Osbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Osbp
Entrez Gene ID	365410
Full Name	oxysterol binding protein
General protein information	Preferred Names oxysterol binding protein Names oxysterol-binding protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108927.1	NP_001102397.1	oxysterol-binding protein 1
XM_006231090.1	XP_006231152.1	oxysterol-binding protein 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OSBP	XP_508451.1
	OSBP	XP_001090190.1
Magnaporthe oryzae (rice blast fungus)	MGG_17877	XP_003720634.1
Homo sapiens (human)	OSBP	NP_002547.1
Canis lupus familiaris (dog)	OSBP	XP_005631235.1
Bos taurus (cattle)	OSBP	NP_001192899.1
Danio rerio (zebrafish)	osbp	NP_001139057.1
Oryza sativa (rice)	Os08g0154900	NP_001061017.1
Xenopus tropicalis (tropical clawed frog)	osbp	XP_002943168.2
Schizosaccharomyces pombe (fission yeast)	SPBC2F12.05c	NP_595710.1
Mus musculus (house mouse)	Osbp	NP_001028346.1
Neurospora crassa	NCU00579	XP_965719.1
Arabidopsis thaliana (thale cress)	ORP2B	NP_192983.2
Rattus norvegicus (Norway rat)	Osbp	NP_001102397.1
Gallus gallus (chicken)	LOC101747893	XP_004941338.1
Arabidopsis thaliana (thale cress)	ORP2A	NP_567662.1

Gene Ontology
Bibliography

Related articles in PubMed

A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.
Mesmin B, Bigay J, Moser von Filseck J, Lacas-Gervais S, Drin G, Antonny B
Cell155(4)830-43(2013 Nov)

Oxysterol-binding protein (OSBP) enhances replication of intracellular Salmonella and binds the Salmonella SPI-2 effector SseL via its N-terminus.
Auweter SD, Yu HB, Arena ET, Guttman JA, Finlay BB
Microbes and infection14(2)148-54(2012 Feb)

Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.
Furuita K, Jee J, Fukada H, Mishima M, Kojima C
The Journal of biological chemistry285(17)12961-70(2010 Apr)

Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.
Romeo GR, Kazlauskas A
The Journal of biological chemistry283(15)9595-605(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1
Title: Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.

The following Osbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Osbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08666	NM_001108927.1 Latest version!	Rattus norvegicus oxysterol binding protein (Osbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa23931	XM_006231090.1 Latest version!	Rattus norvegicus oxysterol binding protein (Osbp), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Osbp ( NM_001108927.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102397.1 Rattus norvegicus oxysterol binding protein (Osbp), mRNA.

