Map2k7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map2k7
Entrez Gene ID	363855
Full Name	mitogen activated protein kinase kinase 7
Synonyms	JNKK,Jnkk2,Mapkk7,Mek7,Mkk7
General protein information	Preferred Names mitogen activated protein kinase kinase 7 Names dual specificity mitogen-activated protein kinase kinase 7 JNK kinase 2 JNK-activating kinase 2 JNKK 2 MAP kinase kinase 7 MAPK/ERK kinase 7 MAPKK 7 MEK 7 c-Jun N-terminal kinase kinase 2 map2k7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p12

mRNA and Protein(s)

mRNA	Protein	Name
XM_006248769.2	XP_006248831.1	dual specificity mitogen-activated protein kinase kinase 7 isoform X2
XM_006248768.3	XP_006248830.1	dual specificity mitogen-activated protein kinase kinase 7 isoform X1
NM_001025425.1	NP_001020596.1	dual specificity mitogen-activated protein kinase kinase 7
XM_008768985.2	XP_008767207.1	dual specificity mitogen-activated protein kinase kinase 7 isoform X3

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	map2k7	NP_001177235.1
Homo sapiens (human)	MAP2K7	NP_660186.1
Canis lupus familiaris (dog)	MAP2K7	XP_542122.2
Caenorhabditis elegans (roundworm)	mek-1	NP_001024771.1
Pan troglodytes (chimpanzee)	MAP2K7	XP_003316108.1
Bos taurus (cattle)	MAP2K7	XP_002688882.2
Rattus norvegicus (Norway rat)	Map2k7	NP_001020596.1
Mus musculus (house mouse)	Map2k7	NP_001036022.1
Drosophila melanogaster (fruit fly)	hep	NP_511142.2
Xenopus tropicalis (tropical clawed frog)	map2k7	NP_001027523.1

Gene Ontology
Bibliography

Related articles in PubMed

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion.
Huang YA, Zhou B, Wernig M, S?dhof TC
Cell168(3)427-441.e21(2017 Jan)

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.
Vercelli A, Biggi S, Sclip A, Repetto IE, Cimini S, Falleroni F, Tomasi S, Monti R, Tonna N, Morelli F, Grande V, Stravalaci M, Biasini E, Marin O, Bianco F, di Marino D, Borsello T
Cell death & disease6e1854(2015 Aug)

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.
Itoh T, Horiuchi M, Ikeda RH Jr, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A
The Journal of neuroscience : the official journal of the Society for Neuroscience34(32)10729-42(2014 Aug)

Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia.
Zeng XW, Li MW, Pan J, Ji TL, Yang B, Zhang B, Wang XQ
Chinese medical journal124(20)3367-72(2011 Oct)

High-throughput RNAi screening reveals novel regulators of telomerase.
Cerone MA, Burgess DJ, Naceur-Lombardelli C, Lord CJ, Ashworth A
Cancer research71(9)3328-40(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MKK7 down-regulation is a new therapeutic strategy against excitotoxicity and cerebral ischemia.
Title: Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.

JNK1/2 activation is associated with endogenous NO in response to ischemic insult.
Title: Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia.

MKK7gamma1 is a cue molecule for antagonisation of basic cell programmes and subsequent loss of control with either ongoing proliferation or enhanced cell death.
Title: MKK7?1 reverses nerve growth factor signals: proliferation and cell death instead of neuritogenesis and protection.

MKK7gamma1 affects the function and activity of individual JNK isoforms and the formation of their signalosomes.
Title: Specific regulation of JNK signalling by the novel rat MKK7gamma1 isoform.

Map2k7 activation, translocation and binding to Jun N-terminal kinase (JNK)-interacting protein (JIP)-1 is closely associated with reactive oxygen species and might play a pivotal role in the activation of JNK signaling in brain ischemic injury. [Map2k7]
Title: Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region.

The following Map2k7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map2k7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07737	NM_001025425.1 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa34540	XM_006248768.3 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa34541	XM_006248769.2 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa48628	XM_008768985.2 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map2k7 ( NM_001025425.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020596.1 Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), mRNA.

