Itga8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itga8
Entrez Gene ID	364786
Full Name	integrin subunit alpha 8
Synonyms	RGD1564327
General protein information	Preferred Names integrin subunit alpha 8 Names integrin alpha-8 integrin, alpha 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.3
Summary	acts as a receptor for fibronectin; may be a receptor of matrix ligands and function in glomerular capillary tuft development and physiology [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017600639.1	XP_017456128.1	integrin alpha-8 isoform X1
NM_001173972.1	NP_001167443.1	integrin alpha-8

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ITGA8	NP_990619.1
Caenorhabditis elegans (roundworm)	pat-2	NP_498948.1
Pan troglodytes (chimpanzee)	ITGA8	XP_507671.2
Bos taurus (cattle)	ITGA8	XP_002692127.1
	ITGA8	XP_001089317.1
Drosophila melanogaster (fruit fly)	if	NP_001162778.1
Canis lupus familiaris (dog)	ITGA8	XP_005617255.1
Mus musculus (house mouse)	Itga8	NP_001001309.1
Homo sapiens (human)	ITGA8	NP_003629.1
Rattus norvegicus (Norway rat)	Itga8	NP_001167443.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000032	XP_311131.5
Xenopus tropicalis (tropical clawed frog)	itga8	XP_002939074.2

Gene Ontology
Bibliography

Related articles in PubMed

Decreased Expression of Integrin Subunits ?3, ?6, and ?8 in the Branching Airway Mesenchyme of Nitrofen-Induced Hypoplastic Lungs.
Takahashi T, Friedmacher F, Zimmer J, Puri P
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie28(1)109-114(2018 Feb)

Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.
Humbert C, Silbermann F, Morar B, Parisot M, Zarhrate M, Masson C, Tores F, Blanchet P, Perez MJ, Petrov Y, Khau Van Kien P, Roume J, Leroy B, Gribouval O, Kalaydjieva L, Heidet L, Salomon R, Antignac C, Benmerah A, Saunier S, Jeanpierre C
American journal of human genetics94(2)288-94(2014 Feb)

Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.
Marek I, Volkert G, Hilgers KF, Bieritz B, Rascher W, Reinhardt DP, Hartner A
Cell adhesion & migration8(4)389-95(2014)

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Brafman DA, Phung C, Kumar N, Willert K
Cell death and differentiation20(3)369-81(2013 Mar)

A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
Supriyanto I, Watanabe Y, Mouri K, Shiroiwa K, Ratta-Apha W, Yoshida M, Tamiya G, Sasada T, Eguchi N, Okazaki K, Shirakawa O, Someya T, Hishimoto A
Progress in neuro-psychopharmacology & biological psychiatry40347-52(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fibrillin-1 and alpha8 integrin interact, and thus, regulate mesangial cell adhesion and migration.
Title: Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.

alpha 8 integrin overexpression was associated with the reappearance of vascular smooth muscle cells contractile hallmarks including upregulation of contractile markers, assembly of stress fibres, and increased number of focal adhesions
Title: alpha 8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype.

Short interference RNA (siRNA) targeting alpha8 integrin in VSMCs resulted in reduced DNA synthesis and cell proliferation.
Title: RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth.

