Xk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xk
Entrez Gene ID	497078
Full Name	X-linked Kx blood group
General protein information	Preferred Names X-linked Kx blood group Names membrane transport protein XK Kell blood group precursor (McLeod phenotype) homolog X-linked Kx blood group (McLeod syndrome) homolog XK homolog XK-related protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq12
Summary	human homolog is a red cell membrane protein whose deficiency causes the McLeod syndrome, a disorder characterized by blood group, neuromuscular and hematopoietic abnormalities [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006256692.3	XP_006256754.1	membrane transport protein XK isoform X1
NM_001012227.1	NP_001012227.1	membrane transport protein XK

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Xk	NP_075989.1
	XK	XP_001083067.1
Canis lupus familiaris (dog)	XK	XP_548944.2
Bos taurus (cattle)	XK	XP_002700273.3
Danio rerio (zebrafish)	xk	NP_001012254.1
Homo sapiens (human)	XK	NP_066569.1
Rattus norvegicus (Norway rat)	Xk	NP_001012227.1
Pan troglodytes (chimpanzee)	XK	NP_001073390.1
Gallus gallus (chicken)	XK	NP_001029994.1
Xenopus tropicalis (tropical clawed frog)	xk	NP_001012289.1

Gene Ontology
Bibliography

Related articles in PubMed

Giant axon formation in mice lacking Kell, XK, or Kell and XK: animal models of McLeod neuroacanthocytosis syndrome.
Zhu X, Cho ES, Sha Q, Peng J, Oksov Y, Kam SY, Ho M, Walker RH, Lee S
The American journal of pathology184(3)800-7(2014 Mar)

Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis.
Rivera A, Kam SY, Ho M, Romero JR, Lee S
Blood cells, molecules & diseases50(2)80-5(2013 Feb)

The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system.
Clap?ron A, Hattab C, Armand V, Trottier S, Bertrand O, Ouimet T
Brain research114712-24(2007 May)

Association of XK and Kell blood group proteins.
Russo D, Redman C, Lee S
The Journal of biological chemistry273(22)13950-6(1998 May)

Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.
Ho M, Chelly J, Carter N, Danek A, Crocker P, Monaco AP
Cell77(6)869-80(1994 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Immunohistochemical experiments using adult rat brain indicated widespread XK immunoreactivity in the cerebral cortex, hippocampus, striatum, diencephalon and cerebellum.
Title: The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system.

