Npc1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Npc1l1
Entrez Gene ID	432367
Full Name	NPC1 like intracellular cholesterol transporter 1
Synonyms	SLC66A2
General protein information	Preferred Names NPC1 like intracellular cholesterol transporter 1 Names Niemann-Pick C1-like protein 1 NPC1 (Niemann-Pick disease, type C1, gene)-like 1 NPC1-like 1 Niemann-Pick disease, type C1-like 1 solute carrier family 66 member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	mouse homolog plays a role in intestinal cholesterol absorption [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002025.1	NP_001002025.1	NPC1-like intracellular cholesterol transporter 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NPC1L1	XP_002686936.1
Mus musculus (house mouse)	Npc1l1	NP_997125.2
Homo sapiens (human)	NPC1L1	NP_037521.2
Canis lupus familiaris (dog)	NPC1L1	NP_001091019.1
Danio rerio (zebrafish)	npc1l1	XP_005171497.1
Xenopus tropicalis (tropical clawed frog)	npc1l1	XP_002932620.2
Pan troglodytes (chimpanzee)	NPC1L1	XP_003318442.1
	NPC1L1	NP_001071157.1
Rattus norvegicus (Norway rat)	Npc1l1	NP_001002025.1

Gene Ontology
Bibliography

Related articles in PubMed

Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice.
Kawase A, Araki Y, Ueda Y, Nakazaki S, Iwaki M
European journal of drug metabolism and pharmacokinetics41(4)457-63(2016 Aug)

NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.
Takada T, Yamanashi Y, Konishi K, Yamamoto T, Toyoda Y, Masuo Y, Yamamoto H, Suzuki H
Science translational medicine7(275)275ra23(2015 Feb)

The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
Xie C, Li N, Chen ZJ, Li BL, Song BL
The Journal of biological chemistry286(41)35933-42(2011 Oct)

Increased NPC1L1 and serum cholesterol in a chronic rejection rat.
Zhu Y, Zhou J
Clinical and investigative medicine. Medecine clinique et experimentale34(3)E172-8(2011 Jun)

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL
Proceedings of the National Academy of Sciences of the United States of America108(2)551-6(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased mRNA levels of HNF4alpha and SREBP2 in mice could be involved in the reduction in NPC1L1 expression.
Title: Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice.

demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In
Title: NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.

Cdc42 controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption.
Title: The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.

The increased expression of NPC1L1 might contribute to hypercholesterolemia, which may be involved in the pathogenesis of transplant arteriosclerosis.
Title: Increased NPC1L1 and serum cholesterol in a chronic rejection rat.

flotillins have a role in NPC1L1-mediated cholesterol uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption
Title: Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.

The following Npc1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Npc1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09768	NM_001002025.1 Latest version!	Rattus norvegicus NPC1 like intracellular cholesterol transporter 1 (Npc1l1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Npc1l1 ( NM_001002025.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001002025.1 Rattus norvegicus NPC1 like intracellular cholesterol transporter 1 (Npc1l1), mRNA.

