Carm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Carm1
Entrez Gene ID	363026
Full Name	coactivator-associated arginine methyltransferase 1
Synonyms	Prmt4
General protein information	Preferred Names coactivator-associated arginine methyltransferase 1 Names histone-arginine methyltransferase CARM1 coactivator-associated arginine methyltransferase 1 variant 5 protein arginine N-methyltransferase 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001030041.3	NP_001025212.1	histone-arginine methyltransferase CARM1 isoform a
NM_001034088.2	NP_001029260.1	histone-arginine methyltransferase CARM1 isoform d

Pathways from BioSystems

Homologies

	LOC715977	XP_002801119.1
Bos taurus (cattle)	CARM1	XP_005208862.1
Homo sapiens (human)	CARM1	NP_954592.1
Mus musculus (house mouse)	Carm1	NP_067506.2
Arabidopsis thaliana (thale cress)	PRMT4A	NP_974913.1
Oryza sativa (rice)	Os07g0671700	NP_001060600.1
Rattus norvegicus (Norway rat)	Carm1	NP_001025212.1
Danio rerio (zebrafish)	carm1	NP_001003645.1
Anopheles gambiae (African malaria mosquito)	CARM1_ANOGA	XP_318375.4
Canis lupus familiaris (dog)	CARM1	XP_005632937.1
Drosophila melanogaster (fruit fly)	Art4	NP_649963.1
Arabidopsis thaliana (thale cress)	PRMT4B	NP_850528.1
Xenopus tropicalis (tropical clawed frog)	carm1	XP_002942887.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons.
Lim CS, Alkon DL
The Journal of biological chemistry292(15)6402-6413(2017 04)

High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
Kim DI, Park MJ, Lim SK, Choi JH, Kim JC, Han HJ, Kundu TK, Park JI, Yoon KC, Park SW, Park JS, Heo YR, Park SH
Archives of biochemistry and biophysics56036-43(2014 Oct)

Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.
Kim D, Lim S, Park M, Choi J, Kim J, Han H, Yoon K, Kim K, Lim J, Park S
Cellular signalling26(9)1774-82(2014 Sep)

Readers of histone methylarginine marks.
Gayatri S, Bedford MT
Biochimica et biophysica acta1839(8)702-10(2014 Aug)

H3R42me2a is a histone modification with positive transcriptional effects.
Casadio F, Lu X, Pollock SB, LeRoy G, Garcia BA, Muir TW, Roeder RG, Allis CD
Proceedings of the National Academy of Sciences of the United States of America110(37)14894-9(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that CARM1 is a post-synaptic protein that plays roles in dendritic maturation and synaptic formation and that spatiotemporal regulation of CARM1 activity modulates neuronal connectivity and improves synaptic dysfunction.
Title: Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons.

high-glucose-induced CARM1 expression increases RPE cell apoptosis via H3R17 asymmetric dimethylation
Title: High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.

The silencing of CARM1 using siRNA increased Notch1 expression, the transcriptional activity of Hes, and podocyte apoptosis.
Title: Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.

aberrantly expressed CARM1 in tumor marker-positive cells promotes tumorigenesis in the early stages of hepatocarcinogenesis.
Title: Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis.

PKC may play an important role in neuronal differentiation and synaptogenesis via stimulating HuD-mediated mRNA stability and inhibiting CARM1 in hippocampal neurons
Title: Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture.