The following Itga8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itga8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa59107	XM_017600639.1 Latest version!	Rattus norvegicus integrin subunit alpha 8 (Itga8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa42313	NM_001173972.1 Latest version!	Rattus norvegicus integrin subunit alpha 8 (Itga8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itga8 ( XM_017600639.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017456128.1 Rattus norvegicus integrin subunit alpha 8 (Itga8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59107
Clone ID Related Accession (Same CDS sequence)	XM_017600639.1
Accession Version	XM_017600639.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3261bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGCGA GAACCCACCG GGGTCCCCCG GAGAACTGGG CACCTCCGTT CGCTTGTCTC 
TGTTGCGTCT CGGCCGTGCT GGGGATGCTG TGGTCCCCCG TGTCTCTGGC GTTCAACTTG 
GACGTAGACA AGCTCACGGT GTACAGTGGC CCCGAGGGCA GCTACTTCGG CTACTCGCTG 
GACTTCTACA TACCTGATGC GCGCACAGCC AGTGTCTTGG TGGGGGCGCC CAAAGCCAAC 
ACTAGCCAGC CGGATATCGT AGAAGGGGGA GCTGTCTACT ACTGTCCCTG GCCTGCAGAG 
AGGTCTGCAC AGTGCAAGCA GATACCCTTT GACACCACCA ACAACAGGAA AATCAGAGTT 
AATGGAACCA AAGAGCCTAT AGAATTTAAA TCAAACCAAT GGTTTGGAGC CACAGTGAGA 
GCTCACAAAG GAAAAGTTGT GGCTTGTGCC CCTTTATATC ACTGGAGAAC TCTGAAGCCT 
AATCCAGCAA AGGACCCGGT TGGCACATGC TATGTAGCAA TTCAGAACTT CAGTGCTTAC 
GCTGAGCACT CACCCTGTCG GAACAGCAAC GTTGATCCTG AAGGCCAAGG TTACTGCCAA 
GCCGGCTTCA GTCTAGACTT CTATAAGAAT GGAGACCTTA TAGTGGGAGG ACCTGGAAGC 
TTTTACTGGC AAGGTCAGGT GATCACGGTC AGTGTAGCAG ACATCATTGC AAATTACTCA 
TTCAAAGACA TTCTTCGAAA ACTGGCAGCA GAAAAGCAGA CAGATGTGGC TCCAGCTTCC 
TATGATGACA GCTACCTTGG ATATTCAGTT GCTGCTGGAG AATTCACTGG GGACTCTCTG 
CAAGAATTGG TTGCTGGAAT TCCAAGAGGA GCACAGAACT TTGGATATGT CTCCATCATT 
AACTCCACAG ATATGACCTT CATTCAGAAT TTTACTGGTG AGCAGATGGC ATCTTATTTC 
GGATATACTG TTGTGGTATC AGATGTTAAC AATGATGGCA TGGATGACAT ATTGGTCGGG 
GCACCTCTCT TTATGGAGCG AGAATTTGAA AGTAACCCTA GAGAAGTGGG TCAGGTCTAC 
CTGTACCTAC AAGTGAGCGC CCTCCTCTTC CAAGACCCAC AGGTCCTTAC GGGCACAGAG 
ACTTTTGGGA GATTCGGTAG TTCTGTGGCC CACTTGGGGG ACCTGAACCA AGATGGATAC 
AATGATATTG CCATCGGTGT GCCCTTTGCA GGCAAGGATC AAAGAGGTAA AGTCCTCATT 
TACAACGGAA ACGCCAGAGG CTTGCACAGC AAGCCTTCCC AAGTTCTGCA AGGAATATGG 
GGGTCACAGA CCATCCCTTC TGGATTCGGC TTTTCTCTAA GAGGAGACGC AGACATAGAC 