Price & Availability↑

CloneID	ORa09768
Clone ID Related Accession (Same CDS sequence)	NM_001002025.1
Accession Version	NM_001002025.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	NPC1-like intracellular cholesterol transporter 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY437867.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY437867.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCAGCTG CCTGGCTGGG ATGGCTGCTC TGGGCCCTGC TCCTGAGCGC GGCCCAGGGT 
GAGCTATACA CACCCAAACA CGAAGCTGGG GTCTGCACCT TTTACGAAGA GTGCGGGAAA 
AACCCAGAGC TCTCTGGAGG CCTCACGTCA CTATCCAATG TATCCTGCCT GTCTAACACC 
CCGGCCCGCC ACGTCACGGG TGAACACCTG GCTCTTCTCC AGCGCATCTG TCCCCGCCTG 
TACAACGGCC CCAATACCAC TTTTGCCTGT TGCTCTACCA AGCAGCTGCT GTCCTTAGAA 
AGCAGCATGT CCATCACCAA GGCCCTTCTC ACGCGCTGCC CGGCCTGCTC TGACAATTTT 
GTGAGCTTAC ACTGCCACAA CACTTGCAGC CCTGACCAGA GCCTCTTCAT CAACGTCACC 
CGGGTGGTTG AGCGGGGCGC TGGAGAGCCT CCTGCCGTGG TGGCCTATGA GGCCTTTTAT 
CAGCGCAGCT TTGCTGAGAA GGCCTATGAG TCCTGCAGCC AGGTGCGCAT CCCTGCGGCC 
GCTTCCTTGG CCGTGGGCAG CATGTGTGGA GTGTATGGCT CCGCCCTCTG CAATGCTCAG 
CGCTGGCTCA ACTTCCAAGG AGACACAGGG AATGGCCTGG CTCCGCTGGA TATCACCTTC 
CACCTCTTGG AGCCTGGCCA GGCCCTACCG GATGGGATCC AGCCACTGAA TGGGAAGATC 
GCACCCTGCA ACGAGTCTCA GGGTGATGAC TCAGCAGTCT GCTCCTGCCA GGACTGTGCG 
GCGTCCTGCC CTGTCATCCC TCCGCCCGAG GCCTTGCGCC CTTCCTTCTA CATGGGTCGC 
ATGCCAGGCT GGCTGGCCCT CATCATCATC TTCACTGCTG TCTTTGTGTT GCTCTCTGCA 
GTCCTTGTGC GTCTCCGAGT GGTTTCCAAC AGGAACAAGA ACAAGGCAGA AGGCCCCCAG 
GAAGCCCCCA AACTCCCTCA TAAGCACAAA CTCTCACCCC ATACCATCCT GGGCCGGTTC 
TTCCAGAACT GGGGCACAAG GGTGGCCTCG TGGCCACTCA CCGTCTTAGC ACTGTCCTTC 
ATCGTTGTGA TAGCCTTAGC AGCAGGCCTG ACCTTTATTG AACTCACCAC AGACCCTGTG 
GAACTGTGGT CGGCCCCCAA GAGCCAGGCC CGGAAAGAGA AGTCTTTCCA TGATGAGCAT 
TTCGGCCCCT TCTTTCGAAC CAACCAGATT TTCGTGACAG CTCGGAACAG GTCCAGCTAC 
AAGTACGACT CCCTACTGCT AGGGTCCAAG AACTTCAGTG GGATCCTGTC CCTGGACTTC 
CTGCTGGAGC TGCTGGAGCT TCAGGAGAGG CTTCGACACC TGCAAGTGTG GTCCCCTGAG 
GCAGAGCGCA ACATCTCCCT CCAGGACATC TGCTATGCCC CCCTCAACCC ATATAACACC 
AGCCTCTCCG ACTGCTGTGT CAACAGCCTC CTTCAGTACT TCCAGAACAA CCGCACCCTC 
CTGATGCTCA CGGCCAACCA GACTCTGAAT GGCCAGACCT CCCTGGTGGA CTGGAAGGAC 
CATTTCCTCT ACTGTGCAAA TGCCCCTCTC ACGTTCAAAG ATGGCACGTC TCTGGCCCTG 
AGCTGCATGG CTGACTACGG GGCTCCTGTC TTCCCCTTCC TTGCTGTTGG GGGATACCAA 
GGCACGGACT ATTCCGAGGC AGAAGCGCTG ATCATAACCT TCTCTCTCAA TAACTACCCC 
GCTGATGATC CCCGCATGGC CCAGGCCAAG CTCTGGGAGG AGGCTTTCTT GAAGGAAATG 
GAATCCTTCC AGAGGAACAC AAGTGACAAG TTCCAGGTTG CGTTCTCAGC TGAGCGCTCT 
CTGGAGGATG AGATCAACCG CACCACCATC CAGGACCTGC CTGTCTTTGC CGTCAGCTAC 
