Hus1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hus1
Entrez Gene ID	498411
Full Name	HUS1 checkpoint clamp component
General protein information	Preferred Names HUS1 checkpoint clamp component Names checkpoint protein HUS1 HUS1 checkpoint homolog Hus1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_006251469.2	XP_006251531.1	checkpoint protein HUS1 isoform X2
XM_008770346.2	XP_008768568.1	checkpoint protein HUS1 isoform X3
XM_006251468.1	XP_006251530.1	checkpoint protein HUS1 isoform X1
NM_001109092.1	NP_001102562.1	checkpoint protein HUS1

Pathways from BioSystems

Homologies

	HUS1	XP_001088000.1
Danio rerio (zebrafish)	zgc:162895	NP_001082965.1
Magnaporthe oryzae (rice blast fungus)	MGG_12138	XP_003719779.1
Neurospora crassa	NCU11262	XP_001728351.1
Rattus norvegicus (Norway rat)	Hus1	NP_001102562.1
Caenorhabditis elegans (roundworm)	hus-1	NP_491203.1
Schizosaccharomyces pombe (fission yeast)	hus1	NP_594739.1
Homo sapiens (human)	HUS1	NP_004498.1
Canis lupus familiaris (dog)	HUS1	XP_848291.3
Mus musculus (house mouse)	Hus1	NP_032342.1
Drosophila melanogaster (fruit fly)	Hus1-like	NP_001262267.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011361	XP_317958.4
Xenopus tropicalis (tropical clawed frog)	hus1	NP_001006827.1
Pan troglodytes (chimpanzee)	HUS1	XP_003951051.1
Gallus gallus (chicken)	HUS1	XP_426029.3

Gene Ontology
Bibliography

Related articles in PubMed

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Cotta-Ramusino C, McDonald ER 3rd, Hurov K, Sowa ME, Harper JW, Elledge SJ
Science (New York, N.Y.)332(6035)1313-7(2011 Jun)

The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining.
Wang X, Hu B, Weiss RS, Wang Y
Oncogene25(13)1980-3(2006 Mar)

Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.
Levitt PS, Liu H, Manning C, Weiss RS
Genomics86(2)212-24(2005 Aug)

Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.
Wang X, Guan J, Hu B, Weiss RS, Iliakis G, Wang Y
Nucleic acids research32(2)767-75(2004)

Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.
Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, Sanchez Y
The Journal of biological chemistry278(27)25207-17(2003 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hus1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hus1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa36389	NM_001109092.1 Latest version!	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa36389	XM_006251468.1 Latest version!	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa36390	XM_006251469.2 Latest version!	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa49090	XM_008770346.2 Latest version!	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hus1 ( NM_001109092.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102562.1 Rattus norvegicus HUS1 checkpoint clamp component (Hus1), mRNA.

Price & Availability↑

CloneID	ORa36389
Clone ID Related Accession (Same CDS sequence)	XM_006251468.1 , NM_001109092.1
Accession Version	NM_001109092.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	checkpoint protein HUS1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474055.1. On or before Oct 4, 2007 this sequence version replaced XM_001054510.1, XM_573658.2.

ATGAAGTTTC GTGCCAAGAT CGTGGATCTG GCTTGTCTGA ATCACTTTAC ACGAGTCAGT 
AACATGATAG CCAAGCTTGC CAAAACCTGC ACCCTCCGCA TCAGCCCAGA GAAGCTGAAC 
TTCATCCTCT GTGACAAGCT GGCCAGTGGA GGCGTGAGCA TGTGGTGTGA GCTGGAGCAG 
GAGAACTTTT TTAGTGAATT CCAAATGGAA GGAGTCTCTG AAGAAAACAA TGAGATTTAT 
TTAGAATTAA CGTCGGAAAA CTTAGCTCGA GCCTTGAAGA CTGCCCAGAA CGCCAGAGCC 
TTGAAAATCA AGCTTACTAA CAAGCACTTT CCCTGTCTAA CCGTGTCCGT AGAGCTGTTG 
TCTTCATCAA GCAGTAGCAG AATTGTGGTA CATGATATCC CCATAAAGGT TATTCCGAGA 
AGACTGTGGA AGGACTTACA AGAACCCTCC ATCCCAGAAT CTGATGTCAG TATTTATCTA 
CCAGCCTTGA AGACAATGAA GAGTGTCGTG GATAAAATGA GGAACATCAG CAATCACCTT 
GTTATTGAAG CAAACCTAAA AGGAGAACTA AACCTAAAGA TAGAAACTGA GTCAGTATGT 
GTGACAACAC ACTTTAAGGA TCTTGAAAAC CCTCTACTAC CTTCTGACAG TGTCTCTCAA 
AACAGACACC CAGAAGACAT GGCCAAGGTG CACATCGACA TAAGGAAACT CCTCCAGTTG 
CTTGCTGGAC AGCAAGTGGC TCCCACCAAG GCGGTGTGCA ATATCGTCAA TAACAGAACT 
ATTCACTTTG ATCTGCTCCT GGAAGACGTC TCCCTTCAGT ATTTCATCCC AGCCTTGTCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102562.1
CDS	82..924
Translation	MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLARALKTAQNARALKIKLTNKHFPCLTVSVELLSSSSSSRIVVHDIPIKVIPRRLWKDLQEPSIPESDVSIYLPALKTMKSVVDKMRNISNHLVIEANLKGELNLKIETESVCVTTHFKDLENPLLPSDSVSQNRHPEDMAKVHIDIRKLLQLLAGQQVAPTKAVCNIVNNRTIHFDLLLEDVSLQYFIPALS