AAGAATGATT ACCCAGCTAC ATGGTGGGGC CACTCCAAAT TCATTCAAAC AGAAAACAGT 
GAGGAGGAGT TCCAGACCTA TGGCGGAGAT TTACTTGTCG GGGCATTTGG AGAAGGGAAA 
GTGGCCGTGT ACAGAGCAAG GCCAGTTGTA ACAGTGGATG CCCAGCTTCT GCTGCACCCA 
ATGATTATCA ACCTTGAAAA TAAAACTTGC CAGATTCCAG AATTCCCGAC TCCTGTGGCC 
TGCTTTTCTT TAAGAGTCTG TGCATCTATA GCAGGCCAGA GCATTTCAAA TACAGTAGCC 
CTGATGGCCG AGGTGCAGTT AGATTTCCTG AAGCAAAAAG GAGCCATCAA ACGGACCCTC 
TTCCTCCACA ACCACCAGTC CCACCTCATC TTCCCCTTCG TGATGAGGCA GCAAAAATCC 
CTCCACTGCC AGGATTTTAT GGTTTACCTT CGAGATGAAA CTGAATTCCG AGATAAACTG 
TCTCCAATCA ACGTTAGCCT GAACTACAGT TTGGATGATT CCACCTTTGA AGATGGCCTG 
GAAGTGAAGC CGATTTTGAA CCACTACAGG GAGAATGTCG TTACTGAGCA GGCTCACATC 
CTGGTGGACT GTGGAGAAGA CAACCTCTGT GTTCCTGACT TGAGGCTGTC AGCTAGACCA 
GATAAGCAGG AGATAATTAT TGGGGATGAA AATCACCTAA TGCTCATAAT CAATGCAAGG 
AATGAAGGAG AAGGAGCTTA CGAAGCTGAA CTCTTCGTCA TGATTCCCGA AGAAGCAGAT 
TACGTTGGGA TCGAGCGCAA CAACAAGGGA CTGAGGCTCC TGAGTTGTGA GTACAAGATG 
GAAAACGTAA CCAGGATGGT GGTGTGTGAC CTTGGGAACC CGATGGTGAC TGGAACGAAT 
TTTTCTCTGG GCCTCCGATT TGCTGTTCCT CGTCTTGAGA AAACAAACAT GAGTATTAAC 
TTCGATCTCC AAATCAGAAG CTCCAACAAG GACAATCCTG ACAGCAATTT CGTGAGCGTG 
CAAATCAACG TCACTGCCGT GGCTCAGGTG GAAATCAGAG GAGTGTCCCA CCCTCCCCAA 
ATTGTTCTGC CCATCCACAA CTGGGAGCCA GCAGAGGAGC CCCACAAAGA GGAGGAAGTC 
GGTCCTCTGG TTGAACATAT TTATGAGCTG CACAATATTG GACCCAGCAC CATCAGTGAC 
AGCATTCTCG AAGTGGGCTG GCCATTCTCT GCACGGGAGG AGTTCCTCCT CTATGTCTTT 
CATCTTCAAA CTCTGGGACC TCTACAATGT CAAACAAATC CTGAGATCAA CCCGCAGGAT 
ATAAAGCCTG CTGCCTCCCC AGAGGATACC CCTGAGCTCA GCGCCTTCTT AAGAAATGCT 
ACAATTCCCC ATCTTGTCAG GAAGAGGGAT GTGCCAGTGG TCCAGCCCCA CAGACAGAGC 
CCGGCAAAAA TACTGAACTG TACCAACATT GACTGCTTGC AAATCTCGTG TGCAGTGGGT 
CGCCTGGGAG GAGGAGAAAG TGCAGTTCTG AAGGTCAGAT CGAGATTGTG GGCGCACACA 
TTCCTCCAGA GAAAGAACGA CCCTTATGCT CTTGCATCCC TGGTGTCCTT TGAAGTCAAG 
AAGATACCTT ATAAAGAGCA GCCAGCAAAA CTGCCAGCCG GGAGCACAGC GATTAAGACA 
TCGGTTATTT GGGCCACTCC AAATGTCTCC TTCTCAATTC CACTGTGGGT CATAATACTA 
GCGATCCTTC TTGGCTTGCT GGTTCTGGCC ATCTTAACTT TAGCTTTATG GAAGTGTGGA 
TTCTTTGATA GAGCAAGACC TCCTCAGGAT GAAATGACAG ACAGGGAACA ACTGACCAGT 
GACAAGACCC CGGAGGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017456128.1
CDS	577..3837
Translation	MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPATWWGHSKFIQTENSEEEFQTYGGDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA

Target ORF information:

RefSeq Version	XM_017600639.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha 8 (Itga8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017600639.1

ORF Insert Sequence:

ATGTCTGCGA GAACCCACCG GGGTCCCCCG GAGAACTGGG CACCTCCGTT CGCTTGTCTC 
TGTTGCGTCT CGGCCGTGCT GGGGATGCTG TGGTCCCCCG TGTCTCTGGC GTTCAACTTG 
GACGTAGACA AGCTCACGGT GTACAGTGGC CCCGAGGGCA GCTACTTCGG CTACTCGCTG 
GACTTCTACA TACCTGATGC GCGCACAGCC AGTGTCTTGG TGGGGGCGCC CAAAGCCAAC 
ACTAGCCAGC CGGATATCGT AGAAGGGGGA GCTGTCTACT ACTGTCCCTG GCCTGCAGAG 
AGGTCTGCAC AGTGCAAGCA GATACCCTTT GACACCACCA ACAACAGGAA AATCAGAGTT 
AATGGAACCA AAGAGCCTAT AGAATTTAAA TCAAACCAAT GGTTTGGAGC CACAGTGAGA 
GCTCACAAAG GAAAAGTTGT GGCTTGTGCC CCTTTATATC ACTGGAGAAC TCTGAAGCCT 
AATCCAGCAA AGGACCCGGT TGGCACATGC TATGTAGCAA TTCAGAACTT CAGTGCTTAC 
GCTGAGCACT CACCCTGTCG GAACAGCAAC GTTGATCCTG AAGGCCAAGG TTACTGCCAA 
GCCGGCTTCA GTCTAGACTT CTATAAGAAT GGAGACCTTA TAGTGGGAGG ACCTGGAAGC 
TTTTACTGGC AAGGTCAGGT GATCACGGTC AGTGTAGCAG ACATCATTGC AAATTACTCA 
TTCAAAGACA TTCTTCGAAA ACTGGCAGCA GAAAAGCAGA CAGATGTGGC TCCAGCTTCC 
TATGATGACA GCTACCTTGG ATATTCAGTT GCTGCTGGAG AATTCACTGG GGACTCTCTG 
CAAGAATTGG TTGCTGGAAT TCCAAGAGGA GCACAGAACT TTGGATATGT CTCCATCATT 
AACTCCACAG ATATGACCTT CATTCAGAAT TTTACTGGTG AGCAGATGGC ATCTTATTTC 
GGATATACTG TTGTGGTATC AGATGTTAAC AATGATGGCA TGGATGACAT ATTGGTCGGG 
GCACCTCTCT TTATGGAGCG AGAATTTGAA AGTAACCCTA GAGAAGTGGG TCAGGTCTAC 
CTGTACCTAC AAGTGAGCGC CCTCCTCTTC CAAGACCCAC AGGTCCTTAC GGGCACAGAG 
ACTTTTGGGA GATTCGGTAG TTCTGTGGCC CACTTGGGGG ACCTGAACCA AGATGGATAC 
AATGATATTG CCATCGGTGT GCCCTTTGCA GGCAAGGATC AAAGAGGTAA AGTCCTCATT 
TACAACGGAA ACGCCAGAGG CTTGCACAGC AAGCCTTCCC AAGTTCTGCA AGGAATATGG 
GGGTCACAGA CCATCCCTTC TGGATTCGGC TTTTCTCTAA GAGGAGACGC AGACATAGAC 
AAGAATGATT ACCCAGCTAC ATGGTGGGGC CACTCCAAAT TCATTCAAAC AGAAAACAGT 
GAGGAGGAGT TCCAGACCTA TGGCGGAGAT TTACTTGTCG GGGCATTTGG AGAAGGGAAA 
GTGGCCGTGT ACAGAGCAAG GCCAGTTGTA ACAGTGGATG CCCAGCTTCT GCTGCACCCA 
ATGATTATCA ACCTTGAAAA TAAAACTTGC CAGATTCCAG AATTCCCGAC TCCTGTGGCC 