The following Carm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Carm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13208	NM_001030041.3 Latest version!	Rattus norvegicus coactivator-associated arginine methyltransferase 1 (Carm1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$356.30 $509.00
ORa13320	NM_001034088.2 Latest version!	Rattus norvegicus coactivator-associated arginine methyltransferase 1 (Carm1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Carm1 ( NM_001030041.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001025212.1 Rattus norvegicus coactivator-associated arginine methyltransferase 1 (Carm1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa13208
Clone ID Related Accession (Same CDS sequence)	NM_001030041.3
Accession Version	NM_001030041.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	histone-arginine methyltransferase CARM1 isoform a
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB201114.1. On Jun 15, 2007 this sequence version replaced NM_001030041.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB201114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCGG CGGCAGCGAC GGCGGTGGGG CCGGGTGCGG GGAGCGCTGG GGTGGCGGGC 
CCGGGCGGCG CGGGGCCCTG CGCGACAGTG TCGGTGTTCC CCGGCGCCCG CCTCCTCACT 
ATCGGCGACG CGAACGGCGA GATCCAGCGG CACGCGGAGC AGCAGGCGCT GCGCCTCGAG 
GTGCGCGCCG GACCAGACGC GGCGGGCATC GCCCTCTACA GCCATGAAGA TGTGTGTGTG 
TTCAAGTGCT CAGTGTCCCG AGAGACAGAG TGCAGCCGTG TGGGCAGGCA GTCCTTCATC 
ATCACACTGG GCTGCAACAG CGTCCTCATC CAGTTCGCCA CACCCCACGA TTTCTGTTCT 
TTCTACAACA TCCTGAAAAC CTGCCGGGGC CACACACTGG AGCGCTCTGT GTTCAGTGAG 
CGAACAGAGG AGTCCTCAGC TGTGCAGTAC TTCCAGTTTT ATGGCTACCT GTCCCAGCAG 
CAGAACATGA TGCAGGACTA TGTGCGAACA GGCACCTACC AGCGTGCAAT CCTGCAGAAC 
CACACCGACT TCAAGGACAA GATCGTTCTA GATGTGGGCT GTGGCTCTGG GATCCTGTCA 
TTCTTTGCTG CTCAAGCAGG AGCCAGGAAA ATTTACGCAG TGGAAGCCAG CACCATGGCT 
CAGCATGCCG AGGTCCTGGT GAAGAGTAAC AATCTGACAG ACCGCATCGT GGTCATCCCT 
GGCAAAGTAG AGGAGGTCTC ATTGCCTGAG CAAGTGGACA TTATCATCTC AGAGCCCATG 
GGCTACATGC TCTTCAACGA ACGTATGCTT GAGAGCTACC TCCATGCCAA AAAGTACCTG 
AAGCCCAGCG GCAACATGTT CCCCACCATT GGTGATGTTC ACCTTGCACC CTTCACTGAT 
GAACAGCTCT ACATGGAACA GTTCACCAAA GCCAACTTCT GGTACCAGCC ATCCTTCCAT 
GGAGTGGACC TGTCAGCCCT CCGAGGTGCC GCTGTGGATG AGTACTTCCG GCAACCTGTG 
GTGGACACAT TTGACATCCG GATCCTGATG GCCAAATCTG TCAAGTACAC AGTGAACTTC 
CTAGAAGCCA AAGAAGGCGA TTTGCACAGG ATAGAAATCC CATTCAAATT CCACATGCTG 
CATTCAGGGC TGGTCCACGG CTTGGCCTTC TGGTTCGATG TTGCTTTCAT TGGCTCCATA 
ATGACCGTGT GGCTCTCCAC AGCCCCAACA GAGCCCCTGA CCCACTGGTA CCAGGTCCGG 
TGCCTCTTCC AGTCACCGTT GTTTGCCAAG GCCGGGGACA CGCTCTCAGG GACATGTCTG 
CTTATTGCCA ACAAAAGACA GAGCTATGAC ATCAGTATTG TGGCACAGGT GGACCAGACA 
GGCTCCAAAT CCAGTAACCT GCTGGATCTA AAGAACCCCT TCTTCAGGTA CACAGGTACA 
ACCCCATCAC CCCCGCCTGG CTCACACTAC ACGTCTCCCT CGGAGAATAT GTGGAATACG 
GGAAGCACCT ACAATCTCAG CAGCGGGGTG GCTGTGGCTG GAATGCCTAC TGCCTACGAC 
CTGAGCAGTG TTATTGCTGG CGGCTCCAGC GTGGGTCACA ACAACCTGAT TCCCTTAGCC 
AACACAGGGA TTGTCAATCA CACCCACTCC CGGATGGGCT CCATAATGAG CACGGGCATT 
GTCCAAGGCT CCTCAGGTGC CCAGGGAGGC GGCGGTAGCT CCAGTGCCCA CTATGCAGTC 
AACAACCAGT TCACCATGGG TGGCCCTGCC ATCTCTATGG CCTCGCCCAT GTCCATCCCG 
ACCAACACCA TGCACTATGG GAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025212.1
CDS	91..1917
Translation	MAAAAATAVGPGAGSAGVAGPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDAAGIALYSHEDVCVFKCSVSRETECSRVGRQSFIITLGCNSVLIQFATPHDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGVAVAGMPTAYDLSSVIAGGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGAQGGGGSSSAHYAVNNQFTMGGPAISMASPMSIPTNTMHYGS