Price & Availability↑

CloneID	ORa07737
Clone ID Related Accession (Same CDS sequence)	NM_001025425.1
Accession Version	NM_001025425.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY879265.1. On Jul 15, 2005 this sequence version replaced XM_577203.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY879265.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCACCTTGC AGCTCCCACT GGCCAACGAT GGGGGCAGCC GCTCACCATC CTCAGAGAGC 
TCCCCACAGC ACCCTACGCC CCCCAGCCGG CCCCGCCACA TGCTGGGGCT CCCGTCAACC 
TTGTTCACAC CTCGCAGTAT GGAGAGCATC GAGATTGACC AAAAGCTGCA GGAGATCATG 
AAGCAGACAG GGTACCTGAC TATCGGGGGC CAGCGTTATC AGGCAGAAAT CAATGACTTG 
GAGAACCTGG GAGAGATGGG CAGTGGTACC TGTGGTCAGG TGTGGAAGAT GCGGTTCCGG 
AAGACAGGCC ACATCATTGC TGTTAAGCAA ATGCGGCGCT CGGGGAACAA GGAAGAGAAT 
AAGCGCATCC TAATGGACCT GGACGTAGTA CTCAAGAGCC ACGACTGCCC CTACATTGTT 
CAGTGCTTTG GTACCTTCAT CACCAACACG GACGTCTTTA TTGCCATGGA GCTCATGGGC 
ACGTGTGCGG AGAAGCTGAA GAAACGGATG CAGGGCCCCA TCCCAGAGCG AATCCTTGGC 
AAGATGACCG TGGCGATTGT GAAAGCATTG TACTATCTGA AGGAGAAGCA TGGGGTCATC 
CATCGTGATG TCAAACCCTC CAACATCCTG CTGGATGAGC GGGGTCAGAT CAAGCTCTGT 
GACTTTGGCA TCAGTGGCCG CCTTGTTGAC TCCAAAGCCA AAACACGGAG TGCTGGCTGT 
GCTGCCTATA TGGCTCCTGA GCGCATTGAC CCGCCAGACC CCACCAAGCC AGACTATGAC 
ATCCGGGCCG ATGTGTGGAG CCTGGGCATC TCACTGGTGG AGCTGGCAAC AGGACAGTTC 
CCCTATAAGA ACTGCAAGAC GGACTTTGAG GTCCTCACCA AAGTCCTACA GGAAGAGCCC 
CCGCTCCTGC CTGGTCACAT GGGCTTCTCA GGGGACTTCC AGTCATTTGT CAAAGACTGC 
CTTACTAAAG ACCACAGGAA GAGACCAAAG TATAACAAAC TACTTGAACA CAGCTTCATC 
AAGCACTATG AGACACTCGA AGTGGATGTC GCGTCCTGGT TTAAGGACGT CATGGCAAAG 
ACCGAGTCCC CAAGGACTAG TGGAGTCCTG AGCCAACACC ATCTGCCCTT CTTCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020596.1
CDS	1..1260
Translation	MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPSRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYETLEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFR

Target ORF information:

RefSeq Version	NM_001025425.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025425.1

ORF Insert Sequence:

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCACCTTGC AGCTCCCACT GGCCAACGAT GGGGGCAGCC GCTCACCATC CTCAGAGAGC 
TCCCCACAGC ACCCTACGCC CCCCAGCCGG CCCCGCCACA TGCTGGGGCT CCCGTCAACC 
TTGTTCACAC CTCGCAGTAT GGAGAGCATC GAGATTGACC AAAAGCTGCA GGAGATCATG 
AAGCAGACAG GGTACCTGAC TATCGGGGGC CAGCGTTATC AGGCAGAAAT CAATGACTTG 
GAGAACCTGG GAGAGATGGG CAGTGGTACC TGTGGTCAGG TGTGGAAGAT GCGGTTCCGG 
AAGACAGGCC ACATCATTGC TGTTAAGCAA ATGCGGCGCT CGGGGAACAA GGAAGAGAAT 
AAGCGCATCC TAATGGACCT GGACGTAGTA CTCAAGAGCC ACGACTGCCC CTACATTGTT 
CAGTGCTTTG GTACCTTCAT CACCAACACG GACGTCTTTA TTGCCATGGA GCTCATGGGC 
ACGTGTGCGG AGAAGCTGAA GAAACGGATG CAGGGCCCCA TCCCAGAGCG AATCCTTGGC 
AAGATGACCG TGGCGATTGT GAAAGCATTG TACTATCTGA AGGAGAAGCA TGGGGTCATC 
CATCGTGATG TCAAACCCTC CAACATCCTG CTGGATGAGC GGGGTCAGAT CAAGCTCTGT 
GACTTTGGCA TCAGTGGCCG CCTTGTTGAC TCCAAAGCCA AAACACGGAG TGCTGGCTGT 
GCTGCCTATA TGGCTCCTGA GCGCATTGAC CCGCCAGACC CCACCAAGCC AGACTATGAC 
ATCCGGGCCG ATGTGTGGAG CCTGGGCATC TCACTGGTGG AGCTGGCAAC AGGACAGTTC 
CCCTATAAGA ACTGCAAGAC GGACTTTGAG GTCCTCACCA AAGTCCTACA GGAAGAGCCC 
CCGCTCCTGC CTGGTCACAT GGGCTTCTCA GGGGACTTCC AGTCATTTGT CAAAGACTGC 
CTTACTAAAG ACCACAGGAA GAGACCAAAG TATAACAAAC TACTTGAACA CAGCTTCATC 
AAGCACTATG AGACACTCGA AGTGGATGTC GCGTCCTGGT TTAAGGACGT CATGGCAAAG 
ACCGAGTCCC CAAGGACTAG TGGAGTCCTG AGCCAACACC ATCTGCCCTT CTTCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k7 ( XM_006248768.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248830.1 Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34540
Clone ID Related Accession (Same CDS sequence)	XM_006248768.3
Accession Version	XM_006248768.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248768.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCATTATTG TGATCACTCT AAGCCCTGCT CCTGCCCCGT CCCAGCGAGC AGCCTTGCAG 
CTCCCACTGG CCAACGATGG GGGCAGCCGC TCACCATCCT CAGAGAGCTC CCCACAGCAC 
CCTACGCCCC CCAGCCGGCC CCGCCACATG CTGGGGCTCC CGTCAACCTT GTTCACACCT 
CGCAGTATGG AGAGCATCGA GATTGACCAA AAGCTGCAGG AGATCATGAA GCAGACAGGG 
TACCTGACTA TCGGGGGCCA GCGTTATCAG GCAGAAATCA ATGACTTGGA GAACCTGGGA 
GAGATGGGCA GTGGTACCTG TGGTCAGGTG TGGAAGATGC GGTTCCGGAA GACAGGCCAC 
ATCATTGCTG TTAAGCAAAT GCGGCGCTCG GGGAACAAGG AAGAGAATAA GCGCATCCTA 
ATGGACCTGG ACGTAGTACT CAAGAGCCAC GACTGCCCCT ACATTGTTCA GTGCTTTGGT 
ACCTTCATCA CCAACACGGA CGTCTTTATT GCCATGGAGC TCATGGGCAC GTGTGCGGAG 
AAGCTGAAGA AACGGATGCA GGGCCCCATC CCAGAGCGAA TCCTTGGCAA GATGACCGTG 
GCGATTGTGA AAGCATTGTA CTATCTGAAG GAGAAGCATG GGGTCATCCA TCGTGATGTC 
AAACCCTCCA ACATCCTGCT GGATGAGCGG GGTCAGATCA AGCTCTGTGA CTTTGGCATC 
AGTGGCCGCC TTGTTGACTC CAAAGCCAAA ACACGGAGTG CTGGCTGTGC TGCCTATATG 
GCTCCTGAGC GCATTGACCC GCCAGACCCC ACCAAGCCAG ACTATGACAT CCGGGCCGAT 
GTGTGGAGCC TGGGCATCTC ACTGGTGGAG CTGGCAACAG GACAGTTCCC CTATAAGAAC 
TGCAAGACGG ACTTTGAGGT CCTCACCAAA GTCCTACAGG AAGAGCCCCC GCTCCTGCCT 
GGTCACATGG GCTTCTCAGG GGACTTCCAG TCATTTGTCA AAGACTGCCT TACTAAAGAC 
CACAGGAAGA GACCAAAGTA TAACAAACTA CTTGAACACA GCTTCATCAA GCACTATGAG 
ACACTCGAAG TGGATGTCGC GTCCTGGTTT AAGGACGTCA TGGCAAAGAC CGAGTCCCCA 
AGGACTAGTG GAGTCCTGAG CCAACACCAT CTGCCCTTCT TCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248830.1
CDS	144..1451
Translation	MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPSRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYETLEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFR

Target ORF information:

RefSeq Version	XM_006248768.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248768.3

ORF Insert Sequence:

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCATTATTG TGATCACTCT AAGCCCTGCT CCTGCCCCGT CCCAGCGAGC AGCCTTGCAG 
CTCCCACTGG CCAACGATGG GGGCAGCCGC TCACCATCCT CAGAGAGCTC CCCACAGCAC 
CCTACGCCCC CCAGCCGGCC CCGCCACATG CTGGGGCTCC CGTCAACCTT GTTCACACCT 
CGCAGTATGG AGAGCATCGA GATTGACCAA AAGCTGCAGG AGATCATGAA GCAGACAGGG 
TACCTGACTA TCGGGGGCCA GCGTTATCAG GCAGAAATCA ATGACTTGGA GAACCTGGGA 
GAGATGGGCA GTGGTACCTG TGGTCAGGTG TGGAAGATGC GGTTCCGGAA GACAGGCCAC 
ATCATTGCTG TTAAGCAAAT GCGGCGCTCG GGGAACAAGG AAGAGAATAA GCGCATCCTA 
ATGGACCTGG ACGTAGTACT CAAGAGCCAC GACTGCCCCT ACATTGTTCA GTGCTTTGGT 
ACCTTCATCA CCAACACGGA CGTCTTTATT GCCATGGAGC TCATGGGCAC GTGTGCGGAG 
AAGCTGAAGA AACGGATGCA GGGCCCCATC CCAGAGCGAA TCCTTGGCAA GATGACCGTG 
GCGATTGTGA AAGCATTGTA CTATCTGAAG GAGAAGCATG GGGTCATCCA TCGTGATGTC 
AAACCCTCCA ACATCCTGCT GGATGAGCGG GGTCAGATCA AGCTCTGTGA CTTTGGCATC 
AGTGGCCGCC TTGTTGACTC CAAAGCCAAA ACACGGAGTG CTGGCTGTGC TGCCTATATG 
GCTCCTGAGC GCATTGACCC GCCAGACCCC ACCAAGCCAG ACTATGACAT CCGGGCCGAT 
GTGTGGAGCC TGGGCATCTC ACTGGTGGAG CTGGCAACAG GACAGTTCCC CTATAAGAAC 
TGCAAGACGG ACTTTGAGGT CCTCACCAAA GTCCTACAGG AAGAGCCCCC GCTCCTGCCT 
GGTCACATGG GCTTCTCAGG GGACTTCCAG TCATTTGTCA AAGACTGCCT TACTAAAGAC 
CACAGGAAGA GACCAAAGTA TAACAAACTA CTTGAACACA GCTTCATCAA GCACTATGAG 
ACACTCGAAG TGGATGTCGC GTCCTGGTTT AAGGACGTCA TGGCAAAGAC CGAGTCCCCA 
AGGACTAGTG GAGTCCTGAG CCAACACCAT CTGCCCTTCT TCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k7 ( XM_006248769.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248831.1 Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa34541
Clone ID Related Accession (Same CDS sequence)	XM_006248769.2
Accession Version	XM_006248769.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 7 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248769.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCATTATTG TGATCACTCT AAGCCCTGCT CCTGCCCCGT CCCAGCGAGC AGCCTTGCAG 
CTCCCACTGG CCAACGATGG GGGCAGCCGC TCACCATCCT CAGAGAGCTC CCCACAGCAC 
CCTACGCCCC CCAGCCGGCC CCGCCACATG CTGGGGCTCC CGTCAACCTT GTTCACACCT 
CGCAGTATGG AGAGCATCGA GATTGACCAA AAGCTGCAGG AGATCATGAA GCAGACAGGG 
TACCTGACTA TCGGGGGCCA GCGTTATCAG GCAGAAATCA ATGACTTGGA GAACCTGGGA 
GAGATGGGCA GTGGTACCTG TGGTCAGGTG TGGAAGATGC GGTTCCGGAA GACAGGCCAC 
ATCATTGCTG TTAAGCAAAT GCGGCGCTCG GGGAACAAGG AAGAGAATAA GCGCATCCTA 
ATGGACCTGG ACGTAGTACT CAAGAGCCAC GACTGCCCCT ACATTGTTCA GTGCTTTGGT 
ACCTTCATCA CCAACACGGA CGTCTTTATT GCCATGGAGC TCATGGGCAC GTGTGCGGAG 
AAGCTGAAGA AACGGATGCA GGGCCCCATC CCAGAGCGAA TCCTTGGCAA GATGACCGTG 
GCGATTGTGA AAGCATTGTA CTATCTGAAG GAGAAGCATG GGGTCATCCA TCGTGATGTC 
AAACCCTCCA ACATCCTGCT GGATGAGCGG GGTCAGATCA AGCTCTGTGA CTTTGGCATC 
AGTGGCCGCC TTGTTGACTC CAAAGCCAAA ACACGGAGTG CTGGCTGTGC TGCCTATATG 
GCTCCTGAGC GCATTGACCC GCCAGACCCC ACCAAGCCAG ACTATGACAT CCGGGCCGAT 
GTGTGGAGCC TGGGCATCTC ACTGGTGGAG CTGGCAACAG GACAGTTCCC CTATAAGAAC 
TGCAAGACGG ACTTTGAGGT CCTCACCAAA GTCCTACAGG AAGAGCCCCC GCTCCTGCCT 
GGTCACATGG GCTTCTCAGG GGACTTCCAG TCATTTGTCA AAGACTGCCT TACTAAAGAC 
CACAGGAAGA GACCAAAGTA TAACAAACTA CTTGAACACA GCTTCATCAA GCACTATGAG 
ACACTCGAAG TGGATGTCGC GTCCTGGTTT AAGGACGTCA TGGCAAAGAC CGAGTCCCCA 
AGGACTAGTG GAGTCCTGAG CCAACACCAT CTGCCCTTCT TCAGTGGGAG CCTGGAGGAG 
TCTCCCACTT CCCTACCTTT TCCCAAGTCC TTCCCTCTGT CACCAGCCAT CCCTCTGGCC 
CAGGCAGAGT GGGTCTTGGG CAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248831.1
CDS	147..1553
Translation	MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPSRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYETLEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFSGSLEESPTSLPFPKSFPLSPAIPLAQAEWVLGR