TGCTTTTCTT TAAGAGTCTG TGCATCTATA GCAGGCCAGA GCATTTCAAA TACAGTAGCC 
CTGATGGCCG AGGTGCAGTT AGATTTCCTG AAGCAAAAAG GAGCCATCAA ACGGACCCTC 
TTCCTCCACA ACCACCAGTC CCACCTCATC TTCCCCTTCG TGATGAGGCA GCAAAAATCC 
CTCCACTGCC AGGATTTTAT GGTTTACCTT CGAGATGAAA CTGAATTCCG AGATAAACTG 
TCTCCAATCA ACGTTAGCCT GAACTACAGT TTGGATGATT CCACCTTTGA AGATGGCCTG 
GAAGTGAAGC CGATTTTGAA CCACTACAGG GAGAATGTCG TTACTGAGCA GGCTCACATC 
CTGGTGGACT GTGGAGAAGA CAACCTCTGT GTTCCTGACT TGAGGCTGTC AGCTAGACCA 
GATAAGCAGG AGATAATTAT TGGGGATGAA AATCACCTAA TGCTCATAAT CAATGCAAGG 
AATGAAGGAG AAGGAGCTTA CGAAGCTGAA CTCTTCGTCA TGATTCCCGA AGAAGCAGAT 
TACGTTGGGA TCGAGCGCAA CAACAAGGGA CTGAGGCTCC TGAGTTGTGA GTACAAGATG 
GAAAACGTAA CCAGGATGGT GGTGTGTGAC CTTGGGAACC CGATGGTGAC TGGAACGAAT 
TTTTCTCTGG GCCTCCGATT TGCTGTTCCT CGTCTTGAGA AAACAAACAT GAGTATTAAC 
TTCGATCTCC AAATCAGAAG CTCCAACAAG GACAATCCTG ACAGCAATTT CGTGAGCGTG 
CAAATCAACG TCACTGCCGT GGCTCAGGTG GAAATCAGAG GAGTGTCCCA CCCTCCCCAA 
ATTGTTCTGC CCATCCACAA CTGGGAGCCA GCAGAGGAGC CCCACAAAGA GGAGGAAGTC 
GGTCCTCTGG TTGAACATAT TTATGAGCTG CACAATATTG GACCCAGCAC CATCAGTGAC 
AGCATTCTCG AAGTGGGCTG GCCATTCTCT GCACGGGAGG AGTTCCTCCT CTATGTCTTT 
CATCTTCAAA CTCTGGGACC TCTACAATGT CAAACAAATC CTGAGATCAA CCCGCAGGAT 
ATAAAGCCTG CTGCCTCCCC AGAGGATACC CCTGAGCTCA GCGCCTTCTT AAGAAATGCT 
ACAATTCCCC ATCTTGTCAG GAAGAGGGAT GTGCCAGTGG TCCAGCCCCA CAGACAGAGC 
CCGGCAAAAA TACTGAACTG TACCAACATT GACTGCTTGC AAATCTCGTG TGCAGTGGGT 
CGCCTGGGAG GAGGAGAAAG TGCAGTTCTG AAGGTCAGAT CGAGATTGTG GGCGCACACA 
TTCCTCCAGA GAAAGAACGA CCCTTATGCT CTTGCATCCC TGGTGTCCTT TGAAGTCAAG 
AAGATACCTT ATAAAGAGCA GCCAGCAAAA CTGCCAGCCG GGAGCACAGC GATTAAGACA 
TCGGTTATTT GGGCCACTCC AAATGTCTCC TTCTCAATTC CACTGTGGGT CATAATACTA 
GCGATCCTTC TTGGCTTGCT GGTTCTGGCC ATCTTAACTT TAGCTTTATG GAAGTGTGGA 
TTCTTTGATA GAGCAAGACC TCCTCAGGAT GAAATGACAG ACAGGGAACA ACTGACCAGT 
GACAAGACCC CGGAGGCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itga8 ( NM_001173972.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001167443.1 Rattus norvegicus integrin subunit alpha 8 (Itga8), mRNA.