ATTATCGTCT TCCTGTACAT CTCCCTGGCC CTGGGCAGCT ACTCCAGATG CAGCCGAGTA 
GCGGTGGAGT CCAAGGCTAC TCTGGGCCTA GGTGGGGTGA TTGTTGTGCT GGGAGCAGTT 
CTGGCTGCCA TGGGCTTCTA CTCCTACCTG GGTGTCCCCT CTTCTCTGGT TATCATCCAA 
GTGGTACCTT TCCTGGTGCT AGCTGTGGGA GCTGACAACA TCTTCATCTT TGTTCTTGAG 
TACCAGAGGC TACCTAGGAT GCCTGGGGAA CAGCGAGAGG CTCACATTGG CCGCACCCTG 
GGCAGTGTGG CCCCCAGCAT GCTGCTGTGC AGCCTCTCTG AGGCCATCTG CTTCTTTCTA 
GGGGCCCTGA CCCCCATGCC AGCTGTGAGG ACCTTCGCCT TGACCTCTGG CTTAGCAATT 
ATCCTCGACT TCCTGCTCCA GATGACTGCC TTTGTGGCCC TGCTCTCCCT GGATAGCAAG 
AGGCAGGAGG CCTCTCGCCC GGATGTCTTA TGCTGCTTTT CAACCCGGAA GCTGCCCCCA 
CCTAAAGAAA AAGAAGGCCT CTTACTCCGC TTCTTCCGCA AGATATACGC TCCTTTCCTG 
CTGCACAGAT TCATCCGCCC TGTTGTGATG CTGCTGTTTC TGACCCTGTT TGGAGCAAAT 
CTCTACTTAA TGTGCAACAT CAACGTGGGG CTAGACCAGG AGCTGGCTCT GCCCAAGGAC 
TCGTACTTGA TAGACTACTT CCTCTTTCTG AACCGATACC TTGAAGTGGG GCCTCCAGTG 
TACTTTGTCA CCACCTCGGG CTTCAACTTC TCCAGCGAGG CAGGCATGAA CGCCACTTGC 
TCTAGCGCAG GCTGTAAGAG CTTCTCCCTA ACCCAGAAAA TCCAGTATGC CAGTGAATTC 
CCTGACCAGT CTTACGTGGC TATTGCTGCA TCCTCCTGGG TAGATGACTT CATCGACTGG 
CTGACCCCGT CCTCCTCCTG CTGTCGCCTT TATATACGTG GCCCCCATAA GGATGAGTTC 
TGTCCCTCAA CGGATACTTC CTTCAACTGC TTAAAAAACT GCATGAACCG CACTCTGGGT 
CCTGTGAGGC CCACAGCGGA ACAGTTTCAT AAGTACCTGC CCTGGTTCCT GAATGATCCG 
CCCAATATCA GATGTCCCAA AGGGGGTCTA GCAGCGTATA GAACGTCTGT GAATTTGAGC 
TCAGATGGCC AGGTTATAGC CTCCCAGTTC ATGGCCTACC ACAAGCCCTT AAGGAACTCA 
CAGGACTTCA CAGAAGCTCT CCGGGCGTCC CGGTTGCTAG CAGCCAACAT CACAGCTGAC 
CTACGGAAGG TGCCTGGGAC AGATCCAAAC TTTGAGGTCT TCCCTTACAC GATCTCCAAC 
GTGTTCTACC AGCAATACCT GACGGTCCTT CCTGAGGGAA TCTTCACCCT TGCTCTTTGC 
TTTGTGCCCA CCTTTGTTGT CTGCTACCTC CTACTGGGCC TGGACATGTG CTCAGGGATC 
CTCAACCTAC TCTCCATCAT TATGATTCTC GTGGACACCA TTGGCCTCAT GGCTGTGTGG 
GGTATCAGCT ATAATGCGGT ATCCCTCATC AACCTTGTCA CGGCAGTGGG CATGTCTGTG 
GAGTTTGTGT CCCACATCAC TCGGTCCTTT GCTGTAAGCA CCAAGCCTAC CCGGCTGGAG 
AGGGCTAAAG ATGCTACTGT CTTCATGGGC AGTGCGGTGT TTGCTGGAGT GGCCATGACC 
AACTTCCCAG GCATCCTCAT CTTGGGCTTT GCCCAAGCCC AGCTTATTCA GATCTTCTTC 
TTCCGCCTCA ACCTTCTGAT CACCTTGCTG GGTCTGCTGC ATGGCCTGGT CTTCCTGCCG 
GTTGTCCTCA GCTATCTGGG ACCAGATGTT AACCAAGCTC TGGTACAGGA GGAGAAACTA 
GCCAGCGAGG CAGCAGTGGC CCCAGAGCCT TCTTGCCCAC AGTACCCCTC CCCTGCTGAT 
GCGGATGCCA ATGTTAACTA CGGCTTTGCC CCAGAACTTG CCCACGGAGC TAATGCTGCT 
AGAAGCTCTT TGCCCAAAAG TGACCAAAAG TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002025.1
CDS	1..3996
Translation	MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSAVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAARSSLPKSDQKF

Target ORF information:

RefSeq Version	NM_001002025.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NPC1 like intracellular cholesterol transporter 1 (Npc1l1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002025.1

ORF Insert Sequence:

ATGGCAGCTG CCTGGCTGGG ATGGCTGCTC TGGGCCCTGC TCCTGAGCGC GGCCCAGGGT 
GAGCTATACA CACCCAAACA CGAAGCTGGG GTCTGCACCT TTTACGAAGA GTGCGGGAAA 
AACCCAGAGC TCTCTGGAGG CCTCACGTCA CTATCCAATG TATCCTGCCT GTCTAACACC 
CCGGCCCGCC ACGTCACGGG TGAACACCTG GCTCTTCTCC AGCGCATCTG TCCCCGCCTG 
TACAACGGCC CCAATACCAC TTTTGCCTGT TGCTCTACCA AGCAGCTGCT GTCCTTAGAA 
AGCAGCATGT CCATCACCAA GGCCCTTCTC ACGCGCTGCC CGGCCTGCTC TGACAATTTT 
GTGAGCTTAC ACTGCCACAA CACTTGCAGC CCTGACCAGA GCCTCTTCAT CAACGTCACC 
CGGGTGGTTG AGCGGGGCGC TGGAGAGCCT CCTGCCGTGG TGGCCTATGA GGCCTTTTAT 
CAGCGCAGCT TTGCTGAGAA GGCCTATGAG TCCTGCAGCC AGGTGCGCAT CCCTGCGGCC 
GCTTCCTTGG CCGTGGGCAG CATGTGTGGA GTGTATGGCT CCGCCCTCTG CAATGCTCAG 
CGCTGGCTCA ACTTCCAAGG AGACACAGGG AATGGCCTGG CTCCGCTGGA TATCACCTTC 
CACCTCTTGG AGCCTGGCCA GGCCCTACCG GATGGGATCC AGCCACTGAA TGGGAAGATC 
GCACCCTGCA ACGAGTCTCA GGGTGATGAC TCAGCAGTCT GCTCCTGCCA GGACTGTGCG 
GCGTCCTGCC CTGTCATCCC TCCGCCCGAG GCCTTGCGCC CTTCCTTCTA CATGGGTCGC 
ATGCCAGGCT GGCTGGCCCT CATCATCATC TTCACTGCTG TCTTTGTGTT GCTCTCTGCA 
GTCCTTGTGC GTCTCCGAGT GGTTTCCAAC AGGAACAAGA ACAAGGCAGA AGGCCCCCAG 
GAAGCCCCCA AACTCCCTCA TAAGCACAAA CTCTCACCCC ATACCATCCT GGGCCGGTTC 
TTCCAGAACT GGGGCACAAG GGTGGCCTCG TGGCCACTCA CCGTCTTAGC ACTGTCCTTC 
ATCGTTGTGA TAGCCTTAGC AGCAGGCCTG ACCTTTATTG AACTCACCAC AGACCCTGTG 
GAACTGTGGT CGGCCCCCAA GAGCCAGGCC CGGAAAGAGA AGTCTTTCCA TGATGAGCAT 
TTCGGCCCCT TCTTTCGAAC CAACCAGATT TTCGTGACAG CTCGGAACAG GTCCAGCTAC 
AAGTACGACT CCCTACTGCT AGGGTCCAAG AACTTCAGTG GGATCCTGTC CCTGGACTTC 
CTGCTGGAGC TGCTGGAGCT TCAGGAGAGG CTTCGACACC TGCAAGTGTG GTCCCCTGAG 
GCAGAGCGCA ACATCTCCCT CCAGGACATC TGCTATGCCC CCCTCAACCC ATATAACACC 
AGCCTCTCCG ACTGCTGTGT CAACAGCCTC CTTCAGTACT TCCAGAACAA CCGCACCCTC 
