Cyp46a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp46a1
Entrez Gene ID	362782
Full Name	cytochrome P450, family 46, subfamily a, polypeptide 1
General protein information	Preferred Names cytochrome P450, family 46, subfamily a, polypeptide 1 Names cholesterol 24-hydroxylase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32

mRNA and Protein(s)

mRNA	Protein	Name
XM_006240548.3	XP_006240610.1	cholesterol 24-hydroxylase isoform X1
NM_001108723.1	NP_001102193.1	cholesterol 24-hydroxylase

Pathways from BioSystems

Homologies

	LOC705843	XP_001103455.2
Gallus gallus (chicken)	CYP46A1	NP_001238956.1
Arabidopsis thaliana (thale cress)	CYP97A3	NP_564384.1
Canis lupus familiaris (dog)	CYP46A1	XP_005623990.1
Rattus norvegicus (Norway rat)	Cyp46a1	NP_001102193.1
Magnaporthe oryzae (rice blast fungus)	MGG_04469	XP_003710992.1
Xenopus tropicalis (tropical clawed frog)	mgc108213	NP_001027517.1
Xenopus tropicalis (tropical clawed frog)	mgc108077	NP_001027519.1
Mus musculus (house mouse)	Cyp46a1	NP_034140.1
Xenopus tropicalis (tropical clawed frog)	cyp46a1	NP_001072550.1
Homo sapiens (human)	CYP46A1	NP_006659.1
Pan troglodytes (chimpanzee)	CYP46A1	XP_510158.3
Bos taurus (cattle)	CYP46A1	NP_001070278.1
Magnaporthe oryzae (rice blast fungus)	MGG_14217	XP_003720504.1
Oryza sativa (rice)	Os02g0817900	NP_001048526.1

Gene Ontology
Bibliography

Related articles in PubMed

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.
Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP
Journal of lipid research55(9)1933-43(2014 Sep)

Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
Mast N, Zheng W, Stout CD, Pikuleva IA
The Journal of biological chemistry288(7)4613-24(2013 Feb)

Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
Mast N, Charvet C, Pikuleva IA, Stout CD
The Journal of biological chemistry285(41)31783-95(2010 Oct)

Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in a time-dependent manner.
Smiljanic K, Lavrnja I, Mladenovic Djordjevic A, Ruzdijic S, Stojiljkovic M, Pekovic S, Kanazir S
Histochemistry and cell biology134(2)159-69(2010 Aug)

Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.
Cartagena CM, Ahmed F, Burns MP, Pajoohesh-Ganji A, Pak DT, Faden AI, Rebeck GW
Journal of neurotrauma25(9)1087-98(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

in pathological conditions, like brain injury, Cyp46 displayed atypical expression, being expressed not only in neuronal cells, but also in microglia and astrocytes
Title: Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in a time-dependent manner.

increased microglial Cyp46 activity is part of a system for removal of damaged cell membranes post-injury
Title: Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.

Neural retina specifically expresses cholesterol-24S-hydroxylase, a metabolizing enzyme responsible for the removal of cholesterol in neurons. May be valuable gene candidate for retinal pathologies.
Title: Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina.

The following Cyp46a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp46a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41557	NM_001108723.1 Latest version!	Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa29611	XM_006240548.3 Latest version!	Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp46a1 ( NM_001108723.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102193.1 Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA.