Target ORF information:

RefSeq Version	XM_006248769.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248769.2

ORF Insert Sequence:

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCATTATTG TGATCACTCT AAGCCCTGCT CCTGCCCCGT CCCAGCGAGC AGCCTTGCAG 
CTCCCACTGG CCAACGATGG GGGCAGCCGC TCACCATCCT CAGAGAGCTC CCCACAGCAC 
CCTACGCCCC CCAGCCGGCC CCGCCACATG CTGGGGCTCC CGTCAACCTT GTTCACACCT 
CGCAGTATGG AGAGCATCGA GATTGACCAA AAGCTGCAGG AGATCATGAA GCAGACAGGG 
TACCTGACTA TCGGGGGCCA GCGTTATCAG GCAGAAATCA ATGACTTGGA GAACCTGGGA 
GAGATGGGCA GTGGTACCTG TGGTCAGGTG TGGAAGATGC GGTTCCGGAA GACAGGCCAC 
ATCATTGCTG TTAAGCAAAT GCGGCGCTCG GGGAACAAGG AAGAGAATAA GCGCATCCTA 
ATGGACCTGG ACGTAGTACT CAAGAGCCAC GACTGCCCCT ACATTGTTCA GTGCTTTGGT 
ACCTTCATCA CCAACACGGA CGTCTTTATT GCCATGGAGC TCATGGGCAC GTGTGCGGAG 
AAGCTGAAGA AACGGATGCA GGGCCCCATC CCAGAGCGAA TCCTTGGCAA GATGACCGTG 
GCGATTGTGA AAGCATTGTA CTATCTGAAG GAGAAGCATG GGGTCATCCA TCGTGATGTC 
AAACCCTCCA ACATCCTGCT GGATGAGCGG GGTCAGATCA AGCTCTGTGA CTTTGGCATC 
AGTGGCCGCC TTGTTGACTC CAAAGCCAAA ACACGGAGTG CTGGCTGTGC TGCCTATATG 
GCTCCTGAGC GCATTGACCC GCCAGACCCC ACCAAGCCAG ACTATGACAT CCGGGCCGAT 
GTGTGGAGCC TGGGCATCTC ACTGGTGGAG CTGGCAACAG GACAGTTCCC CTATAAGAAC 
TGCAAGACGG ACTTTGAGGT CCTCACCAAA GTCCTACAGG AAGAGCCCCC GCTCCTGCCT 
GGTCACATGG GCTTCTCAGG GGACTTCCAG TCATTTGTCA AAGACTGCCT TACTAAAGAC 
CACAGGAAGA GACCAAAGTA TAACAAACTA CTTGAACACA GCTTCATCAA GCACTATGAG 
ACACTCGAAG TGGATGTCGC GTCCTGGTTT AAGGACGTCA TGGCAAAGAC CGAGTCCCCA 
AGGACTAGTG GAGTCCTGAG CCAACACCAT CTGCCCTTCT TCAGTGGGAG CCTGGAGGAG 
TCTCCCACTT CCCTACCTTT TCCCAAGTCC TTCCCTCTGT CACCAGCCAT CCCTCTGGCC 
CAGGCAGAGT GGGTCTTGGG CAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k7 ( XM_008768985.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008767207.1 Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X3, mRNA.