Price & Availability↑

CloneID	ORa42313
Clone ID Related Accession (Same CDS sequence)	NM_001173972.1
Accession Version	NM_001173972.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168655.1. On or before May 13, 2010 this sequence version replaced XM_344634.4, XM_001072297.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168655.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCTGCGA GAACCCACCG GGGTCCCCCG GAGAACTGGG CACCTCCGTT CGCTTGTCTC 
TGTTGCGTCT CGGCCGTGCT GGGGATGCTG TGGTCCCCCG TGTCTCTGGC GTTCAACTTG 
GACGTAGACA AGCTCACGGT GTACAGTGGC CCCGAGGGCA GCTACTTCGG CTACTCGCTG 
GACTTCTACA TACCTGATGC GCGCACAGCC AGTGTCTTGG TGGGGGCGCC CAAAGCCAAC 
ACTAGCCAGC CGGATATCGT AGAAGGGGGA GCTGTCTACT ACTGTCCCTG GCCTGCAGAG 
AGGTCTGCAC AGTGCAAGCA GATACCCTTT GACACCACCA ACAACAGGAA AATCAGAGTT 
AATGGAACCA AAGAGCCTAT AGAATTTAAA TCAAACCAAT GGTTTGGAGC CACAGTGAGA 
GCTCACAAAG GAAAAGTTGT GGCTTGTGCC CCTTTATATC ACTGGAGAAC TCTGAAGCCT 
AATCCAGCAA AGGACCCGGT TGGCACATGC TATGTAGCAA TTCAGAACTT CAGTGCTTAC 
GCTGAGCACT CACCCTGTCG GAACAGCAAC GTTGATCCTG AAGGCCAAGG TTACTGCCAA 
GCCGGCTTCA GTCTAGACTT CTATAAGAAT GGAGACCTTA TAGTGGGAGG ACCTGGAAGC 
TTTTACTGGC AAGGTCAGGT GATCACGGTC AGTGTAGCAG ACATCATTGC AAATTACTCA 
TTCAAAGACA TTCTTCGAAA ACTGGCAGCA GAAAAGCAGA CAGATGTGGC TCCAGCTTCC 
TATGATGACA GCTACCTTGG ATATTCAGTT GCTGCTGGAG AATTCACTGG GGACTCTCTG 
CAAGAATTGG TTGCTGGAAT TCCAAGAGGA GCACAGAACT TTGGATATGT CTCCATCATT 
AACTCCACAG ATATGACCTT CATTCAGAAT TTTACTGGTG AGCAGATGGC ATCTTATTTC 
GGATATACTG TTGTGGTATC AGATGTTAAC AATGATGGCA TGGATGACAT ATTGGTCGGG 
GCACCTCTCT TTATGGAGCG AGAATTTGAA AGTAACCCTA GAGAAGTGGG TCAGGTCTAC 
CTGTACCTAC AAGTGAGCGC CCTCCTCTTC CAAGACCCAC AGGTCCTTAC GGGCACAGAG 
ACTTTTGGGA GATTCGGTAG TTCTGTGGCC CACTTGGGGG ACCTGAACCA AGATGGATAC 
AATGATATTG CCATCGGTGT GCCCTTTGCA GGCAAGGATC AAAGAGGTAA AGTCCTCATT 
TACAACGGAA ACGCCAGAGG CTTGCACAGC AAGCCTTCCC AAGTTCTGCA AGGAATATGG 
GGGTCACAGA CCATCCCTTC TGGATTCGGC TTTTCTCTAA GAGGAGACGC AGACATAGAC 
AAGAATGATT ACCCAGATTT ACTTGTCGGG GCATTTGGAG AAGGGAAAGT GGCCGTGTAC 
AGAGCAAGGC CAGTTGTAAC AGTGGATGCC CAGCTTCTGC TGCACCCAAT GATTATCAAC 
CTTGAAAATA AAACTTGCCA GATTCCAGAA TTCCCGACTC CTGTGGCCTG CTTTTCTTTA 
AGAGTCTGTG CATCTATAGC AGGCCAGAGC ATTTCAAATA CAGTAGCCCT GATGGCCGAG 
GTGCAGTTAG ATTTCCTGAA GCAAAAAGGA GCCATCAAAC GGACCCTCTT CCTCCACAAC 
CACCAGTCCC ACCTCATCTT CCCCTTCGTG ATGAGGCAGC AAAAATCCCT CCACTGCCAG 
GATTTTATGG TTTACCTTCG AGATGAAACT GAATTCCGAG ATAAACTGTC TCCAATCAAC 
GTTAGCCTGA ACTACAGTTT GGATGATTCC ACCTTTGAAG ATGGCCTGGA AGTGAAGCCG 
ATTTTGAACC ACTACAGGGA GAATGTCGTT ACTGAGCAGG CTCACATCCT GGTGGACTGT 
GGAGAAGACA ACCTCTGTGT TCCTGACTTG AGGCTGTCAG CTAGACCAGA TAAGCAGGAG 
ATAATTATTG GGGATGAAAA TCACCTAATG CTCATAATCA ATGCAAGGAA TGAAGGAGAA 
GGAGCTTACG AAGCTGAACT CTTCGTCATG ATTCCCGAAG AAGCAGATTA CGTTGGGATC 
GAGCGCAACA ACAAGGGACT GAGGCTCCTG AGTTGTGAGT ACAAGATGGA AAACGTAACC 
AGGATGGTGG TGTGTGACCT TGGGAACCCG ATGGTGACTG GAACGAATTT TTCTCTGGGC 
CTCCGATTTG CTGTTCCTCG TCTTGAGAAA ACAAACATGA GTATTAACTT CGATCTCCAA 
ATCAGAAGCT CCAACAAGGA CAATCCTGAC AGCAATTTCG TGAGCGTGCA AATCAACGTC 
ACTGCCGTGG CTCAGGTGGA AATCAGAGGA GTGTCCCACC CTCCCCAAAT TGTTCTGCCC 
ATCCACAACT GGGAGCCAGC AGAGGAGCCC CACAAAGAGG AGGAAGTCGG TCCCCTGGTT 
GAACATATTT ATGAGCTGCA CAATATTGGA CCCAGCACCA TCAGTGACAG CATTCTCGAA 
GTGGGCTGGC CATTCTCTGC ACGGGAGGAG TTCCTCCTCT ATGTCTTTCA TCTTCAAACT 
CTGGGACCTC TACAATGTCA AACAAATCCT GAGATCAACC CGCAGGATAT AAAGCCTGCT 
GCCTCCCCAG AGGATACCCC TGAGCTCAGC GCCTTCTTAA GAAATGCTAC AATTCCCCAT 
CTTGTCAGGA AGAGGGATGT GCCAGTGGTC CAGCCCCACA GACAGAGCCC GGCAAAAATA 
CTGAACTGTA CCAACATTGA CTGCTTGCAA ATCTCGTGTG CAGTGGGTCG CCTGGGAGGA 
GGAGAAAGTG CAGTTCTGAA GGTCAGATCG AGATTGTGGG CGCACACATT CCTCCAGAGA 
AAGAACGACC CTTATGCTCT TGCATCCCTG GTGTCCTTTG AAGTCAAGAA GATACCTTAT 
AAAGAGCAGC CAGCAAAACT GCCAGCCGGG AGCACAGCGA TTAAGACATC GGTTATTTGG 
GCCACTCCAA ATGTCTCCTT CTCAATTCCA CTGTGGGTCA TAATACTAGC GATCCTTCTT 
GGCTTGCTGG TTCTGGCCAT CTTAACTTTA GCTTTATGGA AGTGTGGATT CTTTGATAGA 
GCAAGACCTC CTCAGGATGA AATGACAGAC AGGGAACAAC TGACCAGTGA CAAGACCCCG 
GAGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001167443.1
CDS	149..3337
Translation	MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA

Target ORF information:

RefSeq Version	NM_001173972.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha 8 (Itga8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173972.1

ORF Insert Sequence:

ATGTCTGCGA GAACCCACCG GGGTCCCCCG GAGAACTGGG CACCTCCGTT CGCTTGTCTC 
TGTTGCGTCT CGGCCGTGCT GGGGATGCTG TGGTCCCCCG TGTCTCTGGC GTTCAACTTG 
GACGTAGACA AGCTCACGGT GTACAGTGGC CCCGAGGGCA GCTACTTCGG CTACTCGCTG 
GACTTCTACA TACCTGATGC GCGCACAGCC AGTGTCTTGG TGGGGGCGCC CAAAGCCAAC 
ACTAGCCAGC CGGATATCGT AGAAGGGGGA GCTGTCTACT ACTGTCCCTG GCCTGCAGAG 
AGGTCTGCAC AGTGCAAGCA GATACCCTTT GACACCACCA ACAACAGGAA AATCAGAGTT 
AATGGAACCA AAGAGCCTAT AGAATTTAAA TCAAACCAAT GGTTTGGAGC CACAGTGAGA 
GCTCACAAAG GAAAAGTTGT GGCTTGTGCC CCTTTATATC ACTGGAGAAC TCTGAAGCCT 
AATCCAGCAA AGGACCCGGT TGGCACATGC TATGTAGCAA TTCAGAACTT CAGTGCTTAC 
GCTGAGCACT CACCCTGTCG GAACAGCAAC GTTGATCCTG AAGGCCAAGG TTACTGCCAA 
GCCGGCTTCA GTCTAGACTT CTATAAGAAT GGAGACCTTA TAGTGGGAGG ACCTGGAAGC 
TTTTACTGGC AAGGTCAGGT GATCACGGTC AGTGTAGCAG ACATCATTGC AAATTACTCA 
TTCAAAGACA TTCTTCGAAA ACTGGCAGCA GAAAAGCAGA CAGATGTGGC TCCAGCTTCC 
TATGATGACA GCTACCTTGG ATATTCAGTT GCTGCTGGAG AATTCACTGG GGACTCTCTG 
CAAGAATTGG TTGCTGGAAT TCCAAGAGGA GCACAGAACT TTGGATATGT CTCCATCATT 
AACTCCACAG ATATGACCTT CATTCAGAAT TTTACTGGTG AGCAGATGGC ATCTTATTTC 
GGATATACTG TTGTGGTATC AGATGTTAAC AATGATGGCA TGGATGACAT ATTGGTCGGG 
GCACCTCTCT TTATGGAGCG AGAATTTGAA AGTAACCCTA GAGAAGTGGG TCAGGTCTAC 
CTGTACCTAC AAGTGAGCGC CCTCCTCTTC CAAGACCCAC AGGTCCTTAC GGGCACAGAG 
ACTTTTGGGA GATTCGGTAG TTCTGTGGCC CACTTGGGGG ACCTGAACCA AGATGGATAC 
AATGATATTG CCATCGGTGT GCCCTTTGCA GGCAAGGATC AAAGAGGTAA AGTCCTCATT 
TACAACGGAA ACGCCAGAGG CTTGCACAGC AAGCCTTCCC AAGTTCTGCA AGGAATATGG 
GGGTCACAGA CCATCCCTTC TGGATTCGGC TTTTCTCTAA GAGGAGACGC AGACATAGAC 
AAGAATGATT ACCCAGATTT ACTTGTCGGG GCATTTGGAG AAGGGAAAGT GGCCGTGTAC 
AGAGCAAGGC CAGTTGTAAC AGTGGATGCC CAGCTTCTGC TGCACCCAAT GATTATCAAC 
CTTGAAAATA AAACTTGCCA GATTCCAGAA TTCCCGACTC CTGTGGCCTG CTTTTCTTTA 
AGAGTCTGTG CATCTATAGC AGGCCAGAGC ATTTCAAATA CAGTAGCCCT GATGGCCGAG 
GTGCAGTTAG ATTTCCTGAA GCAAAAAGGA GCCATCAAAC GGACCCTCTT CCTCCACAAC 
CACCAGTCCC ACCTCATCTT CCCCTTCGTG ATGAGGCAGC AAAAATCCCT CCACTGCCAG 
GATTTTATGG TTTACCTTCG AGATGAAACT GAATTCCGAG ATAAACTGTC TCCAATCAAC 
GTTAGCCTGA ACTACAGTTT GGATGATTCC ACCTTTGAAG ATGGCCTGGA AGTGAAGCCG 
ATTTTGAACC ACTACAGGGA GAATGTCGTT ACTGAGCAGG CTCACATCCT GGTGGACTGT 
GGAGAAGACA ACCTCTGTGT TCCTGACTTG AGGCTGTCAG CTAGACCAGA TAAGCAGGAG 
ATAATTATTG GGGATGAAAA TCACCTAATG CTCATAATCA ATGCAAGGAA TGAAGGAGAA 
GGAGCTTACG AAGCTGAACT CTTCGTCATG ATTCCCGAAG AAGCAGATTA CGTTGGGATC 
