Tp73 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tp73
Entrez Gene ID	362675
Full Name	tumor protein p73
Synonyms	P73,Trp73
General protein information	Preferred Names tumor protein p73 Names tumor protein p73 transformation related protein 73
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108696.1	NP_001102166.1	tumor protein p73

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Tp73	NP_001102166.1
Canis lupus familiaris (dog)	TP73	XP_005620496.1
Mus musculus (house mouse)	Trp73	NP_035772.2
Danio rerio (zebrafish)	tp73	NP_899183.1
Xenopus tropicalis (tropical clawed frog)	tp73	XP_002933901.2
Homo sapiens (human)	TP73	NP_005418.1
	LOC695164	XP_001083217.2
Bos taurus (cattle)	LOC515105	XP_005217245.1
Gallus gallus (chicken)	TP73	XP_004947424.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional interplay between MDM2, p63/p73 and mutant p53.
Stindt MH, Muller PA, Ludwig RL, Kehrloesser S, D?tsch V, Vousden KH
Oncogene34(33)4300-10(2015 Aug)

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].
Polato F, Rusconi P, Zangrossi S, Morelli F, Boeri M, Musi A, Marchini S, Castiglioni V, Scanziani E, Torri V, Broggini M
Journal of the National Cancer Institute106(4)dju053(2014 Apr)

The expression of p73 in the organum vasculosum of the lamina terminalis and choroid plexus of spontaneously hypertensive rats.
Carmona-Calero EM, Casta?eyra-Ruiz L, Gonz?lez-Toledo JM, de Paz-Carmona H, Brage C, Casta?eyra-Ruiz A, Rancel-Torres MN, Gonz?lez-Marrero I, Casta?eyra-Perdomo A
Histology and histopathology28(7)925-32(2013 07)

p53 mutations in cancer.
Muller PA, Vousden KH
Nature cell biology15(1)2-8(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expression of p73 is weaker in the organum vasculosum of the lamina terminalis and stronger in the choroid plexus of hypertensive rats than in control rats
Title: The expression of p73 in the organum vasculosum of the lamina terminalis and choroid plexus of spontaneously hypertensive rats.

glucocorticoids negative impact on fetal brain development likely is due to the modulation of the pro-survival dominant negative p63 and p73 gene variants
Title: Glucocorticoid-induced fetal brain growth restriction is associated with p73 gene activation.

The main upstream stimulus activating the c-Abl/p73 pathway and neuronal apoptosis in Niemann-Pick type C neurons is oxidative stress.
Title: Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons.

The pro-survival response of neurons, initiated through the rapid induction of p63, is mediated ultimately by the transcriptional repression of a pro-apoptotic isoform of p73 by ZEB1.
Title: ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia.

P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
Title: P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.

The following Tp73 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tp73 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42829	NM_001108696.1 Latest version!	Rattus norvegicus tumor protein p73 (Tp73), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$405.30 $579.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tp73 ( NM_001108696.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102166.1 Rattus norvegicus tumor protein p73 (Tp73), mRNA.

Price & Availability↑

CloneID	ORa42829
Clone ID Related Accession (Same CDS sequence)	NM_001108696.1
Accession Version	NM_001108696.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Rattus norvegicus(Norway rat)
Product	tumor protein p73
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473968.1. On or before Oct 4, 2007 this sequence version replaced XM_342992.3, XM_001077013.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMEA2689595 [ECO:0000350] ##Evidence-Data-END##