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CloneID	ORa48628
Clone ID Related Accession (Same CDS sequence)	XM_008768985.2
Accession Version	XM_008768985.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 7 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768985.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCACCTTGC AGCTCCCACT GGCCAACGAT GGGGGCAGCC GCTCACCATC CTCAGAGAGC 
TCCCCACAGC ACCCTACGCC CCCCAGCCGG CCCCGCCACA TGCTGGGGCT CCCGTCAACC 
TTGTTCACAC CTCGCAGTAT GGAGAGCATC GAGATTGACC AAAAGCTGCA GGAGATCATG 
AAGCAGACAG GGTACCTGAC TATCGGGGGC CAGCGTTATC AGGCAGAAAT CAATGACTTG 
GAGAACCTGG GAGAGATGGG CAGTGGTACC TGTGGTCAGG TGTGGAAGAT GCGGTTCCGG 
AAGACAGGCC ACATCATTGC TGTTAAGCAA ATGCGGCGCT CGGGGAACAA GGAAGAGAAT 
AAGCGCATCC TAATGGACCT GGACGTAGTA CTCAAGAGCC ACGACTGCCC CTACATTGTT 
CAGTGCTTTG GTACCTTCAT CACCAACACG GACGTCTTTA TTGCCATGGA GCTCATGGGC 
ACGTGTGCGG AGAAGCTGAA GAAACGGATG CAGGGCCCCA TCCCAGAGCG AATCCTTGGC 
AAGATGACCG TGGCGATTGT GAAAGCATTG TACTATCTGA AGGAGAAGCA TGGGGTCATC 
CATCGTGATG TCAAACCCTC CAACATCCTG CTGGATGAGC GGGGTCAGAT CAAGCTCTGT 
GACTTTGGCA TCAGTGGCCG CCTTGTTGAC TCCAAAGCCA AAACACGGAG TGCTGGCTGT 
GCTGCCTATA TGGCTCCTGA GCGCATTGAC CCGCCAGACC CCACCAAGCC AGACTATGAC 
ATCCGGGCCG ATGTGTGGAG CCTGGGCATC TCACTGGTGG AGCTGGCAAC AGGACAGTTC 
CCCTATAAGA ACTGCAAGAC GGACTTTGAG GTCCTCACCA AAGTCCTACA GGAAGAGCCC 
CCGCTCCTGC CTGGTCACAT GGGCTTCTCA GGGGACTTCC AGTCATTTGT CAAAGACTGC 
CTTACTAAAG ACCACAGGAA GAGACCAAAG TATAACAAAC TACTTGAACA CAGCTTCATC 
AAGCACTATG AGACACTCGA AGTGGATGTC GCGTCCTGGT TTAAGGACGT CATGGCAAAG 
ACCGAGTCCC CAAGGACTAG TGGAGTCCTG AGCCAACACC ATCTGCCCTT CTTCAGTGGG 
AGCCTGGAGG AGTCTCCCAC TTCCCTACCT TTTCCCAAGT CCTTCCCTCT GTCACCAGCC 
ATCCCTCTGG CCCAGGCAGA GTGGGTCTTG GGCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008767207.1
CDS	145..1503
Translation	MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPSRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYETLEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFSGSLEESPTSLPFPKSFPLSPAIPLAQAEWVLGR