Price & Availability↑

CloneID	ORa08666
Clone ID Related Accession (Same CDS sequence)	NM_001108927.1
Accession Version	NM_001108927.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	oxysterol-binding protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473953.1. On or before Oct 4, 2007 this sequence version replaced XM_001075837.1, XM_344995.3. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCACA CCTGCCGAGG CACCATCAAC CTTGCCACAG CCAACATCAC TGTGGAAGAC 
TCTTGCAACT TCATCATTTC CAATGGCGGT GCTCAGACCT ACCACTTGAA GGCCAGCTCG 
GAAGTGGAGC GTCAGCGCTG GGTGACAGCC CTAGAACTGG CCAAGGCCAA GGCTGTGAAG 
ATGCTGGCTG AGTCAGATGA ATCAGGAGAT GAGGAGTCTG TCTCACAAAC TGACAAGACT 
GAGCTCCAGA ATACCCTCCG GACACTCTCC AGCAAAGTGG AGGACCTGAG CACGTGCAAT 
GACTTGATAG CTAAACATGG CACCGCCCTG CAGCGTTCCC TCAGCGAGCT GGAGTCTCTG 
AAGCTGCCTG CTGAGAGCAA TGAGAAAATC AAACAGGTCA ATGAACGAGC CACACTCTTT 
AGGATAACAT CCAATGCCAT GATCAATGCC TGCAGAGATT TCCTCATGTT AGCCCAGACG 
CATAGTAAGA AGTGGCAGAA GTCCCTGCAG TATGAACGGG ACCAGCGTAT CCGACTGGAA 
GAAACTCTTG AGCAGCTGGC GAAGCAGCAC AATCACCTGG AGAGAGCCTT CCGGGGAGCC 
ACAGTGCTGC CAGCAAACAC TCCGGGCAGC ACTGGGTCTG GTAAAGAGCA GTGCTGTTCT 
GGCAAAGGGG ACATGAGCGA TGAAGATGAC GAGAACGAAT TCTTTGACGC ACCAGAGATT 
ATCACCATGC CTGAAAACTT GGGCCACAAA CGTACTGGTA GCAATATCAG TGGAGCCAGC 
AGTGACATCA GCCTTGATGA ACAGTACAAG CATCAGCTGG AGGAGACCAA GAAGGAAAAG 
AGAACCAGAA TACCATATAA GCCAAACTAC AGCCTCAACT TGTGGAGCAT CATGAAGAAC 
TGCATTGGAA AAGAGCTCTC TAAGATCCCA ATGCCGGTAA ACTTTAATGA GCCCTTGTCC 
ATGCTTCAGC GCCTTACTGA AGATCTGGAA TACCATGAGC TGTTAGACCG AGCTGCCAAG 
TGTGAGAACT CTCTAGAACA GCTCTGCTAT GTGGCAGCCT TCACCGTTTC CTCCTATTCC 
ACTACTGTCT TCCGAACCAG CAAGCCATTC AACCCTCTCC TTGGGGAGAC ATTTGAACTA 
GACCGACTGG AGGAGAATGG GTATCGATCC CTCTGTGAGC AGGTGAGTCA TCATCCCCCT 
GCTGCTGCGC ACCATGCTGA ATCCAAAAAT GGCTGGACAT TGCGTCAGGA AATTAAAATC 
ACCAGCAAGT TTCGAGGCAA ATACCTCTCC ATTATGCCCC TTGGTACCAT CCACTGCATT 
TTCCACGCAA CTGGGCACCA TTACACTTGG AAAAAAGTTA CCACAACAGT ACACAACATT 
ATTGTGGGCA AGTTGTGGAT AGATCAGTCT GGTGAGATTG ACATTGTAAA TCACAAGACA 
GGAGACAAGT GTAATCTTAA ATTTGTTCCT TATAGCTACT TCTCTCGGGA TGTAGCAAGA 
AAGGTGACAG GTGAAGTGAC AGACCCATCA GGAAAAGTTC ACTTTGCCCT CCTGGGGACA 
TGGGATGAGA AAATGGATTG TTTCAAAGTA CAACCAGCCT CTGGGGAAAA TGGAGGTGAT 
GCTCGGCAGA GAGGCCATGA AGCAGAAGAA AGTAGGGTCA TGCTATGGAA GAGGAATCCA 
TTACCGAAGA ATGCAGAAAA CATGTACTAC TTCTCAGAGC TTGCGCTCAC TCTCAATGCC 
TGGGAAGGTG GCACTGCTCC TACAGACAGC CGGCTGCGGC CTGACCAGAG ACTGATGGAA 
AATGGGCGCT GGGATGAAGC AAATGCTGAG AAGCAGCGTC TGGAGGAAAA ACAGCGACTT 
TCTAGGAAGA AGAGAGAAGC AGAAGCTATG AAAGCCACAG AAGATGGCAC ACCATATGAC 
CCCTATAAAG CACTGTGGTT TGAGCGGAAG AAGGACCCTG TCACCAAGGA GCTAACCCAT 
GTTTATAGGG GCGAGTACTG GGAATGTAAG GAAAAGCAGG ACTGGGGTTC TTGCCCAGAC 
ATTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102397.1
CDS	263..2311
Translation	MRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGSTGSGKEQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQPASGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHVYRGEYWECKEKQDWGSCPDIF

Target ORF information:

RefSeq Version	NM_001108927.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus oxysterol binding protein (Osbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108927.1

ORF Insert Sequence:

ATGAGGCACA CCTGCCGAGG CACCATCAAC CTTGCCACAG CCAACATCAC TGTGGAAGAC 
TCTTGCAACT TCATCATTTC CAATGGCGGT GCTCAGACCT ACCACTTGAA GGCCAGCTCG 
GAAGTGGAGC GTCAGCGCTG GGTGACAGCC CTAGAACTGG CCAAGGCCAA GGCTGTGAAG 
ATGCTGGCTG AGTCAGATGA ATCAGGAGAT GAGGAGTCTG TCTCACAAAC TGACAAGACT 
GAGCTCCAGA ATACCCTCCG GACACTCTCC AGCAAAGTGG AGGACCTGAG CACGTGCAAT 
GACTTGATAG CTAAACATGG CACCGCCCTG CAGCGTTCCC TCAGCGAGCT GGAGTCTCTG 
AAGCTGCCTG CTGAGAGCAA TGAGAAAATC AAACAGGTCA ATGAACGAGC CACACTCTTT 
AGGATAACAT CCAATGCCAT GATCAATGCC TGCAGAGATT TCCTCATGTT AGCCCAGACG 
CATAGTAAGA AGTGGCAGAA GTCCCTGCAG TATGAACGGG ACCAGCGTAT CCGACTGGAA 
GAAACTCTTG AGCAGCTGGC GAAGCAGCAC AATCACCTGG AGAGAGCCTT CCGGGGAGCC 
ACAGTGCTGC CAGCAAACAC TCCGGGCAGC ACTGGGTCTG GTAAAGAGCA GTGCTGTTCT 
GGCAAAGGGG ACATGAGCGA TGAAGATGAC GAGAACGAAT TCTTTGACGC ACCAGAGATT 
ATCACCATGC CTGAAAACTT GGGCCACAAA CGTACTGGTA GCAATATCAG TGGAGCCAGC 
AGTGACATCA GCCTTGATGA ACAGTACAAG CATCAGCTGG AGGAGACCAA GAAGGAAAAG 
AGAACCAGAA TACCATATAA GCCAAACTAC AGCCTCAACT TGTGGAGCAT CATGAAGAAC 
TGCATTGGAA AAGAGCTCTC TAAGATCCCA ATGCCGGTAA ACTTTAATGA GCCCTTGTCC 
ATGCTTCAGC GCCTTACTGA AGATCTGGAA TACCATGAGC TGTTAGACCG AGCTGCCAAG 
TGTGAGAACT CTCTAGAACA GCTCTGCTAT GTGGCAGCCT TCACCGTTTC CTCCTATTCC 
ACTACTGTCT TCCGAACCAG CAAGCCATTC AACCCTCTCC TTGGGGAGAC ATTTGAACTA 
GACCGACTGG AGGAGAATGG GTATCGATCC CTCTGTGAGC AGGTGAGTCA TCATCCCCCT 
GCTGCTGCGC ACCATGCTGA ATCCAAAAAT GGCTGGACAT TGCGTCAGGA AATTAAAATC 
ACCAGCAAGT TTCGAGGCAA ATACCTCTCC ATTATGCCCC TTGGTACCAT CCACTGCATT 
TTCCACGCAA CTGGGCACCA TTACACTTGG AAAAAAGTTA CCACAACAGT ACACAACATT 
ATTGTGGGCA AGTTGTGGAT AGATCAGTCT GGTGAGATTG ACATTGTAAA TCACAAGACA 
GGAGACAAGT GTAATCTTAA ATTTGTTCCT TATAGCTACT TCTCTCGGGA TGTAGCAAGA 
AAGGTGACAG GTGAAGTGAC AGACCCATCA GGAAAAGTTC ACTTTGCCCT CCTGGGGACA 
TGGGATGAGA AAATGGATTG TTTCAAAGTA CAACCAGCCT CTGGGGAAAA TGGAGGTGAT 
GCTCGGCAGA GAGGCCATGA AGCAGAAGAA AGTAGGGTCA TGCTATGGAA GAGGAATCCA 
TTACCGAAGA ATGCAGAAAA CATGTACTAC TTCTCAGAGC TTGCGCTCAC TCTCAATGCC 
