Tprn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tprn
Entrez Gene ID	499749
Full Name	taperin
General protein information	Preferred Names taperin Names taperin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024309.2	NP_001019480.2	taperin

Pathways from BioSystems

Homologies

	LOC721581	XP_001117763.1
Bos taurus (cattle)	TPRN	NP_001096820.2
Rattus norvegicus (Norway rat)	Tprn	NP_001019480.2
Xenopus tropicalis (tropical clawed frog)	LOC101731408	XP_004917615.1
Homo sapiens (human)	TPRN	NP_001121700.2
Gallus gallus (chicken)	TPRN	XP_415534.4
Mus musculus (house mouse)	Tprn	NP_780495.2

Gene Ontology
Bibliography

Related articles in PubMed

Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice.
Chen M, Wang Q, Zhu GH, Hu P, Zhou Y, Wang T, Lai RS, Xiao ZA, Xie DH
Biochemical and biophysical research communications479(4)703-707(2016 Oct)

Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.
Zhao B, Wu Z, M?ller U
eLife5(2016 06)

Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss.
Li Y, Pohl E, Boulouiz R, Schraders M, N?rnberg G, Charif M, Admiraal RJ, von Ameln S, Baessmann I, Kandil M, Veltman JA, N?rnberg P, Kubisch C, Barakat A, Kremer H, Wollnik B
American journal of human genetics86(3)479-84(2010 Mar)

Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.
Rehman AU, Morell RJ, Belyantseva IA, Khan SY, Boger ET, Shahzad M, Ahmed ZM, Riazuddin S, Khan SN, Riazuddin S, Friedman TB
American journal of human genetics86(3)378-88(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tprn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tprn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06304	NM_001024309.2 Latest version!	Rattus norvegicus taperin (Tprn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$440.30 $629.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tprn ( NM_001024309.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001019480.2 Rattus norvegicus taperin (Tprn), mRNA.

Price & Availability↑

CloneID	ORa06304
Clone ID Related Accession (Same CDS sequence)	NM_001024309.2
Accession Version	NM_001024309.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2262bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	taperin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07051240.1 and BC083928.1. On Jun 11, 2008 this sequence version replaced NM_001024309.1. Sequence Note: This RefSeq record was created from transcript and genomic data because transcript data was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by orthologous data from mouse RefSeq NM_175286. ##Evidence-Data-START## Transcript exon combination :: BC083928.1, FM060402.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGCC TGGGGCGGCT CGATCCGGGG CCGCGAACCG TGATGCCCGC CTGGAAACGG 
GAGATACTTG AGCGGAGGCG AGCTAAACTG GCCGCTCTGA GCGGAGGCCC GGGATCTGGA 
GCGGCACCGG ATGGGCCTAA CGAGCGGCTG GTGCTGGCGG AGAGTCTGGG TCCACTAAGC 
CAGAACCCGT TCATGCGACT TGAATCGGAG AGGCGGCGCG GGGCGCGGCC CGCTCAGCAG 
CTGCTGGAGC TGTACTGTCG TGTGCCCGGC GTGCGGACCA TTCGAGCCGA CAACATCCTC 
ATCATCGAGT CAGCGCCAGG GTTCCCGCCC GCTGTGCCGC CCGCTTCGAG CATCCGCGCT 
GCCGAGGTAG TGGTGTACGA GGAGCCACAG CCCGGCCGGG TCAGCCGCCT GCTAGAAAAG 
TTCGACTCGC CTGCTGCGCC CCGCCGCCGC GGGAGCCCAG AGCGCTTCCG CCCTGCGCTC 
CCGCAGCTTC CCGTGGCGCC TGCATCTGCT GCCACGCGCG CTCCTACCAA TCGGTCGTTG 
GCTCCTGCCC CACCGGTGCT CCCTAGCCAG CCCGCACCCC CTATTTCGCC TGTCCCCGTT 
GCCCAGCGCG CGGGTCAGCG CTCTGCCTGT TGCGAGCCCG CGCACCCCGA CGGCACTGCC 
GGCCCCGGGG CCCGGCGCAG CGACTTCCTA CAAAAGACCG GCAGCAACTC CTTCACTGTC 
CACCCCCGAG GCCTGCCCGG CAGTGCGGTC AATCGCTCGC TTTCTAATGG ACCCATGACT 
CAGGAATCCC CTGCCGGCCC TGCCAATGGG TTGTCGGGCT CTCCGCCTGT ACCGGGCAAG 
TGGAAGCCAA AGGTGGAGTC AAAGGAACCC TCCCTCCACC CACCCCCAAG CCCTGGGACC 
CCAAGTGCCA CTCCAGTTGG GCCCCCTGCC TTCCTGGCGC CCAGCCCAGC CAGTGCCACT 
CCCAGTCAGC GCCAGTGGGT CTCCTCTGCC ACCAGCGCCA ATGACTCCTT CGAAATAAGG 
CCATCCTCCA AGCCAGACAT GGAAACTATC CCAATTGGGG ACCTTCAGGC CAGAGCCCTG 
GCCAACCTCA GAGTGAACTC CCGCAACTCC TTCGTGTTGA TCCCCAAGCG CAAAGCCCCT 
GGGAACTATC CTTCGGCGGC GGGGAGGCAA TTCGAGGAGC CAAAGGGGGA GGTGGGCTGG 
GCCTCTCAGA GCCAGGGGCT CGGATCCCAG CTGGTGTCTA CAGTGGATGG TGCACCTGCC 
CTAGAGAAGA GTTCCTTGGC TGCTGAGATG CAGTGGGCAG TTAGGGAGGG AGGCTGCCCC 
AGGCCAGCCA TTTCTGACAC AGACAAGTCT GTTAGGAGGC AGAGGCCAGC CTCACCACCT 
CCATTTCTAC CAGCCACTAC TGAAGCTGAG CCGGCTGAAG GCTTGGGGGT TCCTGGCTTG 
ACCAAGAATG GCCAGGAGCC TGTGAGGCCA GGACTTCCAG TCACCTTCAT TGATGAAGTA 
GACTCAGAGG AGGCGGCCTT TCAAGAAGCC AAACTGCCCT CTTCAGCAGT TGGTGTGCCT 
TCCCAGTACC ACCTGCACCC TTCCACACCT GGGCACACCT CAGAGCTCCT CAACCGAGGT 
AGCAACACTT TCACAGTAGT GCCCAAGAGG AAGCCAGGGA CCCTTCAGGA GCCACACTTA 
AGTCAGACTA ATGGGCAGTT CCAGCAAGGG GCAGAGGAAC AGGATGCTGA TAGCCTCTCG 
GGACCCCACA CTACCCTGGA GAATGCCCTA AAGAAACGAT ACCCCACTGT GAATGAGATT 
GAGGTGATCG GTGGTTACCT GGCCCTGCAG AAGTCCTGCC TCATCAAGGC TGGCTCCTCC 
AGAAAAAAGA TGAAGATCTC CTTCAATGAC AAGAGCCTGC ACACAACATT TGAGTACCCT 
TCTGAGAGCT CTCTGGCCCA GGAGGAGGCA GAGGAGGAAG AAGAGGAGGA GGAGGAGGAA 
GAAGGAGAGG ATGGTGAAGA GGAGGAAGTG GGGCCTGACT CAGAGAAATC CTTCACAGTT 
CTCTTGCCCC GGGCCACATT TGTAAGCAGT GTGGGACCTG AGAGCAGCTC AGGTCTGTCC 
AGCTACACTC CAAAGCATTC CATGGCCTTC AGCAAGTGGC AGGAGCAGAC ACTGGTGCAG 
GCTCCAACTG AGGTGGAGCT CCCACCAAAA GAGGTCATGC TCACACCTGC CAGTCAGAAT 
GATCTCTCGG ACTTCCGCAG CGAGCCAGCC CTCTATTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019480.2
CDS	1..2262
Translation	MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGPGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGARPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPASSIRAAEVVVYEEPQPGRVSRLLEKFDSPAAPRRRGSPERFRPALPQLPVAPASAATRAPTNRSLAPAPPVLPSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPGSAVNRSLSNGPMTQESPAGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATPVGPPAFLAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPSAAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSSLAAEMQWAVREGGCPRPAISDTDKSVRRQRPASPPPFLPATTEAEPAEGLGVPGLTKNGQEPVRPGLPVTFIDEVDSEEAAFQEAKLPSSAVGVPSQYHLHPSTPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQFQQGAEEQDADSLSGPHTTLENALKKRYPTVNEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEEEEEGEDGEEEEVGPDSEKSFTVLLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQAPTEVELPPKEVMLTPASQNDLSDFRSEPALYF

Target ORF information:

RefSeq Version	NM_001024309.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus taperin (Tprn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024309.2

ORF Insert Sequence:

ATGGCCGGCC TGGGGCGGCT CGATCCGGGG CCGCGAACCG TGATGCCCGC CTGGAAACGG 
GAGATACTTG AGCGGAGGCG AGCTAAACTG GCCGCTCTGA GCGGAGGCCC GGGATCTGGA 
GCGGCACCGG ATGGGCCTAA CGAGCGGCTG GTGCTGGCGG AGAGTCTGGG TCCACTAAGC 
CAGAACCCGT TCATGCGACT TGAATCGGAG AGGCGGCGCG GGGCGCGGCC CGCTCAGCAG 
CTGCTGGAGC TGTACTGTCG TGTGCCCGGC GTGCGGACCA TTCGAGCCGA CAACATCCTC 
ATCATCGAGT CAGCGCCAGG GTTCCCGCCC GCTGTGCCGC CCGCTTCGAG CATCCGCGCT 
GCCGAGGTAG TGGTGTACGA GGAGCCACAG CCCGGCCGGG TCAGCCGCCT GCTAGAAAAG 
TTCGACTCGC CTGCTGCGCC CCGCCGCCGC GGGAGCCCAG AGCGCTTCCG CCCTGCGCTC 
CCGCAGCTTC CCGTGGCGCC TGCATCTGCT GCCACGCGCG CTCCTACCAA TCGGTCGTTG 
GCTCCTGCCC CACCGGTGCT CCCTAGCCAG CCCGCACCCC CTATTTCGCC TGTCCCCGTT 
GCCCAGCGCG CGGGTCAGCG CTCTGCCTGT TGCGAGCCCG CGCACCCCGA CGGCACTGCC 
GGCCCCGGGG CCCGGCGCAG CGACTTCCTA CAAAAGACCG GCAGCAACTC CTTCACTGTC 
CACCCCCGAG GCCTGCCCGG CAGTGCGGTC AATCGCTCGC TTTCTAATGG ACCCATGACT 
CAGGAATCCC CTGCCGGCCC TGCCAATGGG TTGTCGGGCT CTCCGCCTGT ACCGGGCAAG 
TGGAAGCCAA AGGTGGAGTC AAAGGAACCC TCCCTCCACC CACCCCCAAG CCCTGGGACC 
CCAAGTGCCA CTCCAGTTGG GCCCCCTGCC TTCCTGGCGC CCAGCCCAGC CAGTGCCACT 
CCCAGTCAGC GCCAGTGGGT CTCCTCTGCC ACCAGCGCCA ATGACTCCTT CGAAATAAGG 
CCATCCTCCA AGCCAGACAT GGAAACTATC CCAATTGGGG ACCTTCAGGC CAGAGCCCTG 
GCCAACCTCA GAGTGAACTC CCGCAACTCC TTCGTGTTGA TCCCCAAGCG CAAAGCCCCT 
GGGAACTATC CTTCGGCGGC GGGGAGGCAA TTCGAGGAGC CAAAGGGGGA GGTGGGCTGG 
GCCTCTCAGA GCCAGGGGCT CGGATCCCAG CTGGTGTCTA CAGTGGATGG TGCACCTGCC 
CTAGAGAAGA GTTCCTTGGC TGCTGAGATG CAGTGGGCAG TTAGGGAGGG AGGCTGCCCC 
AGGCCAGCCA TTTCTGACAC AGACAAGTCT GTTAGGAGGC AGAGGCCAGC CTCACCACCT 
CCATTTCTAC CAGCCACTAC TGAAGCTGAG CCGGCTGAAG GCTTGGGGGT TCCTGGCTTG 
ACCAAGAATG GCCAGGAGCC TGTGAGGCCA GGACTTCCAG TCACCTTCAT TGATGAAGTA 
GACTCAGAGG AGGCGGCCTT TCAAGAAGCC AAACTGCCCT CTTCAGCAGT TGGTGTGCCT 
TCCCAGTACC ACCTGCACCC TTCCACACCT GGGCACACCT CAGAGCTCCT CAACCGAGGT 
AGCAACACTT TCACAGTAGT GCCCAAGAGG AAGCCAGGGA CCCTTCAGGA GCCACACTTA 
AGTCAGACTA ATGGGCAGTT CCAGCAAGGG GCAGAGGAAC AGGATGCTGA TAGCCTCTCG 
GGACCCCACA CTACCCTGGA GAATGCCCTA AAGAAACGAT ACCCCACTGT GAATGAGATT 
GAGGTGATCG GTGGTTACCT GGCCCTGCAG AAGTCCTGCC TCATCAAGGC TGGCTCCTCC 
AGAAAAAAGA TGAAGATCTC CTTCAATGAC AAGAGCCTGC ACACAACATT TGAGTACCCT 
TCTGAGAGCT CTCTGGCCCA GGAGGAGGCA GAGGAGGAAG AAGAGGAGGA GGAGGAGGAA 
GAAGGAGAGG ATGGTGAAGA GGAGGAAGTG GGGCCTGACT CAGAGAAATC CTTCACAGTT 
CTCTTGCCCC GGGCCACATT TGTAAGCAGT GTGGGACCTG AGAGCAGCTC AGGTCTGTCC 
AGCTACACTC CAAAGCATTC CATGGCCTTC AGCAAGTGGC AGGAGCAGAC ACTGGTGCAG 
GCTCCAACTG AGGTGGAGCT CCCACCAAAA GAGGTCATGC TCACACCTGC CAGTCAGAAT 
GATCTCTCGG ACTTCCGCAG CGAGCCAGCC CTCTATTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice.
Biochemical and biophysical research communications479(4)703-707(2016 Oct)
Chen M,Wang Q,Zhu GH,Hu P,Zhou Y,Wang T,Lai RS,Xiao ZA,Xie DH

Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.
eLife5(2016 06)
Zhao B,Wu Z,M?ller U

Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss.
American journal of human genetics86(3)479-84(2010 Mar)
Li Y,Pohl E,Boulouiz R,Schraders M,N?rnberg G,Charif M,Admiraal RJ,von Ameln S,Baessmann I,Kandil M,Veltman JA,N?rnberg P,Kubisch C,Barakat A,Kremer H,Wollnik B

Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.
American journal of human genetics86(3)378-88(2010 Mar)
Rehman AU,Morell RJ,Belyantseva IA,Khan SY,Boger ET,Shahzad M,Ahmed ZM,Riazuddin S,Khan SN,Riazuddin S,Friedman TB

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Tprn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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