Target ORF information:

RefSeq Version	NM_001030041.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coactivator-associated arginine methyltransferase 1 (Carm1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001030041.3

ORF Insert Sequence:

ATGGCAGCGG CGGCAGCGAC GGCGGTGGGG CCGGGTGCGG GGAGCGCTGG GGTGGCGGGC 
CCGGGCGGCG CGGGGCCCTG CGCGACAGTG TCGGTGTTCC CCGGCGCCCG CCTCCTCACT 
ATCGGCGACG CGAACGGCGA GATCCAGCGG CACGCGGAGC AGCAGGCGCT GCGCCTCGAG 
GTGCGCGCCG GACCAGACGC GGCGGGCATC GCCCTCTACA GCCATGAAGA TGTGTGTGTG 
TTCAAGTGCT CAGTGTCCCG AGAGACAGAG TGCAGCCGTG TGGGCAGGCA GTCCTTCATC 
ATCACACTGG GCTGCAACAG CGTCCTCATC CAGTTCGCCA CACCCCACGA TTTCTGTTCT 
TTCTACAACA TCCTGAAAAC CTGCCGGGGC CACACACTGG AGCGCTCTGT GTTCAGTGAG 
CGAACAGAGG AGTCCTCAGC TGTGCAGTAC TTCCAGTTTT ATGGCTACCT GTCCCAGCAG 
CAGAACATGA TGCAGGACTA TGTGCGAACA GGCACCTACC AGCGTGCAAT CCTGCAGAAC 
CACACCGACT TCAAGGACAA GATCGTTCTA GATGTGGGCT GTGGCTCTGG GATCCTGTCA 
TTCTTTGCTG CTCAAGCAGG AGCCAGGAAA ATTTACGCAG TGGAAGCCAG CACCATGGCT 
CAGCATGCCG AGGTCCTGGT GAAGAGTAAC AATCTGACAG ACCGCATCGT GGTCATCCCT 
GGCAAAGTAG AGGAGGTCTC ATTGCCTGAG CAAGTGGACA TTATCATCTC AGAGCCCATG 
GGCTACATGC TCTTCAACGA ACGTATGCTT GAGAGCTACC TCCATGCCAA AAAGTACCTG 
AAGCCCAGCG GCAACATGTT CCCCACCATT GGTGATGTTC ACCTTGCACC CTTCACTGAT 
GAACAGCTCT ACATGGAACA GTTCACCAAA GCCAACTTCT GGTACCAGCC ATCCTTCCAT 
GGAGTGGACC TGTCAGCCCT CCGAGGTGCC GCTGTGGATG AGTACTTCCG GCAACCTGTG 
GTGGACACAT TTGACATCCG GATCCTGATG GCCAAATCTG TCAAGTACAC AGTGAACTTC 
CTAGAAGCCA AAGAAGGCGA TTTGCACAGG ATAGAAATCC CATTCAAATT CCACATGCTG 
CATTCAGGGC TGGTCCACGG CTTGGCCTTC TGGTTCGATG TTGCTTTCAT TGGCTCCATA 
ATGACCGTGT GGCTCTCCAC AGCCCCAACA GAGCCCCTGA CCCACTGGTA CCAGGTCCGG 
TGCCTCTTCC AGTCACCGTT GTTTGCCAAG GCCGGGGACA CGCTCTCAGG GACATGTCTG 
CTTATTGCCA ACAAAAGACA GAGCTATGAC ATCAGTATTG TGGCACAGGT GGACCAGACA 