TGGGAAGGTG GCACTGCTCC TACAGACAGC CGGCTGCGGC CTGACCAGAG ACTGATGGAA 
AATGGGCGCT GGGATGAAGC AAATGCTGAG AAGCAGCGTC TGGAGGAAAA ACAGCGACTT 
TCTAGGAAGA AGAGAGAAGC AGAAGCTATG AAAGCCACAG AAGATGGCAC ACCATATGAC 
CCCTATAAAG CACTGTGGTT TGAGCGGAAG AAGGACCCTG TCACCAAGGA GCTAACCCAT 
GTTTATAGGG GCGAGTACTG GGAATGTAAG GAAAAGCAGG ACTGGGGTTC TTGCCCAGAC 
ATTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Osbp ( XM_006231090.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231152.1 Rattus norvegicus oxysterol binding protein (Osbp), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23931
Clone ID Related Accession (Same CDS sequence)	XM_006231090.1
Accession Version	XM_006231090.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	oxysterol-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGA CCGAGCTGAG AGGAGTGGTA GGGCCGGGGC CGGCAGCCAT CGCGGCCCCG 
AGCGGCGGCG GTGCGGGTCC ACCCGCTGTG GGAGGCGGCG GCGGACGCGG GGACGCGGGG 
CCCGGCTCTG GGGTGGCAGG CGCGACGGCT GCGACGGCCG GCGGCCCGGG CCCCGGGGCC 
GGAGGAGTGG CGGCAGGCGG CCCGGGCTCT GCACCGCCAG CCGCGGGCTC GGGCGGTTCG 
GGCGCCGGGG GCTCGGGCTC GGCTAGAGAG GGCTGGCTCT TCAAATGGAC CAATTACATC 
AAAGGCTACC AGCGTCGATG GTTCGTGCTG AGCAACGGGC TCCTGAGCTA CTACAGGTCC 
AAGGCAGAGA TGAGGCACAC CTGCCGAGGC ACCATCAACC TTGCCACAGC CAACATCACT 
GTGGAAGACT CTTGCAACTT CATCATTTCC AATGGCGGTG CTCAGACCTA CCACTTGAAG 
GCCAGCTCGG AAGTGGAGCG TCAGCGCTGG GTGACAGCCC TAGAACTGGC CAAGGCCAAG 
GCTGTGAAGA TGCTGGCTGA GTCAGATGAA TCAGGAGATG AGGAGTCTGT CTCACAAACT 
GACAAGACTG AGCTCCAGAA TACCCTCCGG ACACTCTCCA GCAAAGTGGA GGACCTGAGC 
ACGTGCAATG ACTTGATAGC TAAACATGGC ACCGCCCTGC AGCGTTCCCT CAGCGAGCTG 
GAGTCTCTGA AGCTGCCTGC TGAGAGCAAT GAGAAAATCA AACAGGTCAA TGAACGAGCC 
ACACTCTTTA GGATAACATC CAATGCCATG ATCAATGCCT GCAGAGATTT CCTCATGTTA 
GCCCAGACGC ATAGTAAGAA GTGGCAGAAG TCCCTGCAGT ATGAACGGGA CCAGCGTATC 
CGACTGGAAG AAACTCTTGA GCAGCTGGCG AAGCAGCACA ATCACCTGGA GAGAGCCTTC 
CGGGGAGCCA CAGTGCTGCC AGCAAACACT CCGGGCAGCA CTGGGTCTGG TAAAGAGCAG 
