Trhde cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trhde
Entrez Gene ID	366894
Full Name	thyrotropin-releasing hormone degrading enzyme
Synonyms	PAP-II
General protein information	Preferred Names thyrotropin-releasing hormone degrading enzyme Names thyrotropin-releasing hormone-degrading ectoenzyme TRH-DE TRH-degrading ectoenzyme TRH-specific aminopeptidase pyroglutamyl-peptidase II thyroliberinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	membrane-bound enzyme; catalyzes the hydrolysis of Thyrotropin-releasing hormone (TRH) at the pyroGlu-His bond [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108991.1	NP_001102461.1	thyrotropin-releasing hormone-degrading ectoenzyme

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRHDE	NP_037513.1
Pan troglodytes (chimpanzee)	TRHDE	XP_522471.4
Canis lupus familiaris (dog)	TRHDE	XP_005625720.1
Xenopus tropicalis (tropical clawed frog)	trhde	XP_002939988.2
	TRHDE	XP_001109391.2
Bos taurus (cattle)	TRHDE	XP_002687216.3
Rattus norvegicus (Norway rat)	Trhde	NP_001102461.1
Mus musculus (house mouse)	Trhde	NP_666353.1
Gallus gallus (chicken)	TRHDE	XP_425442.3
Danio rerio (zebrafish)	LOC562409	XP_690889.2
Danio rerio (zebrafish)	si:ch211-149p5.1	XP_001345457.3

Gene Ontology
Bibliography

Related articles in PubMed

Fasting Enhances Pyroglutamyl Peptidase II Activity in Tanycytes of the Mediobasal Hypothalamus of Male Adult Rats.
Lazcano I, Cabral A, Uribe RM, Jaimes-Hoy L, Perello M, Joseph-Bravo P, S?nchez-Jaramillo E, Charli JL
Endocrinology156(7)2713-23(2015 Jul)

Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
Alvarez-Salas E, Aceves C, Anguiano B, Uribe RM, Garc?a-Luna C, S?nchez E, de Gortari P
Endocrinology153(8)4067-76(2012 Aug)

Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum.
Lazcano I, Uribe RM, Mart?nez-Ch?vez E, Vargas MA, Matziari M, Joseph-Bravo P, Charli JL
The Journal of pharmacology and experimental therapeutics342(1)222-31(2012 Jul)

Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.
Konishi H, Ogawa T, Kawahara S, Matsumoto S, Kiyama H
Biochemical and biophysical research communications407(1)7-12(2011 Apr)

Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.
S?nchez E, Vargas MA, Singru PS, Pascual I, Romero F, Fekete C, Charli JL, Lechan RM
Endocrinology150(5)2283-91(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Delayed increases in both the median eminence PPII as well as the thyroliberinase activities in fasted male rats may facilitate the maintenance of deep downregulation of the HPT axis function, despite a partial reactivation of TRH expression in the PVN.
Title: Fasting Enhances Pyroglutamyl Peptidase II Activity in Tanycytes of the Mediobasal Hypothalamus of Male Adult Rats.

Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
Title: Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.

Twenty to 35% of Pyroglutamyl peptidase II mRNA-labeled profiles were positive for TRH-receptor 1 (TRH-R1) mRNA.
Title: Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum.

PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress.
Title: Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.

An increase in circulating thyroid hormone up-regulates PPII activity in tanycytes and enhances degradation of extracellular TRH in the median eminence through glial-axonal associations.
Title: Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.

The following Trhde gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trhde cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08789	NM_001108991.1 Latest version!	Rattus norvegicus thyrotropin-releasing hormone degrading enzyme (Trhde), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$783.30 $1119.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trhde ( NM_001108991.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102461.1 Rattus norvegicus thyrotropin-releasing hormone degrading enzyme (Trhde), mRNA.