GGCTCCAAAT CCAGTAACCT GCTGGATCTA AAGAACCCCT TCTTCAGGTA CACAGGTACA 
ACCCCATCAC CCCCGCCTGG CTCACACTAC ACGTCTCCCT CGGAGAATAT GTGGAATACG 
GGAAGCACCT ACAATCTCAG CAGCGGGGTG GCTGTGGCTG GAATGCCTAC TGCCTACGAC 
CTGAGCAGTG TTATTGCTGG CGGCTCCAGC GTGGGTCACA ACAACCTGAT TCCCTTAGCC 
AACACAGGGA TTGTCAATCA CACCCACTCC CGGATGGGCT CCATAATGAG CACGGGCATT 
GTCCAAGGCT CCTCAGGTGC CCAGGGAGGC GGCGGTAGCT CCAGTGCCCA CTATGCAGTC 
AACAACCAGT TCACCATGGG TGGCCCTGCC ATCTCTATGG CCTCGCCCAT GTCCATCCCG 
ACCAACACCA TGCACTATGG GAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Carm1 ( NM_001034088.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029260.1 Rattus norvegicus coactivator-associated arginine methyltransferase 1 (Carm1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	ORa13320
Clone ID Related Accession (Same CDS sequence)	NM_001034088.2
Accession Version	NM_001034088.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1758bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	histone-arginine methyltransferase CARM1 isoform d
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB201117.1. On Jun 15, 2007 this sequence version replaced NM_001034088.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB201117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCGG CGGCAGCGAC GGCGGTGGGG CCGGGTGCGG GGAGCGCTGG GGTGGCGGGC 
CCGGGCGGCG CGGGGCCCTG CGCGACAGTG TCGGTGTTCC CCGGCGCCCG CCTCCTCACT 
ATCGGCGACG CGAACGGCGA GATCCAGCGG CACGCGGAGC AGCAGGCGCT GCGCCTCGAG 
GTGCGCGCCG GACCAGACGC GGCGGGCATC GCCCTCTACA GCCATGAAGA TGTGTGTGTG 
TTCAAGTGCT CAGTGTCCCG AGAGACAGAG TGCAGCCGTG TGGGCAGGCA GTCCTTCATC 
ATCACACTGG GCTGCAACAG CGTCCTCATC CAGTTCGCCA CACCCCACGA TTTCTGTTCT 
TTCTACAACA TCCTGAAAAC CTGCCGGGGC CACACACTGG AGCGCTCTGT GTTCAGTGAG 
CGAACAGAGG AGTCCTCAGC TGTGCAGTAC TTCCAGTTTT ATGGCTACCT GTCCCAGCAG 
