Tysnd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tysnd1
Entrez Gene ID	365571
Full Name	trypsin domain containing 1
General protein information	Preferred Names trypsin domain containing 1 Names peroxisomal leader peptide-processing protease
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108932.1	NP_001102402.1	peroxisomal leader peptide-processing protease

Pathways from BioSystems

Homologies

Homo sapiens (human)	TYSND1	NP_775826.2
Mus musculus (house mouse)	Tysnd1	NP_082188.1
Danio rerio (zebrafish)	tysnd1	NP_001122182.1
Xenopus tropicalis (tropical clawed frog)	tysnd1	XP_002936002.1
Gallus gallus (chicken)	TYSND1	XP_001232633.2
Pan troglodytes (chimpanzee)	TYSND1	XP_001170770.1
	TYSND1	XP_002805742.1
Rattus norvegicus (Norway rat)	Tysnd1	NP_001102402.1

Gene Ontology
Bibliography

Related articles in PubMed

Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility.
Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Sch?nbach C, Okazaki Y
PLoS genetics9(2)e1003286(2013)

Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid ?-oxidation in peroxisomal matrix.
Okumoto K, Kametani Y, Fujiki Y
The Journal of biological chemistry286(52)44367-79(2011 Dec)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids.
Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Sch?nbach C, Okazaki Y
The EMBO journal26(3)835-45(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tysnd1-mediated processing of the peroxisomal enzymes promotes their assembly into a supramolecular complex to enhance the rate of beta-oxidation.
Title: Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids.

The following Tysnd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tysnd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08674	NM_001108932.1 Latest version!	Rattus norvegicus trypsin domain containing 1 (Tysnd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tysnd1 ( NM_001108932.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102402.1 Rattus norvegicus trypsin domain containing 1 (Tysnd1), mRNA.