Price & Availability↑

CloneID	ORa08789
Clone ID Related Accession (Same CDS sequence)	NM_001108991.1
Accession Version	NM_001108991.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3201bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	thyrotropin-releasing hormone-degrading ectoenzyme
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473960.2. On or before Oct 4, 2007 this sequence version replaced XM_345824.3, XM_001078601.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCCTGG ACGGCGAGAG GGGGGAGCAA GAGGAGGAGA AGAAAAAGAA GAAGAAGAAA 
AAGAAGAGGA AGAAGAAGGA GGAGGAGGGG GCCGAGAAGA GCAGTTCACC GTTTGCGGCC 
ACCATGGGAG AAGACGACGC CGCGCTCCGG GCAAGCGGCA GGGGGCTCTC GGACCCGTGG 
GCTGACTCGG TGGGAGTGAG ACCCCGCACC ACGGAGCGCC ACATCGCAGT GCACAAGAGG 
CTTGTGCTGG CTTTTGCCGT GTCCATCGTG GCACTGCTGG CTGTCACCAT GCTGGCCGTA 
CTGCTCAGCC TGCGGTTCGA CGAGTGTGGA GCGAGCGCGG CGATGCCGGG CACCGACGGT 
GGCCTCGGAG GCTTCCCTGA GCGTGGTGGC AACAGCAGCT ACCCAGGATC TGCCCGGCGC 
AACCACCACG CGGGTGAGGA ATCCTCGCAG CGTGAGATCG GCGAGGTGGG CACCGCGGGG 
ACCCCGTCTG CCCATCCGCC GTCGGAGGAA GAGCAGGAGC AGTGGCAGCC CTGGACTCAG 
CTGCGCCTAT CCGGCCACCT TAAGCCGCTG CACTACAATT TGATGCTCAC CGCCTTCATG 
GAGAACTTCA CCTTCTCTGG GGAGGTCAAC GTGGAGATCG CGTGCCAGAA CGCCACCCGC 
TACGTGGTAC TGCACGCCTC CCGGGTGGCG GTGGAGAAGG TGCAAGTAGC GGAAGACCGG 
GCGTTCGGGG CTGTCCCGGT AGCAGGCTTT TTCCTCTACC CACAAACGCA GGTCTTGGTG 
GTGGTGCTGA ATAGAACCCT GGATGCGCAG AGGCACTACA ATCTGAAGAT TATCTACAAT 
GCCCTGATAG AGAACGAGCT TTTGGGCTTC TTCCGCAGCT CCTACGTGAT CCACGGGGAG 
AGAAGATTCC TCGGTGTTAC TCAGTTTTCA CCTACACATG CCAGGAAGGC ATTTCCATGT 
TTTGATGAAC CAATCTACAA GGCCACTTTC AAAATCAGCA TCAAACATCA AGCAACCTAT 
TTGTCTCTCT CCAACATGCC CGTGGAAACA TCTGTGTTTG AGGAAGATGG ATGGGTAACA 
GATCACTTTT CACAGACCCC TCTCATGTCC ACATATTATT TAGCCTGGGC GATTTGCAAC 
TTCACATACA GAGAAACTAC TACCAAGAGT GGGGTTGTAG TTCGATTATA TGCAAGACCC 
GACGCTATCA GAAGAGGATC CGGGGACTAT GCTCTCCACA TTACAAAGAG ATTAATAGAA 
TTTTATGAAG ACTACTTTAA AGTGCCCTAT TCTTTGCCAA AACTAGATCT TTTAGCTGTG 
CCTAAGCATC CTTATGCTGC TATGGAGAAC TGGGGACTAA GTATTTTTGT GGAACAAAGA 
ATACTGCTGG ATCCCAGTGT GTCATCTATT TCTTATTTGC TGGATGTCAC CATGGTCATT 
GTTCATGAAA TATGTCACCA GTGGTTTGGT GACCTTGTGA CCCCAGTGTG GTGGGAAGAT 
GTGTGGTTGA AGGAAGGCTT TGCTCACTAC TTTGAATTTG TGGGTACAGA CTACCTCTAC 
