Dnmt3b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnmt3b
Entrez Gene ID	444985
Full Name	DNA methyltransferase 3 beta
General protein information	Preferred Names DNA methyltransferase 3 beta Names DNA (cytosine-5)-methyltransferase 3B DNA (cytosine-5-)-methyltransferase 3 beta DNA methyltransferase 3B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003959.1	NP_001003959.1	DNA (cytosine-5)-methyltransferase 3B

Pathways from BioSystems

Homologies

Homo sapiens (human)	DNMT3B	NP_008823.1
Pan troglodytes (chimpanzee)	DNMT3B	XP_514580.3
Canis lupus familiaris (dog)	DNMT3B	XP_003433293.1
Bos taurus (cattle)	LOC100848415	XP_003586886.2
Mus musculus (house mouse)	Dnmt3b	NP_001116469.1
Rattus norvegicus (Norway rat)	Dnmt3b	NP_001003959.1
Gallus gallus (chicken)	DNMT3B	NP_001019999.1
Danio rerio (zebrafish)	dnmt4	NP_001020621.1
	DNMT3B	XP_001107440.2

Gene Ontology
Bibliography

Related articles in PubMed

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.
Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, H?rault Y, Guillou F, Bourc'his D
Science (New York, N.Y.)354(6314)909-912(2016 11)

DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Valencia Ant?nez CA, Taja Chayeb L, Rodr?guez-Segura M?, L?pez ?lvarez GS, Garc?a-Cu?llar CM, Villa Trevi?o S
Oncology reports32(5)2093-103(2014 Nov)

Epigenetic regulation of acute inflammatory pain.
Abzianidze E, Kvaratskhelia E, Tkemaladze T, Kankava K, Gurtskaia G, Tsagareli M
Georgian medical news(235)78-81(2014 Oct)

Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis.
Ping J, Wang JF, Liu L, Yan YE, Liu F, Lei YY, Wang H
Toxicology32153-61(2014 Jul)

Playing TETris with DNA modifications.
Delatte B, Deplus R, Fuks F
The EMBO journal33(11)1198-211(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors developed a resistant hepatocyte rat model of liver carcinogenesis showing underexpression of DNMT3a and DNMT3b during the early stages.
Title: DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.

We have found that during acute inflammatory pain induced by the application of 10% mustard oil on the tongues of rats, levels of DNMT3a and 3b were elevated markedly
Title: Epigenetic regulation of acute inflammatory pain.

High resveratrol downregulated DNMT3b and upregulated primarily tumor suppressive miRNAs in hormone sensitive mammary tumors, but not in matched normal mammary tissue.
Title: Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.

A novel role of T-Cad in the NGF-mediated differentiation of PC12 cells to neuronal phenotype associated with Dnmt3b regulation is reported.
Title: Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells.

Data show that DNA methyltransferase 3b (Dnmt3b)-mediated neuronal differentiation is due to its recruitment of histone deacetylase 2 (Hdac2).
Title: DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2.

The following Dnmt3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnmt3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa26555	NM_001003959.1 Latest version!	Rattus norvegicus DNA methyltransferase 3 beta (Dnmt3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnmt3b ( NM_001003959.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001003959.1 Rattus norvegicus DNA methyltransferase 3 beta (Dnmt3b), mRNA.