Target ORF information:

RefSeq Version	NM_001109092.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109092.1

ORF Insert Sequence:

ATGAAGTTTC GTGCCAAGAT CGTGGATCTG GCTTGTCTGA ATCACTTTAC ACGAGTCAGT 
AACATGATAG CCAAGCTTGC CAAAACCTGC ACCCTCCGCA TCAGCCCAGA GAAGCTGAAC 
TTCATCCTCT GTGACAAGCT GGCCAGTGGA GGCGTGAGCA TGTGGTGTGA GCTGGAGCAG 
GAGAACTTTT TTAGTGAATT CCAAATGGAA GGAGTCTCTG AAGAAAACAA TGAGATTTAT 
TTAGAATTAA CGTCGGAAAA CTTAGCTCGA GCCTTGAAGA CTGCCCAGAA CGCCAGAGCC 
TTGAAAATCA AGCTTACTAA CAAGCACTTT CCCTGTCTAA CCGTGTCCGT AGAGCTGTTG 
TCTTCATCAA GCAGTAGCAG AATTGTGGTA CATGATATCC CCATAAAGGT TATTCCGAGA 
AGACTGTGGA AGGACTTACA AGAACCCTCC ATCCCAGAAT CTGATGTCAG TATTTATCTA 
CCAGCCTTGA AGACAATGAA GAGTGTCGTG GATAAAATGA GGAACATCAG CAATCACCTT 
GTTATTGAAG CAAACCTAAA AGGAGAACTA AACCTAAAGA TAGAAACTGA GTCAGTATGT 
GTGACAACAC ACTTTAAGGA TCTTGAAAAC CCTCTACTAC CTTCTGACAG TGTCTCTCAA 
AACAGACACC CAGAAGACAT GGCCAAGGTG CACATCGACA TAAGGAAACT CCTCCAGTTG 
CTTGCTGGAC AGCAAGTGGC TCCCACCAAG GCGGTGTGCA ATATCGTCAA TAACAGAACT 
ATTCACTTTG ATCTGCTCCT GGAAGACGTC TCCCTTCAGT ATTTCATCCC AGCCTTGTCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hus1 ( XM_006251468.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251530.1 Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36389
Clone ID Related Accession (Same CDS sequence)	XM_006251468.1 , NM_001109092.1
Accession Version	XM_006251468.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	checkpoint protein HUS1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTTC GTGCCAAGAT CGTGGATCTG GCTTGTCTGA ATCACTTTAC ACGAGTCAGT 
AACATGATAG CCAAGCTTGC CAAAACCTGC ACCCTCCGCA TCAGCCCAGA GAAGCTGAAC 
TTCATCCTCT GTGACAAGCT GGCCAGTGGA GGCGTGAGCA TGTGGTGTGA GCTGGAGCAG 
GAGAACTTTT TTAGTGAATT CCAAATGGAA GGAGTCTCTG AAGAAAACAA TGAGATTTAT 
TTAGAATTAA CGTCGGAAAA CTTAGCTCGA GCCTTGAAGA CTGCCCAGAA CGCCAGAGCC 
TTGAAAATCA AGCTTACTAA CAAGCACTTT CCCTGTCTAA CCGTGTCCGT AGAGCTGTTG 
TCTTCATCAA GCAGTAGCAG AATTGTGGTA CATGATATCC CCATAAAGGT TATTCCGAGA 
AGACTGTGGA AGGACTTACA AGAACCCTCC ATCCCAGAAT CTGATGTCAG TATTTATCTA 
CCAGCCTTGA AGACAATGAA GAGTGTCGTG GATAAAATGA GGAACATCAG CAATCACCTT 
GTTATTGAAG CAAACCTAAA AGGAGAACTA AACCTAAAGA TAGAAACTGA GTCAGTATGT 
GTGACAACAC ACTTTAAGGA TCTTGAAAAC CCTCTACTAC CTTCTGACAG TGTCTCTCAA 
AACAGACACC CAGAAGACAT GGCCAAGGTG CACATCGACA TAAGGAAACT CCTCCAGTTG 
CTTGCTGGAC AGCAAGTGGC TCCCACCAAG GCGGTGTGCA ATATCGTCAA TAACAGAACT 
ATTCACTTTG ATCTGCTCCT GGAAGACGTC TCCCTTCAGT ATTTCATCCC AGCCTTGTCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251530.1
CDS	77..919
Translation	MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLARALKTAQNARALKIKLTNKHFPCLTVSVELLSSSSSSRIVVHDIPIKVIPRRLWKDLQEPSIPESDVSIYLPALKTMKSVVDKMRNISNHLVIEANLKGELNLKIETESVCVTTHFKDLENPLLPSDSVSQNRHPEDMAKVHIDIRKLLQLLAGQQVAPTKAVCNIVNNRTIHFDLLLEDVSLQYFIPALS