GAGCGCAACA ACAAGGGACT GAGGCTCCTG AGTTGTGAGT ACAAGATGGA AAACGTAACC 
AGGATGGTGG TGTGTGACCT TGGGAACCCG ATGGTGACTG GAACGAATTT TTCTCTGGGC 
CTCCGATTTG CTGTTCCTCG TCTTGAGAAA ACAAACATGA GTATTAACTT CGATCTCCAA 
ATCAGAAGCT CCAACAAGGA CAATCCTGAC AGCAATTTCG TGAGCGTGCA AATCAACGTC 
ACTGCCGTGG CTCAGGTGGA AATCAGAGGA GTGTCCCACC CTCCCCAAAT TGTTCTGCCC 
ATCCACAACT GGGAGCCAGC AGAGGAGCCC CACAAAGAGG AGGAAGTCGG TCCCCTGGTT 
GAACATATTT ATGAGCTGCA CAATATTGGA CCCAGCACCA TCAGTGACAG CATTCTCGAA 
GTGGGCTGGC CATTCTCTGC ACGGGAGGAG TTCCTCCTCT ATGTCTTTCA TCTTCAAACT 
CTGGGACCTC TACAATGTCA AACAAATCCT GAGATCAACC CGCAGGATAT AAAGCCTGCT 
GCCTCCCCAG AGGATACCCC TGAGCTCAGC GCCTTCTTAA GAAATGCTAC AATTCCCCAT 
CTTGTCAGGA AGAGGGATGT GCCAGTGGTC CAGCCCCACA GACAGAGCCC GGCAAAAATA 
CTGAACTGTA CCAACATTGA CTGCTTGCAA ATCTCGTGTG CAGTGGGTCG CCTGGGAGGA 
GGAGAAAGTG CAGTTCTGAA GGTCAGATCG AGATTGTGGG CGCACACATT CCTCCAGAGA 
AAGAACGACC CTTATGCTCT TGCATCCCTG GTGTCCTTTG AAGTCAAGAA GATACCTTAT 
AAAGAGCAGC CAGCAAAACT GCCAGCCGGG AGCACAGCGA TTAAGACATC GGTTATTTGG 
GCCACTCCAA ATGTCTCCTT CTCAATTCCA CTGTGGGTCA TAATACTAGC GATCCTTCTT 
GGCTTGCTGG TTCTGGCCAT CTTAACTTTA GCTTTATGGA AGTGTGGATT CTTTGATAGA 
GCAAGACCTC CTCAGGATGA AATGACAGAC AGGGAACAAC TGACCAGTGA CAAGACCCCG 
GAGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased Expression of Integrin Subunits ?3, ?6, and ?8 in the Branching Airway Mesenchyme of Nitrofen-Induced Hypoplastic Lungs.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie28(1)109-114(2018 Feb)
Takahashi T,Friedmacher F,Zimmer J,Puri P

Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.
American journal of human genetics94(2)288-94(2014 Feb)
Humbert C,Silbermann F,Morar B,Parisot M,Zarhrate M,Masson C,Tores F,Blanchet P,Perez MJ,Petrov Y,Khau Van Kien P,Roume J,Leroy B,Gribouval O,Kalaydjieva L,Heidet L,Salomon R,Antignac C,Benmerah A,Saunier S,Jeanpierre C

Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.
Cell adhesion & migration8(4)389-95(2014)
Marek I,Volkert G,Hilgers KF,Bieritz B,Rascher W,Reinhardt DP,Hartner A

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Cell death and differentiation20(3)369-81(2013 Mar)
Brafman DA,Phung C,Kumar N,Willert K

A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
Progress in neuro-psychopharmacology & biological psychiatry40347-52(2013 Jan)
Supriyanto I,Watanabe Y,Mouri K,Shiroiwa K,Ratta-Apha W,Yoshida M,Tamiya G,Sasada T,Eguchi N,Okazaki K,Shirakawa O,Someya T,Hishimoto A

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Itga8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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