Price & Availability↑

CloneID	ORa26555
Clone ID Related Accession (Same CDS sequence)	NM_001003959.1
Accession Version	NM_001003959.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2580bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-20
Organism	Rattus norvegicus(Norway rat)
Product	DNA (cytosine-5)-methyltransferase 3B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BN000397.1. On Apr 19, 2005 this sequence version replaced XM_579109.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BN000397.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGGGAG ACAGCAGACA TCTTAATGAA GAAGAGGGTG CTAGTGGGTA TGAGGACTGT 
ATCATTGTTA ATGGGAACTG TAGTGACCAG TCCTCGGACA CGAAGGATGC TCCCTCACCC 
CCAGTCTTGG AGGCAATCTG CACAGAGCCA GTCTGTACAC CAGAGACCAG AGGCCGCAGA 
TCAAGCTCAC GGCTGTCTAA GAGGGAGGTC TCCAGCCTTC TGAATTACAC GCAGGACGTG 
GTAGGAGATG GAGATGGTGA AGCGGATGAT GGAGATGGCT CTGATATTCT CATGATGCCA 
AAGCTCACCC GAGAGACCAA GGATGCCAGG ACTCCCTCTG AAAGCCCAGC CGTCCGAACC 
CGAAACAGCA ACAGTATCTC CAGCCTGGAG AGGCAAAGAA CCTCCCCCAG AATCACGCGA 
GGCCGGCAGG GCCGCTACCA CGTTCAGGAG TACCCCGTGG AGTTCCCAGC TACCAAGTCT 
CGGAGGCGGC GAGCATCGTC TTCAGCAAGC ACGCCATGGT CATCCCCTGC CAGCATCGAG 
CTCATGGAAG ATGTGACACC TAAGAGCAGC AGTACGCCAT CGGTTGACTT GAGCCAGGAC 
GGCCCTCAGG AGGGCATGGA TGCCACACAG GTGGATGCGG AGAGCAGGGA TGGTGACAGC 
ACTGAGTATC AGGATGACAA GGAGTTTGGA ATAGGTGACC TTGTGTGGGG AAAGATCAAG 
GGCTTCTCCT GGTGGCCTGC CATGGTGGTG TCCTGGAAAG CCACCTCCAA GCGCCAGGCC 
ATGCCCGGAA TGCGCTGGGT ACAGTGGTTT GGCGATGGCA AGTTTTCTGA GATCGCTGCT 
GACAAGCTGG TGGCTCTGGG TCTGTTCAGC CAGCACTTTA ATCTGGCCAC CTTCAATAAG 
CTGGTTTCTT ATAGGAAGGC CATGTACCAC ACTCTGGAGA AAGCCATGGT GCGAGCTGGC 
AAGACCTTCC CCAGCCGCCC TGGAGACTCA CTGGAGGACC AGCTGAAGCC CATGCTGGAG 
TGGGCCCACG GGGGCTTCAA GCCCACTGGG ATCGAGGGCC TCAAACCCAA CAACAAGCAA 
CCAGAGGTTC ATAAGTCGAA GGTGCGTCGT TCAGGCAGTA GGAACTTAGA AGCCAGGAGA 
CGCGAGAACA AAAGTCGAAG ACGCACAACC ATTGACTTTG CCGCTTCTGA GTACTCCACA 
CCCCCTAAGC GCCTCAAGAC AAATAGCTAT GGTGGGAAGG ACCGAGGGGA AGATGAGGAG 
AGCCGAGAAC GGATGGCTTC TGATGTCACT AACAACAAGG GCAATCTGGA AGACCGCTGT 
CTGTCCTGCG GTAAGAAGAA CCCTGTGTCC TTCCACCCCC TCTTTGAGGG TGGGCTCTGT 
CAGAGTTGCC GGGATCGCTT CCTGGAGCTC TTCTACATGT ACGATGAGGA CGGCTATCAG 
TCCTACTGCA CCGTGTGCTG TGAGGGCCGT GAACTGCTTC TGTGCAGTAA CACAAGCTGC 
TGCAGGTGCT TCTGTGTGGA GTGTCTGGAG GTGCTGGTGG GTACAGGCAC AGCGGAGGAT 
GCCAAGCTGC AGGAACCCTG GAGCTGCTAT ATGTGCCTCC CGCAGCGCTG CCATGGGGTC 
CTGCGGCGCA GGAAGGACTG GAACATGCGC CTGCAAGACT TCTTCACTAC TGATCCTGAC 
CTGGAAGAGT TTGAGCCGCC CAAGTTGTAC CCAGCGATTC CTGCAGCCAA AAGGAGGCCC 
ATTAGGGTCC TGTCCCTGTT TGATGGAATT GCAACAGGGT ACTTGGTGCT CAAGGACTTG 
GGTATTAAAG TGGAGAAGTA CGTTGCCTCT GAAGTCTGTG CAGAGTCCAT TGCTGTAGGA 
ACCATTAAGC ATGAAGGCCA AATCAAATAT GTCAATGACG TCCGGAAAAT CACCAAGAAA 
AATATTGAAG AGTGGGGCCC ATTTGACTTG GTGATTGGCG GAAGCCCATG CAATGATCTT 
TCTAATGTCA ATCCTGCCAG GAAAGGCCTG TATGAGGGCA CAGGAAGGCT CTTCTTTGAG 
TTTTACCACT TGCTGAATTA TACACGCCCC AAGGAGGGCG ACAACCGTCC ATTCTTCTGG 
ATGTTCGAGA ATGTTGTGGC CATGAAAGTG AATGACAAGA AAGACATCTC CCGATTCCTG 
GCATGTAACC CAGTGATGAT CGACGCCATC AAGGTTTCTG CTGCTCACAG GGCCCGGTAC 
TTCTGGGGTA ATCTACCTGG AATGAACAGG CCTGTGATAG CTTCAAAGAA TGATAAGCTC 
GAGCTACAAG ACTGCTTGGA GTTCAGTAGG ACAGCAAAGT TAAAGAAAGT ACAGACAATA 
ACCACCAAGT CGAACTCCAT CAGACAGGGG AAAAACCAGC TTTTCCCTGT AGTCATGAAT 
GGCAAGGATG ACGTTCTGTG GTGCACTGAG CTCGAAAGGA TCTTCGGGTT CCCAGCTCAC 
TACACAGACG TGTCCAACAT GGGCCGGGGC GCCCGCCAGA AGCTACTGGG AAGGTCCTGG 
AGTGTGCCAG TCATCAGACA CCTGTTTGCC CCCTTGAAGG ACTACTTTGC ATGTGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003959.1
CDS	409..2988
Translation	MKGDSRHLNEEEGASGYEDCIIVNGNCSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDVVGDGDGEADDGDGSDILMMPKLTRETKDARTPSESPAVRTRNSNSISSLERQRTSPRITRGRQGRYHVQEYPVEFPATKSRRRRASSSASTPWSSPASIELMEDVTPKSSSTPSVDLSQDGPQEGMDATQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEIAADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKAMVRAGKTFPSRPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNKQPEVHKSKVRRSGSRNLEARRRENKSRRRTTIDFAASEYSTPPKRLKTNSYGGKDRGEDEESRERMASDVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKDLGIKVEKYVASEVCAESIAVGTIKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE

Target ORF information:

RefSeq Version	NM_001003959.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA methyltransferase 3 beta (Dnmt3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003959.1

ORF Insert Sequence:

ATGAAGGGAG ACAGCAGACA TCTTAATGAA GAAGAGGGTG CTAGTGGGTA TGAGGACTGT 
ATCATTGTTA ATGGGAACTG TAGTGACCAG TCCTCGGACA CGAAGGATGC TCCCTCACCC 
CCAGTCTTGG AGGCAATCTG CACAGAGCCA GTCTGTACAC CAGAGACCAG AGGCCGCAGA 
TCAAGCTCAC GGCTGTCTAA GAGGGAGGTC TCCAGCCTTC TGAATTACAC GCAGGACGTG 
GTAGGAGATG GAGATGGTGA AGCGGATGAT GGAGATGGCT CTGATATTCT CATGATGCCA 
AAGCTCACCC GAGAGACCAA GGATGCCAGG ACTCCCTCTG AAAGCCCAGC CGTCCGAACC 
CGAAACAGCA ACAGTATCTC CAGCCTGGAG AGGCAAAGAA CCTCCCCCAG AATCACGCGA 
GGCCGGCAGG GCCGCTACCA CGTTCAGGAG TACCCCGTGG AGTTCCCAGC TACCAAGTCT 
CGGAGGCGGC GAGCATCGTC TTCAGCAAGC ACGCCATGGT CATCCCCTGC CAGCATCGAG 
CTCATGGAAG ATGTGACACC TAAGAGCAGC AGTACGCCAT CGGTTGACTT GAGCCAGGAC 
GGCCCTCAGG AGGGCATGGA TGCCACACAG GTGGATGCGG AGAGCAGGGA TGGTGACAGC 
ACTGAGTATC AGGATGACAA GGAGTTTGGA ATAGGTGACC TTGTGTGGGG AAAGATCAAG 
GGCTTCTCCT GGTGGCCTGC CATGGTGGTG TCCTGGAAAG CCACCTCCAA GCGCCAGGCC 
ATGCCCGGAA TGCGCTGGGT ACAGTGGTTT GGCGATGGCA AGTTTTCTGA GATCGCTGCT 
GACAAGCTGG TGGCTCTGGG TCTGTTCAGC CAGCACTTTA ATCTGGCCAC CTTCAATAAG 
CTGGTTTCTT ATAGGAAGGC CATGTACCAC ACTCTGGAGA AAGCCATGGT GCGAGCTGGC 
AAGACCTTCC CCAGCCGCCC TGGAGACTCA CTGGAGGACC AGCTGAAGCC CATGCTGGAG 
TGGGCCCACG GGGGCTTCAA GCCCACTGGG ATCGAGGGCC TCAAACCCAA CAACAAGCAA 
CCAGAGGTTC ATAAGTCGAA GGTGCGTCGT TCAGGCAGTA GGAACTTAGA AGCCAGGAGA 
CGCGAGAACA AAAGTCGAAG ACGCACAACC ATTGACTTTG CCGCTTCTGA GTACTCCACA 
CCCCCTAAGC GCCTCAAGAC AAATAGCTAT GGTGGGAAGG ACCGAGGGGA AGATGAGGAG 
AGCCGAGAAC GGATGGCTTC TGATGTCACT AACAACAAGG GCAATCTGGA AGACCGCTGT 
CTGTCCTGCG GTAAGAAGAA CCCTGTGTCC TTCCACCCCC TCTTTGAGGG TGGGCTCTGT 
CAGAGTTGCC GGGATCGCTT CCTGGAGCTC TTCTACATGT ACGATGAGGA CGGCTATCAG 
TCCTACTGCA CCGTGTGCTG TGAGGGCCGT GAACTGCTTC TGTGCAGTAA CACAAGCTGC 
TGCAGGTGCT TCTGTGTGGA GTGTCTGGAG GTGCTGGTGG GTACAGGCAC AGCGGAGGAT 
GCCAAGCTGC AGGAACCCTG GAGCTGCTAT ATGTGCCTCC CGCAGCGCTG CCATGGGGTC 