Target ORF information:

RefSeq Version	XM_006251468.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251468.1

ORF Insert Sequence:

ATGAAGTTTC GTGCCAAGAT CGTGGATCTG GCTTGTCTGA ATCACTTTAC ACGAGTCAGT 
AACATGATAG CCAAGCTTGC CAAAACCTGC ACCCTCCGCA TCAGCCCAGA GAAGCTGAAC 
TTCATCCTCT GTGACAAGCT GGCCAGTGGA GGCGTGAGCA TGTGGTGTGA GCTGGAGCAG 
GAGAACTTTT TTAGTGAATT CCAAATGGAA GGAGTCTCTG AAGAAAACAA TGAGATTTAT 
TTAGAATTAA CGTCGGAAAA CTTAGCTCGA GCCTTGAAGA CTGCCCAGAA CGCCAGAGCC 
TTGAAAATCA AGCTTACTAA CAAGCACTTT CCCTGTCTAA CCGTGTCCGT AGAGCTGTTG 
TCTTCATCAA GCAGTAGCAG AATTGTGGTA CATGATATCC CCATAAAGGT TATTCCGAGA 
AGACTGTGGA AGGACTTACA AGAACCCTCC ATCCCAGAAT CTGATGTCAG TATTTATCTA 
CCAGCCTTGA AGACAATGAA GAGTGTCGTG GATAAAATGA GGAACATCAG CAATCACCTT 
GTTATTGAAG CAAACCTAAA AGGAGAACTA AACCTAAAGA TAGAAACTGA GTCAGTATGT 
GTGACAACAC ACTTTAAGGA TCTTGAAAAC CCTCTACTAC CTTCTGACAG TGTCTCTCAA 
AACAGACACC CAGAAGACAT GGCCAAGGTG CACATCGACA TAAGGAAACT CCTCCAGTTG 
CTTGCTGGAC AGCAAGTGGC TCCCACCAAG GCGGTGTGCA ATATCGTCAA TAACAGAACT 
ATTCACTTTG ATCTGCTCCT GGAAGACGTC TCCCTTCAGT ATTTCATCCC AGCCTTGTCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hus1 ( XM_006251469.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251531.1 Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa36390
Clone ID Related Accession (Same CDS sequence)	XM_006251469.2
Accession Version	XM_006251469.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	checkpoint protein HUS1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251469.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATAGCCA AGCTTGCCAA AACCTGCACC CTCCGCATCA GCCCAGAGAA GCTGAACTTC 
ATCCTCTGTG ACAAGCTGGC CAGTGGAGGC GTGAGCATGT GGTGTGAGCT GGAGCAGGAG 
AACTTTTTTA GTGAATTCCA AATGGAAGGA GTCTCTGAAG AAAACAATGA GATTTATTTA 
GAATTAACGT CGGAAAACTT AGCTCGAGCC TTGAAGACTG CCCAGAACGC CAGAGCCTTG 
AAAATCAAGC TTACTAACAA GCACTTTCCC TGTCTAACCG TGTCCGTAGA GCTGTTGTCT 
TCATCAAGCA GTAGCAGAAT TGTGGTACAT GATATCCCCA TAAAGGTTAT TCCGAGAAGA 
CTGTGGAAGG ACTTACAAGA ACCCTCCATC CCAGAATCTG ATGTCAGTAT TTATCTACCA 
GCCTTGAAGA CAATGAAGAG TGTCGTGGAT AAAATGAGGA ACATCAGCAA TCACCTTGTT 
ATTGAAGCAA ACCTAAAAGG AGAACTAAAC CTAAAGATAG AAACTGAGTC AGTATGTGTG 
ACAACACACT TTAAGGATCT TGAAAACCCT CTACTACCTT CTGACAGTGT CTCTCAAAAC 
AGACACCCAG AAGACATGGC CAAGGTGCAC ATCGACATAA GGAAACTCCT CCAGTTGCTT 
GCTGGACAGC AAGTGGCTCC CACCAAGGCG GTGTGCAATA TCGTCAATAA CAGAACTATT 
CACTTTGATC TGCTCCTGGA AGACGTCTCC CTTCAGTATT TCATCCCAGC CTTGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251531.1
CDS	344..1123
Translation	MIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLARALKTAQNARALKIKLTNKHFPCLTVSVELLSSSSSSRIVVHDIPIKVIPRRLWKDLQEPSIPESDVSIYLPALKTMKSVVDKMRNISNHLVIEANLKGELNLKIETESVCVTTHFKDLENPLLPSDSVSQNRHPEDMAKVHIDIRKLLQLLAGQQVAPTKAVCNIVNNRTIHFDLLLEDVSLQYFIPALS

