The following Nphp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nphp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa07918 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001191882.1 | |
| Accession Version | NM_001191882.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3978bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-02 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | nephrocystin-3 | |
| Comment | Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from AABR07071375.1 and AABR07071377.1. On Jul 17, 2010 this sequence version replaced XM_343461.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGCACAG CCTCGTCGTT GGTGAGCCCC GCTGGTGGGG AGGTGATCGA GGACACGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001178811.1 |
| CDS | 1..3978 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001191882.1 |
1 | ATGGGCACAG CCTCGTCGTT GGTGAGCCCC GCTGGTGGGG AGGTGATCGA GGACACGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Renal cyclooxygenase products are higher and lipoxygenase products are lower in early disease in the pcy mouse model of adolescent nephronophthisis. |
3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide. |
Targeting of Nphp3 to the primary cilia is controlled by an N-terminal myristoylation site and coiled-coil domains. |
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. |
Nephrocystin-3 is required for ciliary function in zebrafish embryos. |