CTGCGGCGCA GGAAGGACTG GAACATGCGC CTGCAAGACT TCTTCACTAC TGATCCTGAC 
CTGGAAGAGT TTGAGCCGCC CAAGTTGTAC CCAGCGATTC CTGCAGCCAA AAGGAGGCCC 
ATTAGGGTCC TGTCCCTGTT TGATGGAATT GCAACAGGGT ACTTGGTGCT CAAGGACTTG 
GGTATTAAAG TGGAGAAGTA CGTTGCCTCT GAAGTCTGTG CAGAGTCCAT TGCTGTAGGA 
ACCATTAAGC ATGAAGGCCA AATCAAATAT GTCAATGACG TCCGGAAAAT CACCAAGAAA 
AATATTGAAG AGTGGGGCCC ATTTGACTTG GTGATTGGCG GAAGCCCATG CAATGATCTT 
TCTAATGTCA ATCCTGCCAG GAAAGGCCTG TATGAGGGCA CAGGAAGGCT CTTCTTTGAG 
TTTTACCACT TGCTGAATTA TACACGCCCC AAGGAGGGCG ACAACCGTCC ATTCTTCTGG 
ATGTTCGAGA ATGTTGTGGC CATGAAAGTG AATGACAAGA AAGACATCTC CCGATTCCTG 
GCATGTAACC CAGTGATGAT CGACGCCATC AAGGTTTCTG CTGCTCACAG GGCCCGGTAC 
TTCTGGGGTA ATCTACCTGG AATGAACAGG CCTGTGATAG CTTCAAAGAA TGATAAGCTC 
GAGCTACAAG ACTGCTTGGA GTTCAGTAGG ACAGCAAAGT TAAAGAAAGT ACAGACAATA 
ACCACCAAGT CGAACTCCAT CAGACAGGGG AAAAACCAGC TTTTCCCTGT AGTCATGAAT 
GGCAAGGATG ACGTTCTGTG GTGCACTGAG CTCGAAAGGA TCTTCGGGTT CCCAGCTCAC 
TACACAGACG TGTCCAACAT GGGCCGGGGC GCCCGCCAGA AGCTACTGGG AAGGTCCTGG 
AGTGTGCCAG TCATCAGACA CCTGTTTGCC CCCTTGAAGG ACTACTTTGC ATGTGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.
Science (New York, N.Y.)354(6314)909-912(2016 11)
Barau J,Teissandier A,Zamudio N,Roy S,Nalesso V,H?rault Y,Guillou F,Bourc'his D

DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Oncology reports32(5)2093-103(2014 Nov)
Valencia Ant?nez CA,Taja Chayeb L,Rodr?guez-Segura M?,L?pez ?lvarez GS,Garc?a-Cu?llar CM,Villa Trevi?o S

Epigenetic regulation of acute inflammatory pain.
Georgian medical news(235)78-81(2014 Oct)
Abzianidze E,Kvaratskhelia E,Tkemaladze T,Kankava K,Gurtskaia G,Tsagareli M

Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis.
Toxicology32153-61(2014 Jul)
Ping J,Wang JF,Liu L,Yan YE,Liu F,Lei YY,Wang H

Playing TETris with DNA modifications.
The EMBO journal33(11)1198-211(2014 Jun)
Delatte B,Deplus R,Fuks F

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Dnmt3b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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