Target ORF information:

RefSeq Version	XM_008768985.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 7 (Map2k7), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768985.2

ORF Insert Sequence:

ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 
AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 
CCCACCTTGC AGCTCCCACT GGCCAACGAT GGGGGCAGCC GCTCACCATC CTCAGAGAGC 
TCCCCACAGC ACCCTACGCC CCCCAGCCGG CCCCGCCACA TGCTGGGGCT CCCGTCAACC 
TTGTTCACAC CTCGCAGTAT GGAGAGCATC GAGATTGACC AAAAGCTGCA GGAGATCATG 
AAGCAGACAG GGTACCTGAC TATCGGGGGC CAGCGTTATC AGGCAGAAAT CAATGACTTG 
GAGAACCTGG GAGAGATGGG CAGTGGTACC TGTGGTCAGG TGTGGAAGAT GCGGTTCCGG 
AAGACAGGCC ACATCATTGC TGTTAAGCAA ATGCGGCGCT CGGGGAACAA GGAAGAGAAT 
AAGCGCATCC TAATGGACCT GGACGTAGTA CTCAAGAGCC ACGACTGCCC CTACATTGTT 
CAGTGCTTTG GTACCTTCAT CACCAACACG GACGTCTTTA TTGCCATGGA GCTCATGGGC 
ACGTGTGCGG AGAAGCTGAA GAAACGGATG CAGGGCCCCA TCCCAGAGCG AATCCTTGGC 
AAGATGACCG TGGCGATTGT GAAAGCATTG TACTATCTGA AGGAGAAGCA TGGGGTCATC 
CATCGTGATG TCAAACCCTC CAACATCCTG CTGGATGAGC GGGGTCAGAT CAAGCTCTGT 
GACTTTGGCA TCAGTGGCCG CCTTGTTGAC TCCAAAGCCA AAACACGGAG TGCTGGCTGT 
GCTGCCTATA TGGCTCCTGA GCGCATTGAC CCGCCAGACC CCACCAAGCC AGACTATGAC 
ATCCGGGCCG ATGTGTGGAG CCTGGGCATC TCACTGGTGG AGCTGGCAAC AGGACAGTTC 
CCCTATAAGA ACTGCAAGAC GGACTTTGAG GTCCTCACCA AAGTCCTACA GGAAGAGCCC 
CCGCTCCTGC CTGGTCACAT GGGCTTCTCA GGGGACTTCC AGTCATTTGT CAAAGACTGC 
CTTACTAAAG ACCACAGGAA GAGACCAAAG TATAACAAAC TACTTGAACA CAGCTTCATC 
AAGCACTATG AGACACTCGA AGTGGATGTC GCGTCCTGGT TTAAGGACGT CATGGCAAAG 
ACCGAGTCCC CAAGGACTAG TGGAGTCCTG AGCCAACACC ATCTGCCCTT CTTCAGTGGG 
AGCCTGGAGG AGTCTCCCAC TTCCCTACCT TTTCCCAAGT CCTTCCCTCT GTCACCAGCC 
ATCCCTCTGG CCCAGGCAGA GTGGGTCTTG GGCAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion.
Cell168(3)427-441.e21(2017 Jan)
Huang YA,Zhou B,Wernig M,S?dhof TC

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.
Cell death & disease6e1854(2015 Aug)
Vercelli A,Biggi S,Sclip A,Repetto IE,Cimini S,Falleroni F,Tomasi S,Monti R,Tonna N,Morelli F,Grande V,Stravalaci M,Biasini E,Marin O,Bianco F,di Marino D,Borsello T

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(32)10729-42(2014 Aug)
Itoh T,Horiuchi M,Ikeda RH Jr,Xu J,Bannerman P,Pleasure D,Penninger JM,Tournier C,Itoh A

Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia.
Chinese medical journal124(20)3367-72(2011 Oct)
Zeng XW,Li MW,Pan J,Ji TL,Yang B,Zhang B,Wang XQ

High-throughput RNAi screening reveals novel regulators of telomerase.
Cancer research71(9)3328-40(2011 May)
Cerone MA,Burgess DJ,Naceur-Lombardelli C,Lord CJ,Ashworth A

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Map2k7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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