CCTTCCTGGA ACATGGAAAA GCAGAGGTTT CTGACAGATG TTCTGCATGA AGTGATGCTG 
CTTGACGGGT TGGCCAGTTC CCATCCAGTA TCACAGGAAG TGCTACGGGC AACAGATATT 
GACAAAGTGT TTGACTGGAT CGCATACAAA AAGGGTGCTG CTTTAATAAG AATGCTGGCT 
AATTTTATGG GCCATTCAGT TTTTCAGAGG GGATTGCAAG ATTATTTAAC CATTCACAAG 
TATGGCAATG CAGCCAGAAA TGATCTCTGG AATACATTAT CAGAGGCTTT AAAAAGGAAT 
GGAAAATATG TGAACATACA AGAGGTAATG GATCAGTGGA CACTCCAGAT GGGATATCCT 
GTTATCACCA TCCTGGGGAA CATGACGGCA GAAAACAGAA TACTCATCAC CCAACAGCAC 
TTCATTTACG ATATCGGTGC TAAAACCAAA GCACTTCAAC TTCAAAACAG CAGTTACCTG 
TGGCAGATTC CATTAACCAT CGTCGTAGGA AATAGAAGCC ATGTGTCTTC AGAAGCAATT 
ATTTGGGTGT CCAACAAATC AGAACATCAC AGAATAACAT ACTTAGACAA AGGAAGCTGG 
ATCCTTGGAA ACATCAATCA AACTGGCTAC TTCAGAGTCA ACTATGACCT AAGGAACTGG 
AGATTACTGA TCGATCAGTT AATCAGGAAC CATGAGGTAC TTTCTGTCAG TAACCGTGCA 
GGCCTGATTG ATGATGCCTT CAGCCTGGCC AGGGCAGGCT ATTTGCCTCA GAATATTCCC 
CTAGAGATCA TCAGATACCT CTCTGAGGAA AAGGATTTTC TTCCTTGGCA TGCTGCCAGC 
CGAGCTCTTT ATCCTCTGGA TAAATTACTG GACCGCATGG AAAACTACAA TATCTTCAAT 
GAATATATTC TAAAACAAGT GGCAACAACC TACAGCAAGC TTGGATGGCC AAAGAACAAC 
TTCAATGGCT CTGTCGTTCA AGCTTCCTAT CAACATGAAG AGCTACGGAG GGAAGTGATA 
ATGTTGGCCT GTAGCTTTGG GAACAAGCAC TGTCACCAGC AGGCGTCAAC TCTTATTTCA 
GACTGGATTT CCAGCAATAG AAACAGAATA CCACTGAATG TTAGAGACAT CGTCTACTGC 
ACAGGAGTGT CCCTGCTGGA TGAGGATGTC TGGGAATTCA TCTGGATGAA ATTCCACTCC 
ACCACTGCAG TTTCTGAGAA AAAGATATTG CTGGAGGCGC TAACTTGCAG TGATGACAGG 
AATTTACTAA GTAGGCTTCT GAATCTGTCT CTGAATTCTG AGGTGGTGTT GGATCAAGAT 
GCAATTGATG TAATAATCCA CGTAGCCAGA AATCCACATG GCCGAGACCT TGCCTGGAAG 
TTTTTCAGAG ATAAATGGAA AATACTAAAT ACCAGGTATG GAGAAGCATT ATTTATGAAT 
TCCAAACTTA TCAGTGGAGT TACAGAATTT CTTAATACAG AAGGTGAACT TAAAGAGCTA 
AAGAACTTCA TGAAGTCCTA TGATGGGGTA GCATCTGCTT CTTTCTCACG AGCCGTGGAA 
ACCGTGGAAG CCAATGTGCG CTGGAAAAGG CTTTATCAAG ATGAGCTTTT CCAGTGGCTG 
GGAAAAGCCA TGAGGCACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102461.1
CDS	891..4091
Translation	MALDGERGEQEEEKKKKKKKKKRKKKEEEGAEKSSSPFAATMGEDDAALRASGRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSIVALLAVTMLAVLLSLRFDECGASAAMPGTDGGLGGFPERGGNSSYPGSARRNHHAGEESSQREIGEVGTAGTPSAHPPSEEEQEQWQPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSKLGWPKNNFNGSVVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKSYDGVASASFSRAVETVEANVRWKRLYQDELFQWLGKAMRH