CTGATGCTCA CGGCCAACCA GACTCTGAAT GGCCAGACCT CCCTGGTGGA CTGGAAGGAC 
CATTTCCTCT ACTGTGCAAA TGCCCCTCTC ACGTTCAAAG ATGGCACGTC TCTGGCCCTG 
AGCTGCATGG CTGACTACGG GGCTCCTGTC TTCCCCTTCC TTGCTGTTGG GGGATACCAA 
GGCACGGACT ATTCCGAGGC AGAAGCGCTG ATCATAACCT TCTCTCTCAA TAACTACCCC 
GCTGATGATC CCCGCATGGC CCAGGCCAAG CTCTGGGAGG AGGCTTTCTT GAAGGAAATG 
GAATCCTTCC AGAGGAACAC AAGTGACAAG TTCCAGGTTG CGTTCTCAGC TGAGCGCTCT 
CTGGAGGATG AGATCAACCG CACCACCATC CAGGACCTGC CTGTCTTTGC CGTCAGCTAC 
ATTATCGTCT TCCTGTACAT CTCCCTGGCC CTGGGCAGCT ACTCCAGATG CAGCCGAGTA 
GCGGTGGAGT CCAAGGCTAC TCTGGGCCTA GGTGGGGTGA TTGTTGTGCT GGGAGCAGTT 
CTGGCTGCCA TGGGCTTCTA CTCCTACCTG GGTGTCCCCT CTTCTCTGGT TATCATCCAA 
GTGGTACCTT TCCTGGTGCT AGCTGTGGGA GCTGACAACA TCTTCATCTT TGTTCTTGAG 
TACCAGAGGC TACCTAGGAT GCCTGGGGAA CAGCGAGAGG CTCACATTGG CCGCACCCTG 
GGCAGTGTGG CCCCCAGCAT GCTGCTGTGC AGCCTCTCTG AGGCCATCTG CTTCTTTCTA 
GGGGCCCTGA CCCCCATGCC AGCTGTGAGG ACCTTCGCCT TGACCTCTGG CTTAGCAATT 
ATCCTCGACT TCCTGCTCCA GATGACTGCC TTTGTGGCCC TGCTCTCCCT GGATAGCAAG 
AGGCAGGAGG CCTCTCGCCC GGATGTCTTA TGCTGCTTTT CAACCCGGAA GCTGCCCCCA 
CCTAAAGAAA AAGAAGGCCT CTTACTCCGC TTCTTCCGCA AGATATACGC TCCTTTCCTG 
CTGCACAGAT TCATCCGCCC TGTTGTGATG CTGCTGTTTC TGACCCTGTT TGGAGCAAAT 
CTCTACTTAA TGTGCAACAT CAACGTGGGG CTAGACCAGG AGCTGGCTCT GCCCAAGGAC 
TCGTACTTGA TAGACTACTT CCTCTTTCTG AACCGATACC TTGAAGTGGG GCCTCCAGTG 
TACTTTGTCA CCACCTCGGG CTTCAACTTC TCCAGCGAGG CAGGCATGAA CGCCACTTGC 
TCTAGCGCAG GCTGTAAGAG CTTCTCCCTA ACCCAGAAAA TCCAGTATGC CAGTGAATTC 
CCTGACCAGT CTTACGTGGC TATTGCTGCA TCCTCCTGGG TAGATGACTT CATCGACTGG 
CTGACCCCGT CCTCCTCCTG CTGTCGCCTT TATATACGTG GCCCCCATAA GGATGAGTTC 
TGTCCCTCAA CGGATACTTC CTTCAACTGC TTAAAAAACT GCATGAACCG CACTCTGGGT 
CCTGTGAGGC CCACAGCGGA ACAGTTTCAT AAGTACCTGC CCTGGTTCCT GAATGATCCG 
CCCAATATCA GATGTCCCAA AGGGGGTCTA GCAGCGTATA GAACGTCTGT GAATTTGAGC 
TCAGATGGCC AGGTTATAGC CTCCCAGTTC ATGGCCTACC ACAAGCCCTT AAGGAACTCA 
CAGGACTTCA CAGAAGCTCT CCGGGCGTCC CGGTTGCTAG CAGCCAACAT CACAGCTGAC 
