Elavl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Elavl1
Entrez Gene ID	363854
Full Name	ELAV like RNA binding protein 1
Synonyms	HuR,Hua
General protein information	Preferred Names ELAV like RNA binding protein 1 Names ELAV-like protein 1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) ELAV like 1 hu-antigen R mRNA-stabilizing factor HuR
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p12
Summary	RNA binding protein; involved in posttranscriptional regulation of VEGF expression [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108848.1	NP_001102318.1	ELAV-like protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ELAVL1	NP_990164.1
Danio rerio (zebrafish)	hug	NP_570984.1
Canis lupus familiaris (dog)	ELAVL1	XP_854218.1
Rattus norvegicus (Norway rat)	Elavl1	NP_001102318.1
Xenopus tropicalis (tropical clawed frog)	elavl1	NP_001005461.1
Homo sapiens (human)	ELAVL1	NP_001410.2
	ELAVL1	XP_001092907.2
Bos taurus (cattle)	ELAVL1	NP_001069922.1
Pan troglodytes (chimpanzee)	ELAVL1	XP_001156587.2
Mus musculus (house mouse)	Elavl1	NP_034615.2

Gene Ontology
Bibliography

Related articles in PubMed

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.
Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M
Biochimica et biophysica acta1864(1)296-306(2018 Jan)

Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.
Maeda A, Uchida M, Nishikawa S, Nishino T, Konishi H
Biochemical and biophysical research communications495(1)1249-1256(2018 01)

HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation.
Liu L, Zhuang R, Xiao L, Chung HK, Luo J, Turner DJ, Rao JN, Gorospe M, Wang JY
Molecular and cellular biology37(7)(2017 Apr)

Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H
Biochimica et biophysica acta1861(11)1816-1827(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
Title: HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation.

These results identify HuR as a novel mediator of cardiac hypertrophy downstream of the Gq-p38 MAPK pathway.
Title: Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy.

siRNA can be efficiently delivered into the rat retina using lipid-based nanocarriers, and some of the lipoplexes loaded with siRNA silencing HuR expression are potential candidates to manage retinal diseases.
Title: Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat.

Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
Title: Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.

HuR, but not CREB, is responsible for the reduction of beta-1 and beta-2 adrenoreceptor expression in isoproterenol induced cardiac remodeling.
Title: Downregulation of ?-Adrenoceptors in Isoproterenol-Induced Cardiac Remodeling through HuR.

The following Elavl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Elavl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00397	NM_001108848.1 Latest version!	Rattus norvegicus ELAV like RNA binding protein 1 (Elavl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Elavl1 ( NM_001108848.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102318.1 Rattus norvegicus ELAV like RNA binding protein 1 (Elavl1), mRNA.

Price & Availability↑

CloneID	ORa00397
Clone ID Related Accession (Same CDS sequence)	NM_001108848.1
Accession Version	NM_001108848.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Rattus norvegicus(Norway rat)
Product	ELAV-like protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474084.1. On or before Oct 4, 2007 this sequence version replaced XM_344063.3, XM_001065476.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168972.1, EV766896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTAATG GTTATGAAGA CCACATGGCG GAAGACTGCA GGGATGACAT TGGGAGAACG 
AATTTAATTG TCAACTACCT CCCTCAGAAC ATGACCCAGG AGGAACTACG GAGTCTGTTC 
AGCAGCATTG GCGAGGTTGA ATCTGCAAAA CTTATTCGGG ATAAAGTTGC AGGACACAGC 
TTGGGCTACG GCTTTGTGAA CTATGTTACT GCAAAAGATG CAGAGAGAGC AATCAGCACA 
CTGAACGGCT TGAGGCTTCA GTCCAAAACC ATTAAGGTAT CATATGCTCG CCCAAGCTCA 
GAGGTTATCA AAGATGCCAA CTTGTACATC AGTGGGCTTC CAAGGACCAT GACTCAGAAG 
GATGTGGAAG ACATGTTTTC TCGGTTTGGG CGAATCATCA ACTCCAGGGT CCTTGTGGAT 
CAGACCACAG GTTTGTCCAG AGGGGTTGCC TTTATCCGGT TTGACAAACG GTCTGAAGCA 
GAAGAGGCAA TTACCAGTTT CAATGGTCAT AAACCCCCGG GTTCCTCCGA GCCCATCACA 
GTGAAGTTTG CAGCCAATCC CAACCAGAAC AAAAACATGG CTCTCCTCTC GCAGCTGTAC 
CACTCGCCTG CTAGGAGGTT TGGAGGCCCT GTGCATCACC AGGCACAGAG ATTCAGGTTC 
TCCCCTATGG GTGTAGATCA CATGAGTGGG ATTTCTGGTG TCAATGTCCC CGGCAATGCT 
TCCTCGGGCT GGTGCATCTT CATCTACAAC CTTGGGCAAG ACGCCGATGA GGGGATCCTC 
TGGCAGATGT TTGGCCCCTT TGGTGCAGTT ACCAATGTGA AAGTGATTCG TGATTTCAAC 
ACCAACAAGT GCAAAGGGTT TGGTTTTGTG ACCATGACAA ACTATGAAGA AGCTGCAATG 
GCCATAGCAA GTCTGAACGG CTACCGCCTG GGGGACAAAA TTTTACAGGT TTCCTTCAAA 
ACCAACAAGT CCCACAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102318.1
CDS	153..1133
Translation	MSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQEELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAISTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNMALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGISGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK

Target ORF information:

RefSeq Version	NM_001108848.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ELAV like RNA binding protein 1 (Elavl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108848.1

ORF Insert Sequence:

ATGTCTAATG GTTATGAAGA CCACATGGCG GAAGACTGCA GGGATGACAT TGGGAGAACG 
AATTTAATTG TCAACTACCT CCCTCAGAAC ATGACCCAGG AGGAACTACG GAGTCTGTTC 
AGCAGCATTG GCGAGGTTGA ATCTGCAAAA CTTATTCGGG ATAAAGTTGC AGGACACAGC 
TTGGGCTACG GCTTTGTGAA CTATGTTACT GCAAAAGATG CAGAGAGAGC AATCAGCACA 
CTGAACGGCT TGAGGCTTCA GTCCAAAACC ATTAAGGTAT CATATGCTCG CCCAAGCTCA 
GAGGTTATCA AAGATGCCAA CTTGTACATC AGTGGGCTTC CAAGGACCAT GACTCAGAAG 
GATGTGGAAG ACATGTTTTC TCGGTTTGGG CGAATCATCA ACTCCAGGGT CCTTGTGGAT 
CAGACCACAG GTTTGTCCAG AGGGGTTGCC TTTATCCGGT TTGACAAACG GTCTGAAGCA 
GAAGAGGCAA TTACCAGTTT CAATGGTCAT AAACCCCCGG GTTCCTCCGA GCCCATCACA 
GTGAAGTTTG CAGCCAATCC CAACCAGAAC AAAAACATGG CTCTCCTCTC GCAGCTGTAC 
CACTCGCCTG CTAGGAGGTT TGGAGGCCCT GTGCATCACC AGGCACAGAG ATTCAGGTTC 
TCCCCTATGG GTGTAGATCA CATGAGTGGG ATTTCTGGTG TCAATGTCCC CGGCAATGCT 
TCCTCGGGCT GGTGCATCTT CATCTACAAC CTTGGGCAAG ACGCCGATGA GGGGATCCTC 
TGGCAGATGT TTGGCCCCTT TGGTGCAGTT ACCAATGTGA AAGTGATTCG TGATTTCAAC 
ACCAACAAGT GCAAAGGGTT TGGTTTTGTG ACCATGACAA ACTATGAAGA AGCTGCAATG 
GCCATAGCAA GTCTGAACGG CTACCGCCTG GGGGACAAAA TTTTACAGGT TTCCTTCAAA 
ACCAACAAGT CCCACAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.
Biochimica et biophysica acta1864(1)296-306(2018 Jan)
Smedowski A,Liu X,Podracka L,Akhtar S,Trzeciecka A,Pietrucha-Dutczak M,Lewin-Kowalik J,Urtti A,Ruponen M,Kaarniranta K,Varjosalo M,Amadio M

Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.
Biochemical and biophysical research communications495(1)1249-1256(2018 01)
Maeda A,Uchida M,Nishikawa S,Nishino T,Konishi H

HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation.
Molecular and cellular biology37(7)(2017 Apr)
Liu L,Zhuang R,Xiao L,Chung HK,Luo J,Turner DJ,Rao JN,Gorospe M,Wang JY

Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Biochimica et biophysica acta1861(11)1816-1827(2016 11)
Nishino T,Matsunaga R,Jikihara H,Uchida M,Maeda A,Qi G,Abe T,Kiyonari H,Tashiro S,Inagaki-Ohara K,Shimamoto F,Konishi H

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Elavl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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