Cnrip1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnrip1
Entrez Gene ID	364208
Full Name	cannabinoid receptor interacting protein 1
Synonyms	Crip1a,RGD1308373
General protein information	Preferred Names cannabinoid receptor interacting protein 1 Names CB1 cannabinoid receptor-interacting protein 1 CB1 cannabinoid receptor interacting CRIP-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014232.1	NP_001014254.1	CB1 cannabinoid receptor-interacting protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CNRIP1	XP_515523.2
	CNRIP1	XP_001094135.1
Rattus norvegicus (Norway rat)	Cnrip1	NP_001014254.1
Xenopus tropicalis (tropical clawed frog)	cnrip1	NP_001120556.1
Mus musculus (house mouse)	Cnrip1	NP_084137.1
Canis lupus familiaris (dog)	CNRIP1	XP_005642505.1
Bos taurus (cattle)	CNRIP1	NP_001069651.1
Gallus gallus (chicken)	CNRIP1	NP_001264459.1
Homo sapiens (human)	CNRIP1	NP_056278.1
Danio rerio (zebrafish)	cnrip1b	XP_684894.2

Gene Ontology
Bibliography

Related articles in PubMed

Cannabinoid Receptor Interacting Protein 1a Competition with ?-Arrestin for CB1 Receptor Binding Sites.
Blume LC, Patten T, Eldeeb K, Leone-Kabler S, Ilyasov AA, Keegan BM, O'Neal JE, Bass CE, Hantgan RR, Lowther WT, Selley DE, Howlett AL
Molecular pharmacology91(2)75-86(2017 Feb)

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertov? M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE
Molecular pharmacology87(4)747-65(2015 Apr)

Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and ? opioid systems.
Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC
Journal of neurochemistry124(6)808-20(2013 Mar)

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.
Bojnik E, Turun? E, Arma?an G, Kan?t L, Benyhe S, Yal??n A, Borsodi A
Epilepsy research99(1-2)64-8(2012 Mar)

Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats.
Malinen H, Hyyti? P
Alcoholism, clinical and experimental research32(11)1976-83(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R.
Title: Cannabinoid Receptor Interacting Protein 1a Competition with ?-Arrestin for CB1 Receptor Binding Sites.

CRIP1a appears to act as a broad negative regulator of CB1 receptor function
Title: Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.

Increased expression of CRIP1a in corpus striatum occurs after knockdown of CB1 receptor or dopamine D2 receptor.
Title: Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and ? opioid systems.

Gene expression levels of both cannabinoid receptor interacting protein 1 and CB1 receptor were elevated following kainic acid induced seizures.
Title: Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.

Replication of the suppressive effects by CB1 antagonism in the nucleus accumbens and ventral tegmental area suggests that endocannabinoids and their receptors mediate ethanol reinforcement through interaction with the mesolimbic dopamine pathway.
Title: Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats.

The following Cnrip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnrip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12808	NM_001014232.1 Latest version!	Rattus norvegicus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnrip1 ( NM_001014232.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014254.1 Rattus norvegicus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.

Price & Availability↑

CloneID	ORa12808
Clone ID Related Accession (Same CDS sequence)	NM_001014232.1
Accession Version	NM_001014232.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-14
Organism	Rattus norvegicus(Norway rat)
Product	CB1 cannabinoid receptor-interacting protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088754.1. On Apr 20, 2005 this sequence version replaced XM_344268.2. ##Evidence-Data-START## Transcript exon combination :: BC088754.1, DY315509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGATC TACCGGGGAT CGTGCGCCTT TCCATCGCGC TGCGCATCCA ACCCAATGAT 
GGCCCTGTTT TCTTCAAGGT GGACGGGCAG CGCTTTGGGC AGAACCGTAC AATCAAGCTG 
CTCACCGGTT CCTCCTACAA GGTGGAGGTG AAGATTAAGC CCACAACACT GCAGGTCGAG 
AACATTTCCA TTGGTGGTGT GCTTGTCCCA CTGGAGCTGA AGTGTAAAGA GCCTGATGGG 
GAAAGAGTTG TCTACACCGG CATATACGAT ACAGAAGGGG TAGCCCCAAC CAAAAGTGGA 
GAGCGACAAC CCATCCAGAT CACCATGCCG TTCACAGACA TTGGGACCTT CGAGACGGTG 
TGGCAAGTCA AGTTCTACAA TTACCACAAG CGAGACCACT GCCAGTGGGG AAGCCCGTTC 
TCCGTCATTG AGTATGAATG CAAGCCCAAT GAGACGCGCA GCCTCATGTG GGTGAATAAG 
GAGTCCTTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014254.1
CDS	156..650
Translation	MGDLPGIVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKCKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL

Target ORF information:

RefSeq Version	NM_001014232.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cannabinoid receptor interacting protein 1 (Cnrip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014232.1

ORF Insert Sequence:

ATGGGGGATC TACCGGGGAT CGTGCGCCTT TCCATCGCGC TGCGCATCCA ACCCAATGAT 
GGCCCTGTTT TCTTCAAGGT GGACGGGCAG CGCTTTGGGC AGAACCGTAC AATCAAGCTG 
CTCACCGGTT CCTCCTACAA GGTGGAGGTG AAGATTAAGC CCACAACACT GCAGGTCGAG 
AACATTTCCA TTGGTGGTGT GCTTGTCCCA CTGGAGCTGA AGTGTAAAGA GCCTGATGGG 
GAAAGAGTTG TCTACACCGG CATATACGAT ACAGAAGGGG TAGCCCCAAC CAAAAGTGGA 
GAGCGACAAC CCATCCAGAT CACCATGCCG TTCACAGACA TTGGGACCTT CGAGACGGTG 
TGGCAAGTCA AGTTCTACAA TTACCACAAG CGAGACCACT GCCAGTGGGG AAGCCCGTTC 
TCCGTCATTG AGTATGAATG CAAGCCCAAT GAGACGCGCA GCCTCATGTG GGTGAATAAG 
GAGTCCTTCC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cannabinoid Receptor Interacting Protein 1a Competition with ?-Arrestin for CB1 Receptor Binding Sites.
Molecular pharmacology91(2)75-86(2017 Feb)
Blume LC,Patten T,Eldeeb K,Leone-Kabler S,Ilyasov AA,Keegan BM,O'Neal JE,Bass CE,Hantgan RR,Lowther WT,Selley DE,Howlett AL

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Molecular pharmacology87(4)747-65(2015 Apr)
Smith TH,Blume LC,Straiker A,Cox JO,David BG,McVoy JR,Sayers KW,Poklis JL,Abdullah RA,Egertov? M,Chen CK,Mackie K,Elphick MR,Howlett AC,Selley DE

Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and ? opioid systems.
Journal of neurochemistry124(6)808-20(2013 Mar)
Blume LC,Bass CE,Childers SR,Dalton GD,Roberts DC,Richardson JM,Xiao R,Selley DE,Howlett AC

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.
Epilepsy research99(1-2)64-8(2012 Mar)
Bojnik E,Turun? E,Arma?an G,Kan?t L,Benyhe S,Yal??n A,Borsodi A

Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats.
Alcoholism, clinical and experimental research32(11)1976-83(2008 Nov)
Malinen H,Hyyti? P

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Cnrip1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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