CTACGGAAGG TGCCTGGGAC AGATCCAAAC TTTGAGGTCT TCCCTTACAC GATCTCCAAC 
GTGTTCTACC AGCAATACCT GACGGTCCTT CCTGAGGGAA TCTTCACCCT TGCTCTTTGC 
TTTGTGCCCA CCTTTGTTGT CTGCTACCTC CTACTGGGCC TGGACATGTG CTCAGGGATC 
CTCAACCTAC TCTCCATCAT TATGATTCTC GTGGACACCA TTGGCCTCAT GGCTGTGTGG 
GGTATCAGCT ATAATGCGGT ATCCCTCATC AACCTTGTCA CGGCAGTGGG CATGTCTGTG 
GAGTTTGTGT CCCACATCAC TCGGTCCTTT GCTGTAAGCA CCAAGCCTAC CCGGCTGGAG 
AGGGCTAAAG ATGCTACTGT CTTCATGGGC AGTGCGGTGT TTGCTGGAGT GGCCATGACC 
AACTTCCCAG GCATCCTCAT CTTGGGCTTT GCCCAAGCCC AGCTTATTCA GATCTTCTTC 
TTCCGCCTCA ACCTTCTGAT CACCTTGCTG GGTCTGCTGC ATGGCCTGGT CTTCCTGCCG 
GTTGTCCTCA GCTATCTGGG ACCAGATGTT AACCAAGCTC TGGTACAGGA GGAGAAACTA 
GCCAGCGAGG CAGCAGTGGC CCCAGAGCCT TCTTGCCCAC AGTACCCCTC CCCTGCTGAT 
GCGGATGCCA ATGTTAACTA CGGCTTTGCC CCAGAACTTG CCCACGGAGC TAATGCTGCT 
AGAAGCTCTT TGCCCAAAAG TGACCAAAAG TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice.
European journal of drug metabolism and pharmacokinetics41(4)457-63(2016 Aug)
Kawase A,Araki Y,Ueda Y,Nakazaki S,Iwaki M

NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.
Science translational medicine7(275)275ra23(2015 Feb)
Takada T,Yamanashi Y,Konishi K,Yamamoto T,Toyoda Y,Masuo Y,Yamamoto H,Suzuki H

The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
The Journal of biological chemistry286(41)35933-42(2011 Oct)
Xie C,Li N,Chen ZJ,Li BL,Song BL

Increased NPC1L1 and serum cholesterol in a chronic rejection rat.
Clinical and investigative medicine. Medecine clinique et experimentale34(3)E172-8(2011 Jun)
Zhu Y,Zhou J

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Proceedings of the National Academy of Sciences of the United States of America108(2)551-6(2011 Jan)
Ge L,Qi W,Wang LJ,Miao HH,Qu YX,Li BL,Song BL

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Npc1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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