAAAG 
GGAAAGTTGA CCATGGCCCA GCTGATTCTA CACTTGGGGC CCAGGTCCTA CCATTACCTG 
CAGCTGGAGC TGGTGGTGGC TGTATCTGTG GTTCAGGATC GTGGTGTGTG GGGGCGATCC 
CACCCTAAGC TGGGCAGGTT GCTCGTTCAG AAGTCTGTCC TGGGACCTCA AGGTTCTCTT 
CAGTTCAACC TGCAGGGTGT GGTTAAGGAT TGGAACCGCC ACCAACTGAA GAATTTGGAC 
TTATACTTAG AGATTCTGGT CAAAGAGGAC AGATACTCCA GGGTAAATGC CCAGCTTGAT 
AACCCCTGTA ACCAGCTGAT GCACTCTCTT CATGCCTCCC TGCTGGTGGT GACCCTCAAC 
CTTAAACACT GTCACCCTTC TTCCAGAAAG AAGAGGGCAG CCATCCCTAT TCCCAAGGGT 
CTTTGTAGGA ACCTCTGCCA TCGTCACCAA CTGTTCGTCA ACTTCCAGGA CCTGGGTTGG 
CACAAGTGGG TCATTGCCCC TAAGGGTTTC ATGGCAAACT ACTGTCATGG AGATTGCCCC 
TTCACAATGA CCACGTATTT GAATAGCTCC AATTATGCCT TCATGCAGGC TCTGATGCAT 
ATGGCTGACC CCAGGGTCCC CAAGGCTGTC TGTATCCCCA CCAAGCTGTC TCCAATCTCC 
ATGCTCTATC AAGATAACGA GAAGAACGTC ATTCTCCGAC ATTATGAAGA CATGGTAGTG 
GATGAGTGTG GGTGTGGGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.
PloS one8(7)e68068(2013)
Ge Y,Waldemer RJ,Nalluri R,Nuzzi PD,Chen J

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.
Cell death and differentiation19(6)1003-12(2012 Jun)
Ferland-McCollough D,Fernandez-Twinn DS,Cannell IG,David H,Warner M,Vaag AA,Bork-Jensen J,Br?ns C,Gant TW,Willis AE,Siddle K,Bushell M,Ozanne SE

The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
Molecular and cellular biochemistry359(1-2)115-23(2012 Jan)
Li Q,Liu X,Wu Y,An J,Hexige S,Ling Y,Zhang M,Yang X,Yu L

Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.
Human molecular genetics19(2)287-98(2010 Jan)
Ye M,Berry-Wynne KM,Asai-Coakwell M,Sundaresan P,Footz T,French CR,Abitbol M,Fleisch VC,Corbett N,Allison WT,Drummond G,Walter MA,Underhill TM,Waskiewicz AJ,Lehmann OJ

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses.
Developmental biology325(1)43-8(2009 Jan)
Levine AJ,Levine ZJ,Brivanlou AH

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Gdf3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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