Price & Availability↑

CloneID	ORa08674
Clone ID Related Accession (Same CDS sequence)	NM_001108932.1
Accession Version	NM_001108932.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1704bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	peroxisomal leader peptide-processing protease
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474016.2. On or before Oct 4, 2007 this sequence version replaced XM_345106.2, XM_001056113.1. ##Evidence-Data-START## Transcript exon combination :: BC160877.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGACGGC AATGGGGACC GTCTTTGAGA GTGGCAGAGC AGGCGGGTTG CGTAGTGAGC 
GCCTCGCGAG CAGGACAGCC CGATGCGGGC TCGTGGAGCT GCAGCGGGGT GATCCTGAGC 
CGCAGCCCAG GCCTGGTGCT GTGCCACGGG GGCATTTTCA CCCCCTTCCT CAGAACTGGT 
AGCGCGGCTT TGACCCAAAC GGGAGCCGCC TTCCTACCGG GCGACAGTTG CAGCGATGAC 
CTGCGCCTCC ACGTGCAGTG GGGACCCACG GCTGCCAGCC CCGCCGGCCG CGCGGACCAG 
GAACTTCCAG GGCTGTGCAC GCCTCAGTGC GCAAGCCTGG GCCTCGAACC CGGTGCCCCG 
AGCCGGGCCC GCGCGCGGCC TCTGCAGCCT CCGCGGCCGG CGCAGCTGCT GTTGCTGCTC 
AGCTGCCCGG CCTTCCGCTC GCACTTCGCG CGGCTCTTCG GGGCCGAAGC GGCGGATCAA 
TGGCACTTCG TGAGCTCGGC GCCCGACGAC GCGGTGTCAG AGGAGGAGGA GGAGGATCAG 
CTGCGCGCGC TCGGCTGGTT CGCCCTCCTG CGGGTGCAGC GGGGCGCGGC GGCCGAGGAG 
AGGCGCGGGC CGGCGGTGAC CGTGGCACCG CTCGGGGCCG TGGCCAAGGG CGCACCGCTG 
CTGGCTTGTG GCTCTCCGTT CGGTGCCTTC TGCCCGGACA TCTTCCTCAA CACGCTGAGC 
CGGGGCGTGC TCAGCAACGC GGCCGGTCCG CTGTTGCTCA CCGACGCGCG CTGCCTGCCG 
GGCACAGAAG GCGGCGGAGT GTTCGCGGCC CGACCTGCGG GCGCGCTGGT GGCTCTGGTG 
GCCGCGCCTC TATGCTGGAA GGCCCGCGAG TGGGTGGGCC TCACGTTGCT GTGCGCCGCT 
GCCCCTCTGC TTCAGGTTGC TCGCTCGGCT CTCTCTCGCC TGCATCCGGA CTCCACCTCT 
CTGTCCGCGC TGCTGCCACC CGAAGTGGGC GCGCCAAGGG GCCTGTCCCT ACGAGATCTC 
GGATCCTCGT GGGCAGCCGC GGCGGTGCTG GTGGAGTGTG GTGCCGTGTG GGGCTCCGGA 
GTGGCTGTGG CGCCTCGCCT GGTGGTGACC TGCCGTCATG TGGCACCCCG GGAAACAGCC 
AGGGTCTTGG TACACTCAGC TACACCCAGG AATGTGGCAA TCTGGGGACG AGTGGTATTT 
GCCACTCAGG AGACCTCTCC ATATGACATA GCGGTGGTGA GCCTGGAAGA GGAACTGAAT 
GGTGTCCCCG TGCCTGTCCC AGCTGAGCAC TTCCATGAAG GCGAGCCTGT CAGCGTGGTG 
GGCTTTGGCG TGTTTGGCCA GGCCTGCGGG CCCTCAGTGA CCTCAGGCAT CCTGTCGGCC 
GTGGTGCATG TGGATGATGC CCCAGTGATG CTACAGACCA CCTGTGCCGT GCATGGCGGC 
TCTAGCGGAG GACCTCTCTT CTCTACACGC TCGGGGGACC TCTTGGGCAT TGTTGCTAGC 
AACACTCGGG ACAACAACAC GGGGGCCACC TACCCACACC TGAACTTCAG CATCCCCATC 
ACCGTGCTCC AGCCGGCCCT GAAGCAGTAC AGTCAGACTG GTGACCTGTG TGGCCTCAGA 
GAGCTGGACC ACACCACTGA GCCTGTCAGG GTCGTGTGGC GGCTGCAGCG GCCCCTGCCG 
GAAGCCCCCC GGAGCAAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102402.1
CDS	59..1762
Translation	MGRQWGPSLRVAEQAGCVVSASRAGQPDAGSWSCSGVILSRSPGLVLCHGGIFTPFLRTGSAALTQTGAAFLPGDSCSDDLRLHVQWGPTAASPAGRADQELPGLCTPQCASLGLEPGAPSRARARPLQPPRPAQLLLLLSCPAFRSHFARLFGAEAADQWHFVSSAPDDAVSEEEEEDQLRALGWFALLRVQRGAAAEERRGPAVTVAPLGAVAKGAPLLACGSPFGAFCPDIFLNTLSRGVLSNAAGPLLLTDARCLPGTEGGGVFAARPAGALVALVAAPLCWKAREWVGLTLLCAAAPLLQVARSALSRLHPDSTSLSALLPPEVGAPRGLSLRDLGSSWAAAAVLVECGAVWGSGVAVAPRLVVTCRHVAPRETARVLVHSATPRNVAIWGRVVFATQETSPYDIAVVSLEEELNGVPVPVPAEHFHEGEPVSVVGFGVFGQACGPSVTSGILSAVVHVDDAPVMLQTTCAVHGGSSGGPLFSTRSGDLLGIVASNTRDNNTGATYPHLNFSIPITVLQPALKQYSQTGDLCGLRELDHTTEPVRVVWRLQRPLPEAPRSKL

Target ORF information:

RefSeq Version	NM_001108932.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus trypsin domain containing 1 (Tysnd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108932.1

ORF Insert Sequence:

ATGGGACGGC AATGGGGACC GTCTTTGAGA GTGGCAGAGC AGGCGGGTTG CGTAGTGAGC 
GCCTCGCGAG CAGGACAGCC CGATGCGGGC TCGTGGAGCT GCAGCGGGGT GATCCTGAGC 
CGCAGCCCAG GCCTGGTGCT GTGCCACGGG GGCATTTTCA CCCCCTTCCT CAGAACTGGT 
AGCGCGGCTT TGACCCAAAC GGGAGCCGCC TTCCTACCGG GCGACAGTTG CAGCGATGAC 
CTGCGCCTCC ACGTGCAGTG GGGACCCACG GCTGCCAGCC CCGCCGGCCG CGCGGACCAG 
GAACTTCCAG GGCTGTGCAC GCCTCAGTGC GCAAGCCTGG GCCTCGAACC CGGTGCCCCG 
AGCCGGGCCC GCGCGCGGCC TCTGCAGCCT CCGCGGCCGG CGCAGCTGCT GTTGCTGCTC 
AGCTGCCCGG CCTTCCGCTC GCACTTCGCG CGGCTCTTCG GGGCCGAAGC GGCGGATCAA 
TGGCACTTCG TGAGCTCGGC GCCCGACGAC GCGGTGTCAG AGGAGGAGGA GGAGGATCAG 
CTGCGCGCGC TCGGCTGGTT CGCCCTCCTG CGGGTGCAGC GGGGCGCGGC GGCCGAGGAG 
AGGCGCGGGC CGGCGGTGAC CGTGGCACCG CTCGGGGCCG TGGCCAAGGG CGCACCGCTG 
CTGGCTTGTG GCTCTCCGTT CGGTGCCTTC TGCCCGGACA TCTTCCTCAA CACGCTGAGC 
CGGGGCGTGC TCAGCAACGC GGCCGGTCCG CTGTTGCTCA CCGACGCGCG CTGCCTGCCG 
GGCACAGAAG GCGGCGGAGT GTTCGCGGCC CGACCTGCGG GCGCGCTGGT GGCTCTGGTG 
GCCGCGCCTC TATGCTGGAA GGCCCGCGAG TGGGTGGGCC TCACGTTGCT GTGCGCCGCT 
GCCCCTCTGC TTCAGGTTGC TCGCTCGGCT CTCTCTCGCC TGCATCCGGA CTCCACCTCT 
CTGTCCGCGC TGCTGCCACC CGAAGTGGGC GCGCCAAGGG GCCTGTCCCT ACGAGATCTC 
GGATCCTCGT GGGCAGCCGC GGCGGTGCTG GTGGAGTGTG GTGCCGTGTG GGGCTCCGGA 
GTGGCTGTGG CGCCTCGCCT GGTGGTGACC TGCCGTCATG TGGCACCCCG GGAAACAGCC 
AGGGTCTTGG TACACTCAGC TACACCCAGG AATGTGGCAA TCTGGGGACG AGTGGTATTT 
GCCACTCAGG AGACCTCTCC ATATGACATA GCGGTGGTGA GCCTGGAAGA GGAACTGAAT 
GGTGTCCCCG TGCCTGTCCC AGCTGAGCAC TTCCATGAAG GCGAGCCTGT CAGCGTGGTG 
GGCTTTGGCG TGTTTGGCCA GGCCTGCGGG CCCTCAGTGA CCTCAGGCAT CCTGTCGGCC 
GTGGTGCATG TGGATGATGC CCCAGTGATG CTACAGACCA CCTGTGCCGT GCATGGCGGC 
TCTAGCGGAG GACCTCTCTT CTCTACACGC TCGGGGGACC TCTTGGGCAT TGTTGCTAGC 
AACACTCGGG ACAACAACAC GGGGGCCACC TACCCACACC TGAACTTCAG CATCCCCATC 
ACCGTGCTCC AGCCGGCCCT GAAGCAGTAC AGTCAGACTG GTGACCTGTG TGGCCTCAGA 
GAGCTGGACC ACACCACTGA GCCTGTCAGG GTCGTGTGGC GGCTGCAGCG GCCCCTGCCG 
GAAGCCCCCC GGAGCAAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility.
PLoS genetics9(2)e1003286(2013)
Mizuno Y,Ninomiya Y,Nakachi Y,Iseki M,Iwasa H,Akita M,Tsukui T,Shimozawa N,Ito C,Toshimori K,Nishimukai M,Hara H,Maeba R,Okazaki T,Alodaib AN,Al Amoudi M,Jacob M,Alkuraya FS,Horai Y,Watanabe M,Motegi H,Wakana S,Noda T,Kurochkin IV,Mizuno Y,Sch?nbach C,Okazaki Y

Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid ?-oxidation in peroxisomal matrix.
The Journal of biological chemistry286(52)44367-79(2011 Dec)
Okumoto K,Kametani Y,Fujiki Y

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids.
The EMBO journal26(3)835-45(2007 Feb)
Kurochkin IV,Mizuno Y,Konagaya A,Sakaki Y,Sch?nbach C,Okazaki Y

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Tysnd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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