Price & Availability↑

CloneID	ORa41557
Clone ID Related Accession (Same CDS sequence)	NM_001108723.1
Accession Version	NM_001108723.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	cholesterol 24-hydroxylase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474034.2. On or before Oct 4, 2007 this sequence version replaced XM_001069311.1, XM_343108.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTCCACCA AGTACAACAA GGACTCCAAG ATGTACCGTG CGATTCAGAC TGTGTTCGGA 
GAGAGACTGT TTGGCCAGGG CTTGGTGTCT GAATGTGACT ATGGGCGCTG GTATAAGCAG 
AGAAGAGTCA TGGACTTGGC CTTCAGTCGC AGCTCCTTGG TTAGCCTGAT GGGGACGTTC 
AATGAGAAGG CAGAGCAGCT GATGGAAATT CTAGAAGCTA AGGCGGACGG ACAGACACCG 
GTGTCCATGC AGGACATGCT GACCTGTGCC ACCATCGACA TCCTGGCCAA GGCAGCTTTT 
GGGATGGAGA CCAGTATGCT ACTGGGCGCC CAGAAACCCC TGTCCCAGGC AGTGAAGGTC 
ATGCTGGAGG GTATCAGTGC GTCCCGTAAC ACCCTGGCGA AGTTCATGCC AGGGAAGAGA 
AAGCAGCTTC GGGAGATCCG AGAGAGCATC CGCCTGTTAC GCCAGGTGGG GAAGGATTGG 
GTGCAGCGCC GCCGTGAGGC CCTGAAGAGG GGTGAGGACG TGCCGGCCGA CATCCTCACG 
CAGATTCTCA AAGCTGAAGA GGGAGCCCAG GACGACGAGG TTCTGCTCGA CAACTTTGTT 
ACCTTCTTCA TTGCGGGTCA TGAGACTTCC GCCAACCATC TGGCATTCAC AGTGATGGAG 
TTGTCTCGAC AGCCGGAGAT CGTGGCAAGG CTGCAGGCCG AGGTGGATGA GGTGGTCGGT 
TCCAAGCGGC ACCTGGACTA CGAGGATCTG GGGAGACTGC AGTACCTGTC ACAGGTCCTC 
AAAGAGTCTC TGAGGCTGTA CCCACCAGCA TGGGGCACCT TTCGCCTGCT GGAAGAGGAG 
ACCTTGATTG ATGGGGTCAG AGTCCCTGGC AACACTCCTC TCCTGTTCAG CACCTATGTC 
ATGGGGAGGA TGGACACCTA CTTTGAGGAT CCACTGACTT TCAACCCTGA CCGCTTCGGC 
CCTGGAGCGC CCAAGCCGAG GTTTACCTAC TTCCCCTTTT CCCTGGGCCA CCGGTCCTGC 
ATCGGGCAGC AGTTTGCTCA GATGGAGGTG AAAGTCGTTA TGGCCAAGCT GCTTCAGAGG 
CTCGAATTCC GGCTGGTACC TGGGCAGCGC TTTGGGCTGC AAGAGCAGGC TACGCTCAAG 
CCACTGGACC CTGTGCTGTG CACCCTGAGG CCCCGGGGCT GGCAGCCTGC ACCCCCACCC 
CCACCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102193.1
CDS	698..1909
Translation	MSTKYNKDSKMYRAIQTVFGERLFGQGLVSECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDVPADILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC

Target ORF information:

RefSeq Version	NM_001108723.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108723.1

ORF Insert Sequence:

ATGTCCACCA AGTACAACAA GGACTCCAAG ATGTACCGTG CGATTCAGAC TGTGTTCGGA 
GAGAGACTGT TTGGCCAGGG CTTGGTGTCT GAATGTGACT ATGGGCGCTG GTATAAGCAG 
AGAAGAGTCA TGGACTTGGC CTTCAGTCGC AGCTCCTTGG TTAGCCTGAT GGGGACGTTC 
AATGAGAAGG CAGAGCAGCT GATGGAAATT CTAGAAGCTA AGGCGGACGG ACAGACACCG 
GTGTCCATGC AGGACATGCT GACCTGTGCC ACCATCGACA TCCTGGCCAA GGCAGCTTTT 
GGGATGGAGA CCAGTATGCT ACTGGGCGCC CAGAAACCCC TGTCCCAGGC AGTGAAGGTC 
ATGCTGGAGG GTATCAGTGC GTCCCGTAAC ACCCTGGCGA AGTTCATGCC AGGGAAGAGA 
AAGCAGCTTC GGGAGATCCG AGAGAGCATC CGCCTGTTAC GCCAGGTGGG GAAGGATTGG 
GTGCAGCGCC GCCGTGAGGC CCTGAAGAGG GGTGAGGACG TGCCGGCCGA CATCCTCACG 
CAGATTCTCA AAGCTGAAGA GGGAGCCCAG GACGACGAGG TTCTGCTCGA CAACTTTGTT 
ACCTTCTTCA TTGCGGGTCA TGAGACTTCC GCCAACCATC TGGCATTCAC AGTGATGGAG 
TTGTCTCGAC AGCCGGAGAT CGTGGCAAGG CTGCAGGCCG AGGTGGATGA GGTGGTCGGT 
TCCAAGCGGC ACCTGGACTA CGAGGATCTG GGGAGACTGC AGTACCTGTC ACAGGTCCTC 
AAAGAGTCTC TGAGGCTGTA CCCACCAGCA TGGGGCACCT TTCGCCTGCT GGAAGAGGAG 
ACCTTGATTG ATGGGGTCAG AGTCCCTGGC AACACTCCTC TCCTGTTCAG CACCTATGTC 
ATGGGGAGGA TGGACACCTA CTTTGAGGAT CCACTGACTT TCAACCCTGA CCGCTTCGGC 
CCTGGAGCGC CCAAGCCGAG GTTTACCTAC TTCCCCTTTT CCCTGGGCCA CCGGTCCTGC 
ATCGGGCAGC AGTTTGCTCA GATGGAGGTG AAAGTCGTTA TGGCCAAGCT GCTTCAGAGG 
CTCGAATTCC GGCTGGTACC TGGGCAGCGC TTTGGGCTGC AAGAGCAGGC TACGCTCAAG 
CCACTGGACC CTGTGCTGTG CACCCTGAGG CCCCGGGGCT GGCAGCCTGC ACCCCCACCC 
CCACCCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cyp46a1 ( XM_006240548.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240610.1 Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29611
Clone ID Related Accession (Same CDS sequence)	XM_006240548.3
Accession Version	XM_006240548.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cholesterol 24-hydroxylase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240548.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCCCCG GGCTGCTGTT GCTCGGCAGT GCCGTCCTGC TCGCCTTCGG CCTCTGCTGC 
ACCTTCGTGC ATCGCGCTCG CAGCCGCTAT GAGCACATCC CCGGGCCGCC GCGGCCCAGC 
TTCCTTCTGG GACATCTCCC CTACTTTTGG AAAAAGGACG AAGCTTGTGG CCGTGTGCTC 
CAAGACGTGT TTTTGGATTG GGCTAAGAAG TATGGTCCTG TTGTGAGAGT CAATGTCTTC 
CACAAAACCT CAGTCATCGT CACGAGTCCT GAGTCAGTCA AGAAGTTCCT GATGTCCACC 
AAGTACAACA AGGACTCCAA GATGTACCGT GCGATTCAGA CTGTGTTCGG AGAGAGACTG 
TTTGGCCAGG GCTTGGTGTC TGAATGTGAC TATGGGCGCT GGTATAAGCA GAGAAGAGTC 
ATGGACTTGG CCTTCAGTCG CAGCTCCTTG GTTAGCCTGA TGGGGACGTT CAATGAGAAG 
GCAGAGCAGC TGATGGAAAT TCTAGAAGCT AAGGCGGACG GACAGACACC GGTGTCCATG 
CAGGACATGC TGACCTGTGC CACCATCGAC ATCCTGGCCA AGGCAGCTTT TGGGATGGAG 
ACCAGTATGC TACTGGGCGC CCAGAAACCC CTGTCCCAGG CAGTGAAGGT CATGCTGGAG 
GGTATCAGTG CGTCCCGTAA CACCCTGGCG AAGTTCATGC CAGGGAAGAG AAAGCAGCTT 
CGGGAGATCC GAGAGAGCAT CCGCCTGTTA CGCCAGGTGG GGAAGGATTG GGTGCAGCGC 
CGCCGTGAGG CCCTGAAGAG GGGTGAGGAC GTGCCGGCCG ACATCCTCAC GCAGATTCTC 
AAAGCTGAAG AGGGAGCCCA GGACGACGAG GTTCTGCTCG ACAACTTTGT TACCTTCTTC 
ATTGCGGGTC ATGAGACTTC CGCCAACCAT CTGGCATTCA CAGTGATGGA GTTGTCTCGA 
CAGCCGGAGA TCGTGGCAAG GCTGCAGGCC GAGGTGGATG AGGTGGTCGG TTCCAAGCGG 
CACCTGGACT ACGAGGATCT GGGGAGACTG CAGTACCTGT CACAGGTCCT CAAAGAGTCT 
CTGAGGCTGT ACCCACCAGC ATGGGGCACC TTTCGCCTGC TGGAAGAGGA GACCTTGATT 
GATGGGGTCA GAGTCCCTGG CAACACTCCT CTCCTGTTCA GCACCTATGT CATGGGGAGG 
ATGGACACCT ACTTTGAGGA TCCACTGACT TTCAACCCTG ACCGCTTCGG CCCTGGAGCG 
CCCAAGCCGA GGTTTACCTA CTTCCCCTTT TCCCTGGGCC ACCGGTCCTG CATCGGGCAG 
CAGTTTGCTC AGATGGAGGT GAAAGTCGTT ATGGCCAAGC TGCTTCAGAG GCTCGAATTC 
CGGCTGGTAC CTGGGCAGCG CTTTGGGCTG CAAGAGCAGG CTACGCTCAA GCCACTGGAC 
CCTGTGCTGT GCACCCTGAG GCCCCGGGGC TGGCAGCCTG CACCCCCACC CCCACCCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240610.1
CDS	133..1635
Translation	MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEACGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFGQGLVSECDYGRWYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDVPADILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC

Target ORF information:

RefSeq Version	XM_006240548.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240548.3

ORF Insert Sequence:

ATGAGCCCCG GGCTGCTGTT GCTCGGCAGT GCCGTCCTGC TCGCCTTCGG CCTCTGCTGC 
ACCTTCGTGC ATCGCGCTCG CAGCCGCTAT GAGCACATCC CCGGGCCGCC GCGGCCCAGC 
TTCCTTCTGG GACATCTCCC CTACTTTTGG AAAAAGGACG AAGCTTGTGG CCGTGTGCTC 
CAAGACGTGT TTTTGGATTG GGCTAAGAAG TATGGTCCTG TTGTGAGAGT CAATGTCTTC 
CACAAAACCT CAGTCATCGT CACGAGTCCT GAGTCAGTCA AGAAGTTCCT GATGTCCACC 
AAGTACAACA AGGACTCCAA GATGTACCGT GCGATTCAGA CTGTGTTCGG AGAGAGACTG 
TTTGGCCAGG GCTTGGTGTC TGAATGTGAC TATGGGCGCT GGTATAAGCA GAGAAGAGTC 
ATGGACTTGG CCTTCAGTCG CAGCTCCTTG GTTAGCCTGA TGGGGACGTT CAATGAGAAG 
GCAGAGCAGC TGATGGAAAT TCTAGAAGCT AAGGCGGACG GACAGACACC GGTGTCCATG 
CAGGACATGC TGACCTGTGC CACCATCGAC ATCCTGGCCA AGGCAGCTTT TGGGATGGAG 
ACCAGTATGC TACTGGGCGC CCAGAAACCC CTGTCCCAGG CAGTGAAGGT CATGCTGGAG 
GGTATCAGTG CGTCCCGTAA CACCCTGGCG AAGTTCATGC CAGGGAAGAG AAAGCAGCTT 
CGGGAGATCC GAGAGAGCAT CCGCCTGTTA CGCCAGGTGG GGAAGGATTG GGTGCAGCGC 
CGCCGTGAGG CCCTGAAGAG GGGTGAGGAC GTGCCGGCCG ACATCCTCAC GCAGATTCTC 
AAAGCTGAAG AGGGAGCCCA GGACGACGAG GTTCTGCTCG ACAACTTTGT TACCTTCTTC 
ATTGCGGGTC ATGAGACTTC CGCCAACCAT CTGGCATTCA CAGTGATGGA GTTGTCTCGA 
CAGCCGGAGA TCGTGGCAAG GCTGCAGGCC GAGGTGGATG AGGTGGTCGG TTCCAAGCGG 
CACCTGGACT ACGAGGATCT GGGGAGACTG CAGTACCTGT CACAGGTCCT CAAAGAGTCT 
CTGAGGCTGT ACCCACCAGC ATGGGGCACC TTTCGCCTGC TGGAAGAGGA GACCTTGATT 
GATGGGGTCA GAGTCCCTGG CAACACTCCT CTCCTGTTCA GCACCTATGT CATGGGGAGG 
ATGGACACCT ACTTTGAGGA TCCACTGACT TTCAACCCTG ACCGCTTCGG CCCTGGAGCG 
CCCAAGCCGA GGTTTACCTA CTTCCCCTTT TCCCTGGGCC ACCGGTCCTG CATCGGGCAG 
CAGTTTGCTC AGATGGAGGT GAAAGTCGTT ATGGCCAAGC TGCTTCAGAG GCTCGAATTC 
CGGCTGGTAC CTGGGCAGCG CTTTGGGCTG CAAGAGCAGG CTACGCTCAA GCCACTGGAC 
CCTGTGCTGT GCACCCTGAG GCCCCGGGGC TGGCAGCCTG CACCCCCACC CCCACCCTGC 
TGA