TGCTGTTCTG GCAAAGGGGA CATGAGCGAT GAAGATGACG AGAACGAATT CTTTGACGCA 
CCAGAGATTA TCACCATGCC TGAAAACTTG GGCCACAAAC GTACTGGTAG CAATATCAGT 
GGAGCCAGCA GTGACATCAG CCTTGATGAA CAGTACAAGC ATCAGCTGGA GGAGACCAAG 
AAGGAAAAGA GAACCAGAAT ACCATATAAG CCAAACTACA GCCTCAACTT GTGGAGCATC 
ATGAAGAACT GCATTGGAAA AGAGCTCTCT AAGATCCCAA TGCCGGTAAA CTTTAATGAG 
CCCTTGTCCA TGCTTCAGCG CCTTACTGAA GATCTGGAAT ACCATGAGCT GTTAGACCGA 
GCTGCCAAGT GTGAGAACTC TCTAGAACAG CTCTGCTATG TGGCAGCCTT CACCGTTTCC 
TCCTATTCCA CTACTGTCTT CCGAACCAGC AAGCCATTCA ACCCTCTCCT TGGGGAGACA 
TTTGAACTAG ACCGACTGGA GGAGAATGGG TATCGATCCC TCTGTGAGCA GGTGAGTCAT 
CATCCCCCTG CTGCTGCGCA CCATGCTGAA TCCAAAAATG GCTGGACATT GCGTCAGGAA 
ATTAAAATCA CCAGCAAGTT TCGAGGCAAA TACCTCTCCA TTATGCCCCT TGGTACCATC 
CACTGCATTT TCCACGCAAC TGGGCACCAT TACACTTGGA AAAAAGTTAC CACAACAGTA 
CACAACATTA TTGTGGGCAA GTTGTGGATA GATCAGTCTG GTGAGATTGA CATTGTAAAT 
CACAAGACAG GAGACAAGTG TAATCTTAAA TTTGTTCCTT ATAGCTACTT CTCTCGGGAT 
GTAGCAAGAA AGGTGACAGG TGAAGTGACA GACCCATCAG GAAAAGTTCA CTTTGCCCTC 
CTGGGGACAT GGGATGAGAA AATGGATTGT TTCAAAGTAC AACCAGCCTC TGGGGAAAAT 
GGAGGTGATG CTCGGCAGAG AGGCCATGAA GCAGAAGAAA GTAGGGTCAT GCTATGGAAG 
AGGAATCCAT TACCGAAGAA TGCAGAAAAC ATGTACTACT TCTCAGAGCT TGCGCTCACT 
CTCAATGCCT GGGAAGGTGG CACTGCTCCT ACAGACAGCC GGCTGCGGCC TGACCAGAGA 
CTGATGGAAA ATGGGCGCTG GGATGAAGCA AATGCTGAGA AGCAGCGTCT GGAGGAAAAA 
CAGCGACTTT CTAGGAAGAA GAGAGAAGCA GAAGCTATGA AAGCCACAGA AGATGGCACA 
CCATATGACC CCTATAAAGC ACTGTGGTTT GAGCGGAAGA AGGACCCTGT CACCAAGGAG 
CTAACCCATG TTTATAGGGG CGAGTACTGG GAATGTAAGG AAAAGCAGGA CTGGGGTTCT 
TGCCCAGACA TTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231152.1
CDS	214..2631
Translation	MAATELRGVVGPGPAAIAAPSGGGAGPPAVGGGGGRGDAGPGSGVAGATAATAGGPGPGAGGVAAGGPGSAPPAAGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGSTGSGKEQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQPASGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHVYRGEYWECKEKQDWGSCPDIF

