Selenom cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenom
Entrez Gene ID	498398
Full Name	selenoprotein M
Synonyms	RGD1565037,Selm
General protein information	Preferred Names selenoprotein M Names selenoprotein M
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001115013.2	NP_001108485.1	selenoprotein M precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SELM	NP_536355.1
Mus musculus (house mouse)	Selm	NP_444497.1
Pan troglodytes (chimpanzee)	SELM	NP_001140172.1
Xenopus tropicalis (tropical clawed frog)	selm	NP_001165078.1
	SELM	NP_001152871.1
Canis lupus familiaris (dog)	SELM	NP_001108486.1
Rattus norvegicus (Norway rat)	Selm	NP_001108485.1
Danio rerio (zebrafish)	selm	NP_840071.2
Gallus gallus (chicken)	SELM	NP_001264788.1
Bos taurus (cattle)	SELM	NP_001156643.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M.
Kim Y, Goo JS, Kim IY, Kim JE, Kwak MH, Go J, Shim S, Hong JT, Hwang DY, Seong JK
International journal of molecular medicine34(6)1688-98(2014 Dec)

Deletion of selenoprotein M leads to obesity without cognitive deficits.
Pitts MW, Reeves MA, Hashimoto AC, Ogawa A, Kremer P, Seale LA, Berry MJ
The Journal of biological chemistry288(36)26121-34(2013 Sep)

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.
Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, Guo C, Yang L, Huang WJ, Fu G, Xu SH, Cheng XP, Yan Q, Zhu ZD, Zhang X, Chen Z, Han ZG, Zhang X
Proceedings of the National Academy of Sciences of the United States of America99(12)8360-5(2002 Jun)

Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.
Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN
Molecular and cellular biology22(5)1402-11(2002 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that new functional protein groups and individual proteins in the brain cortex hSelM transgenic rats are associated with selenium (Sel) biology, including the response to Sel treatment and SelM overexpression.
Title: Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M.

The following Selenom gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenom cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01138	NM_001115013.2 Latest version!	Rattus norvegicus selenoprotein M (Selenom), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenom ( NM_001115013.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001108485.1 Rattus norvegicus selenoprotein M (Selenom), mRNA.

Price & Availability↑

CloneID	ORa01138
Clone ID Related Accession (Same CDS sequence)	NM_001115013.2
Accession Version	NM_001115013.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Rattus norvegicus(Norway rat)
Product	selenoprotein M precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FM066134.1, FM061793.1 and AABR07015887.1. On Dec 13, 2016 this sequence version replaced NM_001115013.1. ##Evidence-Data-START## Transcript exon combination :: BI282694.1, BG663014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACATCC TACTGTCGCC GCCGCCGCTG CTGCTGCTTC TCGCAGCCCT TGTGGCTCCA 
GCCACCTCCA TCACCACCTA CCGACCGGAT TGGAACCGTC TTCGAGGCCT GGCCAGGGGG 
CGGGTGGAGA CCTGTGGAGG ATGACAGTTG AATCGCTTAA AGGAGGTGAA GGCCTTTGTC 
ACTCAGGACA TTCAACTGTA CCACAACCTG GTGATGAAGC ACCTCCCTGG GGCAGACCCC 
GAACTCGTGT TGTTAAGCCG AAATTACCAG GAACTAGAGC GAATCCCACT CAGCCAAATG 
ACCCGGGACG AGATAAACGC GCTGGTACAG GAGCTCGGCT TCTACCGTAA GTCGGCGCCC 
GAAGCGAAGG TGCCCCCCGA GTACCTGTGG GCGCCCGCTA AGCCCCCCGA GGACGCTTCG 
GACCGCGCCG ACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108485.1
CDS	71..508
Translation	MNILLSPPPLLLLLAALVAPATSITTYRPDWNRLRGLARGRVETCGG*QLNRLKEVKAFVTQDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGFYRKSAPEAKVPPEYLWAPAKPPEDASDRADL

Target ORF information:

RefSeq Version	NM_001115013.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selenoprotein M (Selenom), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001115013.2

ORF Insert Sequence:

ATGAACATCC TACTGTCGCC GCCGCCGCTG CTGCTGCTTC TCGCAGCCCT TGTGGCTCCA 
GCCACCTCCA TCACCACCTA CCGACCGGAT TGGAACCGTC TTCGAGGCCT GGCCAGGGGG 
CGGGTGGAGA CCTGTGGAGG ATGACAGTTG AATCGCTTAA AGGAGGTGAA GGCCTTTGTC 
ACTCAGGACA TTCAACTGTA CCACAACCTG GTGATGAAGC ACCTCCCTGG GGCAGACCCC 
GAACTCGTGT TGTTAAGCCG AAATTACCAG GAACTAGAGC GAATCCCACT CAGCCAAATG 
ACCCGGGACG AGATAAACGC GCTGGTACAG GAGCTCGGCT TCTACCGTAA GTCGGCGCCC 
GAAGCGAAGG TGCCCCCCGA GTACCTGTGG GCGCCCGCTA AGCCCCCCGA GGACGCTTCG 
GACCGCGCCG ACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M.
International journal of molecular medicine34(6)1688-98(2014 Dec)
Kim Y,Goo JS,Kim IY,Kim JE,Kwak MH,Go J,Shim S,Hong JT,Hwang DY,Seong JK

Deletion of selenoprotein M leads to obesity without cognitive deficits.
The Journal of biological chemistry288(36)26121-34(2013 Sep)
Pitts MW,Reeves MA,Hashimoto AC,Ogawa A,Kremer P,Seale LA,Berry MJ

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.
Proceedings of the National Academy of Sciences of the United States of America99(12)8360-5(2002 Jun)
Xiao HS,Huang QH,Zhang FX,Bao L,Lu YJ,Guo C,Yang L,Huang WJ,Fu G,Xu SH,Cheng XP,Yan Q,Zhu ZD,Zhang X,Chen Z,Han ZG,Zhang X

Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.
Molecular and cellular biology22(5)1402-11(2002 Mar)
Korotkov KV,Novoselov SV,Hatfield DL,Gladyshev VN

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Selenom cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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