Coch cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Coch
Entrez Gene ID	362735
Full Name	cochlin
General protein information	Preferred Names cochlin Names cochlin coagulation factor C homolog (Limulus polyphemus) coagulation factor C homolog, cochlin (Limulus polyphemus)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q23

mRNA and Protein(s)

mRNA	Protein	Name
XM_017594223.1	XP_017449712.1	cochlin isoform X2
NM_001108710.1	NP_001102180.1	cochlin precursor
XM_017594222.1	XP_017449711.1	cochlin isoform X1
NM_001108710.2	NP_001102180.2	cochlin precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.
Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J
Immunity38(5)1063-72(2013 May)

Cochlin expression in the rat perilymph during postnatal development.
Shiiba K, Shindo S, Ikezono T, Sekine K, Matsumura T, Sekiguchi S, Yagi T, Okubo K
Acta oto-laryngologica132(11)1134-9(2012 Nov)

A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain.
Cho HJ, Park HJ, Trexler M, Venselaar H, Lee KY, Robertson NG, Baek JI, Kang BS, Morton CC, Vriend G, Patthy L, Kim UK
Journal of molecular medicine (Berlin, Germany)90(11)1321-1331(2012 Nov)

Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder.
Jones SM, Robertson NG, Given S, Giersch AB, Liberman MC, Morton CC
Hearing research272(1-2)42-8(2011 Feb)

Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility.
Goel M, Sienkiewicz AE, Picciani R, Lee RK, Bhattacharya SK
PloS one6(8)e23070(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expression in perilymph detected from 3rd day after birth (DAB3), gradually increased to DAB15, then gradually decreased to DAB70
Title: Cochlin expression in the rat perilymph during postnatal development.

The expression of cochlin may be related to the maturation of inner ear function.
Title: Spatiotemporal expression of cochlin in the inner ear of rats during postnatal development.

Cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles.
Title: Ultrastructural co-localization of cochlin and type II collagen in the rat semicircular canal.

The following Coch gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Coch cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08190	NM_001108710.1 Latest version!	Rattus norvegicus cochlin (Coch), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa61656	NM_001108710.2 Latest version!	Rattus norvegicus cochlin (Coch), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa61656	XM_017594222.1 Latest version!	Rattus norvegicus cochlin (Coch), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa61657	XM_017594223.1 Latest version!	Rattus norvegicus cochlin (Coch), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Coch ( NM_001108710.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102180.1 Rattus norvegicus cochlin (Coch), mRNA.

Price & Availability↑

CloneID	ORa08190
Clone ID Related Accession (Same CDS sequence)	NM_001108710.1
Accession Version	NM_001108710.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	cochlin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473947.1. On or before Oct 4, 2007 this sequence version replaced XM_343058.3, XM_001078654.1. ##Evidence-Data-START## Transcript exon combination :: CA340347.1, FQ140478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGGTAGGAAA TGCGAAGCTG TTCCCCTGTT ACCTGGCAAC 
AATTTGGAGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102180.1
CDS	69..563
Translation	MPSSWSPALCLGAWLLLLLLPRLARAEGAVPIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAVSTANPPSGRKCEAVPLLPGNNLEP

Target ORF information:

RefSeq Version	NM_001108710.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cochlin (Coch), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108710.1

ORF Insert Sequence:

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGGTAGGAAA TGCGAAGCTG TTCCCCTGTT ACCTGGCAAC 
AATTTGGAGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Coch ( NM_001108710.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102180.2 Rattus norvegicus cochlin (Coch), mRNA.