ATGTCATCAC CTAGGCAACT GGACGCTTAT GCCACTGCCC TGCCACTGCA AGCCACAGGA 
CCTCCAGCAC CTCTGCCCAA GTCTACGGAC CCATCCAGGG CCCAGGTTCA GCCAAGAATG 
AGCAACGGCG TCGGGGAGAT GGCCCAGTCC TCTTCCTCCT CCTCTTCCTC CTCCACCTTC 
GAGCACCTGT GGAGTTCTCT GGAGCCAGAC AGTACCTACT TTGACCTTCC CCAGCCCAGC 
CAAGGGAATA GCGAGGCAAC GGGCAGCGAG GAGTCCAACA TGGATGTCTT CCACCTGCAA 
GGCATGACCT CCTCCGTCAT GGCCCAGTTC AATTTGCTCA GCAGCGCCAT GGACCAGATG 
GGCAGCCGCG CGGCCCCGGC CAGCCCCTAC ACCCCGGAGC ACGCCGCCAG CGCACCCACC 
CACTCGCCCT ACGCGCAGCC CAGCTCCACC TTCGACACCA TGTCTCCAGC GCCTGTCATC 
CCTTCCAACA CCGACTACCC TGGTCCCCAC CACTTCGAGG TCACCTTCCA GCAGTCGAGC 
ACAGCCAAGT CGGCCACCTG GACATACTCC CCACTTTTGA AGAAGTTGTA CTGTCAGATT 
GCCAAGACAT GCCCCATCCA GATCAAAGTG TCCACACCAC CACCTCCGGG CACGGCCATC 
CGGGCCATGC CCGTCTACAA GAAGGCAGAG CATGTGACCG ACATTGTTAA GCGCTGTCCC 
AACCACGAGC TTGGAAGGGA CTTCAATGAA GGACAGTCTG CTCCGGCTAG TCACCTCATC 
CGTGTGGAAG GCAACAACCT CTCCCAATAT GTGGATGACC CTGTCACCGG CAGGCAGAGT 
GTGGTTGTGC CATATGAACC CCCACAGGTA GGAACAGAAT TCACCACCAT CTTGTACAAC 
TTCATGTGTA ACAGCAGCTG CGTAGGGGGC ATGAATCGGA GACCCATCCT CGTCATCATC 
ACCCTGGAGA CCCGGGATGG ACAGGTACTG GGCCGGCGGT CTTTCGAGGG CCGCATCTGC 
GCCTGTCCTG GCCGTGACCG AAAGGCCGAT GAAGACCATT ACCGGGAGCA ACAGGCTCTG 
AATGAAAGCA CCACCAAGAA CGGGGCTGCC AGCAAACGTG CGTTCAAGCA GAGCCCCCCT 
GCCATCCCTG CCCTGGGTAC CAACGTAAAG AAGAGACGCC ATGGTGACGA GGACATGTTC 
TACATGCATG TTCGAGGCCG GGAGAACTTT GAGATCTTGA TGAAAGTCAA GGAGAGCCTA 
GAGCTGATGG AGCTTGTGCC GCAGCCTTTG GTTGACTCCT ACCGACAGCA ACAGCAGCAG 
CAGCTCCTAC AGAGGCCGAG TCACCTGCAG CCTCCCTCCT ATGGGCCCGT GCTGTCCCCA 
ATGAACAAGG TACACGGTGG TGTCAACAAA CTGCCCTCTG TCAACCAGCT GGTAGGCCAG 
CCTCCCCCAC ACAGCTCTGC AGCTGGGCCC AACCTGGGGT CCATGGGTTC CGGGATACTC 
AACAGCCACA GCCACAGCAT GCCAGCCAAT GGAGAGATGA ATGGAGGCCA CAGCTCCCAG 
ACCATGGTTT CCGGATCCCA CTGCACCCCG CCACCCCCGT ACCATGCCGA CCCCAGCCTC 
GTCAGTTTTT TGACAGGGTT GGGGTGTCCG AACTGTATCG AGTGCTTCAC TTCCCAAGGG 
TTACAGAGCA TCTACCACCT GCAGAACCTC ACCATCGAGG ACCTTGGGGC CCTGAAGATC 
CCTGACCAGT ACCGTATGAC CATCTGGAGG GGCCTACAGG ACCTGAAGCA GAGCCATGAC 
TGCGGTCAGC AGCTTCTACG CTCCAGCAGC AACGCGGCCA CCATCTCCAT CGGCGGCTCT 
GGCGAGCTGC AGCGGCAGCG GGTCATGGAA GCCGTGCATT TCCGCGTGCG CCACACCATC 
ACGATCCCCA ACCGCGGAGG CGCGGGTGGC GTGACGGGCC CCGACGAGTG GGCAGACTTT 
GGCTTTGACC TGCCTGACTG CAAGTCCCGT AAGCAGCCCA TCAAAGAGGA GTTCACAGAG 
ACAGAGAGCC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102166.1
CDS	4..2058
Translation	MSSPRQLDAYATALPLQATGPPAPLPKSTDPSRAQVQPRMSNGVGEMAQSSSSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGNSEATGSEESNMDVFHLQGMTSSVMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGSMGSGILNSHSHSMPANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKIPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGGVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH

Target ORF information:

RefSeq Version	NM_001108696.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tumor protein p73 (Tp73), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108696.1

ORF Insert Sequence:

ATGTCATCAC CTAGGCAACT GGACGCTTAT GCCACTGCCC TGCCACTGCA AGCCACAGGA 
CCTCCAGCAC CTCTGCCCAA GTCTACGGAC CCATCCAGGG CCCAGGTTCA GCCAAGAATG 
AGCAACGGCG TCGGGGAGAT GGCCCAGTCC TCTTCCTCCT CCTCTTCCTC CTCCACCTTC 
GAGCACCTGT GGAGTTCTCT GGAGCCAGAC AGTACCTACT TTGACCTTCC CCAGCCCAGC 
CAAGGGAATA GCGAGGCAAC GGGCAGCGAG GAGTCCAACA TGGATGTCTT CCACCTGCAA 
GGCATGACCT CCTCCGTCAT GGCCCAGTTC AATTTGCTCA GCAGCGCCAT GGACCAGATG 
GGCAGCCGCG CGGCCCCGGC CAGCCCCTAC ACCCCGGAGC ACGCCGCCAG CGCACCCACC 
CACTCGCCCT ACGCGCAGCC CAGCTCCACC TTCGACACCA TGTCTCCAGC GCCTGTCATC 
CCTTCCAACA CCGACTACCC TGGTCCCCAC CACTTCGAGG TCACCTTCCA GCAGTCGAGC 
ACAGCCAAGT CGGCCACCTG GACATACTCC CCACTTTTGA AGAAGTTGTA CTGTCAGATT 
GCCAAGACAT GCCCCATCCA GATCAAAGTG TCCACACCAC CACCTCCGGG CACGGCCATC 
CGGGCCATGC CCGTCTACAA GAAGGCAGAG CATGTGACCG ACATTGTTAA GCGCTGTCCC 
AACCACGAGC TTGGAAGGGA CTTCAATGAA GGACAGTCTG CTCCGGCTAG TCACCTCATC 
CGTGTGGAAG GCAACAACCT CTCCCAATAT GTGGATGACC CTGTCACCGG CAGGCAGAGT 
GTGGTTGTGC CATATGAACC CCCACAGGTA GGAACAGAAT TCACCACCAT CTTGTACAAC 
TTCATGTGTA ACAGCAGCTG CGTAGGGGGC ATGAATCGGA GACCCATCCT CGTCATCATC 
ACCCTGGAGA CCCGGGATGG ACAGGTACTG GGCCGGCGGT CTTTCGAGGG CCGCATCTGC 
GCCTGTCCTG GCCGTGACCG AAAGGCCGAT GAAGACCATT ACCGGGAGCA ACAGGCTCTG 
AATGAAAGCA CCACCAAGAA CGGGGCTGCC AGCAAACGTG CGTTCAAGCA GAGCCCCCCT 
GCCATCCCTG CCCTGGGTAC CAACGTAAAG AAGAGACGCC ATGGTGACGA GGACATGTTC 
TACATGCATG TTCGAGGCCG GGAGAACTTT GAGATCTTGA TGAAAGTCAA GGAGAGCCTA 
GAGCTGATGG AGCTTGTGCC GCAGCCTTTG GTTGACTCCT ACCGACAGCA ACAGCAGCAG 
CAGCTCCTAC AGAGGCCGAG TCACCTGCAG CCTCCCTCCT ATGGGCCCGT GCTGTCCCCA 
ATGAACAAGG TACACGGTGG TGTCAACAAA CTGCCCTCTG TCAACCAGCT GGTAGGCCAG 
CCTCCCCCAC ACAGCTCTGC AGCTGGGCCC AACCTGGGGT CCATGGGTTC CGGGATACTC 
AACAGCCACA GCCACAGCAT GCCAGCCAAT GGAGAGATGA ATGGAGGCCA CAGCTCCCAG 
ACCATGGTTT CCGGATCCCA CTGCACCCCG CCACCCCCGT ACCATGCCGA CCCCAGCCTC 
GTCAGTTTTT TGACAGGGTT GGGGTGTCCG AACTGTATCG AGTGCTTCAC TTCCCAAGGG 
TTACAGAGCA TCTACCACCT GCAGAACCTC ACCATCGAGG ACCTTGGGGC CCTGAAGATC 
CCTGACCAGT ACCGTATGAC CATCTGGAGG GGCCTACAGG ACCTGAAGCA GAGCCATGAC 
TGCGGTCAGC AGCTTCTACG CTCCAGCAGC AACGCGGCCA CCATCTCCAT CGGCGGCTCT 
GGCGAGCTGC AGCGGCAGCG GGTCATGGAA GCCGTGCATT TCCGCGTGCG CCACACCATC 
ACGATCCCCA ACCGCGGAGG CGCGGGTGGC GTGACGGGCC CCGACGAGTG GGCAGACTTT 
GGCTTTGACC TGCCTGACTG CAAGTCCCGT AAGCAGCCCA TCAAAGAGGA GTTCACAGAG 
ACAGAGAGCC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional interplay between MDM2, p63/p73 and mutant p53.
Oncogene34(33)4300-10(2015 Aug)
Stindt MH,Muller PA,Ludwig RL,Kehrloesser S,D?tsch V,Vousden KH

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].
Journal of the National Cancer Institute106(4)dju053(2014 Apr)
Polato F,Rusconi P,Zangrossi S,Morelli F,Boeri M,Musi A,Marchini S,Castiglioni V,Scanziani E,Torri V,Broggini M

The expression of p73 in the organum vasculosum of the lamina terminalis and choroid plexus of spontaneously hypertensive rats.
Histology and histopathology28(7)925-32(2013 07)
Carmona-Calero EM,Casta?eyra-Ruiz L,Gonz?lez-Toledo JM,de Paz-Carmona H,Brage C,Casta?eyra-Ruiz A,Rancel-Torres MN,Gonz?lez-Marrero I,Casta?eyra-Perdomo A

p53 mutations in cancer.
Nature cell biology15(1)2-8(2013 Jan)
Muller PA,Vousden KH

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Tp73 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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