CAGAACATGA TGCAGGACTA TGTGCGAACA GGCACCTACC AGCGTGCAAT CCTGCAGAAC 
CACACCGACT TCAAGGACAA GATCGTTCTA GATGTGGGCT GTGGCTCTGG GATCCTGTCA 
TTCTTTGCTG CTCAAGCAGG AGCCAGGAAA ATTTACGCAG TGGAAGCCAG CACCATGGCT 
CAGCATGCCG AGGTCCTGGT GAAGAGTAAC AATCTGACAG ACCGCATCGT GGTCATCCCT 
GGCAAAGTAG AGGAGGTCTC ATTGCCTGAG CAAGTGGACA TTATCATCTC AGAGCCCATG 
GGCTACATGC TCTTCAACGA ACGTATGCTT GAGAGCTACC TCCATGCCAA AAAGTACCTG 
AAGCCCAGCG GCAACATGTT CCCCACCATT GGTGATGTTC ACCTTGCACC CTTCACTGAT 
GAACAGCTCT ACATGGAACA GTTCACCAAA GCCAACTTCT GGTACCAGCC ATCCTTCCAT 
GGAGTGGACC TGTCAGCCCT CCGAGGTGCC GCTGTGGATG AGTACTTCCG GCAACCTGTG 
GTGGACACAT TTGACATCCG GATCCTGATG GCCAAATCTG TCAAGTACAC AGTGAACTTC 
CTAGAAGCCA AAGAAGGCGA TTTGCACAGG ATAGAAATCC CATTCAAATT CCACATGCTG 
CATTCAGGGC TGGTCCACGG CTTGGCCTTC TGGTTCGATG TTGCTTTCAT TGGCTCCATA 
ATGACCGTGT GGCTCTCCAC AGCCCCAACA GAGCCCCTGA CCCACTGGTA CCAGGTCCGG 
TGCCTCTTCC AGTCACCGTT GTTTGCCAAG GCCGGGGACA CGCTCTCAGG GACATGTCTG 
CTTATTGCCA ACAAAAGACA GAGCTATGAC ATCAGTATTG TGGCACAGGT GGACCAGACA 
GGCTCCAAAT CCAGTAACCT GCTGGATCTA AAGAACCCCT TCTTCAGGTA CACAGGTACA 
ACCCCATCAC CCCCGCCTGG CTCACACTAC ACGTCTCCCT CGGAGAATAT GTGGAATACG 
GGAAGCACCT ACAATCTCAG CAGCGGGGTG GCTGTGGCTG GAATGCCTAC TGCCTACGAC 
CTGAGCAGTG TTATTGCTGG CGGCTCCAGC GTGGGTCACA ACAACCTGAT TCCCTTAGGC 
TCCTCAGGTG CCCAGGGAGG CGGCGGTAGC TCCAGTGCCC ACTATGCAGT CAACAACCAG 
TTCACCATGG GTGGCCCTGC CATCTCTATG GCCTCGCCCA TGTCCATCCC GACCAACACC 
ATGCACTATG GGAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029260.1
CDS	91..1848
Translation	MAAAAATAVGPGAGSAGVAGPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDAAGIALYSHEDVCVFKCSVSRETECSRVGRQSFIITLGCNSVLIQFATPHDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGVAVAGMPTAYDLSSVIAGGSSVGHNNLIPLGSSGAQGGGGSSSAHYAVNNQFTMGGPAISMASPMSIPTNTMHYGS