The following Xk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa39593	XM_006256692.3 Latest version!	Rattus norvegicus X-linked Kx blood group (Xk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa13888	NM_001012227.1 Latest version!	Rattus norvegicus X-linked Kx blood group (Xk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xk ( XM_006256692.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006256754.1 Rattus norvegicus X-linked Kx blood group (Xk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa39593
Clone ID Related Accession (Same CDS sequence)	XM_006256692.3
Accession Version	XM_006256692.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1341bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	membrane transport protein XK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006256692.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAATTCC CGGCCTCAGT GTTAGCGTCC GTGTTCCTGT TCGTGGCCGA GACAATGGCC 
GCGCTCTACC TGAGCAGCAC CTACCGCTCT GCCGGGGACC GCATGTGGCA GGCGCTGACG 
CTGTTCTTCT CCTTGATGCC CTGCACCCTG GTGCAGCTCA CGCTCCTCTT CGTCCACCGC 
GACCTCAGCC GCGATCGCCC ACTGGTGTTG CTTATGCACC TGCTCCAGCT GGGGCCCCTG 
TACAGGTGTT GTGAAGTCTT TTGTATCTAC TGTCAGTCTG ACCAGAATGA AGAACCTTAT 
GTGAGCATCA CTAAGAAACG ACAGATGCCA AAAGATGGCC TTTCAGAAGA GGTCGAGAAA 
GAGGTTGGCC AGTCAGAAGG CAAGCTGTTT ACCCACCGTT CTGCATTCAG TCGGGCATCA 
GTGATACAGG CTTTCCTAGG TTCTGCCCCG CAACTGACCC TACAACTGTA TATAACTGTC 
TTGGAACAGA ACATTACTAC TGGAAGATGC GTCATCATGG TCTTGTCCCT GCTGTCTATC 
GTCTACGGTG CCTTACGTTG CAACATCTTA GCCATCAAAA TCAAGTATGA TGAGTACGAG 
GTCAAAGTCA AACCCCTGGC CTATGTCTGT ATCTTCCTCT GGAGAAGCTT TGAGATTGCC 
ACTCGGGTCA TCGTCCTGGT CCTCTTTACC TCTGTCCTGA AGATCTGGGT GGTGGTGGTC 
ATACTTGTCA ACTTCTTCAG CTTCTTCTTG TACCCGTGGA TCCTTTTCTG GAACAGTGGC 
TCCCCATTCC CTGAGAACAT AGAGAAGGCC CTAACTAGGG TAGGTACCAC CATCGTGCTC 
GGTTTCCTCA CTTTACTCTA CGCCGGTATC AACATGTTCT GCTGGTCAGC CGTACAGCTG 
AAAATCGACA ATCCAGAACT CATCAGCAAG TCCCAGAATT GGTACCGGCT GCTGATTTAC 
TACATGATGA GATTCGTCGA GAATTCTGTC CTCCTGCTCC TGTGGTATTT TTTTAAAACT 
GACATATACA TGTATGTGTG TGCACCGCTG TTGATTTTGC AGCTGCTCAT TGGGTACTGC 
ACCAGCATTC TTTTCATGCT TGTGTTCTAT CAGTTTTTCC ACCCTTGCAA AAAGCTCTTT 
TCTTCTAGTG TTTCTGAAAG CTTTAGCGCA TGTCTCAGGT GTGTCTGTTG GTCCTCCGCG 
AGGAGAAAAT CCACTGAGCC AGTAGGAAGG ATAGACACAG ACTTAAAGGC ATGCACAGAT 
CAAGGTGCAC AGCCTTCTAC CAGTAAACTA ACTCCCGAGG CCACTGAGAT TTGGACCGCT 
GTGGACCTGT GCTCCACTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006256754.1
CDS	947..2287
Translation	MKFPASVLASVFLFVAETMAALYLSSTYRSAGDRMWQALTLFFSLMPCTLVQLTLLFVHRDLSRDRPLVLLMHLLQLGPLYRCCEVFCIYCQSDQNEEPYVSITKKRQMPKDGLSEEVEKEVGQSEGKLFTHRSAFSRASVIQAFLGSAPQLTLQLYITVLEQNITTGRCVIMVLSLLSIVYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFEIATRVIVLVLFTSVLKIWVVVVILVNFFSFFLYPWILFWNSGSPFPENIEKALTRVGTTIVLGFLTLLYAGINMFCWSAVQLKIDNPELISKSQNWYRLLIYYMMRFVENSVLLLLWYFFKTDIYMYVCAPLLILQLLIGYCTSILFMLVFYQFFHPCKKLFSSSVSESFSACLRCVCWSSARRKSTEPVGRIDTDLKACTDQGAQPSTSKLTPEATEIWTAVDLCST

Target ORF information:

RefSeq Version	XM_006256692.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-linked Kx blood group (Xk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006256692.3

ORF Insert Sequence:

ATGAAATTCC CGGCCTCAGT GTTAGCGTCC GTGTTCCTGT TCGTGGCCGA GACAATGGCC 
GCGCTCTACC TGAGCAGCAC CTACCGCTCT GCCGGGGACC GCATGTGGCA GGCGCTGACG 
CTGTTCTTCT CCTTGATGCC CTGCACCCTG GTGCAGCTCA CGCTCCTCTT CGTCCACCGC 
GACCTCAGCC GCGATCGCCC ACTGGTGTTG CTTATGCACC TGCTCCAGCT GGGGCCCCTG 
TACAGGTGTT GTGAAGTCTT TTGTATCTAC TGTCAGTCTG ACCAGAATGA AGAACCTTAT 
GTGAGCATCA CTAAGAAACG ACAGATGCCA AAAGATGGCC TTTCAGAAGA GGTCGAGAAA 
GAGGTTGGCC AGTCAGAAGG CAAGCTGTTT ACCCACCGTT CTGCATTCAG TCGGGCATCA 
GTGATACAGG CTTTCCTAGG TTCTGCCCCG CAACTGACCC TACAACTGTA TATAACTGTC 
TTGGAACAGA ACATTACTAC TGGAAGATGC GTCATCATGG TCTTGTCCCT GCTGTCTATC 
GTCTACGGTG CCTTACGTTG CAACATCTTA GCCATCAAAA TCAAGTATGA TGAGTACGAG 
GTCAAAGTCA AACCCCTGGC CTATGTCTGT ATCTTCCTCT GGAGAAGCTT TGAGATTGCC 
ACTCGGGTCA TCGTCCTGGT CCTCTTTACC TCTGTCCTGA AGATCTGGGT GGTGGTGGTC 
ATACTTGTCA ACTTCTTCAG CTTCTTCTTG TACCCGTGGA TCCTTTTCTG GAACAGTGGC 
TCCCCATTCC CTGAGAACAT AGAGAAGGCC CTAACTAGGG TAGGTACCAC CATCGTGCTC 
GGTTTCCTCA CTTTACTCTA CGCCGGTATC AACATGTTCT GCTGGTCAGC CGTACAGCTG 
AAAATCGACA ATCCAGAACT CATCAGCAAG TCCCAGAATT GGTACCGGCT GCTGATTTAC 
TACATGATGA GATTCGTCGA GAATTCTGTC CTCCTGCTCC TGTGGTATTT TTTTAAAACT 
GACATATACA TGTATGTGTG TGCACCGCTG TTGATTTTGC AGCTGCTCAT TGGGTACTGC 
ACCAGCATTC TTTTCATGCT TGTGTTCTAT CAGTTTTTCC ACCCTTGCAA AAAGCTCTTT 
TCTTCTAGTG TTTCTGAAAG CTTTAGCGCA TGTCTCAGGT GTGTCTGTTG GTCCTCCGCG 
AGGAGAAAAT CCACTGAGCC AGTAGGAAGG ATAGACACAG ACTTAAAGGC ATGCACAGAT 
CAAGGTGCAC AGCCTTCTAC CAGTAAACTA ACTCCCGAGG CCACTGAGAT TTGGACCGCT 
GTGGACCTGT GCTCCACTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Xk ( NM_001012227.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012227.1 Rattus norvegicus X-linked Kx blood group (Xk), mRNA.