Price & Availability↑

CloneID	ORa61656
Clone ID Related Accession (Same CDS sequence)	XM_017594222.1 , NM_001108710.2
Accession Version	NM_001108710.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-03
Organism	Rattus norvegicus(Norway rat)
Product	cochlin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC160874.1. On or before Sep 4, 2019 this sequence version replaced XM_017594222.1, NM_001108710.1. ##Evidence-Data-START## Transcript exon combination :: BC160874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGGTAAAAGA CTGAAGAAAA CACCGGAGAA GAAGACTGGC 
AATAAAGACT GCAAGGCAGA CATTGCATTT CTCATCGATG GAAGCTTTAA TATAGGGCAG 
CGCCGATTTA ATTTGCAGAA GAATTTTGTT GGGAAGGTGG CACTAATGTT GGGAGTTGGA 
ACCGAAGGAC CACACGTGGG CCTCGTTCAA GCCAGTGAAC ACCCCAAAAT AGAATTTTAC 
TTGAAAAACT TTACTTCGGC CAAAGATGTC TTGTTTGCCA TAAAAGAAGT AGGTTTCCGA 
GGGGGTAACT CCAACACAGG AAAAGCTTTG AAGCACACTG CTCAGAAATT CTTTACAGCA 
GACACTGGTG TGAGAAAAGG AATACCAAAA GTGGTGGTGG TGTTTATTGA TGGTTGGCCT 
TCTGATGACA TTGAGGAAGC AGGCATTGTG GCCAGAGAGT TTGGTGTCAA TGTATTTATA 
GTTTCCGTGG CCAAGCCCAT CCCTGAAGAA CTGGGGATGG TTCAAGATGT TGCATTTGTT 
GACAAGGCTG TGTGCAGGAA TAATGGCTTC TTCTCTTATC ACATGCCCAA CTGGTTTGGC 
ACTACAAAAT ATGTAAAGCC TCTGGTGCAG AAGCTCTGTA CTCATGAACA GATGATGTGC 
AGCAAAACCT GTTACAACTC AGTCAATATT GCCTTTCTGA TTGATGGCTC CAGCAGCGTT 
GGAGATAGCA ATTTCCGCCT CATGCTTGAA TTTGTTTCTA ACATAGCGAA GACATTTGAA 
ATCTCAGACA TTGGAGCCAA GATAGCAGCT GTACAGTTCA CTTATGATCA GCGCACAGAA 
TTCAGTTTCA CTGACTATAA CACCAAAGAG AACGTCCTAG CTGTCCTAGC GAATATACGC 
TACATGAGTG GTGGGACAGC TACGGGTGAT GCCATTTCCT TTACTGTTAG AAATGTATTT 
GGTCCCATAA GGGACAGCCC CAACAAAAAC TTCCTGGTTA TTGTCACAGA TGGACAGTCC 
TACGATGATG TCCGAGGTCC AGCTGCAGCT GCCCATGATG CAGGTATCAC CATCTTCTCT 
GTTGGTGTGG CTTGGGCACC TCTGGATGAC CTGAAAGACA TGGCCTCTAA ACCCAAAGAG 
TCCCACGCCT TCTTTACCAG AGAGTTTACA GGATTGGAAC CGATTGTCTC TGATGTCATT 
AGAGGCATCT GTAGAGATTT CTTAGAATCC CAGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102180.2
CDS	40..1698
Translation	MPSSWSPALCLGAWLLLLLLPRLARAEGAVPIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAVSTANPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGVGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYNTKENVLAVLANIRYMSGGTATGDAISFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ

Target ORF information:

RefSeq Version	NM_001108710.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cochlin (Coch), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108710.2

ORF Insert Sequence:

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGGTAAAAGA CTGAAGAAAA CACCGGAGAA GAAGACTGGC 
AATAAAGACT GCAAGGCAGA CATTGCATTT CTCATCGATG GAAGCTTTAA TATAGGGCAG 
CGCCGATTTA ATTTGCAGAA GAATTTTGTT GGGAAGGTGG CACTAATGTT GGGAGTTGGA 
ACCGAAGGAC CACACGTGGG CCTCGTTCAA GCCAGTGAAC ACCCCAAAAT AGAATTTTAC 
TTGAAAAACT TTACTTCGGC CAAAGATGTC TTGTTTGCCA TAAAAGAAGT AGGTTTCCGA 
GGGGGTAACT CCAACACAGG AAAAGCTTTG AAGCACACTG CTCAGAAATT CTTTACAGCA 
GACACTGGTG TGAGAAAAGG AATACCAAAA GTGGTGGTGG TGTTTATTGA TGGTTGGCCT 
TCTGATGACA TTGAGGAAGC AGGCATTGTG GCCAGAGAGT TTGGTGTCAA TGTATTTATA 
GTTTCCGTGG CCAAGCCCAT CCCTGAAGAA CTGGGGATGG TTCAAGATGT TGCATTTGTT 
GACAAGGCTG TGTGCAGGAA TAATGGCTTC TTCTCTTATC ACATGCCCAA CTGGTTTGGC 
ACTACAAAAT ATGTAAAGCC TCTGGTGCAG AAGCTCTGTA CTCATGAACA GATGATGTGC 
AGCAAAACCT GTTACAACTC AGTCAATATT GCCTTTCTGA TTGATGGCTC CAGCAGCGTT 
GGAGATAGCA ATTTCCGCCT CATGCTTGAA TTTGTTTCTA ACATAGCGAA GACATTTGAA 
ATCTCAGACA TTGGAGCCAA GATAGCAGCT GTACAGTTCA CTTATGATCA GCGCACAGAA 
TTCAGTTTCA CTGACTATAA CACCAAAGAG AACGTCCTAG CTGTCCTAGC GAATATACGC 
TACATGAGTG GTGGGACAGC TACGGGTGAT GCCATTTCCT TTACTGTTAG AAATGTATTT 
GGTCCCATAA GGGACAGCCC CAACAAAAAC TTCCTGGTTA TTGTCACAGA TGGACAGTCC 
TACGATGATG TCCGAGGTCC AGCTGCAGCT GCCCATGATG CAGGTATCAC CATCTTCTCT 
GTTGGTGTGG CTTGGGCACC TCTGGATGAC CTGAAAGACA TGGCCTCTAA ACCCAAAGAG 
TCCCACGCCT TCTTTACCAG AGAGTTTACA GGATTGGAAC CGATTGTCTC TGATGTCATT 
AGAGGCATCT GTAGAGATTT CTTAGAATCC CAGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Coch ( XM_017594222.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449711.1 Rattus norvegicus cochlin (Coch), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61656
Clone ID Related Accession (Same CDS sequence)	XM_017594222.1 , NM_001108710.2
Accession Version	XM_017594222.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cochlin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGGTAAAAGA CTGAAGAAAA CACCGGAGAA GAAGACTGGC 
AATAAAGACT GCAAGGCAGA CATTGCATTT CTCATCGATG GAAGCTTTAA TATAGGGCAG 
CGCCGATTTA ATTTGCAGAA GAATTTTGTT GGGAAGGTGG CACTAATGTT GGGAGTTGGA 
ACCGAAGGAC CACACGTGGG CCTCGTTCAA GCCAGTGAAC ACCCCAAAAT AGAATTTTAC 
TTGAAAAACT TTACTTCGGC CAAAGATGTC TTGTTTGCCA TAAAAGAAGT AGGTTTCCGA 
GGGGGTAACT CCAACACAGG AAAAGCTTTG AAGCACACTG CTCAGAAATT CTTTACAGCA 
GACACTGGTG TGAGAAAAGG AATACCAAAA GTGGTGGTGG TGTTTATTGA TGGTTGGCCT 
TCTGATGACA TTGAGGAAGC AGGCATTGTG GCCAGAGAGT TTGGTGTCAA TGTATTTATA 
GTTTCCGTGG CCAAGCCCAT CCCTGAAGAA CTGGGGATGG TTCAAGATGT TGCATTTGTT 
GACAAGGCTG TGTGCAGGAA TAATGGCTTC TTCTCTTATC ACATGCCCAA CTGGTTTGGC 
ACTACAAAAT ATGTAAAGCC TCTGGTGCAG AAGCTCTGTA CTCATGAACA GATGATGTGC 
AGCAAAACCT GTTACAACTC AGTCAATATT GCCTTTCTGA TTGATGGCTC CAGCAGCGTT 
GGAGATAGCA ATTTCCGCCT CATGCTTGAA TTTGTTTCTA ACATAGCGAA GACATTTGAA 
ATCTCAGACA TTGGAGCCAA GATAGCAGCT GTACAGTTCA CTTATGATCA GCGCACAGAA 
TTCAGTTTCA CTGACTATAA CACCAAAGAG AACGTCCTAG CTGTCCTAGC GAATATACGC 
TACATGAGTG GTGGGACAGC TACGGGTGAT GCCATTTCCT TTACTGTTAG AAATGTATTT 
GGTCCCATAA GGGACAGCCC CAACAAAAAC TTCCTGGTTA TTGTCACAGA TGGACAGTCC 
TACGATGATG TCCGAGGTCC AGCTGCAGCT GCCCATGATG CAGGTATCAC CATCTTCTCT 
GTTGGTGTGG CTTGGGCACC TCTGGATGAC CTGAAAGACA TGGCCTCTAA ACCCAAAGAG 
TCCCACGCCT TCTTTACCAG AGAGTTTACA GGATTGGAAC CGATTGTCTC TGATGTCATT 
AGAGGCATCT GTAGAGATTT CTTAGAATCC CAGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449711.1
CDS	129..1787
Translation	MPSSWSPALCLGAWLLLLLLPRLARAEGAVPIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAVSTANPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGVGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYNTKENVLAVLANIRYMSGGTATGDAISFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ

Target ORF information:

RefSeq Version	XM_017594222.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cochlin (Coch), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594222.1

ORF Insert Sequence:

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGGTAAAAGA CTGAAGAAAA CACCGGAGAA GAAGACTGGC 
AATAAAGACT GCAAGGCAGA CATTGCATTT CTCATCGATG GAAGCTTTAA TATAGGGCAG 
CGCCGATTTA ATTTGCAGAA GAATTTTGTT GGGAAGGTGG CACTAATGTT GGGAGTTGGA 
ACCGAAGGAC CACACGTGGG CCTCGTTCAA GCCAGTGAAC ACCCCAAAAT AGAATTTTAC 
TTGAAAAACT TTACTTCGGC CAAAGATGTC TTGTTTGCCA TAAAAGAAGT AGGTTTCCGA 
GGGGGTAACT CCAACACAGG AAAAGCTTTG AAGCACACTG CTCAGAAATT CTTTACAGCA 
GACACTGGTG TGAGAAAAGG AATACCAAAA GTGGTGGTGG TGTTTATTGA TGGTTGGCCT 
TCTGATGACA TTGAGGAAGC AGGCATTGTG GCCAGAGAGT TTGGTGTCAA TGTATTTATA 
GTTTCCGTGG CCAAGCCCAT CCCTGAAGAA CTGGGGATGG TTCAAGATGT TGCATTTGTT 
GACAAGGCTG TGTGCAGGAA TAATGGCTTC TTCTCTTATC ACATGCCCAA CTGGTTTGGC 
ACTACAAAAT ATGTAAAGCC TCTGGTGCAG AAGCTCTGTA CTCATGAACA GATGATGTGC 
AGCAAAACCT GTTACAACTC AGTCAATATT GCCTTTCTGA TTGATGGCTC CAGCAGCGTT 
GGAGATAGCA ATTTCCGCCT CATGCTTGAA TTTGTTTCTA ACATAGCGAA GACATTTGAA 
ATCTCAGACA TTGGAGCCAA GATAGCAGCT GTACAGTTCA CTTATGATCA GCGCACAGAA 
TTCAGTTTCA CTGACTATAA CACCAAAGAG AACGTCCTAG CTGTCCTAGC GAATATACGC 
TACATGAGTG GTGGGACAGC TACGGGTGAT GCCATTTCCT TTACTGTTAG AAATGTATTT 
GGTCCCATAA GGGACAGCCC CAACAAAAAC TTCCTGGTTA TTGTCACAGA TGGACAGTCC 
TACGATGATG TCCGAGGTCC AGCTGCAGCT GCCCATGATG CAGGTATCAC CATCTTCTCT 
GTTGGTGTGG CTTGGGCACC TCTGGATGAC CTGAAAGACA TGGCCTCTAA ACCCAAAGAG 
TCCCACGCCT TCTTTACCAG AGAGTTTACA GGATTGGAAC CGATTGTCTC TGATGTCATT 
AGAGGCATCT GTAGAGATTT CTTAGAATCC CAGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Coch ( XM_017594223.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449712.1 Rattus norvegicus cochlin (Coch), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa61657
Clone ID Related Accession (Same CDS sequence)	XM_017594223.1
