Cadm4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cadm4
Entrez Gene ID	365216
Full Name	cell adhesion molecule 4
Synonyms	Igsf4c,Necl-4,Upar
General protein information	Preferred Names cell adhesion molecule 4 Names cell adhesion molecule 4 immunoglobulin superfamily, member 4C nectin-like protein 4 urokinase plasminogen activator receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001047107.1	NP_001040572.1	cell adhesion molecule 4 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cadm4	NP_001007429.1
Pan troglodytes (chimpanzee)	CADM4	XP_512719.4
Canis lupus familiaris (dog)	CADM4	XP_541580.3
Bos taurus (cattle)	CADM4	XP_002695203.2
Rattus norvegicus (Norway rat)	Cadm4	NP_001040572.1
Homo sapiens (human)	CADM4	NP_660339.1
Mus musculus (house mouse)	Cadm4	NP_694752.1
Xenopus tropicalis (tropical clawed frog)	LOC100488420	XP_002939173.1

Gene Ontology
Bibliography

Related articles in PubMed

Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis
Heffernan C, Jain MR, Liu T, Kim H, Barretto K, Li H, Maurel P
The Journal of biological chemistry292(11)4484-4498(2017 03)

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y
PloS one10(4)e0124259(2015)

Interaction of Necl-4/CADM4 with ErbB3 and integrin ?6 ?4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
Sugiyama H, Mizutani K, Kurita S, Okimoto N, Shimono Y, Takai Y
Genes to cells : devoted to molecular & cellular mechanisms18(6)519-28(2013 Jun)

Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
Maurel P, Einheber S, Galinska J, Thaker P, Lam I, Rubin MB, Scherer SS, Murakami Y, Gutmann DH, Salzer JL
The Journal of cell biology178(5)861-74(2007 Aug)

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.
Spiegel I, Adamsky K, Eshed Y, Milo R, Sabanay H, Sarig-Nadir O, Horresh I, Scherer SS, Rasband MN, Peles E
Nature neuroscience10(7)861-9(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Intracellular choline levels are significantly elevated in NECL4-deficient Schwann cells.
Title: Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis

These results demonstrate a key role for Necl, 2 and 4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode.
Title: Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.

Necl4 protein is important for mediating axon-glia contact during myelination in peripheral nerves
Title: A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.

The following Cadm4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cadm4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09846	NM_001047107.1 Latest version!	Rattus norvegicus cell adhesion molecule 4 (Cadm4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cadm4 ( NM_001047107.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001040572.1 Rattus norvegicus cell adhesion molecule 4 (Cadm4), mRNA.

Price & Availability↑

CloneID	ORa09846
Clone ID Related Accession (Same CDS sequence)	NM_001047107.1
Accession Version	NM_001047107.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	cell adhesion molecule 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ272745.1. On or before Sep 7, 2006 this sequence version replaced XM_001059474.1, XM_001076576.1. ##Evidence-Data-START## Transcript exon combination :: DQ272745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTAC TGTGGGCGGC CGCGGCGGGG 
CCAGGGACGG CACAGGAAGT GCAGACAGAG AATGTGACGG TGGCCGAGGG TGGGGTGGCT 
GAGATCACCT GCCGTCTGCA TCAGTATGAT GGGTCTATAG TCGTCATTCA GAACCCAGCC 
CGGCAGACCC TCTTTTTCAA TGGCACCCGA GCCCTGAAGG ACGAACGATT CCAGCTGGAG 
GAGTTCTCCC CGCGCCGAGT GCGCATCAGG CTCTCAGACG CCCGCCTGGA GGACGAGGGG 
GGCTACTTCT GCCAGCTCTA CACGGAGGAC ACCCACCACC AGATCGCCAC GCTCACTGTC 
TTAGTGGCTC CGGAGAATCC TGTGGTGGAG GTCCGAGAGC AAGCAGTGGA GGGCGGCGAG 
GTGGAACTCA GCTGCCTGGT TCCGCGGTCG CGCCCCGCAG CGGTCCTGCG CTGGTATCGC 
GATCGCAAGG AGCTGAAAGG AGTGAGCAGC GGCCAGGAGA ACGGCAAGGT GTGGAGCGTG 
GCGAGCACTG TGCGGTTCCG CGTGGACCGC AAGGACGACG GCGGTATCGT CATCTGTGAA 
GCGCAGAACC AGGCGCTGCC CTCGGGGCAC AGCAAGCAGA CGCAGTACGT GCTGGATGTG 
CAGTATTCCC CCACAGCTCG GATCCACGCC TCTCAAGCTG TAGTCAGGGA GGGAGACACT 
CTGGTGCTGA CATGTGCTGT CACAGGGAAC CCCAGGCCAA ACCAGATCCG CTGGAACCGT 
GGGAATGAGT CTCTGCCAGA GAGGGCGGAG GCGTTGGGCG AGACGCTCAC GCTGCCTGGC 
CTGGTATCTG CAGATAACGG CACCTACACC TGCGAGGCGG CGAACAAGCA CGGCCACGCC 
AGGGCGCTCT ACGTGCTTGT GGTCTATGAC CCCGGAGCAG TGGTAGAGGC TCAGACATCG 
GTTCCCTACG CCATCGTGGG CGGCATCCTG GCGCTACTGG TGTTTCTGAT CATATGCGTG 
CTAGTAGGCA TGGTGTGGTG CTCTGTCCGA CAGAAGGGCT CCTATCTGAC CCATGAGGCC 
AGTGGCTTGG ATGAGCAGGG AGAAGCCAGA GAAGCCTTCC TCAACGGCAG TGATGGACAC 
AAGCGGAAAG AAGAATTCTT CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001040572.1
CDS	1..1167
Translation	MGRARRFQWPLLLLWAAAAGPGTAQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEALGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI

Target ORF information:

RefSeq Version	NM_001047107.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cell adhesion molecule 4 (Cadm4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001047107.1

ORF Insert Sequence:

ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTAC TGTGGGCGGC CGCGGCGGGG 
CCAGGGACGG CACAGGAAGT GCAGACAGAG AATGTGACGG TGGCCGAGGG TGGGGTGGCT 
GAGATCACCT GCCGTCTGCA TCAGTATGAT GGGTCTATAG TCGTCATTCA GAACCCAGCC 
CGGCAGACCC TCTTTTTCAA TGGCACCCGA GCCCTGAAGG ACGAACGATT CCAGCTGGAG 
GAGTTCTCCC CGCGCCGAGT GCGCATCAGG CTCTCAGACG CCCGCCTGGA GGACGAGGGG 
GGCTACTTCT GCCAGCTCTA CACGGAGGAC ACCCACCACC AGATCGCCAC GCTCACTGTC 
TTAGTGGCTC CGGAGAATCC TGTGGTGGAG GTCCGAGAGC AAGCAGTGGA GGGCGGCGAG 
GTGGAACTCA GCTGCCTGGT TCCGCGGTCG CGCCCCGCAG CGGTCCTGCG CTGGTATCGC 
GATCGCAAGG AGCTGAAAGG AGTGAGCAGC GGCCAGGAGA ACGGCAAGGT GTGGAGCGTG 
GCGAGCACTG TGCGGTTCCG CGTGGACCGC AAGGACGACG GCGGTATCGT CATCTGTGAA 
GCGCAGAACC AGGCGCTGCC CTCGGGGCAC AGCAAGCAGA CGCAGTACGT GCTGGATGTG 
CAGTATTCCC CCACAGCTCG GATCCACGCC TCTCAAGCTG TAGTCAGGGA GGGAGACACT 
CTGGTGCTGA CATGTGCTGT CACAGGGAAC CCCAGGCCAA ACCAGATCCG CTGGAACCGT 
GGGAATGAGT CTCTGCCAGA GAGGGCGGAG GCGTTGGGCG AGACGCTCAC GCTGCCTGGC 
CTGGTATCTG CAGATAACGG CACCTACACC TGCGAGGCGG CGAACAAGCA CGGCCACGCC 
AGGGCGCTCT ACGTGCTTGT GGTCTATGAC CCCGGAGCAG TGGTAGAGGC TCAGACATCG 
GTTCCCTACG CCATCGTGGG CGGCATCCTG GCGCTACTGG TGTTTCTGAT CATATGCGTG 
CTAGTAGGCA TGGTGTGGTG CTCTGTCCGA CAGAAGGGCT CCTATCTGAC CCATGAGGCC 
AGTGGCTTGG ATGAGCAGGG AGAAGCCAGA GAAGCCTTCC TCAACGGCAG TGATGGACAC 
AAGCGGAAAG AAGAATTCTT CATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis
The Journal of biological chemistry292(11)4484-4498(2017 03)
Heffernan C,Jain MR,Liu T,Kim H,Barretto K,Li H,Maurel P

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
PloS one10(4)e0124259(2015)
Yamana S,Tokiyama A,Mizutani K,Hirata K,Takai Y,Rikitake Y

Interaction of Necl-4/CADM4 with ErbB3 and integrin ?6 ?4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
Genes to cells : devoted to molecular & cellular mechanisms18(6)519-28(2013 Jun)
Sugiyama H,Mizutani K,Kurita S,Okimoto N,Shimono Y,Takai Y

Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
The Journal of cell biology178(5)861-74(2007 Aug)
Maurel P,Einheber S,Galinska J,Thaker P,Lam I,Rubin MB,Scherer SS,Murakami Y,Gutmann DH,Salzer JL

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.
Nature neuroscience10(7)861-9(2007 Jul)
Spiegel I,Adamsky K,Eshed Y,Milo R,Sabanay H,Sarig-Nadir O,Horresh I,Scherer SS,Rasband MN,Peles E

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Cadm4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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