Price & Availability↑

CloneID	ORa13888
Clone ID Related Accession (Same CDS sequence)	NM_001012227.1
Accession Version	NM_001012227.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Rattus norvegicus(Norway rat)
Product	membrane transport protein XK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY534256.1. ##Evidence-Data-START## Transcript exon combination :: AY534256.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAATTCC CGGCCTCAGT GTTAGCGTCC GTGTTCCTGT TCGTGGCCGA GACAATGGCC 
GCGCTCTACC TGAGCAGCAC CTACCGCTCT GCCGGGGACC GCATGTGGCA GGCGCTGACG 
CTGTTCTTCT CCTTGATGCC CTGCACCCTG GTGCAGCTCA CGCTCCTCTT CGTCCACCGC 
GACCTCAGCC GCGATCGCCC ACTGGTGTTG CTTATGCACC TGCTCCAGCT GGGGCCCCTG 
TACAGGTGTT GTGAAGTCTT TTGTATCTAC TGTCAGTCTG ACCAGAATGA AGAACCTTAT 
GTGAGCATCA CTAAGAAACG ACAGATGCCA AAAGATGGCC TTTCAGAAGA GGTCGAGAAA 
GAGGTTGGCC AGTCAGAAGG CAAGCTGTTT ACCCACCGTT CTGCATTCAG TCGGGCATCA 
GTGATACAGG CTTTCCTAGG TTCTGCCCCG CAACTGACCC TACAACTGTA TATAACTGTC 
TTGGAACAGA ACATTACTAC TGGAAGATTC ATCATGGTCT TGTCCCTGCT GTCTATCGTC 
TACGGTGCCT TACGTTGCAA CATCTTAGCC ATCAAAATCA AGTATGATGA GTACGAGGTC 
AAAGTCAAAC CCCTGGCCTA TGTCTGTATC TTCCTCTGGA GAAGCTTTGA GATTGCCACT 
CGGGTCATCG TCCTGGTCCT CTTTACCTCT GTCCTGAAGA TCTGGGTGGT GGTGGTCATA 
CTTGTCAACT TCTTCAGCTT CTTCTTGTAC CCGTGGATCC TTTTCTGGAA CAGTGGCTCC 
CCATTCCCTG AGAACATAGA GAAGGCCCTA ACTAGGGTAG GTACCACCAT CGTGCTCGGT 
TTCCTCACTT TACTCTACGC CGGTATCAAC ATGTTCTGCT GGTCAGCCGT ACAGCTGAAA 
ATCGACAATC CAGAACTCAT CAGCAAGTCC CAGAATTGGT ACCGGCTGCT GATTTACTAC 
ATGATGAGAT TCGTCGAGAA CTCCGTCCTC CTGCTCCTGT GGTTTTTTTT TAAAACTGAC 
ATATACATGT ATGTGTGTGC ACCGCTGTTG ATTTTGCAGC TGCTCATTGG GTACTGCACC 
AGCATTCTTT TCATGCTTGT GTTCTATCAG TTTTTCCACC CTTGCAAAAA GCTCTTTTCT 
TCTAGTGTTT CTGAAAGCTT TAGCGCATGT CTCAGGTGTG TCTGTTGGTC CTCCGCGAGG 
AGAAAATCCA CTGAGCCAGT AGGAAGGATA GACACAGACT TAAAGGCATG CACAGATCAA 
GGTGCACAGC CTTCTACCAG TAAACTAACT CCCGAGGCCA CTGAGATTTG GACCGCTGTG 
GACCTGTGCT CCACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012227.1
CDS	100..1437
Translation	MKFPASVLASVFLFVAETMAALYLSSTYRSAGDRMWQALTLFFSLMPCTLVQLTLLFVHRDLSRDRPLVLLMHLLQLGPLYRCCEVFCIYCQSDQNEEPYVSITKKRQMPKDGLSEEVEKEVGQSEGKLFTHRSAFSRASVIQAFLGSAPQLTLQLYITVLEQNITTGRFIMVLSLLSIVYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFEIATRVIVLVLFTSVLKIWVVVVILVNFFSFFLYPWILFWNSGSPFPENIEKALTRVGTTIVLGFLTLLYAGINMFCWSAVQLKIDNPELISKSQNWYRLLIYYMMRFVENSVLLLLWFFFKTDIYMYVCAPLLILQLLIGYCTSILFMLVFYQFFHPCKKLFSSSVSESFSACLRCVCWSSARRKSTEPVGRIDTDLKACTDQGAQPSTSKLTPEATEIWTAVDLCST