Accession Version	XM_017594223.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cochlin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGACTGCAAG GCAGACATTG CATTTCTCAT CGATGGAAGC 
TTTAATATAG GGCAGCGCCG ATTTAATTTG CAGAAGAATT TTGTTGGGAA GGTGGCACTA 
ATGTTGGGAG TTGGAACCGA AGGACCACAC GTGGGCCTCG TTCAAGCCAG TGAACACCCC 
AAAATAGAAT TTTACTTGAA AAACTTTACT TCGGCCAAAG ATGTCTTGTT TGCCATAAAA 
GAAGTAGGTT TCCGAGGGGG TAACTCCAAC ACAGGAAAAG CTTTGAAGCA CACTGCTCAG 
AAATTCTTTA CAGCAGACAC TGGTGTGAGA AAAGGAATAC CAAAAGTGGT GGTGGTGTTT 
ATTGATGGTT GGCCTTCTGA TGACATTGAG GAAGCAGGCA TTGTGGCCAG AGAGTTTGGT 
GTCAATGTAT TTATAGTTTC CGTGGCCAAG CCCATCCCTG AAGAACTGGG GATGGTTCAA 
GATGTTGCAT TTGTTGACAA GGCTGTGTGC AGGAATAATG GCTTCTTCTC TTATCACATG 
CCCAACTGGT TTGGCACTAC AAAATATGTA AAGCCTCTGG TGCAGAAGCT CTGTACTCAT 
GAACAGATGA TGTGCAGCAA AACCTGTTAC AACTCAGTCA ATATTGCCTT TCTGATTGAT 
GGCTCCAGCA GCGTTGGAGA TAGCAATTTC CGCCTCATGC TTGAATTTGT TTCTAACATA 
GCGAAGACAT TTGAAATCTC AGACATTGGA GCCAAGATAG CAGCTGTACA GTTCACTTAT 
GATCAGCGCA CAGAATTCAG TTTCACTGAC TATAACACCA AAGAGAACGT CCTAGCTGTC 
CTAGCGAATA TACGCTACAT GAGTGGTGGG ACAGCTACGG GTGATGCCAT TTCCTTTACT 
GTTAGAAATG TATTTGGTCC CATAAGGGAC AGCCCCAACA AAAACTTCCT GGTTATTGTC 
ACAGATGGAC AGTCCTACGA TGATGTCCGA GGTCCAGCTG CAGCTGCCCA TGATGCAGGT 
ATCACCATCT TCTCTGTTGG TGTGGCTTGG GCACCTCTGG ATGACCTGAA AGACATGGCC 
TCTAAACCCA AAGAGTCCCA CGCCTTCTTT ACCAGAGAGT TTACAGGATT GGAACCGATT 
GTCTCTGATG TCATTAGAGG CATCTGTAGA GATTTCTTAG AATCCCAGCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449712.1
CDS	153..1766
Translation	MPSSWSPALCLGAWLLLLLLPRLARAEGAVPIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAVSTANPPSDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGVGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYNTKENVLAVLANIRYMSGGTATGDAISFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ

Target ORF information:

RefSeq Version	XM_017594223.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cochlin (Coch), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594223.1

ORF Insert Sequence:

ATGCCCTCGT CCTGGAGCCC TGCTCTCTGC CTCGGTGCGT GGCTGCTGCT GCTGCTGCTG 
CCTCGGCTCG CGCGCGCGGA GGGAGCCGTG CCCATCCCCA TCACCTGCTT TACCAGAGGC 
CTGGATATCC GGAAAGAAAA AGCGGATGTT CTCTGCCCAG GAGGCTGCTC TCTGGAGGAA 
TTTTCTGTGT TTGGGAACAT AGTGTATGCC TCGGTGTCCA GCATCTGCGG GGCTGCTGTC 
CACAGGGGAG TGATTGGCAC CTCAGGGGGC CCAGTGCGTG TCTATAGCCT TCCTGGTAGA 
GAGAACTATT CCTCGGTGGC TGCCAATGGC ATTCAGTCTC AGACCCTTTC CAGATGGTCT 
GCTTCCTTCG CTGTGACCAA AGGCAAAAGC AGTACCCAGG AAGCCACGGG ACGGGCAGTG 
TCCACAGCCA ATCCGCCCTC AGACTGCAAG GCAGACATTG CATTTCTCAT CGATGGAAGC 
TTTAATATAG GGCAGCGCCG ATTTAATTTG CAGAAGAATT TTGTTGGGAA GGTGGCACTA 
ATGTTGGGAG TTGGAACCGA AGGACCACAC GTGGGCCTCG TTCAAGCCAG TGAACACCCC 
AAAATAGAAT TTTACTTGAA AAACTTTACT TCGGCCAAAG ATGTCTTGTT TGCCATAAAA 
GAAGTAGGTT TCCGAGGGGG TAACTCCAAC ACAGGAAAAG CTTTGAAGCA CACTGCTCAG 
AAATTCTTTA CAGCAGACAC TGGTGTGAGA AAAGGAATAC CAAAAGTGGT GGTGGTGTTT 
ATTGATGGTT GGCCTTCTGA TGACATTGAG GAAGCAGGCA TTGTGGCCAG AGAGTTTGGT 
GTCAATGTAT TTATAGTTTC CGTGGCCAAG CCCATCCCTG AAGAACTGGG GATGGTTCAA 
GATGTTGCAT TTGTTGACAA GGCTGTGTGC AGGAATAATG GCTTCTTCTC TTATCACATG 
CCCAACTGGT TTGGCACTAC AAAATATGTA AAGCCTCTGG TGCAGAAGCT CTGTACTCAT 
GAACAGATGA TGTGCAGCAA AACCTGTTAC AACTCAGTCA ATATTGCCTT TCTGATTGAT 
GGCTCCAGCA GCGTTGGAGA TAGCAATTTC CGCCTCATGC TTGAATTTGT TTCTAACATA 
GCGAAGACAT TTGAAATCTC AGACATTGGA GCCAAGATAG CAGCTGTACA GTTCACTTAT 
GATCAGCGCA CAGAATTCAG TTTCACTGAC TATAACACCA AAGAGAACGT CCTAGCTGTC 
CTAGCGAATA TACGCTACAT GAGTGGTGGG ACAGCTACGG GTGATGCCAT TTCCTTTACT 
GTTAGAAATG TATTTGGTCC CATAAGGGAC AGCCCCAACA AAAACTTCCT GGTTATTGTC 
ACAGATGGAC AGTCCTACGA TGATGTCCGA GGTCCAGCTG CAGCTGCCCA TGATGCAGGT 
ATCACCATCT TCTCTGTTGG TGTGGCTTGG GCACCTCTGG ATGACCTGAA AGACATGGCC 
TCTAAACCCA AAGAGTCCCA CGCCTTCTTT ACCAGAGAGT TTACAGGATT GGAACCGATT 
GTCTCTGATG TCATTAGAGG CATCTGTAGA GATTTCTTAG AATCCCAGCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.
Immunity38(5)1063-72(2013 May)
Py BF,Gonzalez SF,Long K,Kim MS,Kim YA,Zhu H,Yao J,Degauque N,Villet R,Ymele-Leki P,Gadjeva M,Pier GB,Carroll MC,Yuan J

Cochlin expression in the rat perilymph during postnatal development.
Acta oto-laryngologica132(11)1134-9(2012 Nov)
Shiiba K,Shindo S,Ikezono T,Sekine K,Matsumura T,Sekiguchi S,Yagi T,Okubo K

A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain.
Journal of molecular medicine (Berlin, Germany)90(11)1321-1331(2012 Nov)
Cho HJ,Park HJ,Trexler M,Venselaar H,Lee KY,Robertson NG,Baek JI,Kang BS,Morton CC,Vriend G,Patthy L,Kim UK

Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder.
Hearing research272(1-2)42-8(2011 Feb)
Jones SM,Robertson NG,Given S,Giersch AB,Liberman MC,Morton CC

Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility.
PloS one6(8)e23070(2011)
Goel M,Sienkiewicz AE,Picciani R,Lee RK,Bhattacharya SK

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Coch cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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