Target ORF information:

RefSeq Version	NM_001108991.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thyrotropin-releasing hormone degrading enzyme (Trhde), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108991.1

ORF Insert Sequence:

ATGGCCCTGG ACGGCGAGAG GGGGGAGCAA GAGGAGGAGA AGAAAAAGAA GAAGAAGAAA 
AAGAAGAGGA AGAAGAAGGA GGAGGAGGGG GCCGAGAAGA GCAGTTCACC GTTTGCGGCC 
ACCATGGGAG AAGACGACGC CGCGCTCCGG GCAAGCGGCA GGGGGCTCTC GGACCCGTGG 
GCTGACTCGG TGGGAGTGAG ACCCCGCACC ACGGAGCGCC ACATCGCAGT GCACAAGAGG 
CTTGTGCTGG CTTTTGCCGT GTCCATCGTG GCACTGCTGG CTGTCACCAT GCTGGCCGTA 
CTGCTCAGCC TGCGGTTCGA CGAGTGTGGA GCGAGCGCGG CGATGCCGGG CACCGACGGT 
GGCCTCGGAG GCTTCCCTGA GCGTGGTGGC AACAGCAGCT ACCCAGGATC TGCCCGGCGC 
AACCACCACG CGGGTGAGGA ATCCTCGCAG CGTGAGATCG GCGAGGTGGG CACCGCGGGG 
ACCCCGTCTG CCCATCCGCC GTCGGAGGAA GAGCAGGAGC AGTGGCAGCC CTGGACTCAG 
CTGCGCCTAT CCGGCCACCT TAAGCCGCTG CACTACAATT TGATGCTCAC CGCCTTCATG 
GAGAACTTCA CCTTCTCTGG GGAGGTCAAC GTGGAGATCG CGTGCCAGAA CGCCACCCGC 
TACGTGGTAC TGCACGCCTC CCGGGTGGCG GTGGAGAAGG TGCAAGTAGC GGAAGACCGG 
GCGTTCGGGG CTGTCCCGGT AGCAGGCTTT TTCCTCTACC CACAAACGCA GGTCTTGGTG 
GTGGTGCTGA ATAGAACCCT GGATGCGCAG AGGCACTACA ATCTGAAGAT TATCTACAAT 
GCCCTGATAG AGAACGAGCT TTTGGGCTTC TTCCGCAGCT CCTACGTGAT CCACGGGGAG 
AGAAGATTCC TCGGTGTTAC TCAGTTTTCA CCTACACATG CCAGGAAGGC ATTTCCATGT 
TTTGATGAAC CAATCTACAA GGCCACTTTC AAAATCAGCA TCAAACATCA AGCAACCTAT 
TTGTCTCTCT CCAACATGCC CGTGGAAACA TCTGTGTTTG AGGAAGATGG ATGGGTAACA 
GATCACTTTT CACAGACCCC TCTCATGTCC ACATATTATT TAGCCTGGGC GATTTGCAAC 
TTCACATACA GAGAAACTAC TACCAAGAGT GGGGTTGTAG TTCGATTATA TGCAAGACCC 
GACGCTATCA GAAGAGGATC CGGGGACTAT GCTCTCCACA TTACAAAGAG ATTAATAGAA 
TTTTATGAAG ACTACTTTAA AGTGCCCTAT TCTTTGCCAA AACTAGATCT TTTAGCTGTG 
CCTAAGCATC CTTATGCTGC TATGGAGAAC TGGGGACTAA GTATTTTTGT GGAACAAAGA 
ATACTGCTGG ATCCCAGTGT GTCATCTATT TCTTATTTGC TGGATGTCAC CATGGTCATT 
GTTCATGAAA TATGTCACCA GTGGTTTGGT GACCTTGTGA CCCCAGTGTG GTGGGAAGAT 
GTGTGGTTGA AGGAAGGCTT TGCTCACTAC TTTGAATTTG TGGGTACAGA CTACCTCTAC 
CCTTCCTGGA ACATGGAAAA GCAGAGGTTT CTGACAGATG TTCTGCATGA AGTGATGCTG 
CTTGACGGGT TGGCCAGTTC CCATCCAGTA TCACAGGAAG TGCTACGGGC AACAGATATT 
GACAAAGTGT TTGACTGGAT CGCATACAAA AAGGGTGCTG CTTTAATAAG AATGCTGGCT 
AATTTTATGG GCCATTCAGT TTTTCAGAGG GGATTGCAAG ATTATTTAAC CATTCACAAG 
TATGGCAATG CAGCCAGAAA TGATCTCTGG AATACATTAT CAGAGGCTTT AAAAAGGAAT 
GGAAAATATG TGAACATACA AGAGGTAATG GATCAGTGGA CACTCCAGAT GGGATATCCT 
GTTATCACCA TCCTGGGGAA CATGACGGCA GAAAACAGAA TACTCATCAC CCAACAGCAC 
TTCATTTACG ATATCGGTGC TAAAACCAAA GCACTTCAAC TTCAAAACAG CAGTTACCTG 
