Lsm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lsm1
Entrez Gene ID	364624
Full Name	LSM1 homolog, mRNA degradation associated
General protein information	Preferred Names LSM1 homolog, mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm1 LSM1 homolog, U6 small nuclear RNA associated LSM1 mRNA degradation associated LSM1, U6 small nuclear RNA associated
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108876.1	NP_001102346.1	U6 snRNA-associated Sm-like protein LSm1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LSM1	XP_532806.3
Bos taurus (cattle)	LSM1	NP_001017952.1
Eremothecium gossypii	AGOS_AFL212C	NP_985338.1
Schizosaccharomyces pombe (fission yeast)	lsm1	NP_595520.1
Arabidopsis thaliana (thale cress)	AT3G14080	NP_850580.1
Homo sapiens (human)	LSM1	NP_055277.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001686	XP_321407.3
Caenorhabditis elegans (roundworm)	lsm-1	NP_496385.1
Mus musculus (house mouse)	Lsm1	NP_080308.1
Rattus norvegicus (Norway rat)	Lsm1	NP_001102346.1
Danio rerio (zebrafish)	lsm1	NP_001003551.1
Drosophila melanogaster (fruit fly)	LSm1	NP_611559.1
Kluyveromyces lactis	KLLA0E15159g	XP_454633.1
Magnaporthe oryzae (rice blast fungus)	MGG_03195	XP_003716791.1
Xenopus tropicalis (tropical clawed frog)	lsm1	NP_001011191.1
Pan troglodytes (chimpanzee)	LSM1	XP_001170479.1
Saccharomyces cerevisiae (baker's yeast)	LSM1	NP_012411.1
Oryza sativa (rice)	Os04g0445800	NP_001052905.1
Gallus gallus (chicken)	LSM1	XP_424387.4

Gene Ontology
Bibliography

Related articles in PubMed

An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Yang G, Smibert CA, Kaplan DR, Miller FD
Neuron84(4)723-39(2014 Nov)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control.
di Penta A, Mercaldo V, Florenzano F, Munck S, Ciotti MT, Zalfa F, Mercanti D, Molinari M, Bagni C, Achsel T
The Journal of cell biology184(3)423-35(2009 Feb)

lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.
Chowdhury A, Tharun S
RNA (New York, N.Y.)14(10)2149-58(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results describe a novel mRNP complex, containing LSm1 and CBP80, that is found in neuronal dendrites throughout the central nervous system and in some axonal processes of the spinal cord.
Title: Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control.

These results underscore the importance of Lsm1p-7p-Pat1p complex-mRNA interaction for mRNA decay in vivo and imply that the oligo(A) tail mediated enhancement of such interaction is crucial in that process.
Title: lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.

The following Lsm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lsm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13762	NM_001108876.1 Latest version!	Rattus norvegicus LSM1 homolog, mRNA degradation associated (Lsm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lsm1 ( NM_001108876.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102346.1 Rattus norvegicus LSM1 homolog, mRNA degradation associated (Lsm1), mRNA.

Price & Availability↑

CloneID	ORa13762
Clone ID Related Accession (Same CDS sequence)	NM_001108876.1
Accession Version	NM_001108876.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	U6 snRNA-associated Sm-like protein LSm1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473970.2. On or before Oct 4, 2007 this sequence version replaced XM_344536.3, XM_001071427.1. ##Evidence-Data-START## Transcript exon combination :: FQ220497.1, FQ216033.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906354 [ECO:0000348] ##Evidence-Data-END##

ATGAACTATA TGCCCGGCAC CGCCAGCCTC ATCGAGGACA TCGACAAAAA GCACTTGGTC 
CTACTTCGAG ATGGAAGGAC ACTTATAGGT TTTTTAAGAA GCATTGATCA ATTTGCTAAC 
CTAGTGCTCC ATCAGACTGT GGAGCGAATT CACGTGGGCA GAAAGTACGG TGATATTCCT 
CGAGGGATTT TCGTGGTCAG AGGAGAAAAT GTGGTCCTAC TAGGAGAAAT AGACTTGGAA 
AAGGAAAGTG ACACGCCACT TCAGCAAGTC TCCATTGAAG AGATCCTGGA GGAACAGAGG 
GTAGAGCAGC AGAGCAGGCT GGAGGCAGAG AAGCTGAAGG TCCAGGCCCT TAAAGACCGG 
GGTCTCTCCA TTCCTCGTGC AGACACTCTG GATGAGTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102346.1
CDS	354..755
Translation	MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGRKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQSRLEAEKLKVQALKDRGLSIPRADTLDEY

Target ORF information:

RefSeq Version	NM_001108876.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LSM1 homolog, mRNA degradation associated (Lsm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108876.1

ORF Insert Sequence:

ATGAACTATA TGCCCGGCAC CGCCAGCCTC ATCGAGGACA TCGACAAAAA GCACTTGGTC 
CTACTTCGAG ATGGAAGGAC ACTTATAGGT TTTTTAAGAA GCATTGATCA ATTTGCTAAC 
CTAGTGCTCC ATCAGACTGT GGAGCGAATT CACGTGGGCA GAAAGTACGG TGATATTCCT 
CGAGGGATTT TCGTGGTCAG AGGAGAAAAT GTGGTCCTAC TAGGAGAAAT AGACTTGGAA 
AAGGAAAGTG ACACGCCACT TCAGCAAGTC TCCATTGAAG AGATCCTGGA GGAACAGAGG 
GTAGAGCAGC AGAGCAGGCT GGAGGCAGAG AAGCTGAAGG TCCAGGCCCT TAAAGACCGG 
GGTCTCTCCA TTCCTCGTGC AGACACTCTG GATGAGTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Neuron84(4)723-39(2014 Nov)
Yang G,Smibert CA,Kaplan DR,Miller FD

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control.
The Journal of cell biology184(3)423-35(2009 Feb)
di Penta A,Mercaldo V,Florenzano F,Munck S,Ciotti MT,Zalfa F,Mercanti D,Molinari M,Bagni C,Achsel T

lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.
RNA (New York, N.Y.)14(10)2149-58(2008 Oct)
Chowdhury A,Tharun S

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Lsm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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