Target ORF information:

RefSeq Version	NM_001012227.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-linked Kx blood group (Xk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012227.1

ORF Insert Sequence:

ATGAAATTCC CGGCCTCAGT GTTAGCGTCC GTGTTCCTGT TCGTGGCCGA GACAATGGCC 
GCGCTCTACC TGAGCAGCAC CTACCGCTCT GCCGGGGACC GCATGTGGCA GGCGCTGACG 
CTGTTCTTCT CCTTGATGCC CTGCACCCTG GTGCAGCTCA CGCTCCTCTT CGTCCACCGC 
GACCTCAGCC GCGATCGCCC ACTGGTGTTG CTTATGCACC TGCTCCAGCT GGGGCCCCTG 
TACAGGTGTT GTGAAGTCTT TTGTATCTAC TGTCAGTCTG ACCAGAATGA AGAACCTTAT 
GTGAGCATCA CTAAGAAACG ACAGATGCCA AAAGATGGCC TTTCAGAAGA GGTCGAGAAA 
GAGGTTGGCC AGTCAGAAGG CAAGCTGTTT ACCCACCGTT CTGCATTCAG TCGGGCATCA 
GTGATACAGG CTTTCCTAGG TTCTGCCCCG CAACTGACCC TACAACTGTA TATAACTGTC 
TTGGAACAGA ACATTACTAC TGGAAGATTC ATCATGGTCT TGTCCCTGCT GTCTATCGTC 
TACGGTGCCT TACGTTGCAA CATCTTAGCC ATCAAAATCA AGTATGATGA GTACGAGGTC 
AAAGTCAAAC CCCTGGCCTA TGTCTGTATC TTCCTCTGGA GAAGCTTTGA GATTGCCACT 
CGGGTCATCG TCCTGGTCCT CTTTACCTCT GTCCTGAAGA TCTGGGTGGT GGTGGTCATA 
CTTGTCAACT TCTTCAGCTT CTTCTTGTAC CCGTGGATCC TTTTCTGGAA CAGTGGCTCC 
CCATTCCCTG AGAACATAGA GAAGGCCCTA ACTAGGGTAG GTACCACCAT CGTGCTCGGT 
TTCCTCACTT TACTCTACGC CGGTATCAAC ATGTTCTGCT GGTCAGCCGT ACAGCTGAAA 
ATCGACAATC CAGAACTCAT CAGCAAGTCC CAGAATTGGT ACCGGCTGCT GATTTACTAC 
ATGATGAGAT TCGTCGAGAA CTCCGTCCTC CTGCTCCTGT GGTTTTTTTT TAAAACTGAC 
ATATACATGT ATGTGTGTGC ACCGCTGTTG ATTTTGCAGC TGCTCATTGG GTACTGCACC 
AGCATTCTTT TCATGCTTGT GTTCTATCAG TTTTTCCACC CTTGCAAAAA GCTCTTTTCT 
TCTAGTGTTT CTGAAAGCTT TAGCGCATGT CTCAGGTGTG TCTGTTGGTC CTCCGCGAGG 
AGAAAATCCA CTGAGCCAGT AGGAAGGATA GACACAGACT TAAAGGCATG CACAGATCAA 
GGTGCACAGC CTTCTACCAG TAAACTAACT CCCGAGGCCA CTGAGATTTG GACCGCTGTG 
GACCTGTGCT CCACTTAA