Target ORF information:

RefSeq Version	XM_006231090.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus oxysterol binding protein (Osbp), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231090.1

ORF Insert Sequence:

ATGGCGGCGA CCGAGCTGAG AGGAGTGGTA GGGCCGGGGC CGGCAGCCAT CGCGGCCCCG 
AGCGGCGGCG GTGCGGGTCC ACCCGCTGTG GGAGGCGGCG GCGGACGCGG GGACGCGGGG 
CCCGGCTCTG GGGTGGCAGG CGCGACGGCT GCGACGGCCG GCGGCCCGGG CCCCGGGGCC 
GGAGGAGTGG CGGCAGGCGG CCCGGGCTCT GCACCGCCAG CCGCGGGCTC GGGCGGTTCG 
GGCGCCGGGG GCTCGGGCTC GGCTAGAGAG GGCTGGCTCT TCAAATGGAC CAATTACATC 
AAAGGCTACC AGCGTCGATG GTTCGTGCTG AGCAACGGGC TCCTGAGCTA CTACAGGTCC 
AAGGCAGAGA TGAGGCACAC CTGCCGAGGC ACCATCAACC TTGCCACAGC CAACATCACT 
GTGGAAGACT CTTGCAACTT CATCATTTCC AATGGCGGTG CTCAGACCTA CCACTTGAAG 
GCCAGCTCGG AAGTGGAGCG TCAGCGCTGG GTGACAGCCC TAGAACTGGC CAAGGCCAAG 
GCTGTGAAGA TGCTGGCTGA GTCAGATGAA TCAGGAGATG AGGAGTCTGT CTCACAAACT 
GACAAGACTG AGCTCCAGAA TACCCTCCGG ACACTCTCCA GCAAAGTGGA GGACCTGAGC 
ACGTGCAATG ACTTGATAGC TAAACATGGC ACCGCCCTGC AGCGTTCCCT CAGCGAGCTG 
GAGTCTCTGA AGCTGCCTGC TGAGAGCAAT GAGAAAATCA AACAGGTCAA TGAACGAGCC 
ACACTCTTTA GGATAACATC CAATGCCATG ATCAATGCCT GCAGAGATTT CCTCATGTTA 
GCCCAGACGC ATAGTAAGAA GTGGCAGAAG TCCCTGCAGT ATGAACGGGA CCAGCGTATC 
CGACTGGAAG AAACTCTTGA GCAGCTGGCG AAGCAGCACA ATCACCTGGA GAGAGCCTTC 
CGGGGAGCCA CAGTGCTGCC AGCAAACACT CCGGGCAGCA CTGGGTCTGG TAAAGAGCAG 
TGCTGTTCTG GCAAAGGGGA CATGAGCGAT GAAGATGACG AGAACGAATT CTTTGACGCA 
CCAGAGATTA TCACCATGCC TGAAAACTTG GGCCACAAAC GTACTGGTAG CAATATCAGT 
GGAGCCAGCA GTGACATCAG CCTTGATGAA CAGTACAAGC ATCAGCTGGA GGAGACCAAG 
AAGGAAAAGA GAACCAGAAT ACCATATAAG CCAAACTACA GCCTCAACTT GTGGAGCATC 
ATGAAGAACT GCATTGGAAA AGAGCTCTCT AAGATCCCAA TGCCGGTAAA CTTTAATGAG 
CCCTTGTCCA TGCTTCAGCG CCTTACTGAA GATCTGGAAT ACCATGAGCT GTTAGACCGA 
GCTGCCAAGT GTGAGAACTC TCTAGAACAG CTCTGCTATG TGGCAGCCTT CACCGTTTCC 
TCCTATTCCA CTACTGTCTT CCGAACCAGC AAGCCATTCA ACCCTCTCCT TGGGGAGACA 
TTTGAACTAG ACCGACTGGA GGAGAATGGG TATCGATCCC TCTGTGAGCA GGTGAGTCAT 
CATCCCCCTG CTGCTGCGCA CCATGCTGAA TCCAAAAATG GCTGGACATT GCGTCAGGAA 
ATTAAAATCA CCAGCAAGTT TCGAGGCAAA TACCTCTCCA TTATGCCCCT TGGTACCATC 
CACTGCATTT TCCACGCAAC TGGGCACCAT TACACTTGGA AAAAAGTTAC CACAACAGTA 
CACAACATTA TTGTGGGCAA GTTGTGGATA GATCAGTCTG GTGAGATTGA CATTGTAAAT 
CACAAGACAG GAGACAAGTG TAATCTTAAA TTTGTTCCTT ATAGCTACTT CTCTCGGGAT 
GTAGCAAGAA AGGTGACAGG TGAAGTGACA GACCCATCAG GAAAAGTTCA CTTTGCCCTC 
CTGGGGACAT GGGATGAGAA AATGGATTGT TTCAAAGTAC AACCAGCCTC TGGGGAAAAT 
GGAGGTGATG CTCGGCAGAG AGGCCATGAA GCAGAAGAAA GTAGGGTCAT GCTATGGAAG 
AGGAATCCAT TACCGAAGAA TGCAGAAAAC ATGTACTACT TCTCAGAGCT TGCGCTCACT 
CTCAATGCCT GGGAAGGTGG CACTGCTCCT ACAGACAGCC GGCTGCGGCC TGACCAGAGA 
CTGATGGAAA ATGGGCGCTG GGATGAAGCA AATGCTGAGA AGCAGCGTCT GGAGGAAAAA 
CAGCGACTTT CTAGGAAGAA GAGAGAAGCA GAAGCTATGA AAGCCACAGA AGATGGCACA 
CCATATGACC CCTATAAAGC ACTGTGGTTT GAGCGGAAGA AGGACCCTGT CACCAAGGAG 
CTAACCCATG TTTATAGGGG CGAGTACTGG GAATGTAAGG AAAAGCAGGA CTGGGGTTCT 
TGCCCAGACA TTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.
Cell155(4)830-43(2013 Nov)
Mesmin B,Bigay J,Moser von Filseck J,Lacas-Gervais S,Drin G,Antonny B

Oxysterol-binding protein (OSBP) enhances replication of intracellular Salmonella and binds the Salmonella SPI-2 effector SseL via its N-terminus.
Microbes and infection14(2)148-54(2012 Feb)
Auweter SD,Yu HB,Arena ET,Guttman JA,Finlay BB

Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.
The Journal of biological chemistry285(17)12961-70(2010 Apr)
Furuita K,Jee J,Fukada H,Mishima M,Kojima C

Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.
The Journal of biological chemistry283(15)9595-605(2008 Apr)
Romeo GR,Kazlauskas A

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Osbp cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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