Target ORF information:

RefSeq Version	NM_001034088.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coactivator-associated arginine methyltransferase 1 (Carm1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034088.2

ORF Insert Sequence:

ATGGCAGCGG CGGCAGCGAC GGCGGTGGGG CCGGGTGCGG GGAGCGCTGG GGTGGCGGGC 
CCGGGCGGCG CGGGGCCCTG CGCGACAGTG TCGGTGTTCC CCGGCGCCCG CCTCCTCACT 
ATCGGCGACG CGAACGGCGA GATCCAGCGG CACGCGGAGC AGCAGGCGCT GCGCCTCGAG 
GTGCGCGCCG GACCAGACGC GGCGGGCATC GCCCTCTACA GCCATGAAGA TGTGTGTGTG 
TTCAAGTGCT CAGTGTCCCG AGAGACAGAG TGCAGCCGTG TGGGCAGGCA GTCCTTCATC 
ATCACACTGG GCTGCAACAG CGTCCTCATC CAGTTCGCCA CACCCCACGA TTTCTGTTCT 
TTCTACAACA TCCTGAAAAC CTGCCGGGGC CACACACTGG AGCGCTCTGT GTTCAGTGAG 
CGAACAGAGG AGTCCTCAGC TGTGCAGTAC TTCCAGTTTT ATGGCTACCT GTCCCAGCAG 
CAGAACATGA TGCAGGACTA TGTGCGAACA GGCACCTACC AGCGTGCAAT CCTGCAGAAC 
CACACCGACT TCAAGGACAA GATCGTTCTA GATGTGGGCT GTGGCTCTGG GATCCTGTCA 
TTCTTTGCTG CTCAAGCAGG AGCCAGGAAA ATTTACGCAG TGGAAGCCAG CACCATGGCT 
CAGCATGCCG AGGTCCTGGT GAAGAGTAAC AATCTGACAG ACCGCATCGT GGTCATCCCT 
GGCAAAGTAG AGGAGGTCTC ATTGCCTGAG CAAGTGGACA TTATCATCTC AGAGCCCATG 
GGCTACATGC TCTTCAACGA ACGTATGCTT GAGAGCTACC TCCATGCCAA AAAGTACCTG 
AAGCCCAGCG GCAACATGTT CCCCACCATT GGTGATGTTC ACCTTGCACC CTTCACTGAT 
GAACAGCTCT ACATGGAACA GTTCACCAAA GCCAACTTCT GGTACCAGCC ATCCTTCCAT 
GGAGTGGACC TGTCAGCCCT CCGAGGTGCC GCTGTGGATG AGTACTTCCG GCAACCTGTG 
GTGGACACAT TTGACATCCG GATCCTGATG GCCAAATCTG TCAAGTACAC AGTGAACTTC 
CTAGAAGCCA AAGAAGGCGA TTTGCACAGG ATAGAAATCC CATTCAAATT CCACATGCTG 
CATTCAGGGC TGGTCCACGG CTTGGCCTTC TGGTTCGATG TTGCTTTCAT TGGCTCCATA 
ATGACCGTGT GGCTCTCCAC AGCCCCAACA GAGCCCCTGA CCCACTGGTA CCAGGTCCGG 
TGCCTCTTCC AGTCACCGTT GTTTGCCAAG GCCGGGGACA CGCTCTCAGG GACATGTCTG 
CTTATTGCCA ACAAAAGACA GAGCTATGAC ATCAGTATTG TGGCACAGGT GGACCAGACA 
GGCTCCAAAT CCAGTAACCT GCTGGATCTA AAGAACCCCT TCTTCAGGTA CACAGGTACA 
ACCCCATCAC CCCCGCCTGG CTCACACTAC ACGTCTCCCT CGGAGAATAT GTGGAATACG 
GGAAGCACCT ACAATCTCAG CAGCGGGGTG GCTGTGGCTG GAATGCCTAC TGCCTACGAC 
CTGAGCAGTG TTATTGCTGG CGGCTCCAGC GTGGGTCACA ACAACCTGAT TCCCTTAGGC 
TCCTCAGGTG CCCAGGGAGG CGGCGGTAGC TCCAGTGCCC ACTATGCAGT CAACAACCAG 
TTCACCATGG GTGGCCCTGC CATCTCTATG GCCTCGCCCA TGTCCATCCC GACCAACACC 
ATGCACTATG GGAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of coactivator-associated arginine methyltransferase 1 modulates dendritic arborization and spine maturation of cultured hippocampal neurons.
The Journal of biological chemistry292(15)6402-6413(2017 04)
Lim CS,Alkon DL

High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
Archives of biochemistry and biophysics56036-43(2014 Oct)
Kim DI,Park MJ,Lim SK,Choi JH,Kim JC,Han HJ,Kundu TK,Park JI,Yoon KC,Park SW,Park JS,Heo YR,Park SH

Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.
Cellular signalling26(9)1774-82(2014 Sep)
Kim D,Lim S,Park M,Choi J,Kim J,Han H,Yoon K,Kim K,Lim J,Park S

Readers of histone methylarginine marks.
Biochimica et biophysica acta1839(8)702-10(2014 Aug)
Gayatri S,Bedford MT

H3R42me2a is a histone modification with positive transcriptional effects.
Proceedings of the National Academy of Sciences of the United States of America110(37)14894-9(2013 Sep)
Casadio F,Lu X,Pollock SB,LeRoy G,Garcia BA,Muir TW,Roeder RG,Allis CD

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Carm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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