TGGCAGATTC CATTAACCAT CGTCGTAGGA AATAGAAGCC ATGTGTCTTC AGAAGCAATT 
ATTTGGGTGT CCAACAAATC AGAACATCAC AGAATAACAT ACTTAGACAA AGGAAGCTGG 
ATCCTTGGAA ACATCAATCA AACTGGCTAC TTCAGAGTCA ACTATGACCT AAGGAACTGG 
AGATTACTGA TCGATCAGTT AATCAGGAAC CATGAGGTAC TTTCTGTCAG TAACCGTGCA 
GGCCTGATTG ATGATGCCTT CAGCCTGGCC AGGGCAGGCT ATTTGCCTCA GAATATTCCC 
CTAGAGATCA TCAGATACCT CTCTGAGGAA AAGGATTTTC TTCCTTGGCA TGCTGCCAGC 
CGAGCTCTTT ATCCTCTGGA TAAATTACTG GACCGCATGG AAAACTACAA TATCTTCAAT 
GAATATATTC TAAAACAAGT GGCAACAACC TACAGCAAGC TTGGATGGCC AAAGAACAAC 
TTCAATGGCT CTGTCGTTCA AGCTTCCTAT CAACATGAAG AGCTACGGAG GGAAGTGATA 
ATGTTGGCCT GTAGCTTTGG GAACAAGCAC TGTCACCAGC AGGCGTCAAC TCTTATTTCA 
GACTGGATTT CCAGCAATAG AAACAGAATA CCACTGAATG TTAGAGACAT CGTCTACTGC 
ACAGGAGTGT CCCTGCTGGA TGAGGATGTC TGGGAATTCA TCTGGATGAA ATTCCACTCC 
ACCACTGCAG TTTCTGAGAA AAAGATATTG CTGGAGGCGC TAACTTGCAG TGATGACAGG 
AATTTACTAA GTAGGCTTCT GAATCTGTCT CTGAATTCTG AGGTGGTGTT GGATCAAGAT 
GCAATTGATG TAATAATCCA CGTAGCCAGA AATCCACATG GCCGAGACCT TGCCTGGAAG 
TTTTTCAGAG ATAAATGGAA AATACTAAAT ACCAGGTATG GAGAAGCATT ATTTATGAAT 
TCCAAACTTA TCAGTGGAGT TACAGAATTT CTTAATACAG AAGGTGAACT TAAAGAGCTA 
AAGAACTTCA TGAAGTCCTA TGATGGGGTA GCATCTGCTT CTTTCTCACG AGCCGTGGAA 
ACCGTGGAAG CCAATGTGCG CTGGAAAAGG CTTTATCAAG ATGAGCTTTT CCAGTGGCTG 
GGAAAAGCCA TGAGGCACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fasting Enhances Pyroglutamyl Peptidase II Activity in Tanycytes of the Mediobasal Hypothalamus of Male Adult Rats.
Endocrinology156(7)2713-23(2015 Jul)
Lazcano I,Cabral A,Uribe RM,Jaimes-Hoy L,Perello M,Joseph-Bravo P,S?nchez-Jaramillo E,Charli JL

Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
Endocrinology153(8)4067-76(2012 Aug)
Alvarez-Salas E,Aceves C,Anguiano B,Uribe RM,Garc?a-Luna C,S?nchez E,de Gortari P

Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum.
The Journal of pharmacology and experimental therapeutics342(1)222-31(2012 Jul)
Lazcano I,Uribe RM,Mart?nez-Ch?vez E,Vargas MA,Matziari M,Joseph-Bravo P,Charli JL

Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.
Biochemical and biophysical research communications407(1)7-12(2011 Apr)
Konishi H,Ogawa T,Kawahara S,Matsumoto S,Kiyama H

Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.
Endocrinology150(5)2283-91(2009 May)
S?nchez E,Vargas MA,Singru PS,Pascual I,Romero F,Fekete C,Charli JL,Lechan RM

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Trhde cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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