Target ORF information:

RefSeq Version	XM_006251469.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251469.2

ORF Insert Sequence:

ATGATAGCCA AGCTTGCCAA AACCTGCACC CTCCGCATCA GCCCAGAGAA GCTGAACTTC 
ATCCTCTGTG ACAAGCTGGC CAGTGGAGGC GTGAGCATGT GGTGTGAGCT GGAGCAGGAG 
AACTTTTTTA GTGAATTCCA AATGGAAGGA GTCTCTGAAG AAAACAATGA GATTTATTTA 
GAATTAACGT CGGAAAACTT AGCTCGAGCC TTGAAGACTG CCCAGAACGC CAGAGCCTTG 
AAAATCAAGC TTACTAACAA GCACTTTCCC TGTCTAACCG TGTCCGTAGA GCTGTTGTCT 
TCATCAAGCA GTAGCAGAAT TGTGGTACAT GATATCCCCA TAAAGGTTAT TCCGAGAAGA 
CTGTGGAAGG ACTTACAAGA ACCCTCCATC CCAGAATCTG ATGTCAGTAT TTATCTACCA 
GCCTTGAAGA CAATGAAGAG TGTCGTGGAT AAAATGAGGA ACATCAGCAA TCACCTTGTT 
ATTGAAGCAA ACCTAAAAGG AGAACTAAAC CTAAAGATAG AAACTGAGTC AGTATGTGTG 
ACAACACACT TTAAGGATCT TGAAAACCCT CTACTACCTT CTGACAGTGT CTCTCAAAAC 
AGACACCCAG AAGACATGGC CAAGGTGCAC ATCGACATAA GGAAACTCCT CCAGTTGCTT 
GCTGGACAGC AAGTGGCTCC CACCAAGGCG GTGTGCAATA TCGTCAATAA CAGAACTATT 
CACTTTGATC TGCTCCTGGA AGACGTCTCC CTTCAGTATT TCATCCCAGC CTTGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hus1 ( XM_008770346.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768568.1 Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa49090
Clone ID Related Accession (Same CDS sequence)	XM_008770346.2
Accession Version	XM_008770346.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	checkpoint protein HUS1 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770346.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTTC GTGCCAAGAT CGTGGATCTG GCTTGTCTGA ATCACTTTAC ACGAGTCAGT 
AACATGATAG CCAAGCTTGC CAAAACCTGC ACCCTCCGCA TCAGCCCAGA GAAGCTGAAC 
TTCATCCTCT GTGACAAGCT GGCCAGTGGA GGCGTGAGCA TGTGGTGTGA GCTGGAGCAG 
GAGAACTTTT TTAGTGAATT CCAAATGGAA GGAGTCTCTG AAGAAAACAA TGAGATTTAT 
TTAGAATTAA CGTCGGAAAA CTTAGCTCGA GCCTTGAAGA CTGCCCAGAA CGCCAGAGCC 
TTGAAAATCA AGCTTACTAA CAAGCACTTT CCCTGTCTAA CCGTGTCCGT AGAGCTGTTG 
TCTTCATCAA GCAGTAGCAG AATTGTGGTA CATGATATCC CCATAAAGGT TATTCCGAGA 
AGACTGTGGA AGGACTTACA AGAACCCTCC ATCCCAGAAT CTGATGTCAG TATTTATCTA 
CCAGCCTTGA AGACAATGAA GAGTGTCGTG GATAAAATGA GGAACATCAG CAATCACCTT 
GTTATTGAAG CAAACCTAAA AGGAGAACTA AACCTAAAGA TAGAAACTGA GTCAGTATGT 
GTGACAACAC ACTTTAAGGA TCTTGAAAAC CCTCTACTAC CTTCTGACAA ACGTGTGGAT 
GACCTCGGTT TTCTTGGTGG TGTGTGTGTG TGTGTTCAGA ATACTTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768568.1
CDS	78..788
Translation	MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLARALKTAQNARALKIKLTNKHFPCLTVSVELLSSSSSSRIVVHDIPIKVIPRRLWKDLQEPSIPESDVSIYLPALKTMKSVVDKMRNISNHLVIEANLKGELNLKIETESVCVTTHFKDLENPLLPSDKRVDDLGFLGGVCVCVQNTY

Target ORF information:

RefSeq Version	XM_008770346.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HUS1 checkpoint clamp component (Hus1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770346.2

ORF Insert Sequence:

ATGAAGTTTC GTGCCAAGAT CGTGGATCTG GCTTGTCTGA ATCACTTTAC ACGAGTCAGT 
AACATGATAG CCAAGCTTGC CAAAACCTGC ACCCTCCGCA TCAGCCCAGA GAAGCTGAAC 
TTCATCCTCT GTGACAAGCT GGCCAGTGGA GGCGTGAGCA TGTGGTGTGA GCTGGAGCAG 
GAGAACTTTT TTAGTGAATT CCAAATGGAA GGAGTCTCTG AAGAAAACAA TGAGATTTAT 
TTAGAATTAA CGTCGGAAAA CTTAGCTCGA GCCTTGAAGA CTGCCCAGAA CGCCAGAGCC 
TTGAAAATCA AGCTTACTAA CAAGCACTTT CCCTGTCTAA CCGTGTCCGT AGAGCTGTTG 
TCTTCATCAA GCAGTAGCAG AATTGTGGTA CATGATATCC CCATAAAGGT TATTCCGAGA 
AGACTGTGGA AGGACTTACA AGAACCCTCC ATCCCAGAAT CTGATGTCAG TATTTATCTA 
CCAGCCTTGA AGACAATGAA GAGTGTCGTG GATAAAATGA GGAACATCAG CAATCACCTT 
GTTATTGAAG CAAACCTAAA AGGAGAACTA AACCTAAAGA TAGAAACTGA GTCAGTATGT 
GTGACAACAC ACTTTAAGGA TCTTGAAAAC CCTCTACTAC CTTCTGACAA ACGTGTGGAT 
GACCTCGGTT TTCTTGGTGG TGTGTGTGTG TGTGTTCAGA ATACTTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Science (New York, N.Y.)332(6035)1313-7(2011 Jun)
Cotta-Ramusino C,McDonald ER 3rd,Hurov K,Sowa ME,Harper JW,Elledge SJ

The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining.
Oncogene25(13)1980-3(2006 Mar)
Wang X,Hu B,Weiss RS,Wang Y

Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.
Genomics86(2)212-24(2005 Aug)
Levitt PS,Liu H,Manning C,Weiss RS

Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.
Nucleic acids research32(2)767-75(2004)
Wang X,Guan J,Hu B,Weiss RS,Iliakis G,Wang Y

Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.
The Journal of biological chemistry278(27)25207-17(2003 Jul)
Jiang K,Pereira E,Maxfield M,Russell B,Goudelock DM